Complementary therapies in medicine最新文献

{"title":"Effects of Wenfei Guyuan umbilical moxibustion on patients with stable chronic obstructive pulmonary disease: A multicenter randomized controlled trial","authors":"Qionghua Xiao , Yuanyuan Meng , Gaoming Wang , Minghang Wang , Yong Meng , Miao Zhou","doi":"10.1016/j.ctim.2025.103194","DOIUrl":"10.1016/j.ctim.2025.103194","url":null,"abstract":"<div><h3>Background</h3><div>Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease. Its high disability rate, high mortality rate, and heavy economic burden have made it a major public health problem. Umbilical moxibustion has been reported to have therapeutic effects on COPD, but there is a lack of high-quality evidence-based studies on this intervention. Therefore, the purpose of this study is to evaluate the efficacy and safety of Wenfei Guyuan (WFGY) umbilical moxibustion in the treatment of COPD.</div></div><div><h3>Methods</h3><div>This was a multicenter, open-label, randomized controlled trial (RCT). A total of 220 participants were randomly assigned at a 1:1 ratio to the experimental group (WFGY umbilical moxibustion in combination with conventional drugs) and the control group (conventional drugs). Both groups received 13 weeks of treatment, followed by 26 weeks of follow-up. The primary outcome was the frequency of acute exacerbations, and the secondary outcomes were the 6-minute walk distance (6MWD), modified Medical Research Council dyspnea scale (mMRC) score, clinical symptoms and signs scores, and lung function tests. Statistical analysis was performed using SPSS software (version 25.0).</div></div><div><h3>Results</h3><div>A total of 220 participants were included in the study, and 215 participants completed the trial. There were significant time effects and group effects on the frequency of acute exacerbations (P < 0.001, P = 0.001), but no interaction effects (P = 0.406). Compared with the control group, the frequency of acute exacerbations in the experimental group was significantly reduced at 4 and 13 weeks of treatment and at 13 and 26 weeks of follow-up (P < 0.05). Among the secondary outcomes, there were significant time effects, group effects, and interaction effects on the 6MWD, mMRC scores, and clinical symptoms and signs scores (cough, expectoration, wheezing, chest tightness, shortness of breath, fatigue, cyanosis, and total scores) at different time points between the two groups (P < 0.05). FVC and FEV1 had no time effects, group effects, or interaction effects (P > 0.05). FEV1 % had group effects (P < 0.05) but no time effects or interaction effects (P > 0.05). The overall skin sensitization incidence in the experimental group was 3.74 %, which was slightly higher than the 0 % incidence in the control group, but no statistically significant difference was observed between the two groups (P > 0.05).</div></div><div><h3>Conclusions</h3><div>The experimental group demonstrated superior efficacy to the control group in reducing the frequency of acute exacerbations, enhancing exercise tolerance, reducing dyspnea severity, and improving quality of life. This intervention demonstrated effectiveness and safety in the treatment of stable COPD, providing a foundation for further research.</div></div><div><h3>Trial registration</h3><div><span><span>https://www.chictr.org.cn</sp","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"92 ","pages":"Article 103194"},"PeriodicalIF":3.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music interventions in patients undergoing surgery: A systematic review using strict inclusion criteria","authors":"Roos Geensen ,&nbsp;Thomas L.A. Dirven ,&nbsp;Florine H.E. Bax ,&nbsp;Markus Klimek ,&nbsp;Johannes Jeekel","doi":"10.1016/j.ctim.2025.103195","DOIUrl":"10.1016/j.ctim.2025.103195","url":null,"abstract":"<div><h3>Background</h3><div>Music interventions in healthcare have been proven effective. However, studies often are of low quality and lack adequate methodology. Our objective was to assess literature concerning the effect of music on pain, anxiety, subjective stress and patient satisfaction using narrowed inclusion criteria and assess their methodology (e.g. sample size calculation and randomization method).</div></div><div><h3>Methods</h3><div>Seven databases were searched from 1980 until the 5th of July, 2024. Narrowed exclusion criteria were used. We included randomized controlled trials (RCT) which assessed recorded music versus standard of care in surgical patients. Bias was assessed using the Cochrane Risk-of-Bias 2 tool (RoB 2.0).</div></div><div><h3>Results</h3><div>Ten studies were included (1114 patients). In six articles, anxiety was significantly reduced through a music intervention. Four articles reported a significant reduction of pain. Stress was assessed by one study, and was significantly lower in the intervention group compared to the control group. Patient satisfaction was assessed in three studies, all reporting higher satisfaction in the intervention group. Methodological quality was low, only three studies reported a sufficient sample size. Overall Risk of Bias was considered high.</div></div><div><h3>Conclusion</h3><div>Music interventions pre-, during or post-surgery were associated with a significant decrease in pain, anxiety and a higher patient satisfaction. Despite our narrowed exclusion criteria, overall risk of bias was considered high in all studies. Reproducibility of sample size calculations was considered poor. Future systematic reviews should more strictly assess control groups procedures, randomization procedures and sample size calculations of RCT’s. Future RCT’s should sufficiently implement these methods.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"92 ","pages":"Article 103195"},"PeriodicalIF":3.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different mind-body exercises on pain in patients with knee osteoarthritis: A pairwise, network, and dose-response meta-analysis","authors":"Bei Wu ,&nbsp;Wenyu Liu ,&nbsp;Shuang Wang ,&nbsp;Huimin Li ,&nbsp;Meng Yin","doi":"10.1016/j.ctim.2025.103188","DOIUrl":"10.1016/j.ctim.2025.103188","url":null,"abstract":"<div><h3>Background</h3><div>Osteoarthritis (OA) is a common chronic disease that leads to chronic pain, limited mobility, and reduced quality of life for patients. In recent years, mind-body exercise (e.g., yoga, tai chi, etc.) has been gradually recognized as a comprehensive intervention with positive effects on pain relief and improved function in arthritis patients. However, the evidence on the effect of mind-body exercise on pain relief in arthritis patients is inconsistent, and this meta-analysis aimed to assess the combined effect of mind-body exercise in reducing pain in patients with knee OA.</div></div><div><h3>Methods</h3><div>A systematic search using MEDLINE, Embase, Cochrane Library, and Webof Science was conducted from the beginning of the respective database information until December 2024, to identify randomized controlled trials (RCTs) on the effects of mind-body exercises on outcomes in patients with knee OA. Pairwise and dose-response meta-analyses were performed using Bayesian hierarchical random-effects models to analyze these effects. Cochrane Risk of Bias tool was used to assess the risk of bias of the included studies, and CINeMA was used to evaluate the confidence of the results.</div></div><div><h3>Results</h3><div>A total of 13 RCTs involving 558 participants were included in this study. The average age of participants ranged from 61 to 76 years. Mind-body exercise therapies had a small-to-moderate effect on pain compared to no-intervention controls (Hedges' g = −0.35). Among the mind-body exercise types, tai chi (Hedges' g = −0.41) had the greatest effect on pain levels, followed by yoga (Hedges' g = −0.38) and qigong (Hedges' g = −0.26). Of the 13 studies, eight were categorized as high risk of bias, with the main risk of bias coming from blinded implementation and selective reporting issues. Furthermore, the credibility of all mind-body exercises was extremely low owing to serious within-study bias and several other concerns</div></div><div><h3>Conclusion</h3><div>Mind-body exercise had a small to moderate effect on pain relief in patients with knee OA, with tai chi being the most effective, followed by yoga and qi gong. The mind-body exercise dose is clinically significant when it reaches 250–610 MET-min. Sex and age may affect treatment effects, with women responding more significantly to tai chi. Due to the limitations of risk of bias and low confidence level, future studies should expand the sample size, conduct strict blinding control, etc. to improve the reliability and applicability of research evidence.</div></div><div><h3>PROSPERO registration number</h3><div>CRD42024585874</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"92 ","pages":"Article 103188"},"PeriodicalIF":3.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of quality of reporting and methodology in systematic reviews of moxibustion for chronic diseases using PRISMA 2020 and AMSTAR 2","authors":"Rong Chen ,&nbsp;Xu Zhou ,&nbsp;Guihua Deng ,&nbsp;Shuqing Li ,&nbsp;Linhui Li","doi":"10.1016/j.ctim.2025.103193","DOIUrl":"10.1016/j.ctim.2025.103193","url":null,"abstract":"<div><h3>Background</h3><div>Moxibustion is a simple and low-cost technique for chronic diseases. This study aimed to evaluate the quality of reports and methodologies of systematic reviews (SRs) related to the treatment of chronic diseases with moxibustion.</div></div><div><h3>Methods</h3><div>Six databases were searched to identify moxibustion SRs for the treatment of chronic diseases. The reporting and methodological quality were evaluated based on the PRISMA 2020 statement and AMSTAR 2 standard, respectively. Univariate and multivariate analyses were used to explore impact factors.</div></div><div><h3>Results</h3><div>A total of 200 SRs were included. The median reporting quality score based on the PRISMA 2020 evaluation was 58.33. The incomplete reports involved search strategies, assumptions about missing information, and methods to synthesize and display results. The median methodological quality score of AMSTAR 2 was 40.63. The substandard methodologies included lack of a prespecified protocol, analyses for impacts of the risk of bias, and reports of funding sources. The characteristics of SRs with higher PRISMA 2020 and AMSTAR 2 scores mainly included funding support, English publications, protocol registration, application of PRISMA guidelines, and conduct of GRADE evaluation.</div></div><div><h3>Conclusion</h3><div>Over time, the reporting quality of SRs of moxibustion for chronic diseases has generally improved, but the methodological quality remains unsatisfactory. Conducting a GRADE evidence quality evaluation is crucial for improving the reporting and methodological quality. In the future, it is necessary for both PRISMA 2020 and AMSATR 2 to develop specific extensions for moxibustion to better guide the reporting and methodology of moxibustion SRs.</div></div><div><h3>Study registration</h3><div>PROSPERO ID CRD42020149024</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"92 ","pages":"Article 103193"},"PeriodicalIF":3.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of aromatherapy with Citrus bergamia- Lavandula angustifolia essential oil and/or mindfulness-based therapy on postmenopausal health: A factorial randomized controlled trial","authors":"Hanieh Salehi-Pourmehr ,&nbsp;Mandana Mojtahedi ,&nbsp;Solmaz Asnaashari ,&nbsp;Azizeh Farshbaf-Khalili ,&nbsp;Alireza Ostadrahimi","doi":"10.1016/j.ctim.2025.103190","DOIUrl":"10.1016/j.ctim.2025.103190","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to determine the effects of combined aromatherapy with lavender (<em>Lavandula angustifolia</em> Mill.) essential oil (LEO) and Bergamot (<em>Citrus×bergamia</em> (Risso) Risso &amp; Poit) essential oil (BEO) and/or mindfulness-based therapy (MBT) on menopausal symptoms, sleep quality, and serum cortisol.</div></div><div><h3>Methods</h3><div>This factorial randomized controlled trial included 132 postmenopausal 132 postmenopausal women aged 50–60 years with mild to moderate anxiety. The recruited women were divided into four groups receiving: 1) Control: Usual care + placebo, 2) Therapy: MBT + placebo, 3) Aromatherapy: LEO + BEO Aromatherapy + usual care, and 4) Therapy &amp; Aromatherapy: MBT + LEO-BEO aromatherapy. Participants in the aromatherapy and placebo groups were instructed to apply 2–3 drops of the assigned solution to their forearm skin and inhale it three times daily for eight weeks. Weekly MBT sessions were held over two months.</div></div><div><h3>Results</h3><div>After two months, the aromatherapy group showed reduced total scores for menopausal symptoms [adjusted mean difference (aMD) (95 % CI): −5.7 (−9.5 to −1.8)] and anxiety [aMD (95 % CI): −1.9 (−3.4 to −0.4)] compared to the control group. Sleep quality, measured by the Pittsburgh Sleep Quality Index (PSQI), improved in both the therapy [aMD (95 % CI): −2.6 (−4.2 to −1.0)] and aromatherapy [aMD (95 % CI): −1.7 (−3.3 to −0.1)] groups versus controls. However, the combined intervention showed no significant effects compared to control (p &gt; 0.05). Serum cortisol levels did not differ significantly across groups (p &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>MBT and LEO-BEO aromatherapy demonstrated favorable outcomes in managing menopausal symptoms and sleep quality. The combination therapy did not yield additional benefits.</div><div><strong>The registration number</strong>: IRCT20131009014957N8</div><div><strong>The registration date</strong>: 04/12/2019</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"91 ","pages":"Article 103190"},"PeriodicalIF":3.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of electroacupuncture and electroacupuncture combined with warm needling for subjective tinnitus: A multicenter, three-arm randomized controlled trial","authors":"Lai Fun Ho ,&nbsp;Yuanqi Guo ,&nbsp;Liyi Chen ,&nbsp;Herbert Fung ,&nbsp;Wai Yan Mak ,&nbsp;Siu Chuen Cheung ,&nbsp;Ping Him Tsang ,&nbsp;Min Chen ,&nbsp;Kam Leung Chan ,&nbsp;Hongwei Zhang ,&nbsp;Wai Tsz Chang ,&nbsp;Bacon Fung-Leung Ng ,&nbsp;Zhi Xiu Lin","doi":"10.1016/j.ctim.2025.103191","DOIUrl":"10.1016/j.ctim.2025.103191","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the clinical efficacy and safety of electroacupuncture (EA) and electroacupuncture combined with warm needling (EAWN) on reducing tinnitus loudness and tinnitus-related distress among older adults.</div></div><div><h3>Methods</h3><div>This multicenter, assessor-blinded, parallel-group, randomized clinical trial was conducted from December 2022 to April 2024 at three out-patient clinics in Hong Kong. Ninety eligible participants aged 50–70 years with subjective tinnitus for 0.5–24 months were equally randomized to EA, EAWN, or waitlist groups. Both treatment groups received two standardized treatment sessions per week for 5 weeks. The waitlist group received no treatment during the study period. The outcome measures were numeric rating scale (NRS) scores for tinnitus loudness, Tinnitus Handicap Inventory (THI) scores, and safety outcomes. Assessments were conducted at baseline, weeks 5 and 10.</div></div><div><h3>Results</h3><div>Both EA and EAWN groups showed significantly greater reductions in NRS scores for tinnitus loudness than did the waitlist group at weeks 5 (mean difference [95 % confidence interval]; EA: −1.91 [-2.79 to −1.03]; <em>P</em> &lt; 0.001; EAWN: −1.81 [-2.68 to −0.94]; <em>P</em> &lt; 0.001) and 10 (EA: −2.03 [-2.95 to −1.11]; <em>P</em> &lt; 0.001; EAWN: −1.98 [-2.92 to −1.04]; <em>P</em> &lt; 0.001). Improvements in total THI scores were also greater in the intervention groups at weeks 5 (<em>P</em> &lt; 0.01) and 10 (<em>P</em> &lt; 0.001). The two intervention groups showed no significant differences. No serious adverse events were reported.</div></div><div><h3>Conclusion</h3><div>Both EA and EAWN therapies could be effective and safe treatments for subjective tinnitus in older adults.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"91 ","pages":"Article 103191"},"PeriodicalIF":3.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chamomile: A systematic review of adverse events","authors":"Mohadeseh Ostovar ,&nbsp;Zahra Rezaee ,&nbsp;Seyede Maryam Najibi ,&nbsp;Mohammad Hashem Hashempur","doi":"10.1016/j.ctim.2025.103192","DOIUrl":"10.1016/j.ctim.2025.103192","url":null,"abstract":"<div><h3>Background</h3><div>Chamomile is a well-known plant recognized for its anti-inflammatory, antidepressant, anxiolytic, and analgesic properties. The present study aimed to systematically review the adverse events associated with chamomile as reported in human studies.</div></div><div><h3>Methods</h3><div>PubMed, Scopus, and Web of Science were searched for clinical trials, case-control studies, case reports, and case series published in English up to February 2024. The search utilized the following keywords: ((Chamomile or Camomile or \"<em>Chamomilla recutita</em>\" or \"<em>Matricaria chamomilla</em>\" or \"<em>Matricaria recutita</em>\"), and (\"Side effect\" or \"adverse effect “or \"complicat* or \"complication\")). Studies that involved chamomile under different scientific names (e.g., its other species such as <em>Chamaemelum nobile</em>) or in combination with other herbs were excluded (PROSPERO registration number: CRD42024520053).</div></div><div><h3>Results</h3><div>A total of seventy-two trials and eleven case reports were included in this review. In these trials, 2896 patients received chamomile, and 65 adverse events were reported across 10 trials. Unfortunately, the incomplete reporting of adverse events in these trials, along with the absence of any data on adverse events in 28 trials, limited the scope of our review. The most common adverse events were gastrointestinal complications and drowsiness, both of which were self-limiting and non-serious. No allergic adverse events were reported in the clinical trials; however, among the eleven case reports, six reported adverse events associated with allergic reactions to chamomile, ranging from anaphylactic reactions (in three patients) to short-lasting acute rhinitis.</div></div><div><h3>Conclusions</h3><div>In conclusion, data extracted from clinical trials and published case reports suggest that chamomile is generally safe when used in controlled dosages, with self-limiting minor adverse events. However, case reports indicate that allergic reactions should be taken into consideration. Furthermore, there is insufficient data regarding its safety during pregnancy and lactation.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"91 ","pages":"Article 103192"},"PeriodicalIF":3.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor on “The efficacy and safety of Baduanjin exercise as complementary therapy for pain reduction and functional improvement in knee osteoarthritis: A meta-analysis of randomized controlled trials”","authors":"Wensi Ouyang ,&nbsp;Guimei Guo ,&nbsp;Changwei Zhao","doi":"10.1016/j.ctim.2025.103186","DOIUrl":"10.1016/j.ctim.2025.103186","url":null,"abstract":"","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"91 ","pages":"Article 103186"},"PeriodicalIF":3.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of intermittent fasting diet in overweight and obese postmenopausal women with rheumatoid arthritis: A randomized controlled clinical trial","authors":"Mahsa Ranjbar ,&nbsp;Sakineh Shab-Bidar ,&nbsp;Abdolrahman Rostamian ,&nbsp;Hamed Mohammadi ,&nbsp;Aryan Tavakoli ,&nbsp;Kurosh Djafarian","doi":"10.1016/j.ctim.2025.103189","DOIUrl":"10.1016/j.ctim.2025.103189","url":null,"abstract":"<div><h3>Background and objective</h3><div>Rheumatoid arthritis (RA), in the category of rheumatic diseases, is an autoimmune illness that affects joints and other parts of suffered patients. Intermittent fasting (IF) is a dietary pattern that has had beneficial impacts on several populations. This randomized controlled trial (RCT) hypothesized that IF can improve quality of life, clinical symptoms, inflammation, and oxidative stress in overweight and obese postmenopausal women with RA.</div></div><div><h3>Method</h3><div>This study was a controlled, parallel-group superiority design in which 44 overweight and obese postmenopausal women with RA were randomly allocated to receive either IF (n = 22) or the usual diet (n = 22) for 8 weeks. The intervention group received 16/8 IF, and the control group received the typical diet for 8 weeks. The primary outcome was the Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaire score. The secondary outcomes included body mass index (BMI) and morning joint stiffness (MS) and biochemical indicators, including serum concentrations of erythrocyte sedimentation rate (ESR), high sensitive c-reactive protein (hs-CRP), and total oxidant and antioxidant capacity (TOC and TAC), and oxidative stress index (OSI), and interleukin 6 (IL-6) were assessed at the baseline and end of the study. Disease severity was assessed using the Disease Activity Score-28 (DAS-28) and Clinical Disease Activity Index (CDAI).</div></div><div><h3>Results</h3><div>The IF diet significantly improved BMI, DAS-28, CDAI, and HAQ (p-value&lt;0.05 for all). However, there were no significant effects on the other study outcomes.</div></div><div><h3>Conclusion</h3><div>IF has beneficial effects on some outcomes related to RA patients, while it has no significant impact on inflammation and oxidative stress markers. More studies are needed to determine IF's effects on RA patients.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"91 ","pages":"Article 103189"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on “The efficacy of oral Lavandula angustifolia Mill. essential oil on menopausal symptoms, serum lipid profile, and cortisol concentration in postmenopausal women: A triple-blind, randomized, controlled trial”","authors":"Mei Zhao,&nbsp;Lianwei Xu","doi":"10.1016/j.ctim.2025.103177","DOIUrl":"10.1016/j.ctim.2025.103177","url":null,"abstract":"","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"91 ","pages":"Article 103177"},"PeriodicalIF":3.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}