Effect of acupuncture on patients with chronic obstructive pulmonary disease: A multicenter randomized controlled trial

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine Pub Date : 2025-02-14 DOI:10.1016/j.ctim.2025.103146

Jiansheng Li , Yang Xie , Yanjun Wang , Lei Wu , Xuefeng Yu , Li Bai , Suju Shao , Miao Zhou , Mingli Zhang , Xueqing Yu , Weihong Han , Xuanlin Li , Tao Chen

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引用次数: 0

Abstract

Background

Chronic obstructive pulmonary disease (COPD) is a common and frequently occurring disease that seriously endangers health, causing a heavy economic burden on patients and society. Acupuncture has been reported to have a therapeutic effect on patients with chronic obstructive pulmonary disease (COPD). However, compared with medications, it is difficult to identify a superior therapy. Therefore, the aim of this study was to evaluate the efficacy and safety of acupuncture, conventional drug and acupuncture plus conventional drug in the treatment of COPD.

Methods

This was a multicenter, open-label randomized controlled trial (RCT) through a central randomization system. A total of 150 COPD patients were randomly assigned at a 1:1:1 ratio to the acupuncture group, conventional drug group or acupuncture plus conventional drug group for 12 weeks of treatment, followed by 12 weeks of untreated follow-up. The primary outcomes included the six-minute walk distance (6MWD) and St. George’s Respiratory Questionnaire (SGRQ), and the secondary outcomes included the modified Medical Research Council dyspnea scale (mMRC), acute exacerbation, lung function, and quality of life (COPD assessment test). Statistical analysis was conducted via SPSS software (version 26.0).

Results

A total of 150 patients were included in the study, and 143 patients completed the trial. There were time effects, group effects and interaction effects in the three groups (P < 0.05). Compared with that in the conventional drug group, the 6MWD in the acupuncture plus conventional drug group increased significantly at 4, 8, and 12 weeks of treatment and at 12 weeks of follow-up. The difference was statistically significant (P < 0.05). The symptom scores, motor scores, impact scores and total SGRQ scores at different time points in the three groups tended to change with time, with a time effect (P < 0.05), and there was no group or interaction effect (P > 0.05). Among the secondary outcomes, there were time effects on the number of acute exacerbations, forced expiratory volume in one second (FEV1) and forced expiratory volume in one second/forced vital capacity (FEV1/FVC) at different time points in the three groups (P < 0.05). mMRC had time and group effects (P < 0.05). CAT had time effects, group effects and interaction effects (P < 0.05).

Conclusions

Compared with the acupuncture group and the conventional drug group, the acupuncture plus conventional drug group was better at improving exercise ability, improving quality of life, and reducing dyspnea. It is safe and effective for the treatment of chronic obstructive pulmonary disease in the stable period, which can provide a reference for further related research.

Trial registration:

ClinicalTrials.gov, NCT03169504. Registered on 30 May 2017.

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针刺对慢性阻塞性肺疾病患者的影响：一项多中心随机对照试验

慢性阻塞性肺疾病（chronic obstructive pulmonary disease， COPD）是一种严重危害健康的常见病和多发病，给患者和社会造成了沉重的经济负担。据报道，针灸对慢性阻塞性肺疾病（COPD）患者有治疗效果。然而，与药物治疗相比，很难确定一种更好的治疗方法。因此，本研究的目的是评价针刺与常规药物、针刺加常规药物治疗COPD的疗效和安全性。方法采用中央随机化系统，采用多中心、开放标签随机对照试验（RCT）。将150例COPD患者按1:1:1的比例随机分为针刺组、常规药物组或针刺加常规药物组，治疗12周，随后进行12周未治疗的随访。主要结局包括6分钟步行距离（6MWD）和圣乔治呼吸问卷（SGRQ），次要结局包括改良的医学研究委员会呼吸困难量表（mMRC）、急性加重、肺功能和生活质量（COPD评估测试）。采用SPSS 26.0软件进行统计分析。结果共纳入150例患者，143例患者完成试验。三组间存在时间效应、组效应和交互作用效应（P <； 0.05）。与常规药物组比较，针刺加常规药物组在治疗第4、8、12周及随访第12周时6MWD均显著升高。差异有统计学意义（P <； 0.05）。三组患者不同时间点的症状评分、运动评分、冲击评分和SGRQ总分均有随时间变化的趋势，存在时间效应（P <； 0.05），不存在组间效应和交互效应（P >； 0.05）。次要结局中，三组不同时间点急性加重次数、1秒用力呼气量（FEV1）、1秒用力呼气量/用力肺活量（FEV1/FVC）存在时间效应（P <； 0.05）。mMRC具有时间效应和组效应（P <； 0.05）。CAT有时间效应、组效应和交互效应（P <； 0.05）。结论与针刺组和常规药物组比较，针刺加常规药物组在提高运动能力、改善生活质量、减轻呼吸困难等方面效果更好。对稳定期慢性阻塞性肺疾病的治疗安全有效，可为进一步相关研究提供参考。试验注册：ClinicalTrials.gov, NCT03169504。于2017年5月30日注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Complementary therapies in medicine 医学-全科医学与补充医学

CiteScore

8.60

自引率

2.80%

发文量

101

审稿时长

112 days

期刊介绍： Complementary Therapies in Medicine is an international, peer-reviewed journal that has considerable appeal to anyone who seeks objective and critical information on complementary therapies or who wishes to deepen their understanding of these approaches. It will be of particular interest to healthcare practitioners including family practitioners, complementary therapists, nurses, and physiotherapists; to academics including social scientists and CAM researchers; to healthcare managers; and to patients. Complementary Therapies in Medicine aims to publish valid, relevant and rigorous research and serious discussion articles with the main purpose of improving healthcare.