Complementary therapies in medicine最新文献

{"title":"Effect of shenmai injection on anthracycline-induced cardiotoxicity: A systematic review and meta-analysis","authors":"Lili Yang ,&nbsp;Xiaorui Liu ,&nbsp;Wen Yang ,&nbsp;Siqi Wang ,&nbsp;Zimu Li ,&nbsp;Yiming Lei ,&nbsp;Dongling Liu","doi":"10.1016/j.ctim.2024.103053","DOIUrl":"10.1016/j.ctim.2024.103053","url":null,"abstract":"<div><h3>Objective</h3><p>Shenmai injection is a classic herbal prescription, and is often recommended for the treatment of anthracycline-induced cardiotoxicity. However, the efficacy and safety of Shenmai injection for the treatment of anthracycline-induced cardiotoxicity have not been reported.</p></div><div><h3>Materials and methods</h3><p>We conducted a comprehensive search of eight literature databases and two clinical trial registries, retrieving all randomized controlled trials (RCTs) related to the treatment of anthracycline-induced cardiotoxicity with Shenmai injection from the establishment of the databases to July 1, 2023. Data analysis was performed using the Meta package in RStudio and RevMan 5.4. The GRADE pro3.6.1 software was utilized for assessing the quality of evidence.</p></div><div><h3>Results</h3><p>A total of 16 RCTs including 2140 patients were included in this study. Meta-analysis showed that Shenmai injection had an advantage in improving ST-T segment changes (RR = 0.28; 95 % CI, 0.20 to 0.39; <em>P</em> &lt; 0.0001) (<em>P</em> &lt; 0.01), creatine kinase isoenzyme (SMD = −3.49; 95 % CI, −5.24 to −1.74; <em>P</em> &lt; 0.0001), Prolonged QT interval (RR = 0.46; 95 % CI, 0.28 to 0.75; <em>P</em> = 0.0018), Low QRS Voltage (RR = 0.44; 95 % CI, 0.27 to 0.71; <em>P</em> = 0.0007), sinus tachycardia (RR = 0.41; 95 % CI, 0.28 to 0.60; <em>P</em> &lt; 0.0001), atrial premature beats (RR = 0.55; 95 % CI, 0.35 to 0.87; <em>P</em> = 0.01), Premature Ventricular Contractions (RR = 0.39; 95 % CI, 0.26 to 0.59; <em>P</em> &lt; 0.0001) and creatine kinase (SMD = −1.43; 95 % CI, −2.57 to −0.29; <em>P</em> &lt; 0.0001) in patients with anthracycline-induced cardiotoxicity. advantage, which was supported by sensitivity analyses, but not in improving left ventricular ejection fraction (MD = 16.01; 95 % CI, −3.10 to 35.12; <em>P</em> = 0.10) and atrioventricular block (RR = 0.49; 95 % CI, 0.24 to 1.03; <em>P</em> = 0.06). The literature included in the study did not refer to data regarding the safety aspects of Shenmai injection, so we do not yet know the safety of Shenmai injection. The results of subgroup analyses suggested that heterogeneity was not related to the administered dose and chemotherapy regimen. The publication bias test showed no publication bias. The quality of evidence for the results ranged from “very low” to “moderate.”</p></div><div><h3>Conclusion</h3><p>This study suggests that Shenmai injection is effective in treating anthracycline-induced cardiotoxicity and is a potential treatment for anthracycline-induced cardiotoxicity. However, due to the poor methodological quality of the included RCTs, we recommend rigorous, high-quality, large-sample trials to confirm our findings.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000414/pdfft?md5=33a424fe527865aa08fc5af53ce617e3&pid=1-s2.0-S0965229924000414-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of traditional Thai massage on recovery from gastrocnemius muscle fatigue: A single-blind randomised controlled trial","authors":"Vitsarut Buttagat,&nbsp;Sujittra Kluayhomthong,&nbsp;Pattanasin Areeudomwong","doi":"10.1016/j.ctim.2024.103056","DOIUrl":"10.1016/j.ctim.2024.103056","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the effects of traditional Thai massage (TTM) on improving fatigue recovery and fatigue-related parameters of the gastrocnemius muscle after a heel-raise exercise.</p></div><div><h3>Design</h3><p>A single-blind randomised controlled trial.</p></div><div><h3>Setting</h3><p>Mae Fah Luang University Hospital, Thailand.</p></div><div><h3>Participants</h3><p>Fifty-four healthy participants were randomly assigned to two groups: TTM (n = 27; 51.85 % women; mean age 23.15 ± 4.90 years; number of exercises/week: 4.78 ± 1.58) and control (n = 27; 59.26 % women; mean age 22.63 ± 4.88 years; number of exercises/week: 4.48 ± 1.25).</p></div><div><h3>Interventions</h3><p>After the participants performed a heel-raise exercise to induce fatigue of the gastrocnemius muscle, they received either 30 min of TTM to the gastrocnemius muscle or 30 min of control (29 min of rest and 1 min total gastrocnemius stretching).</p></div><div><h3>Outcome measures</h3><p>The outcome measures were the median frequency (MDF) of the electromyography signal, muscle power (MP) and feelings of muscle fatigue (FMF). All the outcome measures were evaluated before (T1) and after (T2) the fatigue-inducement protocol as well as immediately (T3), 1 h (T4) and 2 h (T5) after the interventions.</p></div><div><h3>Results</h3><p>The results show that MDF and MP were significantly increased and FMF significantly decreased in both groups immediately after the interventions and at 1 h and 2 h after the interventions (repeated measures ANOVA: <em>p</em> &lt; .05). In the between-group comparisons, participants in the TTM group showed significantly greater improvement than those in the control group on all outcomes at all post-intervention assessment time points (T3, T4, T5), reflecting faster recovery from muscle fatigue (ANCOVA: <em>p</em> &lt; .05).</p></div><div><h3>Conclusion</h3><p>TTM proved an effective intervention for maximising recovery from fatigue of the gastrocnemius muscle.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S096522992400044X/pdfft?md5=f4805386e5da6f487c24ecb26e2dfd83&pid=1-s2.0-S096522992400044X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141143840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of auriculotherapy on depression among elderly people: A randomized controlled clinical trial","authors":"Mohammad Abbasian Josheghani,&nbsp;Zahra Tagharrobi,&nbsp;Khadijeh Sharifi,&nbsp;Zahra Sooki,&nbsp;Fatemeh Zare Joshaghani,&nbsp;Mohammad Zare","doi":"10.1016/j.ctim.2024.103054","DOIUrl":"10.1016/j.ctim.2024.103054","url":null,"abstract":"<div><h3>Background</h3><p>Given the high prevalence of depression in elderly people, appropriate interventions are essential. This study aimed to assess the effects of auriculotherapy on depression among elderly people.</p></div><div><h3>Methods</h3><p>This randomized controlled clinical trial was conducted in 2021. Fifty-two elderly were conveniently selected and randomly allocated to the sham (n = 26) and intervention (n = 26) groups through block randomization. The intervention group was subjected to four weeks of auriculotherapy at the Shen-Men, zero, heart, antidepressant, and master cerebral points using Vaccaria seeds fixed with adhesive tape. In the sham group, adhesive tapes were attached to the points with neither seeds nor compression. The elderly and data collector were blinded. The 15-item Geriatric Depression Scale was used to assess depression before, immediately after, and four weeks after the intervention (T1–T3). The statistical methods used were repeated measures analysis of variance and covariance.</p></div><div><h3>Results</h3><p>Groups significantly differed concerning participants' gender, education, and employment (p &lt; 0.05). After adjusting for confounding effects, the time-group interaction significantly affected the mean depression score (p &lt; 0.0001, effect size = 0.54). There was no significant difference between the depression score in the sham and intervention groups at T1 (9.6 ± 2.5 vs 9.5 ± 2.5, p = 0.263); however, this difference was found to be significant at T2 (8.6 ± 2 vs 4.2 ± 1.2, p &lt; 0.0001, effect size = 0.68) and T3 (9.3 ± 2.3 vs 4.3 ± 1.3, p &lt; 0.0001, effect size = 0.65). Within-group analysis revealed significant differences in the depression scores of the intervention group at T1 compared with those at T2 and T3 (p &lt; 0.05). In contrast, the mean depression score in the sham group at T2 was significantly lower than that at T1 (p = 0.003) and greater than that at T3 (p = 0.049).</p></div><div><h3>Conclusions</h3><p>Auriculotherapy alleviates depression and can be used as a complementary therapy for elderly people with depression.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000426/pdfft?md5=800eaccbafe39ed8d736d6cd18d7fc73&pid=1-s2.0-S0965229924000426-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141092902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous electrical acupoint stimulation to prevent dizziness after microvascular decompression for hemifacial spasm: A randomized controlled trial","authors":"Yuantao Hou ,&nbsp;Hansheng Liang ,&nbsp;Cungang Fan ,&nbsp;Ruen Liu ,&nbsp;Yi Feng","doi":"10.1016/j.ctim.2024.103055","DOIUrl":"10.1016/j.ctim.2024.103055","url":null,"abstract":"<div><h3>Background</h3><p>Dizziness often occurs after microvascular decompression (MVD), and therapeutic options are limited. The aim of this trial was to determine the potential efficacy of transcutaneous electrical acupoint stimulation (TEAS), against dizziness and its safety in patients undergoing MVD.</p></div><div><h3>Methods</h3><p>Adult patients scheduled to undergo MVD for hemifacial spasm under total intravenous anesthesia were randomized at a 1:1 ratio to receive, after extubation, 30-min TEAS in the mastoid region as well as Fengchi acupoints (GB20) and Neiguan acupoints (PC6) or 30-min sham stimulation. The primary outcome was the incidence of dizziness at 2 h after surgery. Secondary outcomes included dizziness, postoperative nausea and vomiting (PONV) or headache severity, rescue medication, changes in intraocular pressure before and after surgery, length of stay, dizziness symptoms 4 weeks after discharge, and surgical complications.</p></div><div><h3>Results</h3><p>A total of 86 patients (51.9 ± 9.4 years of age; 67 women) were enrolled. One patient (in the TEAS arm) was excluded from analysis due to conversion to sevoflurane anesthesia. The rate of dizziness at 2 h after surgery was 31.0 % (13/42) in the TEAS arm <em>vs.</em> 53.5 % (23/43) in the sham control arm (<em>P</em> = 0.036). TEAS was also associated with significantly lower severity of dizziness, based on a 10-point scale, during the first 24 h after surgery. None of the other secondary efficacy outcomes differed significantly between the two arms. All postoperative complications were Clavien-Dindo grade I or II. The rate of postoperative complications was 21.4 % (9/42) in the TEAS arm <em>vs.</em> 16.3 % (7/43) in the sham control arm (<em>P</em> = 0.544).</p></div><div><h3>Conclusions</h3><p>Compared with sham control, TEAS was associated with a lower incidence of dizziness within 2 h and lower severity of dizziness within 24 h post-operatively, but no improvement in other outcomes, in adult patients undergoing MVD for hemifacial spasm.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000438/pdfft?md5=cb473f096b37cf611f0111ba772a74f8&pid=1-s2.0-S0965229924000438-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal folic acid supplementation to prevent preeclampsia: a systematic review and meta-analysis","authors":"Huaixing Cui ,&nbsp;Naijin Zhang ,&nbsp;JiaLi An ,&nbsp;Xianyue Zeng ,&nbsp;Ye Zhao ,&nbsp;Xuan Sun ,&nbsp;Huaien Bu ,&nbsp;Hongwu Wang","doi":"10.1016/j.ctim.2024.103052","DOIUrl":"10.1016/j.ctim.2024.103052","url":null,"abstract":"<div><h3>Objective</h3><p>The purpose of this systematic review was to examine the association between folic acid supplementation during pregnancy and the risk of preeclampsia.</p></div><div><h3>Methods</h3><p>Relevant studies were included by searching Embase, PubMed, Scope, Web of science, Cochrane Library databases. Studies were reviewed according to prespecified inclusion and exclusion criteria. Study characteristics were summarized, and study quality was assessed. Risk ratios (RR) and 95<!--> <!-->% confidence intervals (CI) were used as indicators of effect to assess the relationship between folic acid supplementation and risk of preeclampsia.</p></div><div><h3>Results</h3><p>The protocol of this study was prospectively registered with the PROSPERO (registration No. CRD42022380636). A total of nine studies were included, divided into three groups according to the type of study, containing a total of 107 051 and 105 222 women who were supplemented and not supplemented with folic acid during pregnancy. The results showed that folic acid supplementation during pregnancy could not be proven to reduce the risk of preeclampsia.</p></div><div><h3>Conclusion</h3><p>The results of the study suggest that folic acid supplementation alone is not associated with a decreased risk of pre-eclampsia,but the inferences are somewhat limited by the low methodological quality of the included literature, and therefore higher quality studies are needed to prove this point.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000402/pdfft?md5=c558a71e2b030f4264033a15a9acd949&pid=1-s2.0-S0965229924000402-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141049452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for functional dyspepsia: Bayesian meta-analysis","authors":"Xiaoyun Liao ,&nbsp;Yu Tian ,&nbsp;Yajun Zhang ,&nbsp;Zhiyuan Bian ,&nbsp;Pingzhu Wang ,&nbsp;Peiqi Li ,&nbsp;Jianqiao Fang ,&nbsp;Xiaomei Shao","doi":"10.1016/j.ctim.2024.103051","DOIUrl":"10.1016/j.ctim.2024.103051","url":null,"abstract":"<div><h3>Background</h3><p>Acupuncture stands out as a prominent complementary and alternative medicine therapy employed for functional dyspepsia (FD). We conducted a Bayesian meta-analysis to ascertain both the relative effectiveness and safety of various acupuncture methods in the treatment of functional dyspepsia.</p></div><div><h3>Methods</h3><p>We systematically searched eight electronic databases, spanning from their inception to April 2023. The eligibility criteria included randomized controlled trials investigating acupuncture treatments for FD. Study appraisal was conducted using the Cochrane risk of bias tool. Pairwise and network meta-analyses were conducted using RevMan 5.3 and ADDIS V.1.16.6 software. Bayesian network meta-analysis was performed to compare and rank the efficacy of different acupuncture therapies for FD symptoms.</p></div><div><h3>Results</h3><p>This study found that combining different acupuncture methods or using acupuncture in conjunction with Western medicine is more effective in improving symptoms of functional dyspepsia compared to using Western medicine alone. According to the comprehensive analysis results, notably, the combination of Western medicine and acupuncture exhibited superior efficacy in alleviating early satiation and postprandial fullness symptoms. For ameliorating epigastric pain, acupuncture combined with moxibustion proved to be the most effective treatment, while moxibustion emerged as the optimal choice for addressing burning sensations. Warming needle was identified as the preferred method for promoting motilin levels.</p></div><div><h3>Conclusion</h3><p>The findings of this study demonstrate that acupuncture, both independently and in conjunction with other modalities, emerged as a secure and effective treatment option for patients with functional dyspepsia.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000396/pdfft?md5=53b6403007cccbb308c3731c722995bd&pid=1-s2.0-S0965229924000396-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of oral Lavandula angustifolia Mill. essential oil on menopausal symptoms, serum lipid profile, and cortisol concentration in postmenopausal women: A triple-blind, randomized, controlled trial","authors":"Morteza Haramshahi ,&nbsp;Soraya Babaie ,&nbsp;Mahnaz Shahnazi ,&nbsp;Behnam Kafil ,&nbsp;Azizeh Farshbaf-Khalili ,&nbsp;Mina Naghdi","doi":"10.1016/j.ctim.2024.103050","DOIUrl":"10.1016/j.ctim.2024.103050","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the effect of oral Lavandula angustifolia Mill. essential oil (LEO) on menopausal symptoms, serum cortisol level, and lipid profile in postmenopausal women.</p></div><div><h3>Methods</h3><p>This was a triple-blind parallel-armed randomized trial. Seventy-two postmenopausal women aged 50–65 years referring to healthcare centers in Tabriz, Iran with a score of 15–42 on the Green scale were included from May 10, 2022 to May 22, 2023. The participants were randomly assigned to two groups with a 1:1 ratio and using four and six blocks. One group received LEO soft gel 80 mg per day, and another group received a similar placebo for 60 days. A demographic questionnaire and a Greene menopause symptom scale were used for data collection. The lipid profile (total cholesterol, triglyceride, LDL, HDL) and the serum levels of cortisol were measured using biochemical methods. Chi-square, Fisher's exact tests, Independent samples t-test, Analysis of Covariance (ANCOVA), Repeated measure ANOVA, and Paired sample t-test were utilized for analyses. A p-value less than 0.05 was considered statistically significant.</p></div><div><h3>Results</h3><p>The demographic and personal characteristics of the participants were similar. After two months of intervention, all symptoms in psychological, physical, vasomotor, anxiety, depression, and sexual dysfunction domains were significantly relieved (decreased) among both groups (p &lt; 0.003), except for sexual dysfunction, the reduction of which was not significant in the placebo group (p = 0.317). The mean (SD) total score of menopausal symptoms reduced from 27.4 (6.3) at baseline to 17.7 (4.9) at the end of the study in the LEO group (p &lt; 0.001). It also decreased from 27.4 (7.1) to 17.6 (5.1) in the placebo group (p &lt; 0.001). However, between-group analyses revealed that this reduction was significantly greater in the LEO group compared to the placebo group only in the sexual dysfunction (Mean (SD): 1.3 (0.6) vs. 1.0 (0.5); adjusted mean difference (95% confidence interval); p: − 0.35 (−0.67 to −0.02); 0.039). No significant within-group changes or between-group differences were observed (p &gt; 0.05) in terms of studied serum markers.</p></div><div><h3>Conclusion</h3><p>The oral LEO exhibited a significant enhancement in sexual dysfunction among postmenopausal women. Therefore, it can be used alongside other therapies to improve sexual dysfunction during menopause. LEO did not affect lipid profile and serum cortisol level in this study.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000384/pdfft?md5=d620aec51a85eca1632a64b596be38fb&pid=1-s2.0-S0965229924000384-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of quantitative-effectiveness association between acupuncture temporal parameters and stable chronic obstructive pulmonary disease: A systematic review and dose-response meta-analysis of randomized controlled trials","authors":"Qin Luo ,&nbsp;Mingsheng Sun ,&nbsp;Guixing Xu ,&nbsp;Hao Tian ,&nbsp;Chunyan Yang ,&nbsp;Liuyang Huang ,&nbsp;Xi Li ,&nbsp;Ziwen Wang ,&nbsp;Guangbing Lu ,&nbsp;Zuoqin Yang ,&nbsp;Laixi Ji ,&nbsp;Fanrong Liang","doi":"10.1016/j.ctim.2024.103048","DOIUrl":"10.1016/j.ctim.2024.103048","url":null,"abstract":"<div><h3>Introduction</h3><p>Chronic Obstructive Pulmonary Disease (COPD) is a globally common chronic respiratory disease with a high morbidity and mortality rate. Acupuncture has been proven effective for COPD. A dose-response meta-analysis was conducted to assess the correlation between the acupuncture temporal parameters(session, frequency, and duration) and its effectiveness in patients with stable COPD.</p></div><div><h3>Methods</h3><p>Acupuncture randomized controlled trials on COPD were searched in eight databases from their inception to June 2023. The \"doses\" were defined as the acupuncture session, frequency, and duration. The outcomes mainly included Forced Expiratory Volume in one-second rate (FEV1%) and Six-minute Walking Distance (6MWD). The assessment of bias risk and literature quality were conducted independently using the Cochrane risk of bias tool and the Standards for reporting interventions in clinical trials of acupuncture. The dose-response relationship was modeled using robust error element regression, and meta-analysis was operated by R 4.3.1 and Stata 15.0. The protocol was registered in PROSPERO with the registration number CRD42023401406.</p></div><div><h3>Result</h3><p>Out of 1669 records, 17 RCTs with 1165 participants were finally included in the meta-analysis. There was notable heterogeneity among the studies, but sensitivity analysis demonstrated good robustness. The findings revealed a significant improvement in the following outcomes for stable COPD patients in the acupuncture group: FEV1% (MD=3.50, 95%CI: 2.05–4.95), 6MWD (MD=47.39, 95%CI: 29.29–65.50), St. George's respiratory questionnaire (SGRQ; MD=−8.25, 95%CI: −11.38 to −5.12); COPD assessment test (CAT; MD=−2.91, 95%CI: −3.99 to −1.83). The relationship between the acupuncture session, duration, and FEV1%, 6MWD followed a \"Λ\" curve pattern, while the relationship between acupuncture frequency and FEV1%, 6MWD exhibited logarithmic growth. Firstly, After 12 acupuncture sessions, FEV1% and 6MWD increased by 7.06% (95%CI: 4.56–9.55) and 36.28 m (95%CI: 20.37–52.20), respectively. The peak improvement in FEV1% and 6MWD was observed after 18 acupuncture sessions (MD=7.89, 95% CI: 5.33–10.45) and 45 sessions (MD=125.43, 95% CI: 72.80–178.07) each. Additionally, weekly acupuncture resulted in a 4.14% improvement in FEV1% (95% CI: 2.55–5.72) and a 42.49 m increase in 6MWD (95%CI: 17.16–67.81). Notably, the maximum effects on FEV1% and 6MWD improvement were achieved with different acupuncture frequencies, specifically three times a week (MD=6.00, 95% CI: 5.34–6.66) and once a day(MD=112.41, 95% CI: 77.27–147.56), respectively. Furthermore, after a 28-day duration of acupuncture treatment, FEV1% increased by 4.74% (95% CI: 3.73–5.75) and 6MWD increased by 47.34 m (95%CI: 22.01–72.67). During 60 days of acupuncture treatment, the FEV1% and 6MWD improvement reached their highest levels at 8.76% (95% CI: 7.05–10.47) and 88.06 m (95% CI: 45.96–130.16), respectively.</p>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000360/pdfft?md5=580d26e67e88fe32eb28f690bdbf1f26&pid=1-s2.0-S0965229924000360-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140908304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture improves neurological function and anti-inflammatory effect in patients with acute ischemic stroke: A double-blinded randomized controlled trial","authors":"Chueh-Yi Tsai ,&nbsp;Wen-Ling Liao ,&nbsp;Hung-Ming Wu ,&nbsp;Chia-Wei Chang ,&nbsp;Wei-Liang Chen ,&nbsp;Ching-Liang Hsieh","doi":"10.1016/j.ctim.2024.103049","DOIUrl":"10.1016/j.ctim.2024.103049","url":null,"abstract":"<div><h3>Background and purpose</h3><p>Acupuncture exerts an anti-inflammatory effect and is recommended by the World Health Organization as a complementary therapy for stroke. This study investigated the improvement in neurological function outcome in acute-stage intervention of acute ischemic stroke (AIS), and the anti-inflammatory effect of early acupuncture.</p></div><div><h3>Methods</h3><p>Fifty patients with AIS were randomly assigned to either a control group (CG, 25 patients, received sham acupuncture) or treatment group (TG, 25 patients, received acupuncture treatment). Acupuncture intervention was administered twice a week for a total of 8 sessions over 4 consecutive weeks. The primary outcome was the changes in the National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), and Barthel Index (BI) scores. The secondary outcome was the changes in serum inflammation-related biomarker levels.(ANAIS trial)</p></div><div><h3>Results</h3><p>A total of 35 patients (18 patients in the CG and 17 patients in the TG) completed the trial. The reduction in NIHSS scores was greater in the TG than in the CG between V2 (second assessment administered after acupuncture intervention) and V1 (first assessment administered before acupuncture intervention; 4.33 ± 1.91 vs. 2.68 ± 1.42, <em>p</em> = 0.005) and between V3 (third assessment administered 28 days after last acupuncture intervention) and V1 (6.00 ± 2.53 vs. 3.83 ± 2.31, <em>p</em> = 0.012). The increase in BI scores was greater in the TG than in the CG between V2 and V1 (28.89 ± 15.39 vs. 14.21 ± 19.38, <em>p</em> = 0.016) and between V3 and V1 (39.41 ± 20.98 vs. 25.00 ± 18.47, <em>p</em> = 0.038). Among participants with high inflammation, the increase in serum IL-12p70 level between V2 and V1 was greater in the TG than in the CG (0.20 ± 0.19 vs. −0.14 ± 0.30, pg/mL <em>p</em> = 0.006).</p></div><div><h3>Conclusions</h3><p>Acupuncture improved the neurological function of patients with AIS, and the relationship between acupuncture improving neurological function and anti-inflammatory effect needs further study. In addition, studies with larger sample sizes and longer follow-ups as well as multicenter clinical trials are expected in the future.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000372/pdfft?md5=f5c89d360b852f218f5c198ef41e2abb&pid=1-s2.0-S0965229924000372-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of probiotic supplements on Parkinson's disease: A systematic review and meta-analysis","authors":"Xiaxia Jin ,&nbsp;Wendi Dong ,&nbsp;Kaile Chang ,&nbsp;Yongmei Yan ,&nbsp;Xiaochun Liu","doi":"10.1016/j.ctim.2024.103045","DOIUrl":"10.1016/j.ctim.2024.103045","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to evaluate the clinical efficacy and safety of probiotics supplementation in the treatment of Parkinson's disease (PD).</p></div><div><h3>Methods</h3><p>We searched China National Knowledge Infrastructure (CNKI), Weipu (VIP) database, Wanfang Database, Sinomed (CBM), PubMed, Embase, Cochrane library and Web of Science databases for eligible studies from inception to January 4th, 2024. Randomized controlled trials (RCTS) comparing the effects of probiotic supplements and placebo in patients with PD. Meta-analysis was conducted with the software Review Manager 5.4. The quality assessment was performed according to Cochrane risk of bias tool.</p></div><div><h3>Results</h3><p>A total of 11 RCTs with 756 PD patients were included in this study. We found that probiotics could increase the number of complete bowel movements (CBMs) per week and improved the scores of Patient Assessment of Constipation Quality of Life Questionnaire (PAC-QOL) (SMD = 0.73, 95 % CI: 0.54 to 0.92, <em>P</em> &lt; 0.00001, I² = 45 %; SMD = − 0.79, 95 % CI: − 1.19 to − 0.39, <em>P</em> &lt; 0.001, I² = 55 %, respectively) compared with the placebo group. However, there was no significant difference between the two groups in improving fecal traits and defecation efforts in PD patients (SMD = 0.87, 95 % CI: 0.01 to 1.74<em>, P =</em> 0.05, I² = 94 %; SMD <em>=</em> 1.24, 95 % CI: − 1.58 to 4.06, <em>P &gt;</em> 0.05, I² = 98 %, respectively). In terms of PD composite scale scores: after treatment, there was no significant difference in Movement Disorder Society-Unified-Parkinson Disease Rating Scale Ⅲ score (MDS-UPDRSⅢ) between the probiotic group and the placebo group (SMD = − 0.09, 95 % CI: − 0.35 to 0.16, <em>P</em> &gt; 0.05, I² = 0 %).</p></div><div><h3>Conclusions</h3><p>In conclusion, based on the overall results of the available RCTs studies, our results suggested the potential value of probiotics in improving constipation symptoms in PD patients. Therefore, probiotics may be one of the adjuvant therapy for PD-related constipation patients. The findings of this study provide more proof supporting the effectiveness of probiotics, encouraging probiotics to be utilized alone or in combination with other therapies in clinical practice for PD patients. However, more well-designed RCTs with large sample sizes are required.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000335/pdfft?md5=8f897457b38db8cc86e0e44c6988fc39&pid=1-s2.0-S0965229924000335-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}