益生菌对神经发育相关的易怒/情绪不稳定症状的治疗效果：安慰剂对照试验的系统回顾和荟萃分析

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine Pub Date : 2025-01-27 DOI:10.1016/j.ctim.2025.103132

Ping-Wen Huang , Chen Chia-Min , Cheuk-Kwan Sun , Yu-Shian Cheng , Yen-Hsiang Tang , Cheng Liu , Kuo-Chuan Hung

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引用次数: 0

摘要

目的：本研究旨在探讨益生菌对神经发育障碍患者的易怒/情绪不稳定症状的缓解作用。方法：通过检索各大电子数据库，筛选成立至2023年12月的随机安慰剂对照试验。兴趣的结果包括易怒/情绪不稳定症状的改善。结果定量表示为效应大小（ES），基于标准化平均差（SMD）， 95%置信区间（CI）。结果：本荟萃分析纳入了7项研究，1479名参与者。初步结果显示，与安慰剂相比，接受益生菌的神经发育障碍患者的易怒/情绪不稳定症状有显著改善（SMD= -0.17, p=0.03）。亚组分析表明，仅在使用多菌株益生菌的研究中（SMD=-0.19, p=0.04, 3项研究，452名参与者），使用益生菌与安慰剂相比，易怒/情绪不稳定症状的显著改善之间存在关联，而在采用单一菌株方案的研究中则没有关联。结论：我们的研究支持使用益生菌来缓解神经发育障碍患者的易怒/情绪不稳定症状，主要是那些服用多菌株益生菌作为补充剂的患者。然而，以易怒为主要结果的研究数量有限，而且大多数研究没有调查其他混杂因素，如饮食习惯或其他营养补充剂的摄入，这可能会削弱证据的稳健性。我们的结果来自有限数量的可用试验，需要进一步的大规模临床研究来验证。

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Therapeutic effects of probiotics on symptoms of irritability/emotional lability associated with neurodevelopmental conditions: A systematic review and meta-analysis of placebo-controlled trials

Objectives

The current study aimed at investigating the efficacies of probiotics in alleviating the symptoms of irritability/emotional lability in individuals with a neurodevelopmental condition.

Methods

Randomized placebo-controlled trials were identified through searching major electronic databases from inception to December, 2023. The outcome of interests included improvements in the symptoms of irritability/emotional lability. Outcomes were quantitatively expressed as effect size (ES) based on standardized mean difference (SMD) with 95 % confidence interval (CI).

Results

Seven studies with 1479 participants were included in this meta-analysis. The primary results revealed a significant improvement in the symptoms of irritability/emotional lability in individuals with neurodevelopmental conditions receiving probiotics compared with the placebos (SMD= −0.17, p = 0.03). Subgroup analyses demonstrated an association between a significant improvement in the symptoms of irritability/emotional lability and the use probiotics relative to placebos only in studies using multiple-strain probiotics (SMD=-0.19, p = 0.04, three studies with 452 participant) but not in those adopting single-strain regimens.

Conclusions

Our study supported the use of probiotics for alleviating the symptoms of irritability/emotional lability in individuals with neurodevelopmental conditions, mainly in those receiving multiple-strain probiotics as supplements. Nevertheless, the limited number of studies targeting irritability as their primary outcomes, and most did not investigate other confounding factors such as dietary habits or consumption of other nutritional supplements may impair the robustness of evidence. Our results, which were derived from a limited number of available trials, warrant further large-scale clinical investigations for verification.

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来源期刊

Complementary therapies in medicine 医学-全科医学与补充医学

CiteScore

8.60

自引率

2.80%

发文量

101

审稿时长

112 days

期刊介绍： Complementary Therapies in Medicine is an international, peer-reviewed journal that has considerable appeal to anyone who seeks objective and critical information on complementary therapies or who wishes to deepen their understanding of these approaches. It will be of particular interest to healthcare practitioners including family practitioners, complementary therapists, nurses, and physiotherapists; to academics including social scientists and CAM researchers; to healthcare managers; and to patients. Complementary Therapies in Medicine aims to publish valid, relevant and rigorous research and serious discussion articles with the main purpose of improving healthcare.