Complementary therapies in medicine最新文献

{"title":"Recent trends in Tuina for chronic pain management: A bibliometric analysis and literature review","authors":"Hui Xu ,&nbsp;Zheng Wang ,&nbsp;Zhen Wang ,&nbsp;Yang Lei ,&nbsp;Juntao Chen ,&nbsp;Hang Zhou ,&nbsp;Mengmeng Li ,&nbsp;Jieyao Diao ,&nbsp;Yanqin Bian ,&nbsp;Bin Zhou ,&nbsp;Yunfeng Zhou","doi":"10.1016/j.ctim.2024.103068","DOIUrl":"https://doi.org/10.1016/j.ctim.2024.103068","url":null,"abstract":"<div><h3>Background</h3><p>The utilization of Tuina as a therapeutic intervention for the management of chronic pain has experienced a gradually increase in its popularity, and the purpose of this bibliometric analysis is to offer a comprehensive understanding of the current state and frontier trends, as well as to provide recommendations for future research directions.</p></div><div><h3>Methods</h3><p>Publications on Tuina for chronic pain published between 2004 and 2023 were retrieved from the Web of Science Core Collection (WoSCC). Microsoft Excel, CiteSpace, VOSViewer, and the R package “bibliometrix” were used to quantitatively analyse the annual publication volume, countries/regions, journals, institutions, cited references, authors, and keywords.</p></div><div><h3>Results</h3><p>A total of 287 publications were retrieved. The number of annual publications on the use of Tuina for treating chronic pain has gradually increased. Most publications were published in China and the United States. Notably, the most productive institution and author were identified as Shanghai University of Traditional Chinese Medicine and Min Fang, respectively. <em>Medicine</em> ranked first as the most influential affiliate and most productive journal. These publications came from 1650 authors, among whom Edzard Ernst had the most co-citations. Keyword analysis revealed that the new research frontier was low back pain.</p></div><div><h3>Conclusion</h3><p>The utilization of Tuina for the treatment of chronic pain has been gaining increasing recognition. Acupuncture, randomised controlled trials, systematic reviews, etc. were the main research subjects. Furthermore, low back pain is the new research frontier. This study provides an in-depth perspective on Tuina for chronic pain, which provides valuable reference material for clinicians with insights of therapeutic strategy, educators with valuable topics, and researchers with new research directions.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000566/pdfft?md5=b8cc264f88cf5e6ec5bd5f017634fa56&pid=1-s2.0-S0965229924000566-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141606499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of flaxseed (Linum usitatissimum) supplementation on anthropometric indices: An updated systematic review and meta-analysis of randomized clinical trials","authors":"","doi":"10.1016/j.ctim.2024.103066","DOIUrl":"10.1016/j.ctim.2024.103066","url":null,"abstract":"<div><h3>Objective</h3><p>Flaxseed (<em>Linum usitatissimum</em>) supplementation has shown promise as an anti-obesity agent in various clinical trials, although results have been inconsistent. To provide a more accurate assessment of the impact of flaxseed supplementation on anthropometric indices, a systematic review and meta-analysis was performed.</p></div><div><h3>Methods</h3><p>We searched several international databases until August 2023, including Scopus, PubMed, Web of Science, Embase, and Cochrane Library. Weighted mean differences (WMDs) were analyzed using a random-effects model.</p></div><div><h3>Results</h3><p>Sixty-four trials comprising 72 treatment arms were included. All studies reported the intervention types (Lignans, Whole flaxseed, and Flaxseed oil) and dosage. However, three studies did testing for purity, and 40 studies reported potency. Also, the risk of contamination with heavy metals was not mentioned in studies. Another limitation was the lack of blind evaluation in the studies. According to three trials included in the systematic review, flaxseed did not affect anthropometric indices. Our meta-analysis revealed significant reductions in body weight (WMD = −0.63 kg; 95 % CI: −1.00, −0.27, P &lt; 0.001; I² = 76.7 %, P &lt; 0.001), body mass index (BMI) (WMD: −0.24 kg/m2, 95 % CI: −0.36, −0.11, P &lt; 0.001; I² = 78.5 %, P &lt; 0.001) and waist circumference (WC) (WMD: −1.43 cm, 95 % CI: −2.06, −0.80, P &lt; 0.001; I² = 81.1 %, P &lt; 0.001) following flaxseed supplementation. Subgroup analyses indicated that interventions lasting 10–20 weeks, and studies involving subjects with higher BMI (&gt;30 kg/m²) showed more significant anti-obesity effects. Based on the GRADE evaluation, body weight, BMI, and WC results were considered as moderate-certainty evidence.</p></div><div><h3>Conclusion</h3><p>Our systematic review and meta-analysis suggests that supplementation with flaxseed <em>(Linum usitatissimum</em>) leads to meaningful improvements in body weight, BMI, and WC. Therefore, flaxseed can be considered as an adjunctive therapeutic approach in improving obesity</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000542/pdfft?md5=478ec8d9c392acdc9fbc30e78ecfa739&pid=1-s2.0-S0965229924000542-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence mapping and quality assessment of systematic reviews on exercise intervention for Alzheimer’s disease","authors":"Zhengdong Xu ,&nbsp;Jiaxing Tang ,&nbsp;Wenjuan Yi","doi":"10.1016/j.ctim.2024.103065","DOIUrl":"10.1016/j.ctim.2024.103065","url":null,"abstract":"<div><h3>Background</h3><p>A significant body of literature suggests that exercise can reverse cognitive impairment and ameliorate somatic function in patients with Alzheimer's disease (AD). Systematic reviews (SRs), a common approach of evidence-based medicine, concentrate on a specific issue of a research area. The objective of this work is to provide an overview of existing evidence on the effects of exercise intervention in AD patients and report related health outcomes by reviewing SRs.</p></div><div><h3>Methods</h3><p>SRs on exercise intervention in AD patients were retrieved from the PubMed, the Cochrane Library, CBMdisc, Scopus, Web of Science, Embase (via Ovid), China National Knowledge Infrastructure, and WanFang databases from the time of inception to February 2023. The quality of the SRs was evaluated utilizing the A Measurement Tool to Assess Systematic Review 2 (AMSTAR 2) checklist. The results were reported according to the population-intervention-comparison-outcome (PICO) framework and the corresponding evidence mapping was illustrated in tables and bubble plots.</p></div><div><h3>Results</h3><p>A total of 26 SRs met the eligibility criteria. In terms of methodological quality, 10 SRs were rated as \"critically low\", 13 SRs were rated as \"low\", and 3 SRs were rated as \"moderate\". Exercise was found to exert a beneficial effect on cognitive function, functional independence, physical function, and neuropsychiatric symptoms in patients with AD.</p></div><div><h3>Conclusion</h3><p>Exercise intervention benefits AD patients mainly by improving cognitive function, physical function, functional independence, and neuropsychiatric symptoms. However, due to the low-to-moderate methodology of most SRs included in this analysis, further investigations are required to support our current findings.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000530/pdfft?md5=6b19dab5c6999ffd0847c0b851782207&pid=1-s2.0-S0965229924000530-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dark chocolate/ cocoa consumption on oxidative stress and inflammation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of controlled trials","authors":"Mehrdad Behzadi ,&nbsp;Mohammad Vesal Bideshki ,&nbsp;Maryam Ahmadi-Khorram ,&nbsp;Meysam Zarezadeh ,&nbsp;Alireza Hatami","doi":"10.1016/j.ctim.2024.103061","DOIUrl":"10.1016/j.ctim.2024.103061","url":null,"abstract":"<div><h3>Background</h3><p>Oxidative stress and inflammation play critical roles in the pathogenesis of many chronic diseases. Dark chocolate (DC)/cocoa, as a rich source of polyphenols like flavonoids, has anti-inflammatory and antioxidant properties that may confer health benefits, but findings in this context are inconsistent.</p></div><div><h3>Objective</h3><p>This systematic review and dose-response meta-analysis aimed to provide a comprehensive overview of the controlled trials (CTs) that have examined the effects of DC/cocoa on oxidative stress and inflammation biomarkers in adults.</p></div><div><h3>Search methods</h3><p>Databases including PubMed, Web of Science, and Scopus, were searched for relevant studies through April 2024.</p></div><div><h3>selection criteria</h3><p>Studies assessed C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), nitric oxide (NO), P-selectin, E-selectin and thiobarbituric acid reactive substances (TBARS) in adults were included.</p></div><div><h3>Data analysis</h3><p>Based on the random-effects model, we calculated WMDs, SMDs and 95 % confidence intervals (CIs). Sensitivity, sub-group, meta-regression and dose-response analyses were also conducted.</p></div><div><h3>Results</h3><p>Thirty-three eligible CTs with 1379 participants were included. All studies reported the intervention types (cocoa powder, beverages and chocolate bars) and dosage. However, sixteen studies didn’t do/report testing for purity and potency by independent groups. Also, none of the studies mentioned the risk of contamination with heavy metals. Another limitation was the lack of blinding assessment in studies. DC/cocoa significantly reduced MDA (SMD: −0.69, 95 %CI: −1.17, −0.2, p = 0.005) and increased NO levels (SMD: 2.43, 95 %CI: 1.11,3.75, p &lt; 0.001); However, it has no significant effects on the other outcomes. Greater anti-inflammatory effects occurred at higher flavonoid doses (&gt;450 mg/day) and for shorter durations (≤4 weeks) in the non-healthy participants. Non-linear dose-response relationships between cocoa dosage and CRP level and also between flavonoid dosage and IL-6 level were observed. Based on the GRADE evaluation, just CRP and MDA results were considered as high certainty evidence and the other outcomes results were categorized as very low to moderate certainty.</p></div><div><h3>Conclusions</h3><p>DC/cocoa may improve systemic oxidative status and inflammation in adults. However, further studies should be performed to determine its benefits.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000499/pdfft?md5=952b37a0f4c496bc52cc0162d035ba0a&pid=1-s2.0-S0965229924000499-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effects of Hibiscus sabdariffa Linn. on obesity treatment: A systematic review and meta-analysis of randomized controlled trials","authors":"Piyameth Dilokthornsakul ,&nbsp;Natnicha Rattanachaisit ,&nbsp;Phiyanuch Thimkorn ,&nbsp;Supawan Pongpattanawut ,&nbsp;Witoo Dilokthornsakul ,&nbsp;Teerapon Dhippayom","doi":"10.1016/j.ctim.2024.103063","DOIUrl":"10.1016/j.ctim.2024.103063","url":null,"abstract":"<div><h3>Introduction</h3><p>Obesity is associated with many chronic non-communicable diseases, including hypertension, diabetes, cardiovascular and cerebrovascular diseases, cancer, gallbladder disease, bone and joint disorders, skin diseases, fatty liver disease, etc. (Wharton et al., 2020)¹ The recent report revealed that overweight and obesity were prevalent in 60 % of the adult population. Several studies have been published to determine the effect of <em>Hibiscus sabdariffa</em> Linn. on obesity treatment, but the findings are still inconclusive. The purpose of this study was to determine the efficacy and safety of <em>H. sabdariffa</em> Linn in the treatment of obesity.</p></div><div><h3>Methods</h3><p>We searched PubMed, EMBASE, and CENTRAL from inception to February 2024. Randomized controlled trials (RCTs) were included if they explored the effect of <em>H. sabdariffa</em> on one of the following outcomes: body weight, body mass index (BMI), waist circumference, and waist-to-hip ratio. A random-effects model was used to meta-analyze the data. <em>I</em>^<em>2</em> was used to quantify statistical heterogeneity among the included RCTs. PROSPERO registered protocol: CRD42023408880.</p></div><div><h3>Results</h3><p>A total of six RCTs with 339 participants were included. Four trials used <em>H. sabdariffa</em> extract in capsules as the intervention of interest compared to placebo, while the other two trials used <em>H. sabdariffa</em> tea compared to black or green tea. Our meta-analyses showed that the mean difference in weight reduction between <em>H. sabdariffa</em> and control was − 0.27 kg (95 % confidence interval (CI); − 1.98 to 1.42, <em>I</em>^<em>2</em> = 0.0 %). The mean differences for BMI and waist circumference reduction were − 0.06 kg/m² (95 % CI; − 0.58 to 0.47, <em>I</em>^<em>2</em> = 0.0 %) and − 0.20 centimeters (95 % CI; − 2.06 to 1.66, <em>I</em>^<em>2</em> = 0.00 %). No safety concerns were reported in the included studies.</p></div><div><h3>Conclusion</h3><p>Our study did not show a clinical benefit of <em>H. sabdariffa</em> extract in obesity treatment. However, further high-quality RCTs with a longer treatment duration and a standard dose are still warranted.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000517/pdfft?md5=1c843e4f77d265f518af87584423c6ba&pid=1-s2.0-S0965229924000517-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of Garcinia cambogia (hydroxycitric acid) on serum leptin concentrations: A systematic review and meta-analysis of randomized controlled trials","authors":"Mohammad Reza Amini ,&nbsp;Marieh Salavatizadeh ,&nbsp;Shervin Kazeminejad ,&nbsp;Fozhan Javadi ,&nbsp;Mahdi Hajiaqaei ,&nbsp;Gholamreza Askari ,&nbsp;Azita Hekmatdoost","doi":"10.1016/j.ctim.2024.103060","DOIUrl":"10.1016/j.ctim.2024.103060","url":null,"abstract":"<div><h3>Objective</h3><p>The observed impacts of <em>Garcinia cambogia (GC)</em> on serum leptin indicate inconsistency. We performed a systematic review and meta-analysis on randomized controlled trials (RCTs) to evaluate the effectiveness of <em>GC</em> on leptin levels.</p></div><div><h3>Methods</h3><p>A thorough literature search was carried out using different online databases, including Scopus, Web of Science, PubMed, and Google Scholar, until May 25, 2024. Using random effects, weighted mean differences (WMDs) and corresponding 95 % confidence intervals (CIs) were computed. Standard procedures were followed to account for publication bias, study quality, and statistical heterogeneity.</p></div><div><h3>Results</h3><p>In this meta-analysis, a total of eight eligible trials with 330 participants were ultimately included. Quality assessment showed that half of the included trials were considered to have fair quality, while the other half were deemed to have poor quality. Our analysis, with no indication of publication bias, showed a significantly decreased effect of <em>GC</em> on leptin compared with the placebo (WMD: −5.01 ng/ml; 95 % CI: −9.22 to −0.80, p = 0.02). However, significant heterogeneity was detected between studies (I² =93.5 %, p &lt; 0.001). The Hartung-Knapp adjustment did not affect our results. Subgroup analysis revealed that <em>GC</em> consumption represents the most effects in trials with sample size ≥ 50 (WMD: −3.63 ng/ml; 95 % CI [−5.51, −1.76], p &lt; 0.001), and mean age of participants ≥ 30 years (WMD: −7.43 ng/ml; 95 % CI [−9.31, −5.56], p &lt; 0.001).</p></div><div><h3>Conclusions</h3><p>The findings of the present study showed that leptin levels might decline following <em>GC</em> administration. <strong>Registration number:</strong> CRD42023486370</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000487/pdfft?md5=1fdd40046f2f7432c19d7a1a236df7f5&pid=1-s2.0-S0965229924000487-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141320718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of music on anxiety, pain, and blood pressure in ophthalmic surgery: A systematic review and meta-analysis","authors":"Xue Chen ,&nbsp;Long Chen ,&nbsp;Yin Gao","doi":"10.1016/j.ctim.2024.103062","DOIUrl":"10.1016/j.ctim.2024.103062","url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate the effectiveness of music therapy in reducing anxiety, pain, and vital sign changes in ophthalmic surgery patients.</p></div><div><h3>Methods</h3><p>An extensive search of databases, including PubMed, Embase, Cochrane, Web of Science, and Google Scholar, identified relevant studies up to Jan 2024. Selection of studies was conducted based on the PICOS criteria. The quality of methodology was assessed using the Cochrane risk-of-bias assessment tool and Review Manager 5.4. Meta-analysis comparing the control group and the music therapy group was performed using R and Stata/SE 15.1 random or fixed effects model.</p></div><div><h3>Results</h3><p>This meta-analysis included fifteen studies comprising 2098 participants. The analysis revealed that music therapy significantly reduced the risk of high anxiety levels as measured by Visual Analogue Scale (VAS) (I² = 0 %, RR(95 %CI): 0.75(0.63, 0.88), <em>p</em> = 0.0006), indicating a substantial effect without heterogeneity. The Anxiety scores determined by State-Trait Anxiety Inventory-State (STAI-S) also showed a significant decrease (SMD(95 %CI): −0.75(−0.88, −0.61), <em>p</em> &lt; 0.0001), albeit with moderate heterogeneity (I² = 36 %). Additionally, music therapy was associated with a reduction in intraoperative pain levels, with no observed heterogeneity (I² = 0 %, SMD(95 %CI): −0.74(−0.93, −0.56), <em>p</em> &lt; 0.0001). In contrast, music intervention did not significantly influence self-reported nervousness, relaxation, or satisfaction levels as determined by VAS. Regarding to physiological parameters, a marginal decrease in systolic blood pressure (SBP) was observed (SMD(95 %CI): −0.42(−0.79, −0.04), <em>p</em> = 0.0286), with considerable heterogeneity (I² = 92 %). Diastolic blood pressure (DBP) experienced a slight reduction (I² = 90 %, SMD(95 %CI): −0.45(−0.79, −0.11), <em>p</em> = 0.0088). However, no significant effect was observed on patients’ heart rate (<em>p</em> = 0.0864).</p></div><div><h3>Conclusion</h3><p>Music therapy effectively reduced anxiety and pain, and moderately improved vital signs in patients undergoing ophthalmic surgery, highlighting its role in enhancing patient well-being. Further in-depth RCTs are needed to confirm its efficacy.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000505/pdfft?md5=9563390f1b06a2e4045408d4c6cb02d7&pid=1-s2.0-S0965229924000505-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141283225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse events of herbal decoction: A systematic review and meta-analysis over past 10 years","authors":"Han-Gyul Lee ,&nbsp;Hyein Jeong ,&nbsp;Chan-Young Kwon ,&nbsp;Kyeong-Han Kim ,&nbsp;Soo Hyun Sung ,&nbsp;Ji Eun Han ,&nbsp;Minjung Park ,&nbsp;Soobin Jang","doi":"10.1016/j.ctim.2024.103057","DOIUrl":"10.1016/j.ctim.2024.103057","url":null,"abstract":"<div><h3>Background</h3><p>Herbal decoctions (HDs) are the oldest and most common herbal medicine formulations. Different HDs exist, and some consumers are concerned that they may become contaminated during manufacturing. Therefore, the need for a safety assessment of HDs has been raised. This study aimed to investigate the adverse events (AEs) associated with HDs by comprehensively analyzing randomized controlled trials (RCTs) using systematic reviews and meta-analyses.</p></div><div><h3>Methods</h3><p>A systematic search was conducted on PubMed, Embase, and the Cochrane Library for articles published up to November 2022. The included RCTs compared HDs with other treatments published between 2013 and 2022, and the risk of bias was assessed using RevMan 5.4. Meta-analyses of the number of AEs associated with HDs reported in the included RCTs were also performed.</p></div><div><h3>Results</h3><p>The systematic review included 26 RCTs, and the meta-analysis included 17 RCTs that reported AEs. The meta-analysis comparing HDs with active controls showed that both the number of AEs (14 studies; risk ratio (RR)= 0.50 cases, 95 % confidence interval (CI) [0.29, 0.88]; I² = 42 %) and the number of patients who complained of AEs (seven studies; RR=0.51 patients, 95 % CI [0.28, 0.94]; I² =9 %) were fewer in the HDs group than in the active control groups.</p></div><div><h3>Conclusion</h3><p>This study showed that HDs are safer than other conventional medications based on the results of qualitative and quantitative syntheses of RCTs.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000451/pdfft?md5=4ff6fcc836b26edc81e32a5a7a6954a0&pid=1-s2.0-S0965229924000451-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141234524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of herbs taken concurrently with antihypertensive drugs in managing hypertension and lipid outcomes. A systematic review and meta-analysis.","authors":"Natalia Shania Francis ,&nbsp;Yang Mooi Lim ,&nbsp;Sumaiyah Mat ,&nbsp;Annaletchumy Loganathan","doi":"10.1016/j.ctim.2024.103058","DOIUrl":"10.1016/j.ctim.2024.103058","url":null,"abstract":"<div><h3>Purpose</h3><p>Hypertension is the primary cause of mortality. Hence globally, there is a growing interest in complementing antihypertensive drugs with herbs to alleviate blood pressure among hypertensive patients. Thus, this review aimed to evaluate the effectiveness of complementing drugs with herbs on blood pressure and lipid profile outcomes, the associated factors and the types of complementary herbs alongside their consumption regimes.</p></div><div><h3>Methods</h3><p>This review is registered in PROSPERO on the National Institute of Health Database with an ID: CRD42021270481. Using the PICOS (population, intervention, comparison, outcome, study type) mnemonic formula and search strategy, we searched (January 2010 to February 2024) five electronic databases including Pubmed, Scopus, Web of Science, CINAHL (Cumulative Index for Nursing and Allied Health Literature) and Psychology &amp; Behavioral Sciences Collection (PBSC). The inclusion criteria of the review were that all included papers had to be randomised control trials in English among hypertensive adults who complemented antihypertensive drugs with herbs. A Cochrane risk of bias assessment as well as a meta-analysis and narrative synthesis were conducted to answer the objectives.</p></div><div><h3>Results</h3><p>Twenty-five randomised controlled trials involving 1996 participants from 14 countries were included. The risk of bias among included articles was assessed and presented using the Cochrane risk of bias tool and the graphs were generated. The effects of complementing antihypertensive drugs with different herb regimes on blood pressure and lipid profile outcomes were compared to those solely on antihypertensive drugs and placebo via a random model effects meta-analysis using the Revman manager. Systolic blood pressure (SBP) and triglycerides gave a significant reduction in favour of the intervention group which complemented herbs. The overall pooled systolic blood pressure showed a reduction of (SMD=0.81, 95 % CI 0.14–1.47, <em>p</em> &lt; 0.02, <em>p</em> for heterogeneity=0.00001, I² =97 %) while triglycerides were (SMD=0.73, 95 % CI 0.17–1.28, <em>p</em> &lt; 0.01, <em>p</em> for heterogeneity=0.00001, I² =85 %). However, diastolic blood pressure, total cholesterol, HDL and LDL did not exert significant outcomes.</p></div><div><h3>Conclusion</h3><p>The complemented herbs with antihypertensive drugs did show improvement in overall blood pressure management in the majority of the studies compared to the placebo group. Blood pressure and lipid profiles are the health outcomes that enable access to complementing herbs in controlling high blood pressure. Some limitations of this review are attributed to performance, detection and attrition bias in a few included articles alongside the presence of a high heterogeneity overall.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000463/pdfft?md5=f89493eb6b1f8cab1da8045ffd0270d6&pid=1-s2.0-S0965229924000463-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study to assess the feasibility and uptake of MindDEC, a mindfulness-based self-management course for type 2 diabetes","authors":"P.S. Deo ,&nbsp;T.M. Barber ,&nbsp;C. Gotts ,&nbsp;M. Villarreal ,&nbsp;H. Randeva ,&nbsp;S. Brown ,&nbsp;J. Bath ,&nbsp;P. O’Hare ,&nbsp;S. Chaggar ,&nbsp;P. Hanson","doi":"10.1016/j.ctim.2024.103059","DOIUrl":"10.1016/j.ctim.2024.103059","url":null,"abstract":"<div><h3>Objective</h3><p>The study aimed to investigate the feasibility of a remote mindfulness based self-management intervention for individuals with type 2 diabetes. It is important to further our understanding of how to improve self-management to improve health outcomes and low levels of uptake to self-management courses.</p></div><div><h3>Method</h3><p>29 participants with type 2 diabetes were recruited from the University Hospital Coventry and Warwickshire NHS trust. Three groups of participants engaged with a remote mindfulness based self-management intervention, which were delivered sequentially. After each intervention was complete, patient feedback was retrieved and implemented into the following intervention. The quantitative analysis comprised of descriptive statistics, independent sample t-test, paired sample t-test and multiple regression analysis. A qualitative analysis was also conducted through reflexive thematic analysis (RTA) to understand participant’s perspective on the intervention.</p></div><div><h3>Results</h3><p>There was a total of 17 who attended the course (59 %) and a total drop out of 12 participants over the three courses (41 %). The qualitative findings reported three main themes: (1) Eating to manage my emotions rather than my diabetes (2) Implementing mindfulness has helped me manage my emotions (3) Medication rather than self-management behaviours control my diabetes. The focus group feedback included participants’ appreciation of the community aspect of the intervention and their perception that the current course was more interactive compared to previous interventions. In addition, participants highlighted the importance of offering the course at an earlier stage of diagnosis to provide further support at the beginning of their diabetes journey. No significant findings were reported for the independent sample t-test, paired sample t-test and multiple regression analysis.</p></div><div><h3>Conclusion</h3><p>The qualitative findings suggested that the course was beneficial, especially in demonstrating how mindfulness could aid self-management for individuals living with type 2 diabetes. Further funding and trials are warranted to improve the quality of technology used and to assess impact on diabetes control and mental health.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000475/pdfft?md5=f69418341ed4e5d6fa7b65a80de54106&pid=1-s2.0-S0965229924000475-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}