Complementary therapies in medicine最新文献

{"title":"Small-world network properties and cortical responses of Tai Chi Yunshou: Insights from fNIRS","authors":"Jin Fan ,&nbsp;Ruijun He ,&nbsp;Dongling Zhong ,&nbsp;Xiaobo Liu ,&nbsp;Huan Liu ,&nbsp;Zhi Chen ,&nbsp;Qinjian Dong ,&nbsp;Yuxi Li ,&nbsp;Chen Xue ,&nbsp;Jiaming Zhang ,&nbsp;Cheng Xie ,&nbsp;XianJun Xiao ,&nbsp;Xiaoshen Hu ,&nbsp;Xi Wu ,&nbsp;Juan Li ,&nbsp;Rongjiang Jin","doi":"10.1016/j.ctim.2025.103224","DOIUrl":"10.1016/j.ctim.2025.103224","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to characterize the time-domain features and functional network properties from Tai Chi Yunshou across four states (rest, observation, imagination, and motion) using functional near-infrared spectroscopy (fNIRS), thereby discriminating the neural mechanisms underlying the mental regulation and integrative body-mind harmony of Tai Chi Yunshou.</div></div><div><h3>Methods</h3><div>100 healthy participants were included and administered with rest, observation, imagination and motion states of Tai Chi Yunshou. The forty-channel wearable fNIRS system was utilized to evaluate the real-time cortical responses during four states. Brain network properties were analyzed with MATLAB and the GRETNA toolbox. Machine learning models, including random forest, AdaBoost, and gradient boosting, were applied for classification.</div></div><div><h3>Results</h3><div>Small-world network properties (γ&gt;1 and λ≈1) across four states were detected. Compared to states of rest and observation, the motion state exhibited significantly higher γ, λ, Cp, and Eloc (<em>P</em> &lt; 0.01). Additionally, λ and Cp were significantly greater in the motion state than that of the imagination state (<em>P</em> &lt; 0.01). The motion state had increased betweenness centrality and nodal efficiency hubs of the dorsolateral prefrontal cortex and frontopolar area. Gradient boosting outperformed both AdaBoost and random forest across all evaluation metric.</div></div><div><h3>Conclusion</h3><div>The motion of Tai Chi Yunshou enhances regulatory capacity in the dorsolateral prefrontal cortex and frontopolar area, boosts local brain processing, and improves network integration. Machine learning models can effectively capture and differentiate the neural features between mental regulation and integrative body-mind harmony.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103224"},"PeriodicalIF":3.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of emotional states by volatile herbal extracts: Multisystem physiological evidence from Rosa rugosa, Acorus tatarinowii, and Cyperus rotundus","authors":"Hui Wang,&nbsp;Dan Qin,&nbsp;Xinjie Shi,&nbsp;Menghan Fan,&nbsp;Wenyan Li,&nbsp;Yun Wang","doi":"10.1016/j.ctim.2025.103218","DOIUrl":"10.1016/j.ctim.2025.103218","url":null,"abstract":"<div><h3>Background</h3><div>Traditional aromatic herbs <em>Rosa rugosa</em> Thunb. (R. rugosa), <em>Acrorus tatarinowii</em> Schott (A. tatarinowii) and <em>Cyperus rotundus</em> L. (C. rotundus) have been used for emotional state regulation, yet their underlying physiological mechanisms and clinical efficacy in modern applications remain underexplored.</div></div><div><h3>Objective</h3><div>To systematically evaluate the emotional state regulatory effects of volatile extracts from R. rugosa, A. tatarinowii, and C. rotundus through multisystem physiological measurements and develop a data-driven quantitative assessment model.</div></div><div><h3>Methods</h3><div>Sixty-six female participants underwent pre/post-intervention recordings of comprehensive biosignals, including 32-channel Electroencephalography (EEG), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Blood Pressure (MBP), Pulse Rate (PR), Heart Rate (HR), Body Temperature (BT), Respiratory Rate (RR), and completed the Symptom Checklist-90 (SCL-90). A logistic regression model was used to integrate multisource biosignals and SCL-90 scores for constructing the emotional state scorecard.</div></div><div><h3>Results</h3><div>The emotional state scorecard showed 82.51 %-97.23 % classification accuracy (area under the receiver operating characteristic curve (AUC) &gt; 0.90) across 11 emotional states. R. rugosa modulated the prefrontal-limbic network, significantly reducing somatization and hostility. A. tatarinowii influenced the limbic-autonomic interface, alleviating depression and anxiety. C. rotundus targeted the default mode network (DMN), mitigating obsessive-compulsive symptoms and depression. In depression-specific analysis, C. rotundus improved symptoms in 53.85 % of cases, while R. rugosa prevented depressive risk in 61.54 % of healthy subjects.</div></div><div><h3>Conclusions</h3><div>This study provides robust quantitative physiological evidence for the emotional state regulatory effects of these herbs, highlighting their translational potential in evidence-based mental health management. Future research should prioritize isolating bioactive compounds and validating efficacy via randomized controlled trials to advance precision herbal medicine.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103218"},"PeriodicalIF":3.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of acupuncture in the treatment of Alzheimer's disease: An exploration from traditional Chinese medicine to modern technology","authors":"Mei Wang ,&nbsp;Li Zhang ,&nbsp;Wendi Huang ,&nbsp;Juan Huang ,&nbsp;Yong Luo ,&nbsp;Nanqu Huang","doi":"10.1016/j.ctim.2025.103222","DOIUrl":"10.1016/j.ctim.2025.103222","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a neurodegenerative disease with the highest prevalence worldwide, and it places considerable life and economic burdens on patients and their families. Currently, treatments for AD only delay symptoms, fail to reverse disease progression, and are often accompanied by significant side effects. Acupuncture, a nonpharmacological therapeutic method originating from China, has a history of thousands of years and is characterized by safety and economy. In recent years, the potential of acupuncture use in AD treatment has received widespread attention. With the rapid development of modern science and technology, the mechanism of action of acupuncture in the treatment of AD has gradually become increasingly clear. Therefore, we searched the databases of China National Knowledge Infrastructure (CNKI), PubMed and Web of Science for relevant studies on acupuncture for AD in recent years. According to the literature, acupuncture can improve cognitive function in AD patients through various mechanisms, such as reducing β-amyloid deposition, inhibiting Tau protein hyperphosphorylation, and attenuating neuroinflammation, and shows good therapeutic potential. Future studies should further explore in depth the mechanisms of acupuncture in treating AD through the rational use of modern science and technology techniques, with the aim of providing new strategies for the treatment of AD.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103222"},"PeriodicalIF":3.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of intraoperative music intervention on anxiety and pain control in patients undergoing kidney surgery: a systematic review and meta-analysis of randomized controlled trials.","authors":"Yan Lou, Shuang Xu, Panpan Gao","doi":"10.1016/j.ctim.2025.103221","DOIUrl":"https://doi.org/10.1016/j.ctim.2025.103221","url":null,"abstract":"<p><strong>Objectives: </strong>To report the first systematic review and meta-analysis of randomized controlled trials (RCT) for the effect of intraoperative music intervention on anxiety and pain control in patients undergoing kidney surgery.</p><p><strong>Methods: </strong>A systematic literature search was conducted across PubMed, Embase, Web of Science, and Cochrane up to November 2024. Outcomes included visual analog score (VAS) and State-Trait Anxiety Inventory (STAI). Standardized mean differences (SMD) and 95% confidence intervals (CI) were used for data pooling of continuous variables. In addition, sensitivity analysis was performed to assess the stability of the results. All analyses were performed using Review Manager 5.4 and STATA 15.1.</p><p><strong>Results: </strong>The meta-analysis revealed that patients in the music intervention group had significantly lower postoperative VAS (SMD: -0.65; 95% CI: -0.93, -0.38; P＜0.00001) and STAI scores (SMD: -0.48; 95% CI: -0.71, -0.26; P＜0.0001) compared to those in the control group. Significant heterogeneity was observed for both outcomes. In addition, sensitivity analysis confirmed the stability of both outcomes, but VAS was found to have significant publication bias.</p><p><strong>Conclusions: </strong>Music intervention can significantly reduce the postoperative VAS and STAI of patients undergoing renal surgery, and effectively control the anxiety and pain caused by surgery. Considering the potential heterogeneity, publication bias, and low regional selection bias in this study, more large-sample, multicenter RCTs are needed in the future to further confirm the effect of music intervention on pain and anxiety relief in individuals undergoing renal surgery and potential influencing factors.</p>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":" ","pages":"103221"},"PeriodicalIF":3.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of acupressure on venous access procedural pain in children: A systematic review and meta-analysis","authors":"Seyed Javad Hosseini ,&nbsp;Matin Abdollahi Yousefabady ,&nbsp;Seyed Reza Hosseini ,&nbsp;Mahbobeh Firooz","doi":"10.1016/j.ctim.2025.103219","DOIUrl":"10.1016/j.ctim.2025.103219","url":null,"abstract":"<div><h3>Background</h3><div>Effective pain management during venous access in children is a clinical priority, but evidence on acupressure remains inconclusive. This study aimed to evaluate the effectiveness of acupressure on venous access pain in children.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted across multiple electronic databases, including PubMed, Scopus, Web of Science, CENTRAL, ClinicalTrials.gov, and Google Scholar. Relevant studies were identified using a combination of keywords related to the research objective, covering all available records up to January 15, 2025. Randomized clinical trials (RCTs) comparing the effects of acupressure on pain intensity during catheter insertion and venipuncture in children versus a control group were included in the review.</div></div><div><h3>Results</h3><div>This systematic review and meta-analysis included eight studies with a total of 537 pediatric participants. The pooled analysis demonstrated that acupressure significantly reduced pain intensity during peripheral catheter insertion and venipuncture compared to the control group (SMD: −2.30; 95 % CI: −3.20 to −1.40; Z = 5.01, P &lt; 0.001, I² = 93.6 %). Subgroup analysis further indicated that acupressure effectively decreased pain severity for both peripheral catheter insertion (SMD: −1.99; 95 % CI: −3.45 to −0.54) and venipuncture (SMD: −2.61; 95 % CI: −3.62 to −1.61), with statistically significant results.</div></div><div><h3>Conclusions</h3><div>Given that only two studies met high-quality criteria and the certainty of the overall evidence remains very low, the interpretation of findings should be approached with caution. To enhance the robustness of future evidence, there is a pressing need for rigorously designed randomized trials incorporating placebo control groups and proper allocation concealment.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103219"},"PeriodicalIF":3.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily intranasal sesame oil instillation to improve nasal barrier function and mucosal immunity for respiratory health: A pilot randomized trial in healthy adults","authors":"Sarika Chaturvedi ,&nbsp;Mahesh Karandikar ,&nbsp;Pallavi Mundada ,&nbsp;Srikanth Tripathy ,&nbsp;Rasika Kolhe ,&nbsp;Babita Yadav ,&nbsp;Rakesh Rana ,&nbsp;Preeti Chavan Gautam ,&nbsp;Sarang Satoor ,&nbsp;Tanuja Phalke ,&nbsp;Poonam Suryawanshi ,&nbsp;Shruti Khanduri ,&nbsp;BCS Rao ,&nbsp;N. Srikanth ,&nbsp;Bhushan Patwardhan","doi":"10.1016/j.ctim.2025.103210","DOIUrl":"10.1016/j.ctim.2025.103210","url":null,"abstract":"<div><h3>Background</h3><div>Nasal barrier function and mucosal immunity are important to respiratory health, especially with growing evidence of health effects of air pollution. Native American, Traditional Chinese and Indian medicine systems recommend intranasal oil instillation for respiratory health. We assessed feasibility, acceptability, and preliminary efficacy of daily intranasal oil instillation for improved respiratory health.</div></div><div><h3>Methods</h3><div>A parallel group three arm randomized controlled trial (RCT) in healthy volunteers (n = 102) allocated equally to intranasal sesame oil, medicated sesame oil (Anu Oil) and control groups tested its feasibility and acceptability. Preliminary efficacy was tested by assessing expression of mucin genes (MUC5B, MUC5AC) that code for nasal barrier function. Other outcomes included expression of Occludin (OCLN), Claudin 9 (CLDN9) and Junction Adhesion Molecules (JAM), cytokines (IL6, IL10, TNF alpha, IFN gamma), pH of nasal mucus, mucosal immunity (sIGA), sleep quality, perceived stress, and incidence and severity of respiratory infections.</div></div><div><h3>Results</h3><div>Recruitment and retention of participants (Mean age= 20.6years) in Pune, India was feasible. Ninety nine participants completed this 12-week study. There were no serious adverse events. We standardized methods for noninvasive collection of nasal mucus samples using Whatman (no.42) paper strips and its processing to optimize RNA yield. Assessment of outcomes was feasible except for expression of JAM and IFN gamma that were undetectable. Downregulation of MUC5B and MUC5AC and no concurrent rise in cytokine levels suggest potential beneficial effect and assure safety of intranasal oil instillation, though nonsignificant in this pilot RCT. Significant improvements in sleep quality (group difference [∆] = −1.33, p = 0.02) and nasal pH (∆ = −0.16, p = 0.01) were found in sesame oil group.</div></div><div><h3>Interpretation</h3><div>Feasibility and preliminary efficacy of self-administered intranasal sesame oil instillation is demonstrated. A definitive RCT to evaluate it as a prophylaxis for respiratory health is needed.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103210"},"PeriodicalIF":3.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exercise on aerobic capacity in people with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials","authors":"Ze Xu ,&nbsp;Yin Liang ,&nbsp;Hao Su ,&nbsp;Yongjie Chen ,&nbsp;Yuanyuan Lv ,&nbsp;Lin Feng ,&nbsp;Laikang Yu","doi":"10.1016/j.ctim.2025.103217","DOIUrl":"10.1016/j.ctim.2025.103217","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the effects of exercise on aerobic capacity in type 2 diabetes mellitus (T2DM) patients through a systematic review and meta-analysis of randomized controlled trials.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in Web of Science, PubMed, Embase, Cochrane, and Scopus from inception to September 8, 2024. The Cochrane risk assessment tool was used to assess the methodological quality of the included literature. Data were pooled using random-effects models to calculate standardized mean difference (SMD) and 95 % confidence interval.</div></div><div><h3>Results</h3><div>Fourteen studies involving 803 participants (437 in exercise groups and 366 in control groups) were included. Exercise significantly improved aerobic capacity inT2DM patients (SMD, 0.62; <em>p</em> &lt; 0.00001). Subgroup analyses revealed that multicomponent training (SMD, 0.74; <em>p</em> = 0.0007), session duration ≥ 60 min (SMD, 0.75; <em>p</em> &lt; 0.00001), frequency &gt; 3 times per week (SMD, 0.89; <em>p</em> = 0.0003), and weekly time ≥ 180 min (SMD, 0.86; <em>p</em> &lt; 0.00001) were more effective. Younger patients (&lt; 45 years) showed greater improvements (SMD, 0.87; <em>p</em> = 0.01) compared to older patients.</div></div><div><h3>Conclusion</h3><div>Exercise improved aerobic capacity in T2DM patients, with multicomponent training emerging as the most effective intervention. Clinicians should recommend that T2DM patients engage in exercise at least 3 times per week, with sessions lasting 60 min or more, to achieve a cumulative weekly time of 180 min or more.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103217"},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of traditional Chinese exercises on cardiopulmonary function in stroke patients: A meta-analysis","authors":"Danmeng Tong ,&nbsp;Hongyu Li ,&nbsp;Wei Zhao ,&nbsp;Wang Guo ,&nbsp;Bin Chen ,&nbsp;Qiang Tang","doi":"10.1016/j.ctim.2025.103209","DOIUrl":"10.1016/j.ctim.2025.103209","url":null,"abstract":"<div><h3>Background</h3><div>Traditional Chinese exercises may be effective in improving cardiorespiratory fitness in post-stroke patients; however, no study has conducted a meta-analysis to assess their its efficacy in meta.</div></div><div><h3>Objective</h3><div>The purpose of this meta-analysis is to evaluate how traditional Chinese exercises affect post-stroke cardiorespiratory fitness.</div></div><div><h3>Methods</h3><div>We conducted a comprehensive search across eight Chinese and English databases, including Wan Fang, VIP, CBM, PubMed, Embase, Web of Science, and the Cochrane Library, from the inception of these databases until May 2025. Our focus was on clinical randomized controlled trials related to stroke, cardiorespiratory function, and traditional Chinese exercises. After assessing the quality of the literature, we utilized Rev Man 5.4 software to analyze the data. Publication bias was assessed using funnel plots as well as Begg's and Egger's tests, employing Stata 17.0 software.</div></div><div><h3>Results</h3><div>A total of 23 studies were included in the analysis, and the results of the meta-analysis indicated that traditional Chinese exercises significantly improved cardiopulmonary function in post-stroke patients: pulmonary function indexes [FVC: SMD = 1.01, 95 %CI(0.66,1.35), I²= 88 %,P &lt; 0.00001; FEV1: SMD = 1.22, 95 % CI (0.77,1.66), I² = 91 %, P &lt; 0.00001; PEF: SMD = 0.87, 95 % CI (0.53,1.21), I²= 83 %, P &lt; 0.00001; MVV: MD = 9.65, 95 % CI (8.60,10.70), I²= 0 %, P = 0.55]; respiratory muscle function indexes [MIP: SMD = 0.72, 95 % CI (0.43,1.01) I²= 67 %, P = 0.001; MEP: SMD = 0.67, 95 %CI (0.49,0.86),I² = 0 %, P = 0.55]; cardiac function index [LVEF: MD = 4.00, 95 % CI (2.28,5.72), I² = 72 %, P = 0.01]; exercise endurance index [6MWT: MD = 4.49, 95 % CI (3.55,5.42), I² = 0 %, P = 0.77]. No serious adverse events related to traditional Chinese exercises were reported. Only one study documented instances of patients experiencing panic attacks and shortness of breath, which resolved upon rest. Following a physician's examination, it was suggested that these symptoms may have been attributed to the patient's failure to consume breakfast, and no subsequent harm was reported.</div></div><div><h3>Conclusions</h3><div>Traditional Chinese exercise positively influences cardiorespiratory function in stroke patients, demonstrating the most significant improvements in athletic endurance and cardiac function. However, due to methodological flaws in the literature quality included in the study, there is a need for a multi-center, large-sample, and more rigorously designed experiment to validate these findings and ensure the accuracy of the results.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103209"},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of acupuncture-based treatment in Chronic Obstructive Pulmonary Disease – A systematic review and meta-analysis","authors":"Menglin Li ,&nbsp;Shengjie Zheng ,&nbsp;Ann-Kathrin Lederer ,&nbsp;Roman Huber","doi":"10.1016/j.ctim.2025.103211","DOIUrl":"10.1016/j.ctim.2025.103211","url":null,"abstract":"<div><h3>Background</h3><div>The COPD population will steadily increase due to continuous exposure to COPD risk factors and the aging demographics. Acupuncture, as a common modality in complementary medicine, has been widely applied in the treatment of COPD in recent years. However, systematic reviews of the efficacy of acupuncture-based traditional Chinese external treatment in COPD are relatively scarce and when considering the quality of randomized controlled trials evidence remains insufficient.</div></div><div><h3>Objective</h3><div>To provide an updated systematic review and meta-analysis of the effectiveness of acupuncture-based treatment for COPD using the latest data and a rigorous evaluation system.</div></div><div><h3>Methods</h3><div>Randomized controlled trials evaluating any form of acupuncture in COPD in a stable phase or acute exacerbation phase (AECOPD) were selected from Medline, Cochrane Library, Web of Science, Embase, CNKI, the Wanfang database, VIP, and SinoMed, encompassing a publication period from January 1st, 2000, to May 1st, 2025. The completeness of each study was evaluated according to the Consolidated Standards of Reporting Trials (CONSORT) and Standards for Reporting Interventions in Clinical Trials of Acupuncture guidelines (STRICTA). A meta-analysis was conducted using Cochrane RevMan.</div></div><div><h3>Results</h3><div>A total of 1294 articles were retrieved from the selected database and 25 articles meeting the criteria were included. According to CONSORT, 8 studies rated as high quality, 16 studies as moderate quality, and 1 study as low quality. Due to the heterogeneity of outcome parameters and the limited number of AECOPD studies, meta-analysis could only be performed for COPD in the stable phase. In the meta-analysis, acupuncture-based treatments were significantly superior to controls in COPD in the primary outcome 6-minute walk distance (6MWD: p &lt; 0.01) and the secondary outcomes Borg Scale (p &lt; 0.05), forced expiratory volume in 1 s (FEV1: p &lt; 0.01) and forced vital capacity (FVC: p &lt; 0.05); no significant differences were found in the St. George's Respiratory Questionnaire (SGRQ) and the COPD Assessment Test (CAT).</div></div><div><h3>Conclusions</h3><div>Acupuncture-based treatments significantly enhance the 6MWD, Borg Scale, FEV1 and FVC in COPD patients. The predominance of moderate quality studies indicates the ongoing need for improvement to ensure the credibility of data.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103211"},"PeriodicalIF":3.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture as an alternative treatment for polycystic ovary syndrome: Effects on ovulation rate, pregnancy rate and endometrial receptivity","authors":"Mengdi Ding ,&nbsp;Xueying Zhu ,&nbsp;Yuxiao Huang ,&nbsp;Zilong Tan ,&nbsp;Xiaotong Zhu ,&nbsp;Shuoshuo Han ,&nbsp;Jianwu Shen ,&nbsp;Ran Luo","doi":"10.1016/j.ctim.2025.103215","DOIUrl":"10.1016/j.ctim.2025.103215","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to evaluate the effect of acupuncture treatment as an alternative therapy on ovulation rate, pregnancy rate, and endometrial receptivity in infertile patients with polycystic ovary syndrome (PCOS).</div></div><div><h3>Methods</h3><div>This was a randomized, single-blind, sham acupuncture-controlled clinical trial that included 134 patients who met the inclusion criteria for PCOS infertility. Both groups received letrozole as the base treatment, with the treatment group receiving additional acupuncture treatment twice a week and the control group receiving placebo acupuncture treatment throughout three menstrual cycles. The study collected data collection at baseline, at the end of treatment, looking at ovulation rate, pregnancy rate, sex hormone levels [follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), estradiol (E2), prolactin (PRL)], endometrial receptivity (Salle Score), assessment of uterine using resistance index (RI), pulsatility index (PI) blood flow.</div></div><div><h3>Results</h3><div>The ovulation and pregnancy rate across treatment cycles of women in the treatment group were significantly higher than those in the control group (77.97 % and 49.74 % ovulation rate and 56.72 % and 29.85 % pregnancy rate across treatment cycles, respectively). Comparison of sex hormone levels showed a significant decrease in testosterone (T) levels in the treatment group (<em>P</em> = 0.005). In comparison of endometrial receptivity by Salle score, the total effective rate of the treatment group (86.4 %) was significantly higher than that of the control group (67.2 %), which was different between the two groups (<em>P</em> = 0.005). In comparison of PI and RI, the PI and RI of the treatment group were significantly lower than that of the control group (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Acupuncture treatment can effectively improve ovulation and pregnancy rate across treatment cycles, reduce androgens, and regulate endometrial receptivity in infertile patients with polycystic ovary syndrome, a finding that supports the use of acupuncture as an alternative therapy for treating infertile patients and provides a reference for individualized treatment strategies.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103215"},"PeriodicalIF":3.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}