Effects of exercise on aerobic capacity in people with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

IF 3.5 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine Pub Date : 2025-07-24 DOI:10.1016/j.ctim.2025.103217

Ze Xu , Yin Liang , Hao Su , Yongjie Chen , Yuanyuan Lv , Lin Feng , Laikang Yu

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引用次数: 0

Abstract

Objective

This study aimed to evaluate the effects of exercise on aerobic capacity in type 2 diabetes mellitus (T2DM) patients through a systematic review and meta-analysis of randomized controlled trials.

Methods

A comprehensive search was conducted in Web of Science, PubMed, Embase, Cochrane, and Scopus from inception to September 8, 2024. The Cochrane risk assessment tool was used to assess the methodological quality of the included literature. Data were pooled using random-effects models to calculate standardized mean difference (SMD) and 95 % confidence interval.

Results

Fourteen studies involving 803 participants (437 in exercise groups and 366 in control groups) were included. Exercise significantly improved aerobic capacity inT2DM patients (SMD, 0.62; p < 0.00001). Subgroup analyses revealed that multicomponent training (SMD, 0.74; p = 0.0007), session duration ≥ 60 min (SMD, 0.75; p < 0.00001), frequency > 3 times per week (SMD, 0.89; p = 0.0003), and weekly time ≥ 180 min (SMD, 0.86; p < 0.00001) were more effective. Younger patients (< 45 years) showed greater improvements (SMD, 0.87; p = 0.01) compared to older patients.

Conclusion

Exercise improved aerobic capacity in T2DM patients, with multicomponent training emerging as the most effective intervention. Clinicians should recommend that T2DM patients engage in exercise at least 3 times per week, with sessions lasting 60 min or more, to achieve a cumulative weekly time of 180 min or more.

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运动对2型糖尿病患者有氧能力的影响：随机对照试验的系统回顾和荟萃分析

目的：本研究旨在通过随机对照试验的系统回顾和荟萃分析，评估运动对2型糖尿病（T2DM）患者有氧能力的影响。方法：综合检索Web of Science、PubMed、Embase、Cochrane、Scopus等数据库，检索时间为建站至2024年9月8日。采用Cochrane风险评估工具评估纳入文献的方法学质量。采用随机效应模型合并数据，计算标准化平均差（SMD）和95%置信区间。结果：共纳入14项研究，涉及803名参与者（运动组437人，对照组366人）。运动显著改善t2dm患者的有氧能力(SMD, 0.62；P < 0.00001)。亚组分析显示，多成分训练(SMD, 0.74；p = 0.0007)，会话持续时间≥60分钟(SMD, 0.75；p < 0.00001)，频率>每周3次(SMD, 0.89；p = 0.0003)，每周时间≥180min (SMD, 0.86；P < 0.00001)更有效。年轻患者（< 45岁）表现出更大的改善(SMD, 0.87；P = 0.01)。结论：运动可提高2型糖尿病患者的有氧能力，多组分训练是最有效的干预措施。临床医生应建议2型糖尿病患者每周至少进行3次运动，每次持续60分钟或更长时间，以达到每周累计180分钟或更长时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Complementary therapies in medicine 医学-全科医学与补充医学

CiteScore

8.60

自引率

2.80%

发文量

101

审稿时长

112 days

期刊介绍： Complementary Therapies in Medicine is an international, peer-reviewed journal that has considerable appeal to anyone who seeks objective and critical information on complementary therapies or who wishes to deepen their understanding of these approaches. It will be of particular interest to healthcare practitioners including family practitioners, complementary therapists, nurses, and physiotherapists; to academics including social scientists and CAM researchers; to healthcare managers; and to patients. Complementary Therapies in Medicine aims to publish valid, relevant and rigorous research and serious discussion articles with the main purpose of improving healthcare.