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Postradiation platinum-etoposide in adult medulloblastomas: retrospective analysis of hematological toxicity. 成人髓母细胞瘤放疗后铂-依托泊苷：血液学毒性回顾性分析。
CNS Oncology Pub Date : 2024-06-06 Epub Date: 2024-03-08 DOI: 10.2217/cns-2023-0029
Edina Komlodi-Pasztor, Vasu Munjapara, Charles G Eberhart, Danielle A Bazer, Mohamed R Sherief, David Olayinka Kamson, Xiaobu Ye, Byram Hirsch Ozer, Matthias Holdhoff
{"title":"Postradiation platinum-etoposide in adult medulloblastomas: retrospective analysis of hematological toxicity.","authors":"Edina Komlodi-Pasztor, Vasu Munjapara, Charles G Eberhart, Danielle A Bazer, Mohamed R Sherief, David Olayinka Kamson, Xiaobu Ye, Byram Hirsch Ozer, Matthias Holdhoff","doi":"10.2217/cns-2023-0029","DOIUrl":"10.2217/cns-2023-0029","url":null,"abstract":"<p><p><b>Aim:</b> Adult medulloblastomas (MB) are rare, and optimal post-craniospinal irradiation (CSI) chemotherapy is not yet defined. We investigated hematological toxicity in patients treated with platinum-etoposide (EP) post-CSI. <b>Methods:</b> Retrospective, single-institution study to determine hematological toxicity in adult MB patients treated with EP (1995-2022). <b>Results:</b> Thirteen patients with a median follow-up of 50 months (range, 10-233) were analyzed. Four discontinued treatment due to toxicity, one after 1, 3 after 3 cycles. Hematological toxicities included grade 3 (5 patients) and grade 4 (6 patients). Two patients experienced post-treatment progression and died 16 and 37 months from diagnosis. <b>Conclusion:</b> Post-CSI EP demonstrates acceptable hematological toxicity in adult MB. However, the small cohort precludes definitive survival outcome conclusions. Prospective studies for comprehensive comparisons with other regimens are needed in this context.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":" ","pages":"CNS107"},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic glioblastoma to the lungs: a case report and literature review. 转移到肺部的胶质母细胞瘤：病例报告和文献综述。
CNS Oncology Pub Date : 2024-06-06 Epub Date: 2024-06-12 DOI: 10.1080/20450907.2024.2351789
Carlen A Yuen, Melike Pekmezci, Silin Bao, Xiao-Tang Kong
{"title":"Metastatic glioblastoma to the lungs: a case report and literature review.","authors":"Carlen A Yuen, Melike Pekmezci, Silin Bao, Xiao-Tang Kong","doi":"10.1080/20450907.2024.2351789","DOIUrl":"10.1080/20450907.2024.2351789","url":null,"abstract":"<p><p>Glioblastoma is the most common malignant primary brain tumor. Despite its infiltrative nature, extra-cranial glioblastoma metastases are rare. We present a case of a 63-year-old woman with metastatic glioblastoma in the lungs. Sarcomatous histology, a reported risk factor for disseminated disease, was found. Genomic alterations of <i>TP53</i> mutation, <i>TERT</i> mutation, <i>PTEN</i> mutation, and +7/-10 were also uncovered. Early evidence suggests these molecular aberrations are common in metastatic glioblastoma. Treatment with third-line lenvatinib resulted in a mixed response. This case contributes to the growing body of evidence for the role of genomic alterations in predictive risk in metastatic glioblastoma. There remains an unmet need for treatment of metastatic glioblastoma.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":"13 1","pages":"2351789"},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11172249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BRAF V600E-mutant colorectal cancer with CNS metastases treated successfully with encorafenib, binimetinib and cetuximab 安戈非尼、替米替尼和西妥昔单抗成功治疗伴有中枢神经系统转移的 BRAF V600E 突变结直肠癌
CNS Oncology Pub Date : 2024-05-20 DOI: 10.1080/20450907.2024.2347824
Toru Imai, H. Shoji, H. Hirano, Kunihito Matsuguma, Takahito Awatsu, T. Hirose, N. Okita, A. Takashima, Ken Kato
{"title":"BRAF\u0000 V600E-mutant colorectal cancer with CNS metastases treated successfully with encorafenib, binimetinib and cetuximab","authors":"Toru Imai, H. Shoji, H. Hirano, Kunihito Matsuguma, Takahito Awatsu, T. Hirose, N. Okita, A. Takashima, Ken Kato","doi":"10.1080/20450907.2024.2347824","DOIUrl":"https://doi.org/10.1080/20450907.2024.2347824","url":null,"abstract":"","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":"42 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141118996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An adult with recurrent atypical teratoid rhabdoid tumor of the spine. 一名患有复发性脊柱非典型畸胎横纹肌瘤的成年人。
CNS Oncology Pub Date : 2024-01-01 Epub Date: 2024-02-21 DOI: 10.2217/cns-2023-0017
Antoinette J Charles, Vanessa L Smith, C Rory Goodwin, Margaret O Johnson
{"title":"An adult with recurrent atypical teratoid rhabdoid tumor of the spine.","authors":"Antoinette J Charles, Vanessa L Smith, C Rory Goodwin, Margaret O Johnson","doi":"10.2217/cns-2023-0017","DOIUrl":"10.2217/cns-2023-0017","url":null,"abstract":"<p><p>Atypical teratoid rhabdoid tumors (AT/RT) are rare and highly malignant CNS neoplasms primarily affecting children. Adult cases are extremely uncommon, with only approximately 92 reported. Spinal AT/RT in adults is particularly rare. Here, we present the case of a 50-year-old patient diagnosed with AT/RT of the spine. Initially, they were diagnosed and treated for a spinal ependymoma. However, after 10 years, a recurrence was detected through magnetic resonance imaging (MRI) and the tumor was reclassified as AT/RT. We discuss the significance of <i>SMARCB1</i> gene mutations in diagnosing AT/RT and describe our unique treatment approach involving surgery, radiation and anti-PD1 therapy in this patient.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":" ","pages":"CNS105"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promising response to vemurafenib and cobimetinib treatment for BRAF V600E mutated craniopharyngioma: a case report and literature review. BRAF V600E突变颅咽管瘤对维莫非尼和克比米替尼治疗的良好反应：病例报告和文献综述。
CNS Oncology Pub Date : 2024-01-01 Epub Date: 2024-02-13 DOI: 10.2217/cns-2023-0018
Nina Yu, Osama A Raslan, Han Sung Lee, Brett J Theeler, Tarek A Raafat, Ruben Fragoso, Kiarash Shahlaie, Orwa Aboud
{"title":"Promising response to vemurafenib and cobimetinib treatment for BRAF V600E mutated craniopharyngioma: a case report and literature review.","authors":"Nina Yu, Osama A Raslan, Han Sung Lee, Brett J Theeler, Tarek A Raafat, Ruben Fragoso, Kiarash Shahlaie, Orwa Aboud","doi":"10.2217/cns-2023-0018","DOIUrl":"10.2217/cns-2023-0018","url":null,"abstract":"<p><p>Craniopharyngiomas are tumors that arise from the remnants of Rathke's pouch along the nasopharynx to the diencephalon. Current standard of care includes maximal surgical resection versus adjuvant radiation if a maximal resection is unfeasible. Pharmacological therapy with MAPK targeted agents is an emerging therapeutic option for tumors with BRAF V600E mutations. We report a 45-year-old male with a strictly third ventricle papillary craniopharyngioma with a BRAF V600E mutation. After initial surgery with subtotal resection, the patient demonstrated durable response to targeted BRAF and MEK inhibitor therapy with vemurafenib and cobimetinib. Our report suggests that targeted therapy may reduce the need for radiation and impact surgical interventions in select cases.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":" ","pages":"CNS106"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment trends in brain metastases from testicular cancer in the United States. 美国睾丸癌脑转移的治疗趋势
CNS Oncology Pub Date : 2023-12-01 Epub Date: 2023-08-31 DOI: 10.2217/cns-2023-0008
Joseph Crooks, Matthew Shepard, Rodney E Wegner
{"title":"Treatment trends in brain metastases from testicular cancer in the United States.","authors":"Joseph Crooks, Matthew Shepard, Rodney E Wegner","doi":"10.2217/cns-2023-0008","DOIUrl":"10.2217/cns-2023-0008","url":null,"abstract":"<p><p><b>Aim:</b> We utilized the National Cancer Database to describe the treatment trends in brain metastases from primary testicular cancers. <b>Methods:</b> We analyzed data from the NCDB from 2010 to 2015 for patients with both primary testicular cancers and brain metastases who were treated with brain-directed radiation. We performed multivariable logistic and cox regressions to identify predictors of treatment type and overall survival respectively. <b>Results:</b> Most patients meeting the above criteria received whole brain radiation therapy as opposed to stereotactic radiosurgery (SRS). Predictors of improved survival were age, private insurance coverage, receipt of chemotherapy, and receipt of SRS. The 5-year survival rate was highest for patients who received SRS. <b>Conclusion:</b> This study confirms significantly improved overall survival with the use of SRS.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":" ","pages":"CNS104"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10121356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous T-cell lymphoma with CNS involvement: a case series and review of the literature. 累及中枢神经系统的皮肤t细胞淋巴瘤:一个病例系列和文献回顾。
CNS Oncology Pub Date : 2023-12-01 Epub Date: 2023-10-25 DOI: 10.2217/cns-2023-0014
Joshua D Preston, Caroline S Jansen, Siddhartha Kosaraju, Tim Niyogusaba, Tony Z Zhuang, Sally W Iwamoto, Spencer K Hutto, Mary Jo Lechowicz, Pamela B Allen
{"title":"Cutaneous T-cell lymphoma with CNS involvement: a case series and review of the literature.","authors":"Joshua D Preston, Caroline S Jansen, Siddhartha Kosaraju, Tim Niyogusaba, Tony Z Zhuang, Sally W Iwamoto, Spencer K Hutto, Mary Jo Lechowicz, Pamela B Allen","doi":"10.2217/cns-2023-0014","DOIUrl":"10.2217/cns-2023-0014","url":null,"abstract":"<p><p>Cutaneous T-cell lymphoma (CTCL) is a rare hematologic malignancy that traditionally presents with cutaneous lesions, though metastases are not uncommon in progressive disease. We describe four cases of CTCL with central nervous system (CNS) involvement, detailing the history, pathological characteristics, treatment response, and progression. Median time from initial diagnosis to CNS metastasis was ∼5.4 years (range 3.4-15.5 years) and survival after metastasis was ∼160 days (range 19 days-4.4 years). No patients achieved long-term (>5 years) survival, though some displayed varying degrees of remission following CNS-directed therapy. We conclude that clinicians must be attentive to the development of CNS metastases in patients with CTCL. The growing body of literature on such cases will inform evolving therapeutic guidelines on this rare CTCL complication.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":" ","pages":"CNS105"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50157235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease. Rosai-Dorfman病的脑表现及诊断困境。
CNS Oncology Pub Date : 2023-12-01 Epub Date: 2023-08-08 DOI: 10.2217/cns-2023-0006
Szintia Almási, Tamás Pancsa, László Tiszlavicz, Anita Sejben
{"title":"Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease.","authors":"Szintia Almási, Tamás Pancsa, László Tiszlavicz, Anita Sejben","doi":"10.2217/cns-2023-0006","DOIUrl":"10.2217/cns-2023-0006","url":null,"abstract":"<p><p>Rosai-Dorfman disease (RDD) is a rare, S100-positive histiocytic proliferation, that can cause both nodal and extranodal illness. We present a case of a 53-year-old male patient. Magnetic resonance imaging described a plaque-like meningeal lesion, and the preoperative diagnosis was meningioma. Histologically, dense infiltration of lymphocytes, plasma cells, and histiocytes was seen, furthermore, the presence of emperipolesis in the sample was pronounced. In the histiocytes nuclear and cytoplasmic positivity with S100 protein, and nuclear positivity with Cyclin D1 was observed. The case was concluded as RDD. Morphological appearance of intracranial RDD with imaging procedures can present a differential diagnostic challenge. The correct diagnosis is based on the presence of histiocytes with emperipolesis, and properly defined immunohistochemical characteristics.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":" ","pages":"CNS103"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9954151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-dose bevacizumab for radiation-induced brain necrosis: a case report. 高剂量贝伐单抗治疗放射性脑坏死1例报告。
CNS Oncology Pub Date : 2023-09-01 Epub Date: 2023-05-04 DOI: 10.2217/cns-2023-0002
Emmanouil Panagiotou, Andriani Charpidou, Eleni Fyta, Vasiliki Nikolaidou, Lamprini Stournara, Alexandros Syrigos, Ioannis Gkiozos
{"title":"High-dose bevacizumab for radiation-induced brain necrosis: a case report.","authors":"Emmanouil Panagiotou,&nbsp;Andriani Charpidou,&nbsp;Eleni Fyta,&nbsp;Vasiliki Nikolaidou,&nbsp;Lamprini Stournara,&nbsp;Alexandros Syrigos,&nbsp;Ioannis Gkiozos","doi":"10.2217/cns-2023-0002","DOIUrl":"10.2217/cns-2023-0002","url":null,"abstract":"<p><p>Radiation-induced brain necrosis (RIBN) is a common adverse event from radiation therapy. We present a case of a 56-year-old man, diagnosed with non-small-cell lung cancer with brain metastases 2 years prior, for which he had received whole brain radiotherapy and brain stereotactic radiosurgery, who presented to the oncology unit with headache, dizziness and abnormal gait. MRI of the brain revealed radiological worsening of a cerebellar mass, including edema and mass effect. After a multidisciplinary tumor board meeting, the patient was diagnosed with RIBN and received 4 cycles of high-dose bevacizumab, with complete symptom resolution and significant radiological response. We report the successful use of a high-dose, shorter-duration treatment protocol of bevacizumab for RIBN.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":"12 3","pages":"CNS98"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5d/3f/cns-12-98.PMC10410693.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9960507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
HER2+ esophageal carcinoma leptomeningeal metastases treated with intrathecal trastuzumab regimen. 鞘内注射曲妥珠单抗方案治疗HER2+食管癌软脑膜转移。
CNS Oncology Pub Date : 2023-09-01 Epub Date: 2023-05-23 DOI: 10.2217/cns-2022-0018
Scott A Wu, Dan Tong Jia, Margaret Schwartz, Mary Mulcahy, Kuanghua Guo, Matthew C Tate, Sean Sachdev, Nicolas Kostelecky, David J Escobar, Daniel J Brat, Amy B Heimberger, Rimas V Lukas
{"title":"HER2+ esophageal carcinoma leptomeningeal metastases treated with intrathecal trastuzumab regimen.","authors":"Scott A Wu,&nbsp;Dan Tong Jia,&nbsp;Margaret Schwartz,&nbsp;Mary Mulcahy,&nbsp;Kuanghua Guo,&nbsp;Matthew C Tate,&nbsp;Sean Sachdev,&nbsp;Nicolas Kostelecky,&nbsp;David J Escobar,&nbsp;Daniel J Brat,&nbsp;Amy B Heimberger,&nbsp;Rimas V Lukas","doi":"10.2217/cns-2022-0018","DOIUrl":"10.2217/cns-2022-0018","url":null,"abstract":"<p><p><b>Materials & methods:</b> We recently reported the largest trial of breast cancer patients with HER2 positive leptomeningeal metastases (LM) treated with trastuzumab. An additional treatment indication was explored as part of a single institution retrospective case series of HER2 positive esophageal adenocarcinoma LM (n = 2). <b>Results:</b> One patient received intrathecal trastuzumab (80 mg twice weekly) as part of their treatment regimen with durable long-term response and clearance of circulating tumor cells in the cerebral spinal fluid. The other patient demonstrated rapid progression and death as previously described in the literature. <b>Conclusion:</b> Intrathecal trastuzumab is a well-tolerated and reasonable therapeutic option worthy of further exploration for patients with HER2 positive esophageal carcinoma LM. An associative, but not a causal relationship, can be made regarding therapeutic intervention.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":"12 3","pages":"CNS99"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/66/cns-12-99.PMC10410688.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9960539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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