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Prolonged remission with ibrutinib maintenance therapy following radiation in a patient with relapsed primary CNS lymphoma. 一名原发性中枢神经系统淋巴瘤复发患者在接受伊布替尼放射治疗后，通过伊布替尼维持治疗延长了缓解期。
CNS Oncology Pub Date : 2024-06-06 Epub Date: 2024-05-09 DOI: 10.1080/20450907.2024.2345579
Steven Du, Dan Beverly Fu, Daniela A Bota, Xiao-Tang Kong
{"title":"Prolonged remission with ibrutinib maintenance therapy following radiation in a patient with relapsed primary CNS lymphoma.","authors":"Steven Du, Dan Beverly Fu, Daniela A Bota, Xiao-Tang Kong","doi":"10.1080/20450907.2024.2345579","DOIUrl":"10.1080/20450907.2024.2345579","url":null,"abstract":"<p><p><b>Background:</b> Treatment for refractory or relapsed primary CNS lymphoma (r/r PCNSL) is challenging. Salvage whole-brain radiation therapy (WBRT) is an option but has a short duration of disease control, so additional treatment modalities are warranted. <b>Case:</b> A 75-year-old female with r/r PCNSL who had multiple progressions after multiple lines of treatment underwent salvage WBRT. The patient received ibrutinib, a Bruton's tyrosine kinase inhibitor, as maintenance therapy for 18 months following WBRT with the intention of increasing survival duration after salvage WBRT. She survived 81 months from diagnosis, including 57 months after completion of WBRT. <b>Conclusion:</b> This case presentation describes the experience of using ibrutinib as maintenance therapy in treating r/r PCNSL after salvage WBRT.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":" ","pages":"2345579"},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perspectives from neuro-oncology providers on patient access to electronic records: a survey study. 神经肿瘤科医生对患者访问电子病历的看法：一项调查研究。
CNS Oncology Pub Date : 2024-06-06 Epub Date: 2024-05-28 DOI: 10.1080/20450907.2024.2352414
Keng Lam, Cheuk Hong Leung, Zaid Soomro, Chetna Wathoo, Shiao-Pei Weathers
{"title":"Perspectives from neuro-oncology providers on patient access to electronic records: a survey study.","authors":"Keng Lam, Cheuk Hong Leung, Zaid Soomro, Chetna Wathoo, Shiao-Pei Weathers","doi":"10.1080/20450907.2024.2352414","DOIUrl":"10.1080/20450907.2024.2352414","url":null,"abstract":"<p><p><b>Aim:</b> To evaluate the neuro-oncology providers' experience with patient online access to electronic records. <b>Methods:</b> Cross-sectional survey for physicians and advanced care providers within the field of neuro-oncology in the USA. <b>Results:</b> 65 providers completed the survey, from all major regions of the USA. 58% reported that at least once per month, patients contacted them outside of an office visit about provider notes or a laboratory or imaging finding accessed online. 54% of providers did not think that all laboratory results should be released automatically, and only 25% of providers thought that all radiology reads should be released immediately. 97% thought that some patients suffered substantial distress viewing test results prior to appointments. Qualitative responses aligned with the quantitative results. <b>Conclusion:</b> Most neuro-oncology providers are concerned about the immediate release of laboratory and imaging findings to patients without guidance.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":"13 1","pages":"2352414"},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11152585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracavitary primary effusion lymphoma presenting as a solitary brain mass. 表现为单发脑肿块的腔外原发性渗出淋巴瘤。
CNS Oncology Pub Date : 2024-06-06 Epub Date: 2024-06-12 DOI: 10.1080/20450907.2024.2357535
Tiffany Javadi, Bryan Morales, Jeffery J Olson, Shawn Kothari, Linsheng Zhang, Malak Abedalthagafi
{"title":"Extracavitary primary effusion lymphoma presenting as a solitary brain mass.","authors":"Tiffany Javadi, Bryan Morales, Jeffery J Olson, Shawn Kothari, Linsheng Zhang, Malak Abedalthagafi","doi":"10.1080/20450907.2024.2357535","DOIUrl":"10.1080/20450907.2024.2357535","url":null,"abstract":"<p><p>Primary effusion lymphoma (PEL) is an uncommon B-cell lymphoma associated with human herpesvirus 8 and comprises 3-4% of all HIV-related lymphomas. It traditionally presents as a pleural, pericardial, and/or peritoneal effusion, though it can occasionally manifest as an extracavitary or solid mass in the absence of an effusion. The extracavitary or solid variant of primary effusion lymphoma has been reported in the skin, gastrointestinal tract, lung, and lymph nodes. However, very few cases have been reported in the central nervous system. We describe a case of extracavitary or solid variant of primary effusion lymphoma presenting as a brain mass in an HIV-positive man, highlighting the clinicopathologic and immunophenotypic findings of a rare entity.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":"13 1","pages":"2357535"},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11172242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postradiation platinum-etoposide in adult medulloblastomas: retrospective analysis of hematological toxicity. 成人髓母细胞瘤放疗后铂-依托泊苷：血液学毒性回顾性分析。
CNS Oncology Pub Date : 2024-06-06 Epub Date: 2024-03-08 DOI: 10.2217/cns-2023-0029
Edina Komlodi-Pasztor, Vasu Munjapara, Charles G Eberhart, Danielle A Bazer, Mohamed R Sherief, David Olayinka Kamson, Xiaobu Ye, Byram Hirsch Ozer, Matthias Holdhoff
{"title":"Postradiation platinum-etoposide in adult medulloblastomas: retrospective analysis of hematological toxicity.","authors":"Edina Komlodi-Pasztor, Vasu Munjapara, Charles G Eberhart, Danielle A Bazer, Mohamed R Sherief, David Olayinka Kamson, Xiaobu Ye, Byram Hirsch Ozer, Matthias Holdhoff","doi":"10.2217/cns-2023-0029","DOIUrl":"10.2217/cns-2023-0029","url":null,"abstract":"<p><p><b>Aim:</b> Adult medulloblastomas (MB) are rare, and optimal post-craniospinal irradiation (CSI) chemotherapy is not yet defined. We investigated hematological toxicity in patients treated with platinum-etoposide (EP) post-CSI. <b>Methods:</b> Retrospective, single-institution study to determine hematological toxicity in adult MB patients treated with EP (1995-2022). <b>Results:</b> Thirteen patients with a median follow-up of 50 months (range, 10-233) were analyzed. Four discontinued treatment due to toxicity, one after 1, 3 after 3 cycles. Hematological toxicities included grade 3 (5 patients) and grade 4 (6 patients). Two patients experienced post-treatment progression and died 16 and 37 months from diagnosis. <b>Conclusion:</b> Post-CSI EP demonstrates acceptable hematological toxicity in adult MB. However, the small cohort precludes definitive survival outcome conclusions. Prospective studies for comprehensive comparisons with other regimens are needed in this context.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":" ","pages":"CNS107"},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic glioblastoma to the lungs: a case report and literature review. 转移到肺部的胶质母细胞瘤：病例报告和文献综述。
CNS Oncology Pub Date : 2024-06-06 Epub Date: 2024-06-12 DOI: 10.1080/20450907.2024.2351789
Carlen A Yuen, Melike Pekmezci, Silin Bao, Xiao-Tang Kong
{"title":"Metastatic glioblastoma to the lungs: a case report and literature review.","authors":"Carlen A Yuen, Melike Pekmezci, Silin Bao, Xiao-Tang Kong","doi":"10.1080/20450907.2024.2351789","DOIUrl":"10.1080/20450907.2024.2351789","url":null,"abstract":"<p><p>Glioblastoma is the most common malignant primary brain tumor. Despite its infiltrative nature, extra-cranial glioblastoma metastases are rare. We present a case of a 63-year-old woman with metastatic glioblastoma in the lungs. Sarcomatous histology, a reported risk factor for disseminated disease, was found. Genomic alterations of <i>TP53</i> mutation, <i>TERT</i> mutation, <i>PTEN</i> mutation, and +7/-10 were also uncovered. Early evidence suggests these molecular aberrations are common in metastatic glioblastoma. Treatment with third-line lenvatinib resulted in a mixed response. This case contributes to the growing body of evidence for the role of genomic alterations in predictive risk in metastatic glioblastoma. There remains an unmet need for treatment of metastatic glioblastoma.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":"13 1","pages":"2351789"},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11172249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BRAF V600E-mutant colorectal cancer with CNS metastases treated successfully with encorafenib, binimetinib and cetuximab 安戈非尼、替米替尼和西妥昔单抗成功治疗伴有中枢神经系统转移的 BRAF V600E 突变结直肠癌
CNS Oncology Pub Date : 2024-05-20 DOI: 10.1080/20450907.2024.2347824
Toru Imai, H. Shoji, H. Hirano, Kunihito Matsuguma, Takahito Awatsu, T. Hirose, N. Okita, A. Takashima, Ken Kato
{"title":"BRAF\u0000 V600E-mutant colorectal cancer with CNS metastases treated successfully with encorafenib, binimetinib and cetuximab","authors":"Toru Imai, H. Shoji, H. Hirano, Kunihito Matsuguma, Takahito Awatsu, T. Hirose, N. Okita, A. Takashima, Ken Kato","doi":"10.1080/20450907.2024.2347824","DOIUrl":"https://doi.org/10.1080/20450907.2024.2347824","url":null,"abstract":"","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":"42 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141118996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An adult with recurrent atypical teratoid rhabdoid tumor of the spine. 一名患有复发性脊柱非典型畸胎横纹肌瘤的成年人。
CNS Oncology Pub Date : 2024-01-01 Epub Date: 2024-02-21 DOI: 10.2217/cns-2023-0017
Antoinette J Charles, Vanessa L Smith, C Rory Goodwin, Margaret O Johnson
{"title":"An adult with recurrent atypical teratoid rhabdoid tumor of the spine.","authors":"Antoinette J Charles, Vanessa L Smith, C Rory Goodwin, Margaret O Johnson","doi":"10.2217/cns-2023-0017","DOIUrl":"10.2217/cns-2023-0017","url":null,"abstract":"<p><p>Atypical teratoid rhabdoid tumors (AT/RT) are rare and highly malignant CNS neoplasms primarily affecting children. Adult cases are extremely uncommon, with only approximately 92 reported. Spinal AT/RT in adults is particularly rare. Here, we present the case of a 50-year-old patient diagnosed with AT/RT of the spine. Initially, they were diagnosed and treated for a spinal ependymoma. However, after 10 years, a recurrence was detected through magnetic resonance imaging (MRI) and the tumor was reclassified as AT/RT. We discuss the significance of <i>SMARCB1</i> gene mutations in diagnosing AT/RT and describe our unique treatment approach involving surgery, radiation and anti-PD1 therapy in this patient.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":" ","pages":"CNS105"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promising response to vemurafenib and cobimetinib treatment for BRAF V600E mutated craniopharyngioma: a case report and literature review. BRAF V600E突变颅咽管瘤对维莫非尼和克比米替尼治疗的良好反应：病例报告和文献综述。
CNS Oncology Pub Date : 2024-01-01 Epub Date: 2024-02-13 DOI: 10.2217/cns-2023-0018
Nina Yu, Osama A Raslan, Han Sung Lee, Brett J Theeler, Tarek A Raafat, Ruben Fragoso, Kiarash Shahlaie, Orwa Aboud
{"title":"Promising response to vemurafenib and cobimetinib treatment for BRAF V600E mutated craniopharyngioma: a case report and literature review.","authors":"Nina Yu, Osama A Raslan, Han Sung Lee, Brett J Theeler, Tarek A Raafat, Ruben Fragoso, Kiarash Shahlaie, Orwa Aboud","doi":"10.2217/cns-2023-0018","DOIUrl":"10.2217/cns-2023-0018","url":null,"abstract":"<p><p>Craniopharyngiomas are tumors that arise from the remnants of Rathke's pouch along the nasopharynx to the diencephalon. Current standard of care includes maximal surgical resection versus adjuvant radiation if a maximal resection is unfeasible. Pharmacological therapy with MAPK targeted agents is an emerging therapeutic option for tumors with BRAF V600E mutations. We report a 45-year-old male with a strictly third ventricle papillary craniopharyngioma with a BRAF V600E mutation. After initial surgery with subtotal resection, the patient demonstrated durable response to targeted BRAF and MEK inhibitor therapy with vemurafenib and cobimetinib. Our report suggests that targeted therapy may reduce the need for radiation and impact surgical interventions in select cases.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":" ","pages":"CNS106"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment trends in brain metastases from testicular cancer in the United States. 美国睾丸癌脑转移的治疗趋势
CNS Oncology Pub Date : 2023-12-01 Epub Date: 2023-08-31 DOI: 10.2217/cns-2023-0008
Joseph Crooks, Matthew Shepard, Rodney E Wegner
{"title":"Treatment trends in brain metastases from testicular cancer in the United States.","authors":"Joseph Crooks, Matthew Shepard, Rodney E Wegner","doi":"10.2217/cns-2023-0008","DOIUrl":"10.2217/cns-2023-0008","url":null,"abstract":"<p><p><b>Aim:</b> We utilized the National Cancer Database to describe the treatment trends in brain metastases from primary testicular cancers. <b>Methods:</b> We analyzed data from the NCDB from 2010 to 2015 for patients with both primary testicular cancers and brain metastases who were treated with brain-directed radiation. We performed multivariable logistic and cox regressions to identify predictors of treatment type and overall survival respectively. <b>Results:</b> Most patients meeting the above criteria received whole brain radiation therapy as opposed to stereotactic radiosurgery (SRS). Predictors of improved survival were age, private insurance coverage, receipt of chemotherapy, and receipt of SRS. The 5-year survival rate was highest for patients who received SRS. <b>Conclusion:</b> This study confirms significantly improved overall survival with the use of SRS.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":" ","pages":"CNS104"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10121356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease. Rosai-Dorfman病的脑表现及诊断困境。
CNS Oncology Pub Date : 2023-12-01 Epub Date: 2023-08-08 DOI: 10.2217/cns-2023-0006
Szintia Almási, Tamás Pancsa, László Tiszlavicz, Anita Sejben
{"title":"Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease.","authors":"Szintia Almási, Tamás Pancsa, László Tiszlavicz, Anita Sejben","doi":"10.2217/cns-2023-0006","DOIUrl":"10.2217/cns-2023-0006","url":null,"abstract":"<p><p>Rosai-Dorfman disease (RDD) is a rare, S100-positive histiocytic proliferation, that can cause both nodal and extranodal illness. We present a case of a 53-year-old male patient. Magnetic resonance imaging described a plaque-like meningeal lesion, and the preoperative diagnosis was meningioma. Histologically, dense infiltration of lymphocytes, plasma cells, and histiocytes was seen, furthermore, the presence of emperipolesis in the sample was pronounced. In the histiocytes nuclear and cytoplasmic positivity with S100 protein, and nuclear positivity with Cyclin D1 was observed. The case was concluded as RDD. Morphological appearance of intracranial RDD with imaging procedures can present a differential diagnostic challenge. The correct diagnosis is based on the presence of histiocytes with emperipolesis, and properly defined immunohistochemical characteristics.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":" ","pages":"CNS103"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9954151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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