CNS Oncology最新文献

Atypical behavior of recurrent glioblastoma tumor cells with a highly adherent radial glial phenotype. 复发性胶质母细胞瘤肿瘤细胞具有高度粘附的放射状胶质表型的不典型行为。

CNS Oncology Pub Date : 2025-12-01 Epub Date: 2025-09-19 DOI: 10.1080/20450907.2025.2559576

Manjusha Vaidya, Jonhoi Smith, Julia Pessaia, Melvin Field, Kiminobu Sugaya

{"title":"Atypical behavior of recurrent glioblastoma tumor cells with a highly adherent radial glial phenotype.","authors":"Manjusha Vaidya, Jonhoi Smith, Julia Pessaia, Melvin Field, Kiminobu Sugaya","doi":"10.1080/20450907.2025.2559576","DOIUrl":"10.1080/20450907.2025.2559576","url":null,"abstract":"Glioblastoma (GBM) is the most common malignant primary brain tumor, characterized by a high recurrence rate despite aggressive therapy. We present a case of a 32-year-old male with a recurrent WHO Grade IV IDH1-mutant astrocytoma after undergoing standard Stupp protocol chemoradiation and tumor-treating field therapy. Repeat surgery was performed where in vitro analysis of recurrent GBM cells revealed atypical behavior, rapid adhesion within minutes of plating, and the formation of radial glial-like cells (RGCs) with 3D aggregated cells, phenotypes absent in the primary tumor. These brain lipid-binding protein positive RGCs exhibited elongated processes that facilitated cancer cell migration, potentially contributing to tumor invasiveness. Extensive treatment between the primary and recurrent tumors may have induced this phenotypic shift, highlighting therapy-induced plasticity as a key factor in recurrence. The emergence of RGCs in recurrent GBM underscores the need for targeted therapies addressing tumor adaptability to improve treatment outcomes.","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":"14 1","pages":"2559576"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple brain lesions in a patient with relapsed hairy cell leukemia: a case report and review of the literature. 复发性毛细胞白血病多发脑损伤1例报告及文献复习。

CNS Oncology Pub Date : 2025-12-01 Epub Date: 2025-09-26 DOI: 10.1080/20450907.2025.2563981

Katell Le Dû, Jacques Delaunay, Maud Voldoire, Thomas Cuvier, Pierre-Yves Renard, Benoît Quilichini, Eric Wafflart, Julien Dubreuil, Sophie Sadot-Lebouvier

{"title":"Multiple brain lesions in a patient with relapsed hairy cell leukemia: a case report and review of the literature.","authors":"Katell Le Dû, Jacques Delaunay, Maud Voldoire, Thomas Cuvier, Pierre-Yves Renard, Benoît Quilichini, Eric Wafflart, Julien Dubreuil, Sophie Sadot-Lebouvier","doi":"10.1080/20450907.2025.2563981","DOIUrl":"10.1080/20450907.2025.2563981","url":null,"abstract":"Cerebral lesions are rare in hairy cell leukemia (HCL), and its incidence remains to be determined. Identifying the cause can be challenging. In this report, we present a case of brain lesions occurring several years after diagnosis. A 76-year-old male patient presented to the Emergency Department with confusion. He had been diagnosed with HCL in 1999 and had received five lines of treatment. Cerebral imaging revealed multiple nodular lesions, with edema and a hemorrhagic appearance. Cerebrospinal fluid tests were negative. The tumor origin was retained due to concomitant relapse (blood, lymph nodes). Despite the partial efficacy of rituximab-cladribine treatment, the patient died of Candida pneumonia. A review of the literature (PubMed, CrossRef, Google Scholar) identified seventeen cases between 1966 and 2024, with a median age of 59 years (33-80). Cladribine, with or without rituximab, was the most widely prescribed treatment regimen with a complete response rate of 57%. Four (23.5%) patients died (two from infection, one from gastrointestinal bleeding and one from an unknown cause). These atypical presentations suggest that brain imaging and advanced biological investigations should be performed to guide management.","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":"14 1","pages":"2563981"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustained response to larotrectinib in a pediatric patient with recurrent STRN3::NTRK2 fusion-positive pilocytic astrocytoma. 复发性STRN3::NTRK2融合阳性毛细胞星形细胞瘤患儿对larorectinib的持续应答

CNS Oncology Pub Date : 2025-12-01 Epub Date: 2025-10-03 DOI: 10.1080/20450907.2025.2558455

Kishore Balasubramanian, Kar-Ming Fung, Rene Y McNall-Knapp, Karl Balsara

{"title":"Sustained response to larotrectinib in a pediatric patient with recurrent STRN3::NTRK2 fusion-positive pilocytic astrocytoma.","authors":"Kishore Balasubramanian, Kar-Ming Fung, Rene Y McNall-Knapp, Karl Balsara","doi":"10.1080/20450907.2025.2558455","DOIUrl":"10.1080/20450907.2025.2558455","url":null,"abstract":"A 7-year-old female with recurrent midline pilocytic astrocytoma harboring a rare STRN3::NTRK2 fusion achieved sustained near-complete radiographic and clinical response to larotrectinib, a selective TRK inhibitor. Initial subtotal resection of the midbrain/thalamic tumor was followed by progression, prompting molecular profiling that identified the STRN3::NTRK2 fusion. Larotrectinib therapy initiated at recurrence resulted in a rapid reduction by 3 months, resolution of pontine extension by 6 months, and near-complete resolution by 15 months. This case highlights the potential of molecular diagnostics in pediatric neuro-oncology, particularly for BRAF-negative midline gliomas where NTRK fusions are rare but actionable. The durable response supports prioritizing larotrectinib over conventional chemotherapy in unresectable/progressive NTRK-driven gliomas. Routine fusion screening in BRAF-negative cases should be considered to identify candidates for targeted therapy. This report expands the known spectrum of NTRK2 partners in pilocytic astrocytoma and reinforces the use of TRK inhibitors as a treatment for molecularly defined subsets of pediatric glioma.","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":"14 1","pages":"2558455"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12498535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autologous stem cell transplantation in adults with atypical teratoid rhabdoid tumor: a case report and review. 成人非典型畸胎性横纹肌瘤患者的自体干细胞移植：病例报告与综述。

CNS Oncology Pub Date : 2024-12-31 Epub Date: 2024-07-23 DOI: 10.1080/20450907.2024.2375960

Jackson Griffith-Linsley, William Robert Bell, Aaron Cohen-Gadol, Diane Donegan, Angela Richardson, Michael Robertson, Kevin Shiue, Kathryn Nevel

引用次数: 0

Development of brain metastases in non-small-cell lung cancer: high-risk features. 非小细胞肺癌脑转移的发展：高风险特征。

CNS Oncology Pub Date : 2024-12-31 Epub Date: 2024-09-12 DOI: 10.1080/20450907.2024.2395804

Nolan Winslow, Jacqueline Boyle, William Miller, Yanzhi Wang, Francois Geoffroy, Andrew J Tsung

{"title":"Development of brain metastases in non-small-cell lung cancer: high-risk features.","authors":"Nolan Winslow, Jacqueline Boyle, William Miller, Yanzhi Wang, Francois Geoffroy, Andrew J Tsung","doi":"10.1080/20450907.2024.2395804","DOIUrl":"10.1080/20450907.2024.2395804","url":null,"abstract":"Aim: Brain metastases (BM) are a common site of disease progression and treatment failure in non-small-cell lung cancer (NSCLC) and can be identified in up to 30-50% of patients. Although they are common, there is no standardized screening protocol for development of BM in NSCLC. Multiple clinical variables predict increased BM occurrence, and, when present, should be used to initiate screening MRI.Materials & methods: We performed a single center retrospective review of NSCLC patients, examining BM development and overall survival. Available clinical, radiographic and molecular data were reviewed for association with BM and overall survival. A predictive model for BM development was created for multivariate analysis.Results: Risk factors for new BM development in NSCLC included younger age, larger primary lung tumor, Karnofsky performance score (KPS) <70, pre-existing liver or bone metastases, large cell histology and family history of cancer. Factors associated with decreased OS were larger primary lung tumor, extracranial metastases at time of diagnosis, large cell histology and poorly-differentiated carcinoma histology.Conclusion: There are multiple high risk features for developing BM in NSCLC. Each of these factors should routinely be investigated, and presence should prompt brain MRI to allow earlier diagnosis and treatment of BM.","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":"13 1","pages":"2395804"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radio-pathomic estimates of cellular growth kinetics predict survival in recurrent glioblastoma. 细胞生长动力学的放射病理估算可预测复发性胶质母细胞瘤的存活率。

CNS Oncology Pub Date : 2024-12-31 Epub Date: 2024-11-13 DOI: 10.1080/20450907.2024.2415285

Sonoko Oshima, Jingwen Yao, Samuel Bobholz, Raksha Nagaraj, Catalina Raymond, Ashley Teraishi, Anna-Marie Guenther, Asher Kim, Francesco Sanvito, Nicholas S Cho, Blaine S. C. Eldred, Jennifer M Connelly, Phioanh L Nghiemphu, Albert Lai, Noriko Salamon, Timothy F Cloughesy, Peter S LaViolette, Benjamin M Ellingson

{"title":"Radio-pathomic estimates of cellular growth kinetics predict survival in recurrent glioblastoma.","authors":"Sonoko Oshima, Jingwen Yao, Samuel Bobholz, Raksha Nagaraj, Catalina Raymond, Ashley Teraishi, Anna-Marie Guenther, Asher Kim, Francesco Sanvito, Nicholas S Cho, Blaine S. C. Eldred, Jennifer M Connelly, Phioanh L Nghiemphu, Albert Lai, Noriko Salamon, Timothy F Cloughesy, Peter S LaViolette, Benjamin M Ellingson","doi":"10.1080/20450907.2024.2415285","DOIUrl":"10.1080/20450907.2024.2415285","url":null,"abstract":"Aim: A radio-pathomic machine learning (ML) model has been developed to estimate tumor cell density, cytoplasm density (Cyt) and extracellular fluid density (ECF) from multimodal MR images and autopsy pathology. In this multicenter study, we implemented this model to test its ability to predict survival in patients with recurrent glioblastoma (rGBM) treated with chemotherapy.Methods: Pre- and post-contrast T1-weighted, FLAIR and ADC images were used to generate radio-pathomic maps for 51 patients with longitudinal pre- and post-treatment scans. Univariate and multivariate Cox regression analyses were used to test the influence of contrast-enhancing tumor volume, total cellularity, mean Cyt and mean ECF at baseline, immediately post-treatment and the pre- and post-treatment rate of change in volume and cellularity on overall survival (OS).Results: Smaller Cyt and larger ECF after treatment were significant predictors of OS, independent of tumor volume and other clinical prognostic factors (HR = 3.23 × 10-6, p < 0.001 and HR = 2.39 × 105, p < 0.001, respectively). Both post-treatment volumetric growth rate and the rate of change in cellularity were significantly correlated with OS (HR = 1.17, p = 0.003 and HR = 1.14, p = 0.01, respectively).Conclusion: Changes in histological characteristics estimated from a radio-pathomic ML model are a promising tool for evaluating treatment response and predicting outcome in rGBM.","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":"13 1","pages":"2415285"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurofilament light chain in serum of cancer patients with acute neurological complications. 患有急性神经并发症的癌症患者血清中的神经丝蛋白轻链。

CNS Oncology Pub Date : 2024-12-31 Epub Date: 2024-08-13 DOI: 10.1080/20450907.2024.2386233

Amulya Gottiparthy, Keng Lam, Suprateek Kundu, Zixi Yang, Ivo Tremont-Lukats, Sudhakar Tummala

引用次数: 0

Novel insights toward diagnosis and treatment of glioneuronal and neuronal tumors in young adults. 诊断和治疗青壮年胶质细胞瘤和神经元肿瘤的新见解。

CNS Oncology Pub Date : 2024-12-31 Epub Date: 2024-06-14 DOI: 10.1080/20450907.2024.2357532

Vincenzo Di Nunno, Marta Aprile, Lidia Gatto, Alicia Tosoni, Lucia Ranieri, Stefania Bartolini, Enrico Franceschi

引用次数: 0

Complete resection of a giant epidermoid cyst of the occipital bone: case report and systematic review. 完全切除枕骨巨大表皮样囊肿：病例报告和系统综述。

CNS Oncology Pub Date : 2024-12-31 Epub Date: 2024-11-19 DOI: 10.1080/20450907.2024.2415279

Ishwarya Nair, Adrian Zammit, Timothy Williamson, Ananthababu Pattavilakom Sadasivan

引用次数: 0

The challenges and clinical landscape of glioblastoma immunotherapy. 胶质母细胞瘤免疫疗法面临的挑战和临床前景。

CNS Oncology Pub Date : 2024-12-31 Epub Date: 2024-10-29 DOI: 10.1080/20450907.2024.2415878

Andrew Timothy Ng, Tyler Steve, Kevin T Jamouss, Abdul Arham, Sarah Kawtharani, Hazem I Assi

引用次数: 0