Clinical immunology最新文献_第5页

IKZF1: An important target for the treatment of autoimmune diseases IKZF1：治疗自身免疫性疾病的重要靶点

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-13 DOI: 10.1016/j.clim.2025.110544

Siyuan Bu, Cong Ye, Shaozhe Cai, Lingli Dong

引用次数: 0

A national survey of four decades of hereditary angioedema prophylaxis: Efficacy and safety of old and new drugs 一项关于40年遗传性血管性水肿预防的全国调查：新旧药物的有效性和安全性。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-11 DOI: 10.1016/j.clim.2025.110542

Hanga Réka Horváth , Beáta Visy , Kinga Viktória Kőhalmi , Zsuzsanna Balla , Noémi Andrási , Ibolya Czaller , Zsuzsanna Zotter , Henriette Farkas

{"title":"A national survey of four decades of hereditary angioedema prophylaxis: Efficacy and safety of old and new drugs","authors":"Hanga Réka Horváth , Beáta Visy , Kinga Viktória Kőhalmi , Zsuzsanna Balla , Noémi Andrási , Ibolya Czaller , Zsuzsanna Zotter , Henriette Farkas","doi":"10.1016/j.clim.2025.110542","DOIUrl":"10.1016/j.clim.2025.110542","url":null,"abstract":"<div><h3>Background</h3><div>Hereditary angioedema (HAE) imposes a significant burden on patients due to the unpredictability of attacks. Long-term prophylaxis (LTP) aims to prevent these episodes and improve quality of life. Over the past five decades, LTP options have evolved from non-specific treatments (fresh frozen plasma, attenuated androgens, antifibrinolytics) to more targeted therapies (intravenous or subcutaneous C1 inhibitor (C1INH), lanadelumab, berotralstat).</div></div><div><h3>Objective</h3><div>To assess the use, efficacy, and safety of various LTP therapies among Hungarian HAE patients.</div></div><div><h3>Methods</h3><div>Data from the Hungarian HAE Registry (1979–2023) were analysed, including LTP usage, attack rates, side effects, and laboratory parameters.</div></div><div><h3>Results</h3><div>Danazol and tranexamic acid use increased over the first 30 years but has declined in the last decade. Conversely, the use of modern LTP therapies and the proportion of patients relying solely on on-demand medication have significantly increased over the past decade. Danazol and tranexamic acid reduced attack rates in 60 % of patients without significant changes in the laboratory parameters at the lowest effective doses. Furthermore, 100 % of patients on subcutaneous C1INH, lanadelumab, and berotralstat experienced fewer attacks and improved quality of life compared to pre-treatment periods, with no serious side effects or significant laboratory abnormalities.</div></div><div><h3>Conclusion</h3><div>Modern prophylaxis usage is increasing among Hungarian HAE-C1INH patients, following the global trends. Both modern and traditional LTP options proved safe and effective in our patient population when used with appropriate monitoring.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"279 ","pages":"Article 110542"},"PeriodicalIF":4.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activated CD4+ T cells upregulate PD-L1 expression on B cells through CD40/CD40L signaling and direct contact in systemic lupus erythematosus 在系统性红斑狼疮中，活化的CD4+ T细胞通过CD40/CD40L信号传导和直接接触上调B细胞的PD-L1表达

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-09 DOI: 10.1016/j.clim.2025.110535

Siyuan Lai , Ning Li , Songyue Chen , Yanxin Wang , Dengxiao Hong , Wenyan Xu , Zhongxin Chen , Baiqing Li , Changhao Xie

{"title":"Activated CD4+ T cells upregulate PD-L1 expression on B cells through CD40/CD40L signaling and direct contact in systemic lupus erythematosus","authors":"Siyuan Lai , Ning Li , Songyue Chen , Yanxin Wang , Dengxiao Hong , Wenyan Xu , Zhongxin Chen , Baiqing Li , Changhao Xie","doi":"10.1016/j.clim.2025.110535","DOIUrl":"10.1016/j.clim.2025.110535","url":null,"abstract":"<div><div>Programmed cell death protein 1 (PD-1) expression on T cells has been implicated in the pathogenesis of autoimmune diseases; however, the functional role of programmed death-ligand 1 (PD-L1) expression on B cells remains insufficiently characterized, particularly in the context of CD4<sup>+</sup> T cell–mediated regulation in systemic lupus erythematosus (SLE). Flow cytometric analysis revealed that PD-L1<sup>+</sup> B cells exhibited upregulated surface expression of the co-stimulatory molecules CD80 and CD86, alongside a concomitant downregulation in the expression of the antigen-presenting molecule human leukocyte antigen DR (HLA-DR). Furthermore, an elevated frequency of class-switched PD-L1<sup>+</sup> B cells was observed in the peripheral blood of patients with SLE. Using co-culture systems and transwell assays, we demonstrated that CD4<sup>+</sup> T cells modulate PD-L1 expression on B cells via direct cell–cell interactions. Mechanistically, this regulation was shown to be dependent on bidirectional CD40/CD40L signaling. These findings advance our understanding of PD-L1-mediated immunoregulation in SLE pathogenesis and identify PD-L1<sup>+</sup> B cells as potential targets for therapeutic intervention.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"278 ","pages":"Article 110535"},"PeriodicalIF":4.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ProBNP, cytokines, and the Nrf2/HO-1 signaling pathway: A cross-sectional study on cardiovascular risk in rheumatoid arthritis ProBNP、细胞因子和Nrf2/HO-1信号通路：类风湿关节炎心血管风险的横断面研究

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-09 DOI: 10.1016/j.clim.2025.110541

Christiane Aguiar Nobre , Carlos Ewerton Maia Rodrigues , Natacha Xavier Cavalcante , Thácilla Siqueira Eugênio Nascimento , João Gabriel Marques Brayner , Giovanna Azevedo Sousa , Nayara Alves de Sousa , Regislane Pinto Ribeiro , Vanessa Maria Eufrásio de Fiqueirêdo , Giulia Albuquerque Paiva , José Jackson do Nascimento Costa , Paula Goes , Hellíada Vasconcelos Chaves , Ticiana Mont'Alverne Parente Feijão , Mirna Marques Bezerra

{"title":"ProBNP, cytokines, and the Nrf2/HO-1 signaling pathway: A cross-sectional study on cardiovascular risk in rheumatoid arthritis","authors":"Christiane Aguiar Nobre , Carlos Ewerton Maia Rodrigues , Natacha Xavier Cavalcante , Thácilla Siqueira Eugênio Nascimento , João Gabriel Marques Brayner , Giovanna Azevedo Sousa , Nayara Alves de Sousa , Regislane Pinto Ribeiro , Vanessa Maria Eufrásio de Fiqueirêdo , Giulia Albuquerque Paiva , José Jackson do Nascimento Costa , Paula Goes , Hellíada Vasconcelos Chaves , Ticiana Mont'Alverne Parente Feijão , Mirna Marques Bezerra","doi":"10.1016/j.clim.2025.110541","DOIUrl":"10.1016/j.clim.2025.110541","url":null,"abstract":"<div><div>We evaluated associations between clinical/laboratory findings and serum cytokines, Nrf2/HO-1 pathway expression and cardiovascular risk in both RA patients and controls. Sixty RA patients and 60 controls were included in the study. Serum cytokine and proBNP levels were assessed by ELISA, while serum Nrf2 and HO-1 mRNA levels were quantified by qRT-PCR. The RA group (91.7 % women) and the control group (90 % women) were aged 52 ± 12 and 52 ± 13 years, respectively. ProBNP levels were higher in the RA group than in controls (<em>p</em> = 0.009). Nrf2 mRNA levels were higher (<em>p</em> < 0.001) and HO-1 mRNA levels were lower (<em>p</em> = 0.030) in the RA group than in controls. CDAI scores were significantly associated with serum IL-6 levels (<em>p</em> = 0.033). This study found a significant dysregulation in Nrf2/HO-1 pathway activity in RA patients, although without association with cardiovascular risk, RA-related clinical and laboratory variables. Moderate/high disease activity was positively associated with IL-6 levels.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"278 ","pages":"Article 110541"},"PeriodicalIF":4.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics, risk factors and predictors of Parvovirus B19 infection in patients with autoimmune rheumatic inflammatory diseases: A nested case–control study 自身免疫性风湿性炎症患者细小病毒B19感染的临床特征、危险因素及预测因素：一项巢式病例对照研究

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-06 DOI: 10.1016/j.clim.2025.110537

Xinyue Zhang , Peixuan Liang , Ziwei Hu , Ziyun Zhang , Shaozhe Cai , Lingli Dong

{"title":"Clinical characteristics, risk factors and predictors of Parvovirus B19 infection in patients with autoimmune rheumatic inflammatory diseases: A nested case–control study","authors":"Xinyue Zhang , Peixuan Liang , Ziwei Hu , Ziyun Zhang , Shaozhe Cai , Lingli Dong","doi":"10.1016/j.clim.2025.110537","DOIUrl":"10.1016/j.clim.2025.110537","url":null,"abstract":"<div><div>This nested case-control study explored the clinical features and risk factors of Parvovirus B19 (B19V) infection in autoimmune rheumatic inflammatory disease (AIIRD) patients. A total of 86 B19V-positive cases and 172 matched controls were analyzed. Chronic liver diseases, cardiovascular diseases, a higher number of total infections, and the use of Mycophenolate Mofetil (MMF) were associated with an increased risk of B19V infection, whereas Iguratimod (IGU) was identified as a protective factor. Anemia, pneumonia, fever, myalgia, and hepatitis were significantly more common in B19V-infected patients, who were also more likely to experience varying degrees of cytopenia, particularly pancytopenia. Secondary hemophagocytic syndrome potentially attributable to B19V infection was observed in the case. Laboratory results showed lower blood cell counts and electrolytes, and higher anti-histone antibody positivity. Serum calcium, complement C4, and IgM were identified as key predictors in logistic and Lasso regression models.</div></div><div><h3>Trial registration</h3><div>Chinese Clinical Trial Register; <span><span>https://www.chictr.org.cn/</span><svg><path></path></svg></span>; ChiCTR2400089902.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"278 ","pages":"Article 110537"},"PeriodicalIF":4.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral microbiota in allergic diseases, and sublingual allergen immunotherapy 过敏性疾病的口腔微生物群，以及舌下过敏原免疫治疗。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-06 DOI: 10.1016/j.clim.2025.110538

Umut Gazi , Nerin Nadir Bahceciler

引用次数: 0

Differential control of mycobacterial growth ex vivo by COVID-19 patients is associated with CD8+ CD28+ T cells COVID-19患者体外分枝杆菌生长的差异控制与CD8+ CD28+ T细胞有关。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-06 DOI: 10.1016/j.clim.2025.110539

Alba Llibre , Henna Siddiqui , Julie G. Burel , Jamie Pillaye , Charlotte Jones , Harriet Hill , Sian E. Faustini , Ella F Windle , Hanfa Karim , Emma Sherry , Christopher A. Green , Martin Dedicoat , Zania Stamataki , Adam F. Cunningham , Matthew K. O'Shea

{"title":"Differential control of mycobacterial growth ex vivo by COVID-19 patients is associated with CD8+ CD28+ T cells","authors":"Alba Llibre , Henna Siddiqui , Julie G. Burel , Jamie Pillaye , Charlotte Jones , Harriet Hill , Sian E. Faustini , Ella F Windle , Hanfa Karim , Emma Sherry , Christopher A. Green , Martin Dedicoat , Zania Stamataki , Adam F. Cunningham , Matthew K. O'Shea","doi":"10.1016/j.clim.2025.110539","DOIUrl":"10.1016/j.clim.2025.110539","url":null,"abstract":"<div><div>Diseases caused by SARS-CoV-2 and <em>Mycobacterium tuberculosis</em> (<em>M.tb</em>) represent two public health emergencies. In severe presentations of disease, both pathogens may share a biological niche in the lower respiratory tract. There is significant potential for SARS-CoV-2 and <em>M.tb</em> infections to be co-present within individuals and modulate the respective outcomes of either infection. Here, we investigated how whole blood samples, as well as CD4+ and CD8+ T cells, from individuals hospitalised with acute COVID-19 disease respond to mycobacterial challenge. To do this, samples were assessed by ex vivo mycobacterial growth inhibition assays, immune cell phenotyping by mass cytometry, and whole blood cytokine responses to mycobacterial antigens assessed by flow cytometry. These studies identified a subgroup of COVID-19 patients whose blood had an enhanced capacity to inhibit mycobacterial growth. The ability to control mycobacterial growth was associated with the presence of a distinct non-<em>M.tb</em>-specific CD8+ CD28+ T cell population. This work improves our understanding of factors involved in mycobacterial control.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"279 ","pages":"Article 110539"},"PeriodicalIF":4.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency of the AC-2 pattern's new variant (AC-30) and detection of different immunological relationships AC-2型新变异（AC-30）的频率及不同免疫学关系的检测

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-05 DOI: 10.1016/j.clim.2025.110536

Mehmet Akif Durmuş , Selda Kömeç

引用次数: 0

PD‐1 monoclonal antibody (Tislelizumab)-induced DRESS syndrome in an intrahepatic cholangiocarcinoma patient with FGFR3 mutation and elevated IgG4:A case report PD - 1单克隆抗体（Tislelizumab）诱导的FGFR3突变和IgG4升高的肝内胆管癌患者的DRESS综合征：1例报告

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-05-28 DOI: 10.1016/j.clim.2025.110534

Wei Qin , Xiaoying Wu , Qiongyuan Xu , Min Deng , Xiangling Lin , Nan Cai , Wei Chen , Chenya Zhuo , Li Liu , Li Wang , Xingyu Qian , Huan Tian , Songlin Peng

{"title":"PD‐1 monoclonal antibody (Tislelizumab)-induced DRESS syndrome in an intrahepatic cholangiocarcinoma patient with FGFR3 mutation and elevated IgG4:A case report","authors":"Wei Qin , Xiaoying Wu , Qiongyuan Xu , Min Deng , Xiangling Lin , Nan Cai , Wei Chen , Chenya Zhuo , Li Liu , Li Wang , Xingyu Qian , Huan Tian , Songlin Peng","doi":"10.1016/j.clim.2025.110534","DOIUrl":"10.1016/j.clim.2025.110534","url":null,"abstract":"<div><h3>Background</h3><div>Immune-related adverse events (irAEs) include a rare, idiosyncratic but potentially life-threatening drug reaction with eosinophilia and systemic symptoms (DRESS), characterized by exanthem, fever, as well as hematologic and visceral organ involvement.</div></div><div><h3>Case presentation</h3><div>We describe a 54-year-old man under the novel sequential treatment including all-trans retinoic acid (ATRA) and programmed death protein 1(PD-1) antibody (Tislelizumab) for advanced intrahepatic cholangiocarcinoma (iCCA)<em>.</em> He was found to have Tislelizumab-induced DRESS syndrome during adjuvant therapy, and also showed the evidence of IgG4-related lymphadenopathy (IgG4-RLAD) as well as Epstein-Barr virus (EBV) infection in the absence of hemophagocytic lymphohistiocytosis (HLH) and T cell lymphoma. The patient's clinical status was successfully ameliorated through the administration of corticosteroids, intravenous immunoglobulin (IVIG), and antiviral agents, demonstrating a positive response to the treatment protocol<em>.</em> He was the first-ever case report of Tislelizumab-induced DRESS syndrome in the context of IgG4-RLAD with an exploration of potential mechanisms. Furthermore, we found that a somatic fibroblast growth factor receptor (FGFR) 3 p.P774L mutation at the frequency of 1.96 % was detected in his iCCA tissue.</div></div><div><h3>Conclusion</h3><div>These findings indicated that this novel therapy, based on ARTA and PD-1 antibody, is more effective and could guide the clinical application of PD-1 antibody in the iCCA patients with elevated IgG4. Human leukocyte antigen (HLA) typing assay might help to screen the potential susceptible individuals to avoid immune checkpoint inhibitors (ICIs)-induced DRESS syndrome.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"278 ","pages":"Article 110534"},"PeriodicalIF":4.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased levels of Foxp3+CD4+NKT-like cells are associated with HIV disease progression Foxp3+CD4+ nkt样细胞水平升高与HIV疾病进展相关。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-05-27 DOI: 10.1016/j.clim.2025.110533

Na Chen , Leidan Zhang , Xinyue Wang , Zhijiao He , Di Wang , Juan Du , Meiju Deng , Mengyuan Zhang , Meiqing Jiang , Yuqing Wei , Meng Zhao , Ying Liu , Xiaolei Wang , Hongxin Zhao , Yaxian Kong

{"title":"Increased levels of Foxp3+CD4+NKT-like cells are associated with HIV disease progression","authors":"Na Chen , Leidan Zhang , Xinyue Wang , Zhijiao He , Di Wang , Juan Du , Meiju Deng , Mengyuan Zhang , Meiqing Jiang , Yuqing Wei , Meng Zhao , Ying Liu , Xiaolei Wang , Hongxin Zhao , Yaxian Kong","doi":"10.1016/j.clim.2025.110533","DOIUrl":"10.1016/j.clim.2025.110533","url":null,"abstract":"<div><div>Persistent immune activation is a key factor contributing to AIDS progression and non-AIDS-associated complications. NKT-like cells were found to exert immunosuppressive roles under some pathological situations by Foxp3 upregulation. Here, we found that Foxp3 was mainly expressed on CD4<sup>+</sup>NKT-like cells in untreated people living with HIV (PLWH) and the frequencies of Foxp3<sup>+</sup>CD4<sup>+</sup>NKT-like cells were correlated with HIV disease progression. Furthermore, the percentage of Foxp3<sup>+</sup>CD4<sup>+</sup>NKT-like cells was positively associated with immune activation and systematic inflammation. Foxp3<sup>+</sup>CD4<sup>+</sup>NKT-like cells might exert immunomodulatory effects by elevating the expression of TGF-β, IL-10, CD39, CD25, GITR, Ki67 and TIGIT. However, our analyses further identified Foxp3<sup>+</sup>CD4<sup>+</sup>NKT-like cells as a distinct subset that differed from conventional regulatory T cells. Notably, patients with higher baseline levels of Foxp3<sup>+</sup>CD4<sup>+</sup>NKT-like cells had a greater risk of poor immune reconstitution. These findings emphasized the importance of Foxp3<sup>+</sup>CD4<sup>+</sup>NKT-like cells during HIV infection and revealed its predictive role in immune reconstitution.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"278 ","pages":"Article 110533"},"PeriodicalIF":4.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0