Clinical immunology最新文献

PD‐1 monoclonal antibody (Tislelizumab)-induced DRESS syndrome in an intrahepatic cholangiocarcinoma patient with FGFR3 mutation and elevated IgG4:A case report PD - 1单克隆抗体（Tislelizumab）诱导的FGFR3突变和IgG4升高的肝内胆管癌患者的DRESS综合征：1例报告

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-05-28 DOI: 10.1016/j.clim.2025.110534

Wei Qin , Xiaoying Wu , Qiongyuan Xu , Min Deng , Xiangling Lin , Nan Cai , Wei Chen , Chenya Zhuo , Li Liu , Li Wang , Xingyu Qian , Huan Tian , Songlin Peng

{"title":"PD‐1 monoclonal antibody (Tislelizumab)-induced DRESS syndrome in an intrahepatic cholangiocarcinoma patient with FGFR3 mutation and elevated IgG4:A case report","authors":"Wei Qin , Xiaoying Wu , Qiongyuan Xu , Min Deng , Xiangling Lin , Nan Cai , Wei Chen , Chenya Zhuo , Li Liu , Li Wang , Xingyu Qian , Huan Tian , Songlin Peng","doi":"10.1016/j.clim.2025.110534","DOIUrl":"10.1016/j.clim.2025.110534","url":null,"abstract":"<div><h3>Background</h3><div>Immune-related adverse events (irAEs) include a rare, idiosyncratic but potentially life-threatening drug reaction with eosinophilia and systemic symptoms (DRESS), characterized by exanthem, fever, as well as hematologic and visceral organ involvement.</div></div><div><h3>Case presentation</h3><div>We describe a 54-year-old man under the novel sequential treatment including all-trans retinoic acid (ATRA) and programmed death protein 1(PD-1) antibody (Tislelizumab) for advanced intrahepatic cholangiocarcinoma (iCCA)<em>.</em> He was found to have Tislelizumab-induced DRESS syndrome during adjuvant therapy, and also showed the evidence of IgG4-related lymphadenopathy (IgG4-RLAD) as well as Epstein-Barr virus (EBV) infection in the absence of hemophagocytic lymphohistiocytosis (HLH) and T cell lymphoma. The patient's clinical status was successfully ameliorated through the administration of corticosteroids, intravenous immunoglobulin (IVIG), and antiviral agents, demonstrating a positive response to the treatment protocol<em>.</em> He was the first-ever case report of Tislelizumab-induced DRESS syndrome in the context of IgG4-RLAD with an exploration of potential mechanisms. Furthermore, we found that a somatic fibroblast growth factor receptor (FGFR) 3 p.P774L mutation at the frequency of 1.96 % was detected in his iCCA tissue.</div></div><div><h3>Conclusion</h3><div>These findings indicated that this novel therapy, based on ARTA and PD-1 antibody, is more effective and could guide the clinical application of PD-1 antibody in the iCCA patients with elevated IgG4. Human leukocyte antigen (HLA) typing assay might help to screen the potential susceptible individuals to avoid immune checkpoint inhibitors (ICIs)-induced DRESS syndrome.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"278 ","pages":"Article 110534"},"PeriodicalIF":4.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: Allergy and autoinflammation drive persistent systemic inflammatory response in Ménière's disease: A longitudinal study. 评论：过敏和自身炎症驱动持续的全身炎症反应在membroinitre病：一项纵向研究。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-05-26 DOI: 10.1016/j.clim.2025.110531

Emel Tahir

引用次数: 0

Proteomic profiling of serum small extracellular vesicles predicts post-COVID syndrome development 血清细胞外小泡的蛋白质组学分析预测covid后综合征的发展。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-05-24 DOI: 10.1016/j.clim.2025.110532

Gabriella Dobra , Edina Gyukity-Sebestyen , Matyas Bukva , Timea Boroczky , Szabolcs Nyiraty , Barbara Bordacs , Tamas Varkonyi , Andrea Kocsis , Zoltan Szabo , Gabor Kecskemeti , Tamas Ferenc Polgar , Marta Szell , Krisztina Buzas

{"title":"Proteomic profiling of serum small extracellular vesicles predicts post-COVID syndrome development","authors":"Gabriella Dobra , Edina Gyukity-Sebestyen , Matyas Bukva , Timea Boroczky , Szabolcs Nyiraty , Barbara Bordacs , Tamas Varkonyi , Andrea Kocsis , Zoltan Szabo , Gabor Kecskemeti , Tamas Ferenc Polgar , Marta Szell , Krisztina Buzas","doi":"10.1016/j.clim.2025.110532","DOIUrl":"10.1016/j.clim.2025.110532","url":null,"abstract":"<div><div>Post-COVID syndrome affects 10–35 % of COVID-19 patients, and up to 85 % of hospitalized individuals, underscoring the need for early identification of high-risk cases. We hypothesized that the proteomic profile of serum small extracellular vesicles (sEVs) obtained during acute SARS-CoV-2 infection could predict post-COVID syndrome.</div><div>Serum samples from 59 patients, stratified as asymptomatic, moderate, or severe, were analyzed. sEVs were isolated, characterized by electron microscopy, nanoparticle tracking, and flow cytometry, then profiled via LC-MS.</div><div>Classification models integrating comorbidities, acute symptoms, and sEV proteomics distinguished the three groups, with sEV data outperforming conventional measures. Of 620 identified proteins, 30 showed significant differences between symptomatic and asymptomatic patients, including 12 linked to complement activation. ELISA confirmed LC-MS results that serum sEVs of post-COVID patients had altered C1 inhibitor, C3, and C5 levels.</div><div>These results suggest that sEV-based proteomics can enable earlier detection and more targeted follow-up for individuals at risk of post-COVID syndrome.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"278 ","pages":"Article 110532"},"PeriodicalIF":4.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The type of the first prime/boost vaccine against SARS-CoV-2 exerts long-term effects on the humoral immune response 针对SARS-CoV-2的第一种初级/加强疫苗类型对体液免疫反应具有长期影响

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-05-15 DOI: 10.1016/j.clim.2025.110523

Franz Mai , Emil C. Reisinger , Brigitte Müller-Hilke

引用次数: 0

Association of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity 与先天性免疫错误有关的患者的临床表现和免疫改变与不确定意义的遗传变异的关系

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-05-10 DOI: 10.1016/j.clim.2025.110513

Samantha Novotny , Noelle Yoo , Jiaye Chen , Michael Granoth , Anita Kohli-Pamnani , Florence Ida Hsu , Mario Rodenas , Ryan Steele , Kelsey Kaman , Gary Soffer , Christina Price , John K. Kuster , Insoo Kang , Lais Osmani , Junghee J. Shin

引用次数: 0

Autoimmune hemolytic anemia in COVID-19 patients: A systematic review of 105 cases on clinical characteristics and outcomes COVID-19患者自身免疫性溶血性贫血：105例临床特征和结局的系统回顾

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-05-08 DOI: 10.1016/j.clim.2025.110512

Mohammed Ayyad , Walaa Abu Alya , Anas Mufeed Barabrah , Sara Mohammed Darawish , Yazan AlHabil , Majdeddin MohammedAli , Mustafa Zafer Nabilsi , Diya Asad , Laith A. Ayasa , Daniel Matassa

{"title":"Autoimmune hemolytic anemia in COVID-19 patients: A systematic review of 105 cases on clinical characteristics and outcomes","authors":"Mohammed Ayyad , Walaa Abu Alya , Anas Mufeed Barabrah , Sara Mohammed Darawish , Yazan AlHabil , Majdeddin MohammedAli , Mustafa Zafer Nabilsi , Diya Asad , Laith A. Ayasa , Daniel Matassa","doi":"10.1016/j.clim.2025.110512","DOIUrl":"10.1016/j.clim.2025.110512","url":null,"abstract":"<div><h3>Background</h3><div>COVID-19 has been linked to autoimmune hemolytic anemia (AIHA), a rare but serious condition causing red blood cell destruction. This systematic review examines the clinical characteristics, management, and outcomes of AIHA in COVID-19 patients.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, CINAHL, and Scopus identified 85 studies encompassing 105 patients. Data on demographics, clinical features, and treatment outcomes were extracted.</div></div><div><h3>Results</h3><div>Of 1402 articles, 85 met inclusion criteria. Most patients were male (54.3 %) with a mean age of 50.6 years, predominantly from Asia (83.5 %). Cold agglutinin AIHA was most common (48.2 %). Presenting symptoms included fatigue, dyspnea, and fever. Steroids were the most effective treatment, used in 95 % of recovered cases. Mortality was 14.3 %, with 26.7 % of deaths directly related to AIHA.</div></div><div><h3>Conclusions</h3><div>COVID-19 is associated with AIHA, often presenting with non-specific symptoms. Early recognition and prompt steroid therapy are critical for improving outcomes. Further research is needed to guide management.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"277 ","pages":"Article 110512"},"PeriodicalIF":4.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and risk factors for CMV and EBV infection in infants with low T-cell receptor excision circles on newborn screen 新生儿筛查低t细胞受体切除圆环的婴儿巨细胞病毒和EBV感染的发病率和危险因素

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-04-30 DOI: 10.1016/j.clim.2025.110510

Megan E. Day-Lewis , Laura Berbert , Michele DeGrazia , Christina Yee , Ari J. Fried , Alan A. Nguyen , Jaime E. Hale , Anne Counihan , Anne Marie Comeau , Elsa R. Treffeisen , Mary Poyner Reed , Craig D. Platt , Janet Chou

{"title":"Incidence and risk factors for CMV and EBV infection in infants with low T-cell receptor excision circles on newborn screen","authors":"Megan E. Day-Lewis , Laura Berbert , Michele DeGrazia , Christina Yee , Ari J. Fried , Alan A. Nguyen , Jaime E. Hale , Anne Counihan , Anne Marie Comeau , Elsa R. Treffeisen , Mary Poyner Reed , Craig D. Platt , Janet Chou","doi":"10.1016/j.clim.2025.110510","DOIUrl":"10.1016/j.clim.2025.110510","url":null,"abstract":"<div><h3>Background</h3><div>Newborn screening for severe combined immunodeficiency (SCID) using T cell receptor excision circles (TRECs) identifies patients with other causes of lymphopenia. The risk of opportunistic infection in patients with non-SCID lymphopenia is poorly understood. We aim to describe incidence and risk factors associated with cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infection in patients with low TRECs.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed 289 patients with ≥1 abnormal TREC result.</div></div><div><h3>Results</h3><div>Nineteen patients had CMV or EBV detected by PCR. Most had resolution of infection (<em>n</em> = 13). Two have chronic viremia, and four expired due to disseminated CMV. Risk factors included undetectable TRECs, consanguinity, family history, low NK, naïve CD4, naïve CD8 cells, and phytohemagglutinin.</div></div><div><h3>Conclusion</h3><div>Infection with CMV and EBV in patients with low TRECs is rare, however some may benefit from preventative measures. Consideration of risk factors may aid in decision-making and improve outcomes.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"277 ","pages":"Article 110510"},"PeriodicalIF":4.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolonged alterations in red blood cell rheology following mild SARS-CoV-2 infection: Implications for microvascular health 轻度SARS-CoV-2感染后红细胞流变学的长期改变：对微血管健康的影响

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-04-30 DOI: 10.1016/j.clim.2025.110511

Loredana Pazara , Monica Tudorache , Daniela Dusa , Geir Bjørklund , Maryam Dadar , Monica Daniela Doşa , Salvatore Chirumbolo , Claudia Cambrea

{"title":"Prolonged alterations in red blood cell rheology following mild SARS-CoV-2 infection: Implications for microvascular health","authors":"Loredana Pazara , Monica Tudorache , Daniela Dusa , Geir Bjørklund , Maryam Dadar , Monica Daniela Doşa , Salvatore Chirumbolo , Claudia Cambrea","doi":"10.1016/j.clim.2025.110511","DOIUrl":"10.1016/j.clim.2025.110511","url":null,"abstract":"<div><div>The COVID-19 pandemic has prompted widespread investigation into its systemic effects, focusing on the consequences of even mild SARS-CoV-2 infections. This study explores the impact of mild COVID-19 on red blood cell (RBC) rheology, specifically deformability and aggregation, both critical for efficient microvascular perfusion and oxygen delivery. Using advanced microfluidic techniques, blood samples from 23 individuals recovering from mild COVID-19 were analyzed and compared to 21 healthy controls. Results revealed significant reductions in RBC deformability and increased aggregation tendencies in the post-COVID group, particularly among females. These rheological changes correlated with fibrinogen and D-dimer levels, suggesting links to systemic inflammation and hypercoagulability. Persistent alterations in RBC functionality may underlie the microvascular dysfunction and symptoms of post-acute COVID-19 syndrome (PACS), including fatigue and cognitive impairment. These findings underscore the need for targeted therapeutic approaches and longitudinal studies to address the hematological dimensions of PACS and improve recovery outcomes.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"277 ","pages":"Article 110511"},"PeriodicalIF":4.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent IP-10/CXCL10 dysregulation following mild Omicron breakthrough infection: Immune network signatures across COVID-19 waves and implications for mRNA vaccine outcomes 轻度组粒突破感染后持续的IP-10/CXCL10失调：跨COVID-19波的免疫网络特征及其对mRNA疫苗结果的影响

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-04-28 DOI: 10.1016/j.clim.2025.110507

Vimvara Vacharathit , Mutita Pluempreecha , Suwimon Manopwisedjaroen , Chanya Srisaowakarn , Sirawat Srichatrapimuk , Paskorn Sritipsukho , Naiyana Sritipsukho , Arunee Thitithanyanont

{"title":"Persistent IP-10/CXCL10 dysregulation following mild Omicron breakthrough infection: Immune network signatures across COVID-19 waves and implications for mRNA vaccine outcomes","authors":"Vimvara Vacharathit , Mutita Pluempreecha , Suwimon Manopwisedjaroen , Chanya Srisaowakarn , Sirawat Srichatrapimuk , Paskorn Sritipsukho , Naiyana Sritipsukho , Arunee Thitithanyanont","doi":"10.1016/j.clim.2025.110507","DOIUrl":"10.1016/j.clim.2025.110507","url":null,"abstract":"<div><div>This study explores immune responses in mild Omicron-era COVID-19 breakthrough cases, focusing on cytokine dysregulation, antibody dynamics, and Long COVID. We analyzed samples from 114 mild symptomatic COVID-19 patients across multiple pandemic waves, each dominated by different SARS-CoV-2 variants, at three timepoints: (T1: 2–4 weeks, T2: 3–4 months, T3: 6–8 months post-infection). Persistent IP-10 elevation up to 8 months post–Omicron breakthrough infection suggests sustained low-grade immune activation that appears unique to this wave. Hybrid immunity from Omicron breakthrough infections elicited broad cross-variant antibody recognition but showed declining neutralization over time. Among vaccination regimens, mRNA-inclusive combinations were associated with lower Long COVID scores. CoV-229E antibody levels correlated with Long COVID scores. These findings underscore the need for extended monitoring of even mild COVID-19 cases and highlight the potential of mRNA vaccines in reducing post-COVID-19 complications. Insights into post-infection immune alterations and vaccine effects can inform the development of future vaccination strategies and approaches for managing post-COVID-19 conditions.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"278 ","pages":"Article 110507"},"PeriodicalIF":4.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel heterozygous SPI1c.538C>T p.(Leu180Phe) variant causes PU.1 haploinsufficiency leading to agammaglobulinemia 新型杂合子SPI1c。538C b> T p.（Leu180Phe）变异引起PU.1单倍不全，导致双球蛋白血症

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-04-26 DOI: 10.1016/j.clim.2025.110503

Ravindra Daddali , Kaisa Kettunen , Tanja Turunen , Ainsley V.C. Knox , Pia Laine , Iftekhar Chowdhury , Markku Vänttinen , Nanni Mamia , Amy L. Stiegler , Titus J. Boggon , Juha Kere , Neil Romberg , Mikko R.J. Seppänen , Markku Varjosalo , Timi Martelius , Juha Grönholm

{"title":"Novel heterozygous SPI1c.538C>T p.(Leu180Phe) variant causes PU.1 haploinsufficiency leading to agammaglobulinemia","authors":"Ravindra Daddali , Kaisa Kettunen , Tanja Turunen , Ainsley V.C. Knox , Pia Laine , Iftekhar Chowdhury , Markku Vänttinen , Nanni Mamia , Amy L. Stiegler , Titus J. Boggon , Juha Kere , Neil Romberg , Mikko R.J. Seppänen , Markku Varjosalo , Timi Martelius , Juha Grönholm","doi":"10.1016/j.clim.2025.110503","DOIUrl":"10.1016/j.clim.2025.110503","url":null,"abstract":"<div><div>PU.1 is an Ets family transcription factor crucial for hematopoietic cell fate. Complete PU.1 deficiency lethally arrests lympho- and myelopoiesis in mice. Individuals with <em>SPI1</em> heterozygous loss-of-function variants exhibit disrupted gene expression patterns associated with B cell development. We identified the vertical transmission of a heterozygous <em>SPI1</em>c.538C>T p.(L180F) variant in a Finnish family. The index patient and his mother had severe bacterial infections, agammaglobulinemia, and low myeloid and plasmacytoid dendritic cell counts. The variant carrier sister had slightly reduced B cell counts, isolated IgA deficiency, and reduced dendritic cell counts. All individuals had diminished PU.1 protein expression in monocytes. <em>In vitro</em> studies showed that PU.1 L180F variant is less expressed and predominantly located in the cytoplasm. PU.1 WT mainly interacts with chromatin and centrosome-associated proteins, while the L180F variant showed fewer interactions. Our findings describe a novel PU.1 variant leading to agammaglobulinemia with variable penetrance.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"277 ","pages":"Article 110503"},"PeriodicalIF":4.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0