IKZF1: An important target for the treatment of autoimmune diseases

IF 3.8 3区医学 Q2 IMMUNOLOGY

Clinical immunology Pub Date : 2025-06-13 DOI:10.1016/j.clim.2025.110544

Siyuan Bu, Cong Ye, Shaozhe Cai, Lingli Dong

引用次数: 0

Abstract

IKZF1 is a member of the Ikaros transcription factor family. It is involved in the regulation of the development and function of a variety of immune cells. Mutations or aberrant expression of IKZF1 are closely associated with the development of various immune-related diseases, including hematologic malignancies, solid tumors, and autoimmune diseases. In recent years, more and more studies have revealed the important role of IKZF1 in regulating immune responses, maintaining immune tolerance, and inhibiting the overactivation of immune cells. What's more, IKZF1 has been discovered to have a significant connection to the pathogenesis of autoimmune diseases. This review will summarize the role of IKZF1 in autoimmune diseases and its potential clinical applications.

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IKZF1：治疗自身免疫性疾病的重要靶点

IKZF1是Ikaros转录因子家族的一员。它参与调节多种免疫细胞的发育和功能。IKZF1的突变或异常表达与各种免疫相关疾病的发展密切相关，包括血液恶性肿瘤、实体瘤和自身免疫性疾病。近年来，越来越多的研究揭示了IKZF1在调节免疫应答、维持免疫耐受、抑制免疫细胞过度活化等方面的重要作用。更重要的是，IKZF1已被发现与自身免疫性疾病的发病机制有重要的联系。本文就IKZF1在自身免疫性疾病中的作用及其潜在的临床应用进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical immunology 医学-免疫学

CiteScore

12.30

自引率

1.20%

发文量

212

审稿时长

34 days

期刊介绍： Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.