Oral microbiota in allergic diseases, and sublingual allergen immunotherapy

IF 3.8 3区医学 Q2 IMMUNOLOGY

Clinical immunology Pub Date : 2025-06-06 DOI:10.1016/j.clim.2025.110538

Umut Gazi , Nerin Nadir Bahceciler

{"title":"Oral microbiota in allergic diseases, and sublingual allergen immunotherapy","authors":"Umut Gazi , Nerin Nadir Bahceciler","doi":"10.1016/j.clim.2025.110538","DOIUrl":null,"url":null,"abstract":"<div><div>Allergic diseases with their epidemic prevalence on the rise have been one of the major global health problems of the 21st century. The association of increased prevalence with lifestyle changes including increased urbanization, and hygiene practices highlighted the importance of host-microbiome interactions for maintaining immune homeostasis. In support, numerous studies demonstrated altered gut microbiome composition in allergic patients, and suggested dysbiosis as a possible cause of allergic diseases. Nevertheless, despite being the second largest microbiota in the human body, oral microbiota has not yet received the attention it deserves in the literature. With this review article, we aim to highlight its significance by summarizing the data obtained from studies evaluating oral microbiome composition in patients with allergic respiratory diseases. Additionally, their importance will be further elaborated by discussing the findings presented by animal and human studies investigating the possible effect of oral probiotic uptake to the clinical efficacy of sublingual allergen immunotherapy.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"279 ","pages":"Article 110538"},"PeriodicalIF":3.8000,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical immunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1521661625001135","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Allergic diseases with their epidemic prevalence on the rise have been one of the major global health problems of the 21st century. The association of increased prevalence with lifestyle changes including increased urbanization, and hygiene practices highlighted the importance of host-microbiome interactions for maintaining immune homeostasis. In support, numerous studies demonstrated altered gut microbiome composition in allergic patients, and suggested dysbiosis as a possible cause of allergic diseases. Nevertheless, despite being the second largest microbiota in the human body, oral microbiota has not yet received the attention it deserves in the literature. With this review article, we aim to highlight its significance by summarizing the data obtained from studies evaluating oral microbiome composition in patients with allergic respiratory diseases. Additionally, their importance will be further elaborated by discussing the findings presented by animal and human studies investigating the possible effect of oral probiotic uptake to the clinical efficacy of sublingual allergen immunotherapy.

查看原文本刊更多论文

过敏性疾病的口腔微生物群，以及舌下过敏原免疫治疗。

过敏性疾病的流行率呈上升趋势，已成为21世纪全球主要的健康问题之一。发病率的增加与生活方式的改变（包括城市化程度的提高）和卫生习惯的关系突出了宿主-微生物组相互作用对维持免疫稳态的重要性。为了支持这一观点，大量研究表明，过敏患者肠道微生物组组成发生改变，并提示生态失调可能是过敏性疾病的原因。然而，尽管口腔微生物群是人体第二大微生物群，但在文献中尚未得到应有的重视。在这篇综述文章中，我们旨在通过总结从评估过敏性呼吸道疾病患者口腔微生物组组成的研究中获得的数据来强调其重要性。此外，它们的重要性将通过讨论动物和人类研究的结果进一步阐述，这些研究调查了口服益生菌对舌下过敏原免疫治疗临床疗效的可能影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical immunology 医学-免疫学

CiteScore

12.30

自引率

1.20%

发文量

212

审稿时长

34 days

期刊介绍： Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.