ProBNP, cytokines, and the Nrf2/HO-1 signaling pathway: A cross-sectional study on cardiovascular risk in rheumatoid arthritis

IF 4.5 3区医学 Q2 IMMUNOLOGY

Clinical immunology Pub Date : 2025-06-09 DOI:10.1016/j.clim.2025.110541

Christiane Aguiar Nobre , Carlos Ewerton Maia Rodrigues , Natacha Xavier Cavalcante , Thácilla Siqueira Eugênio Nascimento , João Gabriel Marques Brayner , Giovanna Azevedo Sousa , Nayara Alves de Sousa , Regislane Pinto Ribeiro , Vanessa Maria Eufrásio de Fiqueirêdo , Giulia Albuquerque Paiva , José Jackson do Nascimento Costa , Paula Goes , Hellíada Vasconcelos Chaves , Ticiana Mont'Alverne Parente Feijão , Mirna Marques Bezerra

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Abstract

We evaluated associations between clinical/laboratory findings and serum cytokines, Nrf2/HO-1 pathway expression and cardiovascular risk in both RA patients and controls. Sixty RA patients and 60 controls were included in the study. Serum cytokine and proBNP levels were assessed by ELISA, while serum Nrf2 and HO-1 mRNA levels were quantified by qRT-PCR. The RA group (91.7 % women) and the control group (90 % women) were aged 52 ± 12 and 52 ± 13 years, respectively. ProBNP levels were higher in the RA group than in controls (p = 0.009). Nrf2 mRNA levels were higher (p < 0.001) and HO-1 mRNA levels were lower (p = 0.030) in the RA group than in controls. CDAI scores were significantly associated with serum IL-6 levels (p = 0.033). This study found a significant dysregulation in Nrf2/HO-1 pathway activity in RA patients, although without association with cardiovascular risk, RA-related clinical and laboratory variables. Moderate/high disease activity was positively associated with IL-6 levels.

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ProBNP、细胞因子和Nrf2/HO-1信号通路：类风湿关节炎心血管风险的横断面研究

我们评估了RA患者和对照组的临床/实验室结果与血清细胞因子、Nrf2/HO-1通路表达和心血管风险之间的关系。60名RA患者和60名对照者被纳入研究。ELISA法检测血清细胞因子和proBNP水平，qRT-PCR法检测血清Nrf2和HO-1 mRNA水平。RA组（91.7%为女性）和对照组（90%为女性）的年龄分别为52±12岁和52±13岁。RA组ProBNP水平高于对照组（p = 0.009）。Nrf2 mRNA水平升高(p <；0.001)， RA组HO-1 mRNA水平低于对照组（p = 0.030）。CDAI评分与血清IL-6水平显著相关（p = 0.033）。本研究发现RA患者Nrf2/HO-1通路活性明显失调，尽管与心血管风险、RA相关的临床和实验室变量无关。中度/高度疾病活动度与IL-6水平呈正相关。

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来源期刊

Clinical immunology 医学-免疫学

CiteScore

12.30

自引率

1.20%

发文量

212

审稿时长

34 days

期刊介绍： Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.