Clinical immunology最新文献_第4页

Tumor-associated neutrophils: a complex role in cancer 肿瘤相关中性粒细胞：在癌症中的复杂作用。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-07-07 DOI: 10.1016/j.clim.2025.110558

Xukang Gao , Min Xu , Hao Xiao , Zeping Han , Zhutao Wang , Guoqiang Sun , Dai Zhang , Qiu Shuangjian , Ning Ren , Chenhao Zhou , Yong Yi

引用次数: 0

Animal models of IgG4-related disease igg4相关疾病的动物模型。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-07-06 DOI: 10.1016/j.clim.2025.110559

Manqi Tang , Weicheng Shen , Yanying Liu

引用次数: 0

LSP1 deficiency increases IL-17-expressing T cells and accelerates primary Sjögren's syndrome LSP1缺乏增加表达il -17的T细胞，加速原发性Sjögren综合征。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-28 DOI: 10.1016/j.clim.2025.110548

Jayhyun Kim , Jung Gon Kim , Yingjin Li , Sungyong You , Naeun Lee , Wan-Uk Kim

引用次数: 0

IL-33 regulates abnormally increased expression of ST2 in bone marrow follicular helper T cell in SLE with hematological abnormalities IL-33调节SLE伴血液学异常患者骨髓滤泡辅助T细胞ST2表达异常升高。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-24 DOI: 10.1016/j.clim.2025.110550

Shaowei Pan , Xiaoyun Xie , Tong Li , Shiyao Wu , Ying Jiang , Huali Zhang , Xiaoli Zhang

{"title":"IL-33 regulates abnormally increased expression of ST2 in bone marrow follicular helper T cell in SLE with hematological abnormalities","authors":"Shaowei Pan , Xiaoyun Xie , Tong Li , Shiyao Wu , Ying Jiang , Huali Zhang , Xiaoli Zhang","doi":"10.1016/j.clim.2025.110550","DOIUrl":"10.1016/j.clim.2025.110550","url":null,"abstract":"<div><div>Systemic lupus erythematosus (SLE) is often accompanied by hematological complications, with T follicular helper (Tfh) cells playing a pivotal role in its pathogenesis. This study explores the relationship between bone marrow Tfh and Interleukin-33 (IL-33) in SLE patients with hematological abnormalities. Using flow cytometry and ELISA, we found elevated percentages of bone marrow ST2+ Tfh cells in SLE patients, which correlated with disease activity, white blood cell count, and B cell percentage. Increased bone marrow IL-33 and BLyS levels were also observed. Keyhole-limpet hemocyanin (KLH)-immunized mouse model demonstrated IL-33-dependent Tfh expansion, while ST2 knockdown reduced Tfh frequency. In vitro co-culture experiments demonstrated that the IL-33/ST2 axis plays a pivotal role in enhancing the function of Tfh and T peripheral helper (Tph) cells, thereby promoting B cell differentiation into antibody-secreting plasma cells. These findings establish IL-33/ST2 as a key regulator of humoral immunity and a potential therapeutic target for SLE.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"279 ","pages":"Article 110550"},"PeriodicalIF":4.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Etiopathogenesis of Behçet's disease: A systematic literature review behaperet病的发病机制：系统的文献综述。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-24 DOI: 10.1016/j.clim.2025.110549

Nabil Belfeki , Nouha Ghriss , Alexandre Le Joncour , David Saadoun

引用次数: 0

Comment on: “A national survey of four decades of hereditary angioedema prophylaxis” — The emerging role of Garadacimab 评论：“一项关于40年遗传性血管性水肿预防的全国性调查”——加拉达西单抗的新作用

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-23 DOI: 10.1016/j.clim.2025.110547

Haris Afridi, Kainat Afzal

引用次数: 0

Scavenger receptors: An auspicious therapeutic target for autoimmune diseases 清道夫受体：自身免疫性疾病的理想治疗靶点

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-19 DOI: 10.1016/j.clim.2025.110546

Yi-Kai Liu , Meng Hao , Fan Yang , Ke-Xin Jing , Shun Zhao , Changhao Wu , Hai-Feng Pan

{"title":"Scavenger receptors: An auspicious therapeutic target for autoimmune diseases","authors":"Yi-Kai Liu , Meng Hao , Fan Yang , Ke-Xin Jing , Shun Zhao , Changhao Wu , Hai-Feng Pan","doi":"10.1016/j.clim.2025.110546","DOIUrl":"10.1016/j.clim.2025.110546","url":null,"abstract":"<div><div>Scavenger receptors (SRs) belong to a large receptor family expressed on immune and non- immune cells. Initially, SRs are regarded as removers able to recognize and clear modified lipoproteins; However, it is now realized that they are pattern recognition receptors (PRRs) that identify damage-associated molecular pattern (DAMP) and pathogen-associated molecular patterns (PAMPs). The wide range of ligands that bind to SRs demonstrates their diverse functions, including pathogen clearance, lipid transport, cellular differentiation, and signaling pathway activation. Previous studies have revealed the significance of SRs in regulating innate immunity and adaptive immunity. Recently, a large body of evidence further indicates the involvement of SRs in autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1D) and inflammatory bowel disease (IBD). In this comprehensive review, we will summarize molecular structure and immunological functions of different types of SRs, and discuss the recent insights into the involvement of SRs in the development and pathogenesis of autoimmune diseases and their clinical implications and therapeutic potential.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"279 ","pages":"Article 110546"},"PeriodicalIF":4.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High activity of human cytomegalovirus in patients with Sjögren's disease Sjögren病患者巨细胞病毒高活性研究。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-18 DOI: 10.1016/j.clim.2025.110545

Mattia Russel Pantalone , Xinling Xu , Nerea Martín Almazán , Christina Gerstner , Marie Fischer , Marika Kvarnström , Cecilia Söderberg-Nauclér , Marie Wahren-Herlenius , Afsar Rahbar

{"title":"High activity of human cytomegalovirus in patients with Sjögren's disease","authors":"Mattia Russel Pantalone , Xinling Xu , Nerea Martín Almazán , Christina Gerstner , Marie Fischer , Marika Kvarnström , Cecilia Söderberg-Nauclér , Marie Wahren-Herlenius , Afsar Rahbar","doi":"10.1016/j.clim.2025.110545","DOIUrl":"10.1016/j.clim.2025.110545","url":null,"abstract":"<div><div>Sjögren's disease (SD) is a chronic autoimmune disease characterized by immune-mediated damage to salivary and lacrimal glands. This study aimed to explore the potential link between SD and human cytomegalovirus (HCMV), by analyzing presence of HCMV proteins in salivary gland tissue specimens and prevalence of HCMV-specific antibodies in serum samples from SD patients and controls. HCMV-immediate early (IE) and late proteins (LA and pp65) were highly abundant in tissue specimens from SD patients (88.9 %, 69.2 %, 45.8 %, respectively), and less abundant in patients with Sicca symptoms without SD (70.5 %, 20.0 %, 12.5 %, respectively). Samples in the SD group were also positive at higher scores for the HCMV proteins than Sicca symptom patients without SD. IgM prevalence was higher in SD patients than in healthy controls (32.1 % vs. 13.4 %, <em>P</em> = 0.04) and HCMV-IgG titers were higher (<em>P</em> < 0.0001). Understanding the potential role of HCMV in SD pathogenesis may contribute to advancements in disease prevention and treatment.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"279 ","pages":"Article 110545"},"PeriodicalIF":4.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic variability associates with ancestry, age at disease onset, organ involvement and disease severity in juvenile-onset systemic lupus erythematosus 遗传变异与祖先、发病年龄、器官受累和青少年系统性红斑狼疮的疾病严重程度有关。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-15 DOI: 10.1016/j.clim.2025.110540

Valentina Natoli , Amandine Charras , Megan S.R. Hasoon , Andrea L. Jorgensen , Eve M.D. Smith , Eva Caamaño Gutiérrez , Michael W. Beresford , Christian M. Hedrich

{"title":"Genetic variability associates with ancestry, age at disease onset, organ involvement and disease severity in juvenile-onset systemic lupus erythematosus","authors":"Valentina Natoli , Amandine Charras , Megan S.R. Hasoon , Andrea L. Jorgensen , Eve M.D. Smith , Eva Caamaño Gutiérrez , Michael W. Beresford , Christian M. Hedrich","doi":"10.1016/j.clim.2025.110540","DOIUrl":"10.1016/j.clim.2025.110540","url":null,"abstract":"<div><div>Juvenile-onset systemic lupus erythematosus (jSLE) is a complex autoimmune/inflammatory disease in which genetic factors likely contribute to pathophysiology and clinical expression. This study explored associations between general (alternate allele counts; AAC) and gene-specific (alternate allele scores; GAAS) sequence variability, age at onset, sex, ancestry, disease activity/severity, organ involvement and treatments in jSLE. 289 participants from the UK JSLE Cohort Study underwent panel sequencing of 62 genes/genomic regions. Weighted AAC and GAAS were calculated. Correlation analyses and generalized linear models assessed associations between genetic burden, ancestry, age at diagnosis and clinical variables. AAC inversely correlated with age at diagnosis (R = -0.15, <em>p</em> = 0.01), primarily driven by South Asians (R = -0.28, <em>p</em> < 0.001). African/Caribbean patients exhibited higher AAC (p < 0.001). Clinical variables, including severity of renal involvement (<em>ACP5</em>, <em>ITGAM</em>, <em>LYN</em>, p < 0.001; <em>TNFAIP3</em>, <em>p</em> = 0.007), associated with GAAS. Genetic variability likely contributes to early disease expression and severity in jSLE, supporting patient stratification and personalised care.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"279 ","pages":"Article 110540"},"PeriodicalIF":4.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of immune cells glycolysis in neuroinflammation secondary to intracerebral hemorrhage 免疫细胞糖酵解在脑出血继发神经炎症中的作用

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-06-14 DOI: 10.1016/j.clim.2025.110543

Baochun Luo , Sifan Liu , Lei Zheng , Baiwen Zhang , Yaxin Shang , Tong Shang , Jia Zheng , Binglin Kuang , Wei Zou

{"title":"The role of immune cells glycolysis in neuroinflammation secondary to intracerebral hemorrhage","authors":"Baochun Luo , Sifan Liu , Lei Zheng , Baiwen Zhang , Yaxin Shang , Tong Shang , Jia Zheng , Binglin Kuang , Wei Zou","doi":"10.1016/j.clim.2025.110543","DOIUrl":"10.1016/j.clim.2025.110543","url":null,"abstract":"<div><div>Intracerebral hemorrhage (ICH) is the most lethal subtype of stroke, making the effective prevention and treatment of inflammatory secondary injury crucial. Recently, the role of immune cell metabolism in ICH has gained attention, particularly the regulatory mechanisms of glycolytic reprogramming in neuroinflammation. This review explores how glycolysis activation in peripheral immune cells (including neutrophils, macrophages, T cells, and natural killer cells), central immune cells (microglia), and other glial cells (including astrocytes and oligodendrocytes) involved in immune regulation influences the inflammatory response following ICH. We analyze the metabolic shifts in glycolysis within these immune cells, highlighting its dual role in neuroinflammation: glycolysis not only provides rapid energy to immune cells, which can either promote or inhibit inflammation, but lactate—a glycolysis byproduct—can modulate inflammatory damage by altering pH and immune cell function. Furthermore, we explore the therapeutic potential of targeting glycolysis in immune cells for neuroinflammation treatment. A deeper understanding of the glycolytic mechanism in ICH may facilitate the development of clinical therapeutic strategies targeting metabolism.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"279 ","pages":"Article 110543"},"PeriodicalIF":4.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0