Sjögren病患者巨细胞病毒高活性研究。

IF 3.8 3区医学 Q2 IMMUNOLOGY

Clinical immunology Pub Date : 2025-06-18 DOI:10.1016/j.clim.2025.110545

Mattia Russel Pantalone , Xinling Xu , Nerea Martín Almazán , Christina Gerstner , Marie Fischer , Marika Kvarnström , Cecilia Söderberg-Nauclér , Marie Wahren-Herlenius , Afsar Rahbar

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引用次数: 0

摘要

Sjögren's disease （SD）是一种慢性自身免疫性疾病，其特征是免疫介导的唾液腺和泪腺损伤。本研究旨在通过分析SD患者和对照组唾液腺组织标本中HCMV蛋白的存在以及血清样本中HCMV特异性抗体的流行情况，探讨SD与人巨细胞病毒（HCMV）之间的潜在联系。hcmv早期（IE）和晚期蛋白（LA和pp65）在SD患者的组织标本中含量较高（分别为88.9% %、69.2% %、45.8% %），而在无SD的Sicca症状患者中含量较低（分别为70.5 %、20.0 %、12.5 %）。与没有SD的Sicca症状患者相比，SD组样本的HCMV蛋白得分也更高。SD患者IgM患病率高于健康对照组（32.1% % vs. 13.4 %,P = 0.04），HCMV-IgG滴度高于健康对照组（P < 0.05）

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High activity of human cytomegalovirus in patients with Sjögren's disease

Sjögren's disease (SD) is a chronic autoimmune disease characterized by immune-mediated damage to salivary and lacrimal glands. This study aimed to explore the potential link between SD and human cytomegalovirus (HCMV), by analyzing presence of HCMV proteins in salivary gland tissue specimens and prevalence of HCMV-specific antibodies in serum samples from SD patients and controls. HCMV-immediate early (IE) and late proteins (LA and pp65) were highly abundant in tissue specimens from SD patients (88.9 %, 69.2 %, 45.8 %, respectively), and less abundant in patients with Sicca symptoms without SD (70.5 %, 20.0 %, 12.5 %, respectively). Samples in the SD group were also positive at higher scores for the HCMV proteins than Sicca symptom patients without SD. IgM prevalence was higher in SD patients than in healthy controls (32.1 % vs. 13.4 %, P = 0.04) and HCMV-IgG titers were higher (P < 0.0001). Understanding the potential role of HCMV in SD pathogenesis may contribute to advancements in disease prevention and treatment.

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来源期刊

Clinical immunology 医学-免疫学

CiteScore

12.30

自引率

1.20%

发文量

212

审稿时长

34 days

期刊介绍： Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.