肿瘤相关中性粒细胞：在癌症中的复杂作用。

IF 3.8 3区医学 Q2 IMMUNOLOGY

Clinical immunology Pub Date : 2025-07-07 DOI:10.1016/j.clim.2025.110558

Xukang Gao , Min Xu , Hao Xiao , Zeping Han , Zhutao Wang , Guoqiang Sun , Dai Zhang , Qiu Shuangjian , Ning Ren , Chenhao Zhou , Yong Yi

{"title":"肿瘤相关中性粒细胞：在癌症中的复杂作用。","authors":"Xukang Gao , Min Xu , Hao Xiao , Zeping Han , Zhutao Wang , Guoqiang Sun , Dai Zhang , Qiu Shuangjian , Ning Ren , Chenhao Zhou , Yong Yi","doi":"10.1016/j.clim.2025.110558","DOIUrl":null,"url":null,"abstract":"<div><div>Neutrophils, constituting 50–70 % of circulating leukocytes, serve as first responders in innate immunity. In recent years, as research into the tumor immune microenvironment has intensified, the role of neutrophils in tumor has gained increasing attention. Studies have shown that neutrophils are involved in tumor growth, metastasis, angiogenesis, and immune regulation. However, because tumor-associated neutrophils (TANs) often exhibit dual-edged effects and significant heterogeneity, it remains challenging to determine whether they act as allies or adversaries. This review systematically summarizes the classification and functions of neutrophils in tumor. Additionally, the current challenges in tumor-associated neutrophils are discussed, aiming to provide new insights for the development of neutrophil-related immunotherapies.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"280 ","pages":"Article 110558"},"PeriodicalIF":3.8000,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tumor-associated neutrophils: a complex role in cancer\",\"authors\":\"Xukang Gao , Min Xu , Hao Xiao , Zeping Han , Zhutao Wang , Guoqiang Sun , Dai Zhang , Qiu Shuangjian , Ning Ren , Chenhao Zhou , Yong Yi\",\"doi\":\"10.1016/j.clim.2025.110558\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Neutrophils, constituting 50–70 % of circulating leukocytes, serve as first responders in innate immunity. In recent years, as research into the tumor immune microenvironment has intensified, the role of neutrophils in tumor has gained increasing attention. Studies have shown that neutrophils are involved in tumor growth, metastasis, angiogenesis, and immune regulation. However, because tumor-associated neutrophils (TANs) often exhibit dual-edged effects and significant heterogeneity, it remains challenging to determine whether they act as allies or adversaries. This review systematically summarizes the classification and functions of neutrophils in tumor. Additionally, the current challenges in tumor-associated neutrophils are discussed, aiming to provide new insights for the development of neutrophil-related immunotherapies.</div></div>\",\"PeriodicalId\":10392,\"journal\":{\"name\":\"Clinical immunology\",\"volume\":\"280 \",\"pages\":\"Article 110558\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-07-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1521661625001330\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical immunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1521661625001330","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

中性粒细胞占循环白细胞的50- 70% %，是先天免疫的第一反应者。近年来，随着对肿瘤免疫微环境研究的深入，中性粒细胞在肿瘤中的作用越来越受到重视。研究表明，中性粒细胞参与肿瘤的生长、转移、血管生成和免疫调节。然而，由于肿瘤相关中性粒细胞（TANs）经常表现出双刃剑效应和显著的异质性，因此确定它们是盟友还是对手仍然具有挑战性。本文就中性粒细胞在肿瘤中的分类及功能作一综述。此外，本文还讨论了目前肿瘤相关中性粒细胞面临的挑战，旨在为中性粒细胞相关免疫疗法的发展提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Tumor-associated neutrophils: a complex role in cancer

Neutrophils, constituting 50–70 % of circulating leukocytes, serve as first responders in innate immunity. In recent years, as research into the tumor immune microenvironment has intensified, the role of neutrophils in tumor has gained increasing attention. Studies have shown that neutrophils are involved in tumor growth, metastasis, angiogenesis, and immune regulation. However, because tumor-associated neutrophils (TANs) often exhibit dual-edged effects and significant heterogeneity, it remains challenging to determine whether they act as allies or adversaries. This review systematically summarizes the classification and functions of neutrophils in tumor. Additionally, the current challenges in tumor-associated neutrophils are discussed, aiming to provide new insights for the development of neutrophil-related immunotherapies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Clinical immunology 医学-免疫学

CiteScore

12.30

自引率

1.20%

发文量

212

审稿时长

34 days

期刊介绍： Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.