Clinical immunology最新文献_第3页

Anti-interferon gamma-inducible protein 16 antibodies: Identification of a novel autoantigen in idiopathic interstitial pneumonia and its clinical characteristics based on a multicenter cohort study 抗干扰素γ诱导蛋白16抗体：基于多中心队列研究的特发性间质性肺炎新型自身抗原鉴定及其临床特征。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-09-30 DOI: 10.1016/j.clim.2024.110372

Tsuneo Sasai , Ran Nakashima , Tomohiro Handa , Yasuhiko Yamano , Yasuhiro Kondo , Shogo Matsuda , Takuya Kotani , Hiromi Tomioka , Ryo Tachikawa , Keisuke Tomii , Kiminobu Tanizawa , Yasuhiro Nohda , Toshiaki Kogame , Mirei Shirakashi , Ryosuke Hiwa , Hideaki Tsuji , Shuji Akizuki , Hajime Yoshifuji , Tsuneyo Mimori , Kenji Kabashima , Akio Morinobu

{"title":"Anti-interferon gamma-inducible protein 16 antibodies: Identification of a novel autoantigen in idiopathic interstitial pneumonia and its clinical characteristics based on a multicenter cohort study","authors":"Tsuneo Sasai , Ran Nakashima , Tomohiro Handa , Yasuhiko Yamano , Yasuhiro Kondo , Shogo Matsuda , Takuya Kotani , Hiromi Tomioka , Ryo Tachikawa , Keisuke Tomii , Kiminobu Tanizawa , Yasuhiro Nohda , Toshiaki Kogame , Mirei Shirakashi , Ryosuke Hiwa , Hideaki Tsuji , Shuji Akizuki , Hajime Yoshifuji , Tsuneyo Mimori , Kenji Kabashima , Akio Morinobu","doi":"10.1016/j.clim.2024.110372","DOIUrl":"10.1016/j.clim.2024.110372","url":null,"abstract":"<div><div>Autoantibodies are detected in idiopathic interstitial pneumonias (IIPs) without a clear connective tissue disease diagnosis, and their clinical significance is unclear. This study aimed to identify a novel autoantibody in IIPs. We screened 295 IIP patients using a <sup>35</sup>S-methionine labeled protein immunoprecipitation assay. Candidate autoantigens were identified via protein array and confirmed by immunoprecipitation. Six sera from 295 IIP patients immunoprecipitated common tetrameric proteins (100 kDa). The protein array identified interferon gamma-inducible protein 16 (IFI16) as the candidate autoantigen. Patients with anti-IFI16 antibodies received immunosuppressants less frequently. Five-year survival rates were 50 %, 69 %, and 63 % (<em>P</em> = 0.60), and acute exacerbation-free rates were 50 %, 96 %, and 84 % (<em>P</em> = 0.15) for patients with anti-IFI16, anti-aminoacyl tRNA antibodies, and others. Anti-IFI16 is a novel autoantibody in IIPs. Patients with this antibody often receive less immunosuppressive therapy and could have a poor prognosis. Further research is needed to refine patient stratification and management.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"268 ","pages":"Article 110372"},"PeriodicalIF":4.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Broad applicability of the Goldspire™ platform for the treatment of solid tumors Goldspire™ 平台广泛适用于实体瘤的治疗。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-09-28 DOI: 10.1016/j.clim.2024.110373

Jenny Zilberberg , Christopher Uhl , Charles B. Scott , David W. Andrews , Mark A. Exley

{"title":"Broad applicability of the Goldspire™ platform for the treatment of solid tumors","authors":"Jenny Zilberberg , Christopher Uhl , Charles B. Scott , David W. Andrews , Mark A. Exley","doi":"10.1016/j.clim.2024.110373","DOIUrl":"10.1016/j.clim.2024.110373","url":null,"abstract":"<div><div>Goldspire™ is a personalized immunotherapy platform that combines whole tumor-derived cells with antisense oligonucleotide (IMV-001) against Insulin-Like Growth Factor-1 Receptor (IGF-1R) in biodiffusion chambers (BDCs; 0.1 μm pore). BDCs are exposed to 5–6 Gy and implanted at abdominal sites for ∼48 h to deliver an antigenic payload and immunostimulatory factors to train the immune system. Lead product IGV-001 was evaluated in newly diagnosed glioblastoma (ndGBM) patients in Phase 1a and 1b trials (<span><span>NCT02507583</span><svg><path></path></svg></span>). A Phase 2b study (<span><span>NCT04485949</span><svg><path></path></svg></span>) recently completed enrollment.</div><div>Preventative treatment with tumor-specific products manufactured with Goldspire limited tumor progression and extended overall survival in mice challenged with bladder, pancreatic, ovarian, colorectal, or renal carcinomas. The benefit of this immunotherapy was enhanced with anti-PD-1; combination treatment was superior to either monotherapy in orthotopic GBM and melanoma models. Lastly, Goldspire elicited immune T cell activation and memory phenotypes against patient-derived endometrial tumor-derived products in co-cultures with matching immune cells.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"268 ","pages":"Article 110373"},"PeriodicalIF":4.5,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bisphenol A triggers activation of ocular immune system and aggravates allergic airway inflammation 双酚 A 会引发眼部免疫系统激活，加重过敏性气道炎症。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-09-28 DOI: 10.1016/j.clim.2024.110370

Tatsuo Ueda , Takumi Adachi , Tomoya Hayashi , Koubun Yasuda , Kazufumi Matsushita , Eiko Koike , Rie Yanagisawa , Takahiro Nagatake , Jun Kunisawa , Ken J. Ishii , Kenzo Tsuzuki , Etsushi Kuroda

{"title":"Bisphenol A triggers activation of ocular immune system and aggravates allergic airway inflammation","authors":"Tatsuo Ueda , Takumi Adachi , Tomoya Hayashi , Koubun Yasuda , Kazufumi Matsushita , Eiko Koike , Rie Yanagisawa , Takahiro Nagatake , Jun Kunisawa , Ken J. Ishii , Kenzo Tsuzuki , Etsushi Kuroda","doi":"10.1016/j.clim.2024.110370","DOIUrl":"10.1016/j.clim.2024.110370","url":null,"abstract":"<div><div>Bisphenol A (BPA) is widely used in manufacturing plastic products, and it has been reported that exposure through the airway or orally aggravates allergic airway inflammation. Because BPA is detected in the atmosphere and indoor environments, the eyes can also be exposed to BPA. After ocular exposure to BPA and antigen via eye drops, we observed enhanced antigen uptake of antigen-presenting cells (APCs) in tear duct-associated lymphoid tissue (TALT). Additionally, we observed the formation of germinal center (GC) B cells in TALT and induction of allergic airway inflammation in mice sensitized with BPA and antigen via eye drops, followed by airway antigen exposure. We also found that DNAX-activating protein of 12 kDa (DAP12)-deficient mice displayed impaired activation of APCs enhanced by ocular exposure to BPA. These results indicate that ocular sensitization to BPA and allergen triggers allergic inflammation via TALT activation, and that DAP12 might be a key molecule for modulating the ocular immune system.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"268 ","pages":"Article 110370"},"PeriodicalIF":4.5,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune response in vaccinated healthcare workers with frequent COVID-19 infections is characterised by blunted IFNγ and IL-2 responses to SARS-CoV-2 variants 频繁感染 COVID-19 的接种过疫苗的医护人员对 SARS-CoV-2 变体的免疫反应特点是 IFNγ 和 IL-2 反应减弱。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-09-27 DOI: 10.1016/j.clim.2024.110371

Liam Townsend , Jean Dunne , Jacklyn Sui , Carla Sanchez Perez , Matt McElheron , Cian Reid , William McCormack , Colm Bergin , Catherine Fleming , Cliona O'Farrelly , Gareth Brady , PRECISE Steering group, Niall Conlon

{"title":"Immune response in vaccinated healthcare workers with frequent COVID-19 infections is characterised by blunted IFNγ and IL-2 responses to SARS-CoV-2 variants","authors":"Liam Townsend , Jean Dunne , Jacklyn Sui , Carla Sanchez Perez , Matt McElheron , Cian Reid , William McCormack , Colm Bergin , Catherine Fleming , Cliona O'Farrelly , Gareth Brady , PRECISE Steering group, Niall Conlon","doi":"10.1016/j.clim.2024.110371","DOIUrl":"10.1016/j.clim.2024.110371","url":null,"abstract":"<div><div>Healthcare workers (HCWs) are at increased risk of SARS-CoV-2 infection. Despite widespread vaccination, some HCWs develop frequent symptomatic infection. We hypothesised that HCWs with frequent symptomatic COVID-19 have impaired T and B cell mediated immunity to SARS-CoV-2.</div><div>Vaccinated HCWs with no prior COVID infection (<em>n</em> = 9), asymptomatic recent infection (<em>n</em> = 10), and frequent recent infection (<em>n</em> = 15) were recruited from a longitudinal HCW cohort study. Whole blood stimulation with SARS-CoV-2 variants (Wuhan, B.1.617, BA.2, BA.2.75, BA.4/5, XBB.1.5, BQ.1.1) was performed, with IFNγ and IL-2 responses, total IgG produced, and anti-Spike antibody neutralising capacity measured.</div><div>Frequent infections had similar IFNγ and IL-2 responses to the never infected group, with significantly higher responses in the asymptomatic group. The frequent cohort had higher IgG responses to Delta and BA.4/5 and higher neutralising capacity against Omicron variants. An immune signature of blunted IL-2 and IFNγ in frequent infections may identify HCWs at increased risk of further infection.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"268 ","pages":"Article 110371"},"PeriodicalIF":4.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CXCL5 inhibition improves kidney function by protecting renal tubular epithelial cells in diabetic kidney disease 抑制 CXCL5 可保护糖尿病肾病患者的肾小管上皮细胞，从而改善肾功能。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-09-24 DOI: 10.1016/j.clim.2024.110369

Ching Chen , Liang-Yu Lin , Yen-Wen Wu , Jaw-Wen Chen , Ting-Ting Chang

{"title":"CXCL5 inhibition improves kidney function by protecting renal tubular epithelial cells in diabetic kidney disease","authors":"Ching Chen , Liang-Yu Lin , Yen-Wen Wu , Jaw-Wen Chen , Ting-Ting Chang","doi":"10.1016/j.clim.2024.110369","DOIUrl":"10.1016/j.clim.2024.110369","url":null,"abstract":"<div><div>Inflammation is one of exacerbating factors of diabetic kidney disease (DKD). Upregulated CXCL5 is found in clinical and experimental diabetes studies. This study aimed to investigate the impact and mechanism of CXCL5 on DKD. DKD patients with different levels of urine albumin-to-creatinine ratio were enrolled. Lepr<sup>db/db</sup> mice and CXCL5-knockout diabetic mice were used as mouse models for DKD. Human renal tubular epithelial cells were used for in vitro experiments. Circulating CXCL5 were increased in DKD patients compared to the non-DKD subjects. CXCL5 inhibition through CXCL5-neutralizing antibodies or genetic knockout improved kidney function and ameliorated tubular injury and renal fibrosis. In high-glucose-stimulated tubular epithelial cells, administration of CXCL5-neutralizing antibodies or siRNA resulted in reduced phospho-JNK/c-JUN/p65 and the downstream inflammatory, fibrotic, and apoptotic protein expressions. Administration of CXCR2 and JNK inhibitors impeded the CXCL5-induced tubular epithelial cell damages. In conclusion, these findings indicated that anti-CXCL5 strategies may be potential treatments for DKD.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"268 ","pages":"Article 110369"},"PeriodicalIF":4.5,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into the multifaceted role of interleukin-37 on human immune cell regulation 洞察白细胞介素-37 对人类免疫细胞调节的多方面作用。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-09-20 DOI: 10.1016/j.clim.2024.110368

Lisa U. Teufel , Vasiliki Matzaraki , Lukas Folkman , Rob ter Horst , Simone J.C.F.M. Moorlag , Catharina M. Mulders-Manders , Mihai G. Netea , Thomas Krausgruber , Leo A.B. Joosten , Rob J.W. Arts

{"title":"Insights into the multifaceted role of interleukin-37 on human immune cell regulation","authors":"Lisa U. Teufel , Vasiliki Matzaraki , Lukas Folkman , Rob ter Horst , Simone J.C.F.M. Moorlag , Catharina M. Mulders-Manders , Mihai G. Netea , Thomas Krausgruber , Leo A.B. Joosten , Rob J.W. Arts","doi":"10.1016/j.clim.2024.110368","DOIUrl":"10.1016/j.clim.2024.110368","url":null,"abstract":"<div><div>Autoinflammatory diseases, while having a variety of underlying causes, are mediated by dysfunctional innate immune responses. Therefore, standard treatments target innate cytokines or block their receptors. Despite excellent responses in some patients, first-line treatments fail in others, for reasons which remain to be understood.</div><div>We studied the effects of IL-37, an anti-inflammatory cytokine, on immune cells using multi-omics profiling of 325 healthy adults. Our findings show that IL-37 is associated with inflammation control and generally reduced immune cell activity. Further, genetic variants in <em>IL37</em> are associated with impaired trained immunity, a memory phenotype of innate immune cells contributing to autoinflammation. To underpin the medical potential of IL-37, an explorative cohort of seven autoinflammatory disorders was built. <em>In vitro</em> stimulation experiments argue for recombinant IL-37 as a potential therapy in IL-6-, and IL-22-driven conditions.</div><div>Concluding, IL-37 is highlighted as a cytokine with broad anti-inflammatory functions, implicating its potential as therapeutic intervention.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"268 ","pages":"Article 110368"},"PeriodicalIF":4.5,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1521661624004777/pdfft?md5=4e2014b2c0acbcfe8b52c99b9a034331&pid=1-s2.0-S1521661624004777-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptomic studies unravel the molecular and cellular complexity of systemic lupus erythematosus: A review 转录组研究揭示了系统性红斑狼疮分子和细胞的复杂性：综述

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-09-16 DOI: 10.1016/j.clim.2024.110367

Frank Qingyun Wang, Xiao Dang, Wanling Yang

{"title":"Transcriptomic studies unravel the molecular and cellular complexity of systemic lupus erythematosus: A review","authors":"Frank Qingyun Wang, Xiao Dang, Wanling Yang","doi":"10.1016/j.clim.2024.110367","DOIUrl":"10.1016/j.clim.2024.110367","url":null,"abstract":"<div><p>Transcriptomic analysis plays a vital role in investigating Systemic Lupus Erythematosus (SLE), a complex autoimmune disease characterized by diverse clinical manifestations. This approach has yielded valuable insights into gene expression patterns and molecular regulatory mechanisms involved in SLE pathogenesis. Notably, interferon-stimulated gene (ISG) signatures are significantly upregulated in immune cells, skin, and kidney. Although a correlation with serological parameters and clinical symptoms has been proposed, the association with global disease activities remains controversial. Key findings in the field include an upregulated plasmablast signature, which positively correlates with disease activity; a neutrophil signature associated with lupus nephritis; and a decreased lymphocyte signature, reflecting lymphopenia. Tissue-level studies highlight the critical role of infiltrating immune cells in organ damage. Future research should leverage advanced technologies and integrate multi-omics data to deepen our understanding of SLE's molecular underpinnings, facilitating the development of targeted therapies.</p></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"268 ","pages":"Article 110367"},"PeriodicalIF":4.5,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High symptom burden in female X-linked chronic granulomatous disease carriers 女性X连锁慢性肉芽肿病携带者的高症状负担

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-09-13 DOI: 10.1016/j.clim.2024.110364

Mary Ann Miranda , Athanasios Tsalatsanis , Jessica R. Trotter , Danielle E. Arnold , Jacqueline D. Squire , Sharon Kidd , Suhag Parikh , Rebecca A. Marsh , Linda M. Griffith , Kanwaldeep Mallhi , Deepak Chellapandian , Stephanie Si Lim , Eyal Grunebaum , Kathleen E. Sullivan , Peter E. Newburger , Mary C. Dinauer , Morton J. Cowan , Christopher C. Dvorak , Elie Haddad , Donald B. Kohn , Jennifer W. Leiding

引用次数: 0

Enhanced fatty acid oxidation by selective activation of PPARα alleviates autoimmunity through metabolic transformation in T-cells 选择性激活 PPARα 可增强脂肪酸氧化，通过 T 细胞的新陈代谢转变缓解自身免疫。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-09-05 DOI: 10.1016/j.clim.2024.110357

Satoshi Masuyama , Masayuki Mizui , Masashi Morita , Takatomo Shigeki , Hisakazu Kato , Takeshi Yamamoto , Yusuke Sakaguchi , Kazunori Inoue , Tomoko Namba-Hamano , Isao Matsui , Tatsusada Okuno , Ryohei Yamamoto , Seiji Takashima , Yoshitaka Isaka

{"title":"Enhanced fatty acid oxidation by selective activation of PPARα alleviates autoimmunity through metabolic transformation in T-cells","authors":"Satoshi Masuyama , Masayuki Mizui , Masashi Morita , Takatomo Shigeki , Hisakazu Kato , Takeshi Yamamoto , Yusuke Sakaguchi , Kazunori Inoue , Tomoko Namba-Hamano , Isao Matsui , Tatsusada Okuno , Ryohei Yamamoto , Seiji Takashima , Yoshitaka Isaka","doi":"10.1016/j.clim.2024.110357","DOIUrl":"10.1016/j.clim.2024.110357","url":null,"abstract":"<div><p>While fatty acid oxidation (FAO) in mitochondria is a primary energy source for quiescent lymphocytes, the impact of promoting FAO in activated lymphocytes undergoing metabolic reprogramming remains unclear. Here, we demonstrate that pemafibrate, a selective PPARα modulator used clinically for the treatment of hypertriglyceridemia, transforms metabolic system of T-cells and alleviates several autoimmune diseases. Pemafibrate suppresses Th17 cells but not Th1 cells, through the inhibition of glutaminolysis and glycolysis initiated by enhanced FAO. In contrast, a conventional PPARα agonist fenofibrate significantly inhibits cell growth by restraining overall metabolisms even at a dose insufficient to induce fatty acid oxidation. Clinically, patients receiving pemafibrate showed a significant decrease of Th17/Treg ratio in peripheral blood. Our results suggest that augmented FAO by pemafibrate-mediated selective activation of PPARα restrains metabolic programs of Th17 cells and could be a viable option for the treatment of autoimmune diseases.</p></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"268 ","pages":"Article 110357"},"PeriodicalIF":4.5,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1521661624004662/pdfft?md5=1fcc8e3f4383cdc7e6d13a8c3736f1f0&pid=1-s2.0-S1521661624004662-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency 利用多态性确定选择性 IgA 缺乏症的共变体关联。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-09-04 DOI: 10.1016/j.clim.2024.110356

Thomas W. Willis , Effrossyni Gkrania-Klotsas , Nicholas J. Wareham , Eoin F. McKinney , Paul A. Lyons , Kenneth G.C. Smith , Chris Wallace

引用次数: 0