Inflammation among kidney transplant donors with and without HIV: Multicenter HOPE in Action Consortium

IF 3.8 3区医学 Q2 IMMUNOLOGY

Clinical immunology Pub Date : 2025-07-11 DOI:10.1016/j.clim.2025.110563

Fatima Zaman , Xianming Zhu , Joanne H. Hunt , Gracie Rozek , Yolanda Eby , Sarah Hussain , Niraj M. Desai , Sander Florman , Meenakshi M. Rana , Rachel Friedman-Moraco , Marcus R. Pereira , Shikha Mehta , Peter Stock , Alexander Gilbert , Jonathan Hand , Michele I. Morris , Valentina Stosor , Sapna A. Mehta , Catherine B. Small , Joanna Schaenman , Aaron A.R. Tobian

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Abstract

Kidney transplantation from donors with HIV has recently become standard clinical practice, but the plasma inflammatory profile is not well characterized. Thirty-two cytokines and chemokines were evaluated among donors with HIV (n = 63) and without HIV (n = 41). Wilcoxon rank sum test was used to compare cytokines between groups. Donors with and without HIV were generally similar in terms of characteristics, except those with HIV had a non-significantly lower kidney donor profile index, reflecting better graft survival, creatinine, and body mass index. Most cytokine and chemokine levels were similar between groups. However, median IL-8 levels were higher (p < 0.0015) in donors without HIV (32.6 pg/mL, IQR = 13.8–394.9) compared to donors with HIV (15.1 pg/mL, IQR = 8.4–35.5). There were no significant correlations between cytokine and chemokine concentrations and CD4 counts or HIV viral load. In summary, inflammatory profiles were similar or lower among donors with HIV compared to donors without HIV supporting the safety of this emerging kidney transplantation practice.

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有和没有HIV的肾移植供者的炎症：多中心希望在行动联盟。

最近，来自携带HIV病毒供体的肾移植已成为标准的临床实践，但血浆炎症特征尚未得到很好的表征。对感染HIV （n = 63）和未感染HIV （n = 41）的供体进行32种细胞因子和趋化因子的评估。各组间细胞因子比较采用Wilcoxon秩和检验。携带HIV病毒和未携带HIV病毒的供者在特征上大体相似，除了携带HIV病毒的供者的肾供者概况指数不明显较低，反映出更好的移植物存活率、肌酐和体重指数。各组间大多数细胞因子和趋化因子水平相似。然而，中位IL-8水平较高(p

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来源期刊

Clinical immunology 医学-免疫学

CiteScore

12.30

自引率

1.20%

发文量

212

审稿时长

34 days

期刊介绍： Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.