Immune profiling in solid organ transplant recipients with HHV-8 infection: Identification of immunological biomarkers for KICS and Kaposi's sarcoma

IF 3.8 3区医学 Q2 IMMUNOLOGY

Clinical immunology Pub Date : 2025-07-10 DOI:10.1016/j.clim.2025.110562

Rosalia Busà , Francesca Timoneri , Monica Miele , Mariangela Di Bella , Andrea Cona , Salvatore Castelbuono , Mattia Emanuela Ligotti , Alessia Gallo , Francesca Pecoraro , Giuseppe Randazzo , Caterina Amato , Clara Pipia , Giandomenico Amico , Valentina Agnese , Pier Giulio Conaldi , Mario Luppi , Alessandra Mularoni , Matteo Bulati

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引用次数: 0

Abstract

Human Herpesvirus 8 (HHV-8) poses a significant risk in solid organ transplant recipients (SOTRs). HHV-8 is implicated in both neoplastic and non-neoplastic conditions. This study investigates immune dysregulation in HHV-8-infected SOTRs by analysing cytokine profiles and virus-specific T cell responses across different clinical manifestations. Our findings reveal a progressive decline in HHV-8-specific T cell responses correlating with disease severity, alongside a distinct cytokine signature. KICS patients exhibit heightened inflammation with elevated IL-6, IL-10, IFNα, TNFα, IL-1β, IL-17 A, IDO, sCD14, and immune exhaustion markers (PD-1, LAG-3), whereas KS is associated with angiogenic and macrophage activation factors (HGF, CD163). Given these insights, monitoring HHV-8 DNAemia, inflammatory cytokines, and T cell functionality is crucial for early detection and risk stratification. This study underscores the importance of immune monitoring in transplant recipients, paving the way for targeted interventions to mitigate HHV-8-associated complications.

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HHV-8感染实体器官移植受者的免疫谱分析：KICS和卡波西肉瘤的免疫生物标志物鉴定

人类疱疹病毒8 （HHV-8）在实体器官移植受者（SOTRs）中具有显著的风险。HHV-8与肿瘤性和非肿瘤性疾病都有关系。本研究通过分析不同临床表现的细胞因子谱和病毒特异性T细胞反应来研究hhv -8感染SOTRs的免疫失调。我们的研究结果揭示了与疾病严重程度相关的hhv -8特异性T细胞反应的逐渐下降，以及独特的细胞因子特征。KICS患者表现出炎症加剧，IL-6、IL-10、IFNα、TNFα、IL-1β、IL-17 A、IDO、sCD14和免疫衰竭标志物（PD-1、LAG-3）升高，而KS与血管生成和巨噬细胞激活因子（HGF、CD163）相关。鉴于这些见解，监测HHV-8 dna血症、炎症细胞因子和T细胞功能对于早期发现和风险分层至关重要。这项研究强调了移植受者免疫监测的重要性，为靶向干预减轻hhv -8相关并发症铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical immunology 医学-免疫学

CiteScore

12.30

自引率

1.20%

发文量

212

审稿时长

34 days

期刊介绍： Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.