自身免疫性风湿性炎症患者细小病毒B19感染的临床特征、危险因素及预测因素：一项巢式病例对照研究

IF 3.8 3区医学 Q2 IMMUNOLOGY

Clinical immunology Pub Date : 2025-06-06 DOI:10.1016/j.clim.2025.110537

Xinyue Zhang , Peixuan Liang , Ziwei Hu , Ziyun Zhang , Shaozhe Cai , Lingli Dong

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引用次数: 0

摘要

本巢式病例对照研究探讨自身免疫性风湿性炎症（AIIRD）患者细小病毒B19 （B19V）感染的临床特征及危险因素。共分析86例b19v阳性病例和172例匹配对照。慢性肝病、心血管疾病、总感染人数较高以及使用霉酚酸酯（MMF）与B19V感染风险增加相关，而Iguratimod （IGU）被确定为一种保护因素。贫血、肺炎、发热、肌痛和肝炎在感染b19v的患者中更为常见，他们也更容易出现不同程度的细胞减少，尤其是全细胞减少。本病例观察到可能由B19V感染引起的继发性噬血细胞综合征。实验室结果显示血细胞计数和电解质较低，抗组蛋白抗体阳性较高。在logistic和Lasso回归模型中，血清钙、补体C4和IgM被确定为关键预测因子。中国临床试验注册；https://www.chictr.org.cn/;ChiCTR2400089902。

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Clinical characteristics, risk factors and predictors of Parvovirus B19 infection in patients with autoimmune rheumatic inflammatory diseases: A nested case–control study

This nested case-control study explored the clinical features and risk factors of Parvovirus B19 (B19V) infection in autoimmune rheumatic inflammatory disease (AIIRD) patients. A total of 86 B19V-positive cases and 172 matched controls were analyzed. Chronic liver diseases, cardiovascular diseases, a higher number of total infections, and the use of Mycophenolate Mofetil (MMF) were associated with an increased risk of B19V infection, whereas Iguratimod (IGU) was identified as a protective factor. Anemia, pneumonia, fever, myalgia, and hepatitis were significantly more common in B19V-infected patients, who were also more likely to experience varying degrees of cytopenia, particularly pancytopenia. Secondary hemophagocytic syndrome potentially attributable to B19V infection was observed in the case. Laboratory results showed lower blood cell counts and electrolytes, and higher anti-histone antibody positivity. Serum calcium, complement C4, and IgM were identified as key predictors in logistic and Lasso regression models.

Trial registration

Chinese Clinical Trial Register; https://www.chictr.org.cn/; ChiCTR2400089902.

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来源期刊

Clinical immunology 医学-免疫学

CiteScore

12.30

自引率

1.20%

发文量

212

审稿时长

34 days

期刊介绍： Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.