Clinical laboratory最新文献

{"title":"A Case of Relapsed and Refractory Pediatric Anaplastic Large Cell Lymphoma with Complex Karyotype.","authors":"Danqin Zheng, Songjie Zhu, Huajuan Ruan, Wenyun Zhang, Danqin Zheng","doi":"10.7754/Clin.Lab.2024.240841","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240841","url":null,"abstract":"<p><strong>Background: </strong>Anaplastic large cell lymphoma (ALCL) is a rare type of peripheral T-cell lymphoma, accounting for a small percentage of adult and childhood lymphomas. The scarcity of reports on relapsed or refractory ALCL in children, especially with complex karyotypes, highlights the need for detailed case studies.</p><p><strong>Methods: </strong>We report the case of a 9-year-old girl diagnosed with ALK-positive anaplastic large cell lymphoma, complicated by complex karyotype abnormalities and bone marrow involvement. The patient underwent multiple chemotherapy regimens, including the P regimen, AV1, BV1, AV2, BV2, and AV3 protocols, followed by continuous monitoring through bone marrow biopsies and PET/CT imaging. Despite initial treatment efforts, the disease relapsed, and the patient's condition deteriorated.</p><p><strong>Results: </strong>Initial treatment with chemotherapy led to a transient reduction in disease activity, as evidenced by bone marrow biopsies showing no malignancy. However, PET/CT scans revealed persistent metabolic activity in multiple skeletal sites, indicating incomplete remission. The patient's condition further relapsed with significant disease progression, culminating in sepsis, heart failure, and active bleeding, which were unresponsive to treatment.</p><p><strong>Conclusions: </strong>This case underscores the aggressive nature of pediatric ALCL with complex karyotypes and highlights the challenges associated with its treatment. Despite intensive chemotherapy, the disease exhibited rapid relapse and resistance, ultimately leading to a fatal outcome. This report contributes to the limited literature on pediatric ALCL, particularly in cases with complex cytogenetic profiles, and emphasizes the need for novel thera-peutic approaches and early intervention strategies.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 2","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Application of RNA Simultaneous Amplification and Testing for Pathogens Associated with Urogenital Infections.","authors":"Xiaofen Zhong, Hangzhen Zhou, Yuejiao Dong, Xuefen Li","doi":"10.7754/Clin.Lab.2024.240629","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240629","url":null,"abstract":"<p><strong>Background: </strong>RNA simultaneous amplification and testing (RNA-SAT) is a sensitive, specific, and rapid test method for the detection of pathogens in clinical samples. Herein, we used RNA-SAT to understand the detection status and distribution of common pathogens causing infections in patients with clinical urethritis to provide early clinical diagnosis and treatment.</p><p><strong>Methods: </strong>Urine or swab samples were collected from 1,594 patients with suspected urinary tract infections between April 2022 and August 2023. RNA-based detection of common urogenital pathogens, Chlamydia trachomatis, Ureaplasma urealyticum, Neisseria gonorrhoeae, and Mycoplasma genitalium, was performed. Infection rates in different genders and ages were analyzed. Results of pathogen cultures were recorded during the same period.</p><p><strong>Results: </strong>Majority of the patients included in the study were outpatients (99.25%, 1,582/1,594). Out of the 1,594 pa-tients, 828 (51.94%) had a urogenital pathogen infection. U. urealyticum had the highest detection rate (37.50%, 555/1,480), followed by C. trachomatis (17.13%, 223/1,302), N. gonorrhoeae (10.45%, 127/1,215), and M. genitalium (9.98%, 127/1,273). Coinfections of U. urealyticum, C. trachomatis, and/or N. gonorrhoeae were observed in 13.56% (174/1,283) of tested samples. Total RNA detection rate did not significantly differ between sexes; however, the detection rate of U. urealyticum and N. gonorrhoeae in females was significantly higher and lower than in males, respectively. Further, detection rate showed a decreasing trend with age. Finally, the RNA-SAT approach showed a higher detection rate for U. urealyticum, N. gonorrhoeae, and M. genitalium than the conventional culture approach did.</p><p><strong>Conclusions: </strong>U. urealyticum and C. trachomatis are the main pathogens responsible for urogenital tract inflammation. RNA-SAT can identify major pathogen infections at the early stages of the disease, effectively compensate for the deficiency of culture-based detection, and aid in early clinical diagnosis, and hence intervention.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 2","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyrimidine-5'-Nucleotidase Deficiency: a New Homozygous NT5C3A Mutation (c.693+1G>A variant).","authors":"Damla C Patir, Ajda Gunes, Burak Durmaz, Emin Karaca, Nur Soyer","doi":"10.7754/Clin.Lab.2024.240807","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240807","url":null,"abstract":"<p><strong>Background: </strong>Erythrocytes have an average lifespan of 120 days, after which they are typically removed by macrophages in the reticuloendothelial system. Hemolytic anemia can shorten erythrocyte lifespan, leading to varying clinical presentations depending on whether hemolysis occurs intravascularly or extravascularly. Among intrinsic causes of hemolysis, pyrimidine 5'-nucleotidase (P5N) deficiency is a notable condition, often presenting as nonspherocytic hemolytic anemia.</p><p><strong>Methods: </strong>We report a case of a 65-year-old female patient with systemic lupus erythematosus and a history of splenectomy, who was admitted for evaluation of persistent hemolytic crises. Clinical examination, peripheral blood smear analysis, and genetic testing were performed, including next-generation sequencing to identify mutations in the NT5C3A gene associated with P5N deficiency.</p><p><strong>Results: </strong>The patient exhibited macrocytic anemia and basophilic stippling on peripheral blood smear, with normal results from osmotic fragility tests and G6PD levels. Genetic testing revealed a homozygous c.693+1G>A variant in the NT5C3A gene, classified as possibly pathogenic based on ACMG criteria. This variant is linked to P5N deficiency, which aligns with the patient's clinical presentation of non-immune hemolytic anemia.</p><p><strong>Conclusions: </strong>The identification of the NT5C3A gene mutation through next-generation sequencing highlights the significance of molecular technologies in diagnosing rare forms of hemolytic anemia. This case underscores the necessity for genetic counseling for affected individuals and their families, as well as the importance of continued follow-up and supportive care in managing hemolytic anemia related to enzyme deficiencies.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 2","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correlation of Preoperative Serum Thyroglobulin between Benign and Papillary Thyroid Carcinoma.","authors":"Xiaohong Zhang, Yuheng Wang, Xin Song, Xiangyi Liu","doi":"10.7754/Clin.Lab.2024.240631","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240631","url":null,"abstract":"<p><strong>Background: </strong>Papillary thyroid carcinoma (PTC) is the most common thyroid cancer, accounting for about 85 - 90%. Thyroglobulin (Tg) can be produced by normal thyroid follicular epithelial cells and well-differentiated malignant thyroid tumor cells. In our study, we investigated the correlation of preoperative serum Tg between benign thyroid tumors and PTC patients.</p><p><strong>Methods: </strong>The data of 1,074 patients were retrospectively collected, including benign thyroid tumor group (517 cases) and PTC group (557 cases). Preoperative serum Tg and other thyroid function indicators were detected by chemiluminescence immunoassay (CLIA). Serum levels were compared between patients with benign thyroid tumors and PTC using SPSS 22.0.</p><p><strong>Results: </strong>In patients with PTC, the levels of serum Tg were significantly lower than those in patients with benign thyroid tumors (p = 0.000). In both groups, no significant difference of serum Tg was observed between the genders, but there were significant differences of serum Tg among the different ages and tumor sizes. The results of Spearman correlation analysis showed that serum Tg positively correlated with tumor sizes and negatively cor-related with serum thyroglobulin antibody (TgAb) in the two groups. Through the binary regression analysis, the independent predictors of PTC included the sex, tumor sizes, and serum TgAb of patients (p = 0.000, 0.000, and 0.020, respectively). For the PTC patients, serum Tg was markedly higher in the cervical lymph node metastasis (10.84 ng/mL), compared with no metastasis (8.41 ng/mL), with p = 0.017.</p><p><strong>Conclusions: </strong>Serum Tg in the PTC group was significantly lower than in the benign thyroid tumor group; however, serum Tg was not useful as an independent predictor of PTC patients. For the PTC patients, high preoperative serum Tg predicts the cervical lymph node metastasis.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 2","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary Heparin Binding Protein: an Effective Marker in Assessing the Severity of UTI Compared to Microscopic Urinalysis.","authors":"Zaid M Younus, Sameer M Mahmood, Muthear N Dawood, Jehan A Mohammad","doi":"10.7754/Clin.Lab.2024.240912","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240912","url":null,"abstract":"<p><strong>Background: </strong>Proper and fast diagnosis of urinary tract infections (UTIs) is essential for suitable treatment strategy. Urine culture is the mainstay of diagnostic approaches, but it could be time consuming. Relying on clinical features alone may be misleading and may affect the precision of antibiotic regime. That is why utilizing specific biomarkers such as urinary heparin binding protein (UHBP) may support a more accurate diagnosis and thus a suit-able antibiotic choice. In the current work, we aimed to assess the validity of UHBP in distinguishing UTI and whether it is suitable for determining the different severity levels of UTI.</p><p><strong>Methods: </strong>Eighty-seven individuals (71 patients, 16 controls) with different ages were recruited in the current study. Participants were attending the urology outpatient clinic in Al Rabie hospital with suspected UTI based on clinical features, microscopic, and culture analysis. Urine samples were collected and inspected for UHBP by enzyme-linked immunosorbent assay (ELISA) kit. Microscopic analysis involved red blood cells (RBC), epithelial cells (EC), pus cells (PC), white blood cells (WBC), or leukocytes counts.</p><p><strong>Results: </strong>UHBP showed a significantly high level in UTI patients compared to controls, which parallels the microscopic findings. Categorization of individuals' UHBP results according to the different values of microscopic analysis revealed strong association with the level of UHBP. Based on clinical features, UHBP levels varied significant-ly with UTI severity, showing significantly elevated UHBP levels (432.4 ± 82.8 pg/mL) in the severe group com-pared to both the moderate (252.8 ± 79.9 pg/mL, p < 0.001) and mild (55.2 ± 39.3 pg/mL, p < 0.001) groups. Additionally, the moderate group exhibited significantly higher UHBP levels compared to the mild group (p < 0.001). Receiver-operating characteristics (ROC) analysis indicated the power of UHBP in distinguishing the levels of severity of UTI with an area under the curve (AUC) of 0.98 (p < 0.001).</p><p><strong>Conclusions: </strong>UHBP is a valid biomarker in distinguishing UTI individuals. It also emerged as an effective marker in detecting the severity of UTI, which could help in distinguishing upper and lower UTIs and supports a more accurate diagnostic scheme.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 2","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Formation of Eosinophilic Pleural Effusion.","authors":"Hongbo Zhang, Xu Yuan, Hui Zhang, Ming Huang, Xiaohui Wu, Guo Li","doi":"10.7754/Clin.Lab.2024.240918","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240918","url":null,"abstract":"<p><strong>Background: </strong>Eosinophilic pleural effusion constitutes a captivating and salient subject for exploration. In order to find out the reasons behind the formation of eosinophilic pleural effusion, we chose this study, hoping to gradually unravel its mysterious veil.</p><p><strong>Methods: </strong>The absolute value and percentage of eosinophils in healthy people (normal control group), the peripheral blood of patients, and the pleural effusion of patients were compared to analyze their characteristics.</p><p><strong>Results: </strong>In patients with eosinophilic pleural effusion, the absolute level of eosinophils was significantly greater than that in healthy people (normal control group) (p < 0.0001) and the percentage of eosinophils was significantly greater than that in healthy people (p < 0.0001) as well, even within the biological reference interval.</p><p><strong>Conclusions: </strong>Peripheral blood eosinophil counts were higher in patients with eosinophilic pleural effusion than in normal controls, even within the biological reference interval. Moreover, the overall absolute level of eosinophilic cells in the pleural effusion fluid was consistent with that in the peripheral blood. Combining these characteristics, the mechanism of eosinophilic pleural effusion formation was deduced.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 2","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The First Case of Arthrobacter woluwensis Bacteremia Diagnosed using MALDI-TOF MS.","authors":"Takho Kang, Seung Gyu Yun, Myung-Hyun Nam, Yunjung Cho, Keun Ju Kim","doi":"10.7754/Clin.Lab.2024.240920","DOIUrl":"10.7754/Clin.Lab.2024.240920","url":null,"abstract":"<p><strong>Background: </strong>Thus far, seven cases of Arthrobacter woluwensis (A. woluwensis) infections have been reported globally. Its rarity and overlapping characteristics with other bacterial species make identification challenging, necessitating 16S ribosomal RNA sequencing and whole-genome sequencing.</p><p><strong>Methods: </strong>For the first time, A. woluwensis bacteremia was diagnosed using matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS).</p><p><strong>Results: </strong>The isolated A. woluwensis was susceptible to vancomycin. A. woluwensis bacteremia was resolved with the administration of intravenous vancomycin and the removal of the chemoport.</p><p><strong>Conclusions: </strong>MALDI-TOF MS can be useful in diagnosing A. woluwensis infections.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 2","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of TTC39A in Modulating the Immune Microenvironment and Its Impact on Cancer Prognosis.","authors":"Jie Li, Chao Wang, Jianguo Wang","doi":"10.7754/Clin.Lab.2024.240923","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240923","url":null,"abstract":"<p><strong>Background: </strong>TTC39A (tetratricopeptide repeat domain protein 39A) belongs to the structural family of tetratrico-peptide domain proteins. TTC39A had not been researched in cancers. The purpose of this study was to reveal the potential role of TTC39A in cancers.</p><p><strong>Methods: </strong>In total, 33 cancers were included in this study. All the data came from the Cancer Genome Atlas (TCGA) database. The expression of TTC39A was explored in the 33 cancers. The relationship between the expression of TTC39A and prognosis, clinical characteristics, and immune infiltration was also explored. Paraffin-embedded cancer tissue microarrays (TMA) were used to detect the expression of TTC39A in LIHC (liver hepatocellular carcinoma) and LGG (brain lower grade glioma).</p><p><strong>Results: </strong>The expression of TTC39A was higher in many cancers, compared with the corresponding normal tissues. For patients with LGG, LIHC, and SKCM (skin cutaneous melanoma), higher expression of TTC39A indicated worse OS. Survival analysis in clinical samples indicated that high expression of TTC39A was associated with shorter overall survival. The expression of TTC39A was related to the immune infiltration of some immune cells in LGG, LIHC, and SKCM. Also, the expression of TTC39A combined with the immune infiltration level of some immune cells could affect the OS of patients with these three cancers. Functional enrichment analysis and gene set enrichment analysis (GSEA) showed that TTC39A might play a role in many biological processes.</p><p><strong>Conclusions: </strong>The expression of TTC39A was significantly higher in many cancers. TTC39A was associated with the prognosis of patients with LGG, LIHC, and SKCM, whether they were combined with the immune infiltration level of some immune cells or not. In these three cancers, TTC39A might play a role in some important biological processes.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 2","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel RHD Allele Similar to RHD*DIV.4 with Additional c.1025T>C.","authors":"Hong Zhao, Jing Feng, Jian Chen, Guojin Ou","doi":"10.7754/Clin.Lab.2024.240828","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240828","url":null,"abstract":"<p><strong>Background: </strong>Polymorphic RH is one of the most important blood group systems used for transfusion. Use of molecular technologies combined with serological testing help to identify the new RHD variants.</p><p><strong>Methods: </strong>The traditional serological test of blood type was performed for a 28-year-old pregnant female. The result showed a weaker positive reaction result on two different microcolumn gel cards. A molecular genotyping assay was performed to get more information.</p><p><strong>Results: </strong>The gene sequence study indicated 7 nucleotide changes in exon 7, compared with the reference allele. The third-generation sequencing using the long-read PacBio HiFi system showed these variants were all located in the same haplotype. The variant is replaced by the counterpart from RHCE gene in exon 7 with at least 37 bp. Most of its position was located in the sixth extracellular loop.</p><p><strong>Conclusions: </strong>A novel RHD allele was identified with 7 missense mutations that is similar to RHD*DIV.4 and likely causes a partial D phenotype.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 2","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Observation and Analysis of Transient Postoperative CA-125 Elevation in a Patient with Sigmoid Colon Adenocarcinoma.","authors":"Hao Huang, Junqi Huang, Wencheng Huang, Siqi Yang, Yifeng Tao","doi":"10.7754/Clin.Lab.2024.240750","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240750","url":null,"abstract":"<p><strong>Background: </strong>Carbohydrate antigen 125 (CA-125) is commonly utilized as a tumor marker for ovarian cancer. However, CA-125 is also observed to be elevated in other malignancies such as lung cancer, liver cancer, pancreatic cancer, and thyroid cancer. The factors leading to elevated CA-125 levels and their implications are not entirely clear. Accumulation of case reports associated with elevated CA-125 will be instrumental in advancing research in this area.</p><p><strong>Methods and results: </strong>Here, we report a case involving a 45-year-old female patient diagnosed with Sigmoid Colon Adenocarcinoma. Laparoscopic pro-surgery CA-125 levels were 13.3 U/mL (reference range: < 35 U/mL), 12 days post-surgery CA-125 levels spiked to 132.3 U/mL, one month later CA-125 levels decreased to 73.5 U/mL, and three months later they returned to normal levels. Over a five-year follow-up period, there was no evidence of tumor recurrence or metastasis.</p><p><strong>Conclusions: </strong>Laparoscopic surgery induced a secondary elevation in CA-125 levels. The preoperative CA-125 level is more valuable for reference.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 2","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}