Ha-Eun Cho, Kyung Sun Park, Young Jin Kim, Tae Sung Park, Sun Young Cho
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引用次数: 0
Abstract
Background: This study investigated the clinical significance of rods and rings (RR) immunofluorescence patterns in antinuclear antibody (ANA) testing by analyzing their clinical associations.
Methods: A single-center retrospective analysis was conducted between January 2022 and December 2023, examining cases with RR patterns in ANA testing.
Results: Among 40 cases (0.5%) showing RR patterns, 35% coincided with autoimmune diseases, 25% with infections, and 22.5% with other inflammatory conditions. In specimens with high-intensity fluorescence, 45% were as-sociated with infections, and 18% with autoimmune diseases. Elevated inflammatory markers were observed in 54.5% of cases with inflammatory manifestations.
Conclusions: The findings suggest that RR patterns in ANA testing may serve as potential indicators of underlying inflammatory processes.
背景：本研究通过分析抗核抗体（ANA）检测中棒环（rods and rings， RR）免疫荧光图谱的临床相关性，探讨其临床意义。方法：在2022年1月至2023年12月期间进行单中心回顾性分析，检查ANA检测中出现RR模式的病例。结果：在40例（0.5%）出现RR模式的病例中，35%与自身免疫性疾病合并，25%与感染合并，22.5%与其他炎症性疾病合并。在具有高强度荧光的标本中，45%与感染有关，18%与自身免疫性疾病有关。54.5%有炎症表现的患者炎症标志物升高。结论：研究结果表明，ANA检测中的RR模式可能作为潜在炎症过程的潜在指标。
期刊介绍：
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
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