Clinical laboratory最新文献

{"title":"Implementation of an Advanced Automation System in the Laboratory Medicine Department.","authors":"Tze-Kiong Er","doi":"10.7754/Clin.Lab.2024.241140","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241140","url":null,"abstract":"<p><strong>Background: </strong>The implementation of advanced automation systems in the Laboratory Medicine Department at Asia University Hospital represents a significant shift from labor-intensive manual sample handling to a fully automated workflow. This study outlines the adoption of automation in both general and urine analysis systems and examines its impact on diagnostic throughput and patient care.</p><p><strong>Methods: </strong>We implemented two automation systems: a sample classification workstation with six high-speed robotic arms for pre-analytical tasks, connected directly to the blood drawing counter, and a direct track system for urine analysis. These systems minimized manual handling and improved workflow efficiency. Effectiveness was evaluated by comparing pre- and post-implementation data on procedural steps and processing time.</p><p><strong>Results: </strong>Automation reduced procedural steps in pre-analytical activities from eleven to eight and in urine analysis from twelve to eight. Processing time for pre-analytical activities decreased by 33% (from 2,370 to 1,590 seconds), while urine analysis time dropped by 36% (from 990 to 630 seconds), significantly enhancing laboratory efficiency and reducing turnaround time.</p><p><strong>Conclusions: </strong>Automation significantly improved workflow efficiency and quality of care by minimizing errors and allowing lab technologists to focus on complex tasks. It also enhanced patient privacy during urine sample collection, underscoring the value of integrating advanced technologies into laboratory operations to meet the needs of modern healthcare.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphocyte Subsets in Covid-19 Saudi Patients: Infection Caused Significant Reduction in Peripheral Blood Lymphocyte Subset.","authors":"Abdellatif Bouazzaoui, Khalid M Keedwa, Sami M Sahl, Mohammed S Al-Hashmi, Kamal H Alzabeedi, Mohammad H Albshri, Mamdouh A Bukhari, Fadel H Qabani, Iman A Mula, Omaima I Badr, Ahmed A H Abdellatif, Neda M Bogari","doi":"10.7754/Clin.Lab.2024.241045","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241045","url":null,"abstract":"<p><strong>Background: </strong>In this research study, we aimed to analyze the changes in the lymphocyte subsets in Saudi patients with Covid-19 and assess the possible association of differences in lymphocyte subsets with the infection in local population of Makkah city, Saudi Arabia.</p><p><strong>Methods: </strong>Peripheral blood samples were collected from healthy and from Covid-19 patients admitted to Al Nour Hospital from October through December 2022. Flow cytometry (FCM) was used to measure the absolute and relative counts of lymphocyte subsets.</p><p><strong>Results: </strong>The analysis showed that most patients with Covid-19 disease showed moderate illness. The observed symptoms were cough, fever, and feeling tired. In Covid-19 patients, a significant reduction in CD3+ T-cell, CD4+ T cell, CD8+ T cell, B cell, NK cell, and total lymphocyte cell counts have been seen when compared to the healthy control person. Also, the percentage of CD3+T-cells and CD4+ T-cells was significantly decreased in Covid-19 pa-tients compared to the control. In contrast, the percentage of CD4+CD8+ T-cells, CD16+CD56+ NK cells, and CD19+ B-cells was higher in Covid-19 patients versus the healthy control.</p><p><strong>Conclusions: </strong>Our results showed similar changes as in a previous meta-analysis study including the disease severity and lymphocyte subset counts in patients hospitalized with Covid-19 and could be used as prognostic strategy to predict the outcome and severity of Covid-19 disease. To better understand and explain this reduction, further analysis of other factors, such as IL-4, lymph tissues structure, and N protein-specific antibody, is needed.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian Randomization Analyses Explore the Relationship between Trace Elements and Prostate Cancer.","authors":"Cheng-Hao Zhou, Huai-Lan Wang, Chen-Hao Yu, Gong-Hui Li","doi":"10.7754/Clin.Lab.2024.241010","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241010","url":null,"abstract":"<p><strong>Background: </strong>Trace elements indeed play a significant role in the occurrence and development of cancers, but it remains ambiguous whether a causal relationship exists between trace elements and prostate cancer. This study employed Mendelian randomization analyses to investigate such a causal link between trace elements (Co, Fe, Mg, Se, and Zn) and prostate cancer.</p><p><strong>Methods: </strong>The analyses primarily utilized the inverse variance weighted (IVW) method, supplemented by MR-Egger, weighted median, simple mode, and MR-PRESSO.</p><p><strong>Results: </strong>The results of IVW (OR = 1.005, 95% CI: 1.001 - 1.009, p = 0.014) and MR-PRESSO (OR = 1.005, 95% CI: 1.002 - 1.008, p = 0.015) analyses demonstrated a significant causal effect of Mg on genetically predicted prostate cancer. However, the IVW analysis did not reveal any causal associations between prostate cancer and Co, Fe, Se, or Zn.</p><p><strong>Conclusions: </strong>Our study provided compelling evidence of a causal relationship between magnesium and prostate cancer within the European population. Therefore, maintaining magnesium balance may emerge as a potent strategy for prostate cancer prevention.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposed Method Using the Urinary Albumin-To-Total Protein Ratio for Detection of Urinary Bence Jones Protein.","authors":"Mayumi Imoto, Yoshihisa Nakatani, Katsunori Watanabe, Toshinori Kamisako","doi":"10.7754/Clin.Lab.2024.241107","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241107","url":null,"abstract":"<p><strong>Background: </strong>Detecting urinary Bence Jones protein (BJP) is effective for early diagnosis of malignant diseases, such as multiple myeloma. Currently, BJP is detected by heat coagulation test (Putnam's method), immunoelec-trophoretic (IEP) analysis, and immunofixation electrophoresis (IFE). However, because of their low sensitivity, high cost, and labor intensiveness, alternative biomarkers are being sought. The study aimed to evaluate the use-fulness of the urinary albumin/total protein (U-ALB/U-TP) ratio for early detection of urinary BJP.</p><p><strong>Methods: </strong>U-ALB and U-TP were measured in 85 BJP urine samples confirmed by IEP or IFE and 507 samples from the general patient group, for a total of 592 samples. A total of 592 general patient samples were used to calculate the U-ALB/U-TP ratio for receiver operator characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>The correlation between U-TP and U-ALB was strong in the general group but weak in the BJP group. For a BJP detection cutoff value obtained by ROC curve analysis of 0.362 (area under the curve: 0.941), the sensitivity was 92% and the specificity was 88% for a U-TP ≥ 30 mg/dL. A decreased ratio of U-ALB/U-TP indicates turbid urine (high white blood cell count), bacteriuria, crystalluria, or high urinary free L chain as well as urinary BJP.</p><p><strong>Conclusions: </strong>We demonstrated that BJP could be detected by measuring the U-ALB/U-TP ratio, which may enable early detection of BJP in patients with malignant diseases at the presymptomatic stage.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection Challenges in Myelodysplastic Syndromes: a Case Report of Missed Detection of Nucleated Red Blood Cells.","authors":"Wen Qiu, Yong K Yan, Jian P Kang, Jie Yang, Wei Li","doi":"10.7754/Clin.Lab.2024.241106","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241106","url":null,"abstract":"<p><strong>Background: </strong>Nucleated red blood cells (NRBCs) play a crucial role in automated blood analysis, particularly in the diagnosis and monitoring of blood disorders. This study examines the limitations of the Sysmex XN-9000 fully automated modular hematology analyzer in detecting nucleated red blood cells (NRBCs) in patients with myelodysplastic syndromes (MDS).</p><p><strong>Methods: </strong>Peripheral blood samples from a patient diagnosed with MDS were analyzed using the XN-9000 analyzer. Manual digital microscopy was employed for validation and detailed cell counts.</p><p><strong>Results: </strong>The XN-9000 incorrectly identified nucleated erythrocytes as monocytes and failed to detect an abnormal quantity of NRBCs. Manual review revealed a significantly lower white blood cell count compared to the automated count, and a notable increase in NRBCs alongside a decrease in monocyte percentage.</p><p><strong>Conclusions: </strong>Fully automated hematology analyzers may have limitations in detecting certain hematopathological conditions, and manual microscopy is essential to ensure diagnostic completeness and accuracy.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Effect of Residual Cholesterol on Psoriatic Arthritis: a Mendelian Randomization Study.","authors":"Wenying Long, Quan Miao","doi":"10.7754/Clin.Lab.2025.250118","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250118","url":null,"abstract":"<p><strong>Background: </strong>Accumulating evidence suggests an intimate relationship between residual cholesterol and psoriatic arthritis (PsA). However, owing to confounding and reverse causality, this relationship remains unclear in observational studies. The aim of our study was to identify the causal relationship of residual cholesterol with PsA by Mendelian randomization.</p><p><strong>Methods: </strong>In this study, we obtained genetic variants linked with residual cholesterol levels in the largest genome-wide association study (GWAS) on Europeans. We also selected genetic variants corresponding effect estimates on PsA risk from a large GWAS. To make the results more stable, we used six robust analytical methods for the MR analysis. The results of MR analyses in the discovery/validation set were combined using the fixed-effect model. Furthermore, we also used MR Steiger to assess the possible direction of causal estimate between them.</p><p><strong>Results: </strong>In the discovery set, gene prediction found that for every 1 SD increase in residual cholesterol levels, the relative risk of PsA increased 1.177 (95% CI: 1.024 - 1.353). In the validation set, we observed that for every 1 SD increase in residual cholesterol levels, the relative risk of PsA increased 1.185 (95% CI: 1.068 - 1.316). In the meta-analysis, we found residual cholesterol levels could increase the risk of PsO. In addition, MR Steiger also found reverse causality between them.</p><p><strong>Conclusions: </strong>This study supports evidence of a relationship of residual cholesterol with PsA.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Mycobacterium Marinum Infection in the Middle Finger of the Left Hand.","authors":"Shilu Li, Yun Xing","doi":"10.7754/Clin.Lab.2024.241129","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241129","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;In April 2024, our hospital confirmed a case of Mycobacterium marinum infection in the middle finger of the left hand. The patient sought medical attention at our hospital due to swelling of the left middle finger with tendon contracture for one and a half years and subcutaneous induration of the left palm for one month. In September 2022, the patient's left middle finger was pricked by raw fish bones, resulting in punctate erythema and pain. Self-application of erythromycin ointment did not improve. In November 2022, the left middle finger showed redness and swelling. The local hospital diagnosed it with tenosynovitis, but the effect of anti-inflammatory treatment was not significant. Later, the left middle finger gradually developed tendon contracture and mobility disorders. In May 2023, the patient underwent multiple \"short needle knife\" treatments in an external hospital for \"tenosynovitis\". The swelling and redness of the fingers slightly subsided, and the treatment effect was not ideal. In March 2024, the patient developed subcutaneous induration in the left palm. For additional diagnosis and treatment, the patient went to our hospital for treatment. Clinically admitted with \"1. Hand skin infection (Mycobacterium), 2. Tendon contracture (with infection)\".&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Clinically, ultrasound-guided puncture and aspiration of subcutaneous abscess in the middle finger of the left hand were performed. The extracted pus was subjected to bacterial culture and identification, acid fast staining, Gram staining, NGS (Next-Generation Sequencing) detection of pus and additional related auxiliary examinations such as blood routine, urine routine, liver function, kidney function, and electrocardiogram.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Hand magnetic resonance imaging: 1. Abnormal signals around the third proximal phalanx of the left hand and around the flexor tendon of the third metacarpal finger, suspected of abscess. 2. Increased signal in the left wrist canal, suspected of inflammatory disease. Blood routine + CRP (venous blood): The percentage of neutrophils is 28.9%, the total number of neutrophils is 1.30 x 109/L, and the percentage of lymphocytes is 60.2%. Liver function: Total protein 58.0 g/L, albumin 33.6 g/L, no significant abnormalities observed in the rest. Acid fast staining of pus: positive, culture and identification of pus bacteria (MALDI-TOF MS, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry): Mycobacterium marinum. NGS detection of pus: Mycobacterium marinum. Clinical treatment plan: Rifampicin 0.6 g po qd, clarithromycin 0.5 g po bid for anti-infection treatment, local hot compress. After 5 days of treatment, the patient's flexor digitorum tendon extended towards the proximal end, with a soft texture and mild tenderness. The flexion activity was slightly restricted, and no additional special discomfort was reported. The patient improved and was discharged.","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Integrated Solution for Application of Next-Generation Sequencing in Newborn Screening.","authors":"Zhong-Yao Xu, Shuo-Dan Huang, Jie Zou, Wei-Hong Zeng, Yong-Chao Guo, Jian-Hui Jiang","doi":"10.7754/Clin.Lab.2024.241006","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241006","url":null,"abstract":"<p><strong>Background: </strong>Next-generation sequencing (NGS) has greatly improved the diagnostic process for hereditary diseases, and incorporation of NGS into newborn screening (NBS) programs for more actionable diseases has been widely discussed. The aim of this study was to evaluate an integrated solution for application of NGS in newborn screening.</p><p><strong>Methods: </strong>An NGS panel targeting 155 genes related to inborn errors of metabolism, hearing loss, severe combined immunodeficiency, congenital hypothyroidism, and other actionable genetic diseases, was designed. An all-in-one library preparation strategy was developed to combine multiplex PCR target enrichment and sample barcoding. A clinical genetic analysis system was assembled to facilitate bioinformatics analysis and reporting. The integrated solution was validated using 160 samples with known variants.</p><p><strong>Results: </strong>The end-to-end time from DNA isolation to sequencing was approximately 34 hours, and bioinformatics analysis pipeline took 4 hours for 160 samples in parallel. This allowed reporting of results on day 3. All known variants were confirmed by the NGS workflow, and two large insertion/deletions were additionally detected in two cases with previously clinically but not genetically confirmed diseases.</p><p><strong>Conclusions: </strong>The integrated solution for application of NGS in NBS provided reasonable turnaround time to meet the NBS timeframe and could be implemented at scale.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Pre-Analytical Aspects of Blood Gas Analysis Point-Of-Care-Testing (POCT) and Their Impact on Clinical Decision-Making.","authors":"Siti N A Rahim, Nani Nordin, Hani A Zulkeflee, Wan N F H W Nik, Wan M A W Shuaib, Tuan S T Ismail, Noorazliyana Shafie","doi":"10.7754/Clin.Lab.2024.241029","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241029","url":null,"abstract":"<p><strong>Background: </strong>Laboratory errors can occur during any phase of the total testing process (TTP); however, pre-analytical errors are the most common. Point-of-care testing (POCT) blood gas analysis aids in the reduction of pre-analytical mistakes such as specimen misidentification, analyte degradation, and sample hemolysis caused by analysis delays and vigorous sample handling. Hence, users' understanding of common pre-analytical factors con-founding the results is prudent.</p><p><strong>Methods: </strong>POCT blood gas has been proven to help allow rapid early diagnosis and triage, better control of mechanical ventilation, safer and reduction in risk of disease transmission, measurements of concurrent electrolytes and acid-base parameters at the bedside, diagnosis of methemoglobinemia and carboxyhemoglobinemia, as well as prompt pre-hospitalized care in remote home care or emergency response settings. However, quality limitations are still a concerning issue.</p><p><strong>Results: </strong>Thus, the successful implementation of policy and clinical applicability of blood gas POCT is the responsibility of primary healthcare givers, laboratory professionals, and administrators.</p><p><strong>Conclusions: </strong>Our review highlights the importance of understanding pre-analytical factors affecting parameters in blood gas analysis, their impact on clinical decision-making, and various POCT blood gas analysis applications.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S100A12 Protein Levels in Juvenile Idiopathic Arthritis (JIA): a Systematic Review and Meta-Analysis.","authors":"Tarun K Sharma, Somya Saxena, Pooja Arora, Anil K Sharma","doi":"10.7754/Clin.Lab.2024.241041","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241041","url":null,"abstract":"<p><strong>Background: </strong>Juvenile idiopathic arthritis (JIA) is a childhood inflammatory disease, which is a common cause of disability among the younger population. S100A12 protein level is found to be associated with the patients of JIA; though, the findings on this are inconsistent. Therefore, we conducted a systematic review and meta-analysis to assess the association of S100A12 protein levels with juvenile idiopathic arthritis.</p><p><strong>Methods: </strong>Relevant published studies up to December 2022 were identified by systematic literature searching on Embase, PubMed/Medline, Web of Science, and Scopus for exploring the association of S100A12 protein levels with juvenile idiopathic arthritis (JIA). The data analysis was performed using the R-4.4.0 software.</p><p><strong>Results: </strong>We included 9 eligible studies on serum S100A12 protein levels in JIA and healthy controls, which encompassed 518 JIA patients and 345 healthy control subjects. The pooled analysis revealed that the serum S100A12 protein levels increased significantly (summary SMD = 2.18, 95% CI: 0.63 - 3.74, overall effect size z = 2.76, p < 0.01) in JIA subjects in comparison to healthy control subjects. The pooled results of subgroup analysis for the Europe and Asia group' studies were SMD = 2.75, (95% CI [-0.09 to 5.58]; p < 0.01) and SMD = 1.53, (95% CI [-0.27 to 3.32]; p < 0.01), respectively, and both groups based on geographical regions exhibited significant hetero-geneity (I2 = 97.0% and I2 = 98.0% respectively, p < 0.01). Similarly, in cohort and case-control study groups, the results were SMD = 1.70, (95% CI [0.36 to 3.04]; p < 0.01) and SMD = 1.29, (95% CI [0.03 to 2.55]; p < 0.01), respectively, and both groups based on study type also exhibited significant heterogeneity (I2 = 97.0% and I2 = 96.0%, respectively, p < 0.01).</p><p><strong>Conclusions: </strong>This meta-analysis suggests that the S100A12 protein serum concentrations of JIA were significantly higher than those of healthy controls, which suggests that serum S100A12 protein could be a potential biomarker for JIA.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}