Clinical laboratory最新文献

{"title":"Two Cases of Severe Chlamydia psittaci Pneumonia with Respiratory Failure and Literature Review.","authors":"Gangfeng Li, Ningping Dan, Tao Lu","doi":"10.7754/Clin.Lab.2025.250675","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250675","url":null,"abstract":"<p><strong>Background: </strong>Chlamydia psittaci pneumonia is a zoonotic disease with non-specific clinical manifestations, often leading to delayed diagnosis. Metagenomic next-generation sequencing (mNGS) can help us identify pathogens in a timely manner and quickly adjust treatment strategies.</p><p><strong>Methods: </strong>We reported two cases of severe Chlamydia psittaci pneumonia with respiratory failure and reviewed relevant literature.</p><p><strong>Results: </strong>Both patients were diagnosed with Chlamydia psittaci infection through mNGS after routine pathogen testing failed. After using Omadacycline based treatment, the patients' clinical and radiological characteristics improved significantly and were successfully cured.</p><p><strong>Conclusions: </strong>For patients infected with Chlamydia psittaci pneumonia, timely identification of the pathogen is crucial. mNGS can quickly detect Chlamydia psittaci in critically ill patients, guide clinical timely targeted treatment, and improve patient symptoms.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of ELISA Test Results of the Changing Blood Donor Profile in Istanbul, Single Center Experience (2020 - 2024).","authors":"Kamuran Şanli, Beyza Öncel, Ayşe N Ceylan, Selda Kömeç, Kübra Evren, Nurhadiye Kuru, Mehmet A Durmuş, Alper Gümüş, Nuran Karabulut","doi":"10.7754/Clin.Lab.2025.250619","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250619","url":null,"abstract":"<p><strong>Background: </strong>Ensuring a safe blood supply is a critical responsibility of transfusion services. In Türkiye, demographic shifts, including a growing number of immigrant donors, have necessitated ongoing evaluation of transfusion-transmissible infections (TTIs) and screening protocols to analyze the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and syphilis among blood donors and to evaluate demographic trends and false-positive rates in serological screening.</p><p><strong>Methods: </strong>This retrospective study analyzed ELISA screening results from 110,419 blood donations collected be-tween 2020 and 2024 at a regional blood center in Türkiye. Demographic data, seroprevalence of TTIs, confirmatory testing outcomes, and changes over time were examined.</p><p><strong>Results: </strong>Most donors were male (89.4%) and Turkish citizens (95.8%), with a mean age of 34.5 years. HBV reactivity was observed in 0.4% of donors, significantly higher among Turkish nationals and older individuals (p < 0.05). HCV and HIV reactivity were each detected in 0.2% of donors, while syphilis antibodies were found in 0.2%. Foreign donors, particularly women, exhibited higher reactivity for HBV and HCV. Co-infections were identified in a subset of donors (2.9% of syphilis-positive cases). False-positive rates were notably high for anti-HCV (85.6%) and anti-HIV (80.2%), with HBsAg showing the lowest (4.6%).</p><p><strong>Conclusions: </strong>The evolving donor profile and increasing false-positive rates highlight the need for more specific screening assays and revised donor management strategies. Continuous surveillance and multicenter studies are essential to maintain transfusion safety in an increasingly diverse population.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Dilemma of Milky Yellow Pleural Effusion.","authors":"Jiehua Han, Congcong Cheng, Qiongying Xu","doi":"10.7754/Clin.Lab.2025.250639","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250639","url":null,"abstract":"<p><strong>Background: </strong>Chylothorax, a common complication post-lung cancer surgery, lacks standardized laboratory diagnostic criteria. Misdiagnosis remains prevalent due to variable pleural fluid appearance.</p><p><strong>Methods: </strong>We analyzed pleural fluid via biochemical tests, lipid profiling, and Sudan III staining. Ratios of effusion-to-serum triglycerides (P/S TG > 1) and cholesterol (P/S CHOL < 1) were applied to confirm chylous effusion.</p><p><strong>Results: </strong>The patient's pleural fluid exhibited milky yellow appearance, elevated TG (5.46 mmol/L), P/S TG ratio (3.62), and positive Sudan III staining. P/S CHOL ratio (0.43) and CHOL/TG (0.32) aligned with chylous criteria. Conservative management resolved the lymphatic leak.</p><p><strong>Conclusions: </strong>Integrating TG/CHOL ratios with Sudan III staining enhances diagnostic accuracy for chylothorax, reducing false negatives in non-milky effusions.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and Clinical Significance of Pim-1 and RON in Lung Cancer Patients with Benign and Malignant Pleural Effusion.","authors":"Wei-Ping Huang, Yan Chen, Yin-Dan Song, Jie Chen, Ya-Bo Wenren","doi":"10.7754/Clin.Lab.2025.250670","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250670","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the expression differences and diagnostic value of Pim-1 and RON in lung cancer patients with benign and malignant pleural effusion.</p><p><strong>Methods: </strong>Forty lung cancer patients with benign pleural effusion (BPE) and forty with malignant pleural effusion (MPE) were enrolled. The relative expression levels of Pim-1 and RON mRNA in pleural effusion were measured using real-time quantitative PCR (RT-qPCR). Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic performance of Pim-1 and RON.</p><p><strong>Results: </strong>Compared to the BPE group, Pim-1 expression levels were significantly increased in the MPE group (p < 0.05). RON expression levels were also significantly elevated in the MPE group (p < 0.01). ROC curve analysis revealed that the areas under the curve (AUC) for diagnosing MPE using pleural effusion Pim-1 and RON were 0.646 (95% CI 0.526 - 0.766) and 0.809 (95% CI 0.715 - 0.904), respectively. The AUC for the combined detection of Pim-1 and RON was 0.853 (95% CI 0.773 - 0.934).</p><p><strong>Conclusions: </strong>Pim-1 and RON are highly expressed in malignant pleural effusion, suggesting a role in lung cancer metastasis to the pleural cavity. Detection of Pim-1 and RON in pleural effusion demonstrates potential diagnostic value for MPE.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Immune Cost: How Virtual Life Becomes a Modifiable Risk Factor for Immune Dysregulation.","authors":"Mohamed N Ibrahim","doi":"10.7754/Clin.Lab.2025.250624","DOIUrl":"10.7754/Clin.Lab.2025.250624","url":null,"abstract":"<p><strong>Background: </strong>The emergence of technology-based lifestyles has led to what may be called \"virtual isolation,\" as people spend more and more time in front of screens and less and less time in the world. Though the psychological consequences of this isolation are broadly appreciated, the biological impact of such isolation, especially on the immune system, has not been well-studied.</p><p><strong>Methods: </strong>This letter synthesizes interdisciplinary research in neuroendocrinology, psychoneuroimmunology, and microbiome science to explore the biological implications of digital isolation on immune system regulation.</p><p><strong>Results: </strong>Long-term digital immersion has been linked to higher levels of the stress hormone cortisol, disrupted sleep and reduced oxytocin signaling - all which disarray both innate and adaptive immune function. The lack of social bonding in the real world limits the sharing of microbes and gut microbiome diversity, making immune homeostasis even worse. Digital addiction is also associated with raised inflammatory indicators and increased sus-ceptibility to infections and immune dysregulation.</p><p><strong>Conclusions: </strong>The virtual bubble is nice, psychologically, but carries an insidious and deepening challenge to the integrity of the immune system. Tackling digital over exposure is essential to restore immunological balance, particularly in a post-pandemic society prone to stress-driven immunosuppression.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of NPAR/UAR in MINOCA Patients with Coronary Slow Flow Phenomenon.","authors":"Qiang Li, XuJiao Hu","doi":"10.7754/Clin.Lab.2025.250540","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250540","url":null,"abstract":"<p><strong>Background: </strong>Patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) combined with the coronary slow flow phenomenon (CSFP) often exhibit microvascular dysfunction. However, the underlying inflammation-metabolism interplay and effective prognostic tools remain unclear. This study aimed to investigate the predictive value of two novel inflammation-metabolism composite biomarkers, the neutrophil-to-albumin ratio (NPAR) and the uric acid-to-albumin ratio (UAR), in MINOCA patients with CSFP and to assess the synergistic effect of these markers on short-term outcomes.</p><p><strong>Methods: </strong>A total of 176 MINOCA patients were prospectively enrolled, including 61 with CSFP diagnosed via corrected TIMI frame count (CTFC) and 115 with normal coronary flow as controls. Baseline clinical data, inflammation-metabolism biomarkers (NPAR, UAR), and imaging parameters were collected. Patients were followed for one year to track a composite endpoint, including cardiovascular death, recurrent myocardial infarction, and heart failure hospitalization. Multivariable logistic regression and Cox proportional hazards models were used to analyze the independent and interactive effects of NPAR and UAR. Model performance improvement was evaluated using the net reclassification improvement (NRI) and integrated discrimination improvement (IDI) indices.</p><p><strong>Results: </strong>MINOCA patients with CSFP showed significantly elevated levels of both NPAR and UAR. Multivariate analysis revealed that NPAR (OR = 1.45, p = 0.008), UAR (OR = 1.35, p = 0.04), and their interaction term (OR = 1.30, p = 0.02) were independent predictors of the composite endpoint. Combined assessment of these biomarkers significantly improved risk stratification (AUC increased from 0.73 to 0.75; NRI = 0.12, IDI = 0.015). The Cox model further confirmed an increased risk of 30% of adverse events with NPAR/UAR interaction (HR = 1.30, p = 0.027), with no significant effect modification by CSFP status (p > 0.05).</p><p><strong>Conclusions: </strong>Elevated NPAR and UAR levels jointly predict poor short-term outcomes in MINOCA patients, and their synergistic effect is independent of CSFP status. These findings suggest a novel biomarker-based strategy for risk stratification and targeted intervention in microvascular myocardial infarction.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nontargeted Metabolomics Analysis of Carbapenem-Resistant Pseudomonas aeruginosa.","authors":"Yao Zhang, Xiaona Yin, Yanghu Xie, Xiaoqiong Wang, Yongsheng Wang","doi":"10.7754/Clin.Lab.2025.250922","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250922","url":null,"abstract":"<p><strong>Background: </strong>Carbapenem-resistant Pseudomonas aeruginosa (CRPA) infection is becoming increasingly severe in clinical practice, yet its host metabolic characteristics remain unclear. Based on metabolomics, this study compares the metabolic profiles of patients infected with CRPA versus susceptible strains, aiming to identify potential diagnostic biomarkers and therapeutic targets.</p><p><strong>Method: </strong>This single-center case-control study enrolled 20 inpatients diagnosed with Pseudomonas aeruginosa infection at the Second People's Hospital between May 2023 and May 2024. Based on antimicrobial susceptibility testing, patients were divided into a CRPA group (n = 10) and a carbapenem-susceptible (CSPA) group (n = 10). Plasma samples from all patients underwent untargeted metabolomic analysis using ultrahigh-performance liquid chromatography-mass spectrometry. Differential metabolites were screened by applying principal component analysis, orthogonal partial least squares-discriminant analysis multivariate statistical analysis, and univariate analysis. These metabolites were subsequently annotated and subjected to pathway enrichment analysis using the Kyoto Encyclopedia of Genes and Genomes (KEGG), Human Metabolome Database, and ChemSpider databases.</p><p><strong>Results: </strong>Metabolomic analysis identified 19 differentially abundant metabolites, more than half of which were involved in lipid metabolism. This was primarily characterized by the upregulation of glycerophospholipids (such as phosphatidylserine and phosphatidylinositol) and the downregulation of glycerophosphocholine, phosphatidylethanolamine, and certain sphingolipids. Beyond lipids, compounds such as cholic acids, p-cresol sulfate, and hippuric acid were also significantly upregulated. KEGG enrichment analysis revealed that the differential metabolites were predominantly enriched in pathways related to glycerophospholipid metabolism, sphingolipid metabolism, and ether lipid metabolism, indicating that disrupted lipid metabolism is a core metabolic feature of CRPA infection.</p><p><strong>Conclusions: </strong>This study demonstrates that the metabolic differences in CRPA-infected patients are concentrated in lipid metabolism, suggesting a close association between drug-resistant infections and host-pathogen lipid metabolic remodeling. Changes in relevant lipids hold value as potential diagnostic and prognostic biomarkers, while lipid metabolic pathways may also represent novel targets for future therapeutic interventions.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Maresin-1 Levels and Disease Activity in Patients with Crohn's Disease.","authors":"Tuna Turan, Özlem Gül, Kemal Üreten, Üçler Kisa, Bilal Ergül","doi":"10.7754/Clin.Lab.2025.250622","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250622","url":null,"abstract":"<p><strong>Background: </strong>Maresin-1 is considered to be a potential regulator of inflammatory disease through its anti-inflammatory and pro-resolving properties. However, no study to date has investigated Maresin-1 levels in Crohn's disease (CD). This study aimed to measure serum levels of Maresin-1 in patients with CD and to assess possible effects on disease activity.</p><p><strong>Methods: </strong>Thirty patients with active CD, 30 patients with CD in remission, and 30 healthy individuals were included in the study. Clinical and demographic features of patients were obtained from the hospital database. Serum Maresin-1 levels were determined by enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Maresin-1 level was 215.74 (118.55 - 327.46) pg/mL in the active group, 413.29 (215.82 - 726.82) pg/mL in the remission group, and 753.4 (381.5 - 901.08) pg/mL in controls (p < 0.05). An inverse correlation was found be-tween Maresin-1 and CRP in patients with active CD (p = 0.039). A Maresin-1 cutoff value of < 607.38 pg/mL showed 96.67% sensitivity and 80% specificity for the identification of CD patients in remission from controls (AUC = 0.919), while a < 327.46 pg/L cutoff yielded a sensitivity of 100% and a specificity of 100% to distinguish active CD from controls (AUC = 0.999), and finally, a < 296.28 pg/mL cutoff was also significant in identifying pa-tients with active CD from those with remission (sensitivity: 96.67%, specificity: 80%, AUC = 0.946). According to multivariable logistic regression, CD patients with decreased Maresin-1 had increased likelihood of having active disease (OR: 0.942, 95% CI = 0.892 - 0.994, p = 0.031).</p><p><strong>Conclusions: </strong>This was the first study to examine circulating levels of Maresin-1 in CD patients and showed that patients with active disease and those in remission had significantly lower values compared to controls. Our results suggest that Maresin-1 levels might be involved in the pathogenesis of CD. Serum Maresin-1 could be used as a diagnostic biomarker in predicting inflammation in CD and may emerge as a target for treatment.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in the Diagnosis of Hematogenous Disseminated Pulmonary Tuberculosis with Multiple Organ Involvement.","authors":"Bi X Xie, Yi Chen, Yuan R Tan, Tao Jiang, Min H Huang, You M Zhu, Shan Chen","doi":"10.7754/Clin.Lab.2025.250640","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250640","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis is a public health problem worldwide, and China is a high-burden country. Hematogenous disseminated pulmonary tuberculosis is one of the most serious forms of tuberculosis, and diagnosing hematogenous pulmonary tuberculosis is a challenge, even for the most experienced clinicians, who may also feel perplexed. We report a case of hematogenous disseminated tuberculosis involving multiple organs that was initially misdiagnosed as metastatic malignancy. The diagnosis was finally confirmed by metagenomic Next-Generation Sequencing (m-NGS) of peritoneal and pericardial effusions, which detected Mycobacterium tuberculosis complex.</p><p><strong>Methods: </strong>Appropriate laboratory tests, m-NGS, Chest and abdominal CT, Pericardiocentesis, and Peritoneal puncture.</p><p><strong>Results: </strong>Chest and abdominal CT showed diffuse nodules in both lungs, pericardial effusion, bilateral pleural effusion, and abdominal pelvic effusion. Tuberculosis bacillus antibody was negative, erythrocyte sedimentation rate increased to 42 mm/H, and the carcinoembryonic antigen (CEA) increased to 7.1 ng/mL, peritoneal effusion adenosine deaminase increased to 65.17 U/L, pericardial effusion adenosine deaminase increased to 142.39 U/L. m-NGS of pericardial effusion and peritoneal effusion detected 886,963 M. tuberculosis complex.</p><p><strong>Conclusions: </strong>Miliary tuberculosis is a severe and rare form of tuberculosis. Delayed diagnosis may be the most important factor leading to death from miliary tuberculosis. We report a case where Mycobacterium tuberculosis was identified through mNGS of pericardial and peritoneal effusions, enabling rapid diagnosis of disseminated tuberculosis. This case provides a new approach for the rapid diagnosis of disseminated tuberculosis.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Serum CAR with Postoperative Quality of Life and Hip Recovery in Elderly Patients with Intertrochanteric Fracture.","authors":"Yan Ling, Ming Zhang","doi":"10.7754/Clin.Lab.2025.250616","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250616","url":null,"abstract":"<p><strong>Background: </strong>Intertrochanteric fracture (ITF) is a common but devastating condition with high mortality in the elderly population. Early identification of high-risk patients to prevent poor prognosis is essential as treatment of postoperative adverse outcomes is complex. C-reactive protein (CRP)/albumin (ALB) ratio (CAR) is a predictor of prognosis in many diseases, but its correlation with postoperative prognosis in patients with ITF remains unclear.</p><p><strong>Methods: </strong>One hundred and six elderly patients who underwent ITF surgery between May 2021 and May 2023 were retrospectively analyzed. Patients were evaluated based on postoperative Harris Score and SF-36 Score for good and poor recovery groups. CAR, ALB, and hemoglobin with statistically significant differences in univariate analysis were included in multifactorial logistic regression analysis to screen for independent influences. Predictive efficacy was analyzed using the ROC curve to obtain the area under the curve (AUC). Sample regression models were constructed to test whether there was a nonlinear relationship between ALB and CAR and the prognostic outcomes of patients with ITF. The correlation of ALB and CAR with Harris Score and SF-36 Score was analyzed by Pearson's correlation analysis.</p><p><strong>Results: </strong>Elevated CAR (OR = 2.18, p = 0.00) was an independent risk factor for poor recovery in patients with ITF, while ALB (OR = 0.90, p = 0.03) was an independent protective factor against poor recovery. All CAR showed good predictive efficacy when the cutoff value took CAR > 1.79. In contrast, the predictive efficacy of ALB was low. Restricted cubic spline model and Pearson's correlation analysis showed a linear relationship between CAR, poor recovery in ITF patients, and a negative correlation with Harris Score and SF-36 Score.</p><p><strong>Conclusions: </strong>Serum CAR is significantly associated with poor postoperative prognosis in elderly patients with ITF and may be an independent risk factor for postoperative quality of life and hip recovery.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}