Jun Chen, Mei-Rong Xu, Jin-Bei Yuan, Dong-Ping Liang
{"title":"血清miR-411-3p在急性髓性白血病患者中的诊断和预后能力","authors":"Jun Chen, Mei-Rong Xu, Jin-Bei Yuan, Dong-Ping Liang","doi":"10.7754/Clin.Lab.2025.250149","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study aimed to identify the diagnostic and prognostic ability of serum miR-411-3p in patients with acute myeloid leukemia (AML).</p><p><strong>Methods: </strong>Blood samples were collected from 60 AML patients and 60 healthy controls to measure serum miR-411-3p and thereafter discuss its potential clinical value.</p><p><strong>Results: </strong>Serum miR-411-3p was decreased in AML patients and was even lower in those with M4/M5 subtypes or high white blood cell count or adverse cytogenetic risk. Serum miR-411-3p had a diagnostic value. An association existed between low serum miR-411-3p and worse clinical features and shorter survival, and miR-411-3p was able to predict overall survival and relapse-free survival in AML patients. In addition, serum miR-411-3p was upregulated after treatment, especially in AML patients who achieved complete remission.</p><p><strong>Conclusions: </strong>Serum miR-411-3p is of promising utility regarding AML diagnosis and prognosis.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 9","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diagnostic and Prognostic Ability of Serum miR-411-3p in Patients with Acute Myeloid Leukemia.\",\"authors\":\"Jun Chen, Mei-Rong Xu, Jin-Bei Yuan, Dong-Ping Liang\",\"doi\":\"10.7754/Clin.Lab.2025.250149\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This study aimed to identify the diagnostic and prognostic ability of serum miR-411-3p in patients with acute myeloid leukemia (AML).</p><p><strong>Methods: </strong>Blood samples were collected from 60 AML patients and 60 healthy controls to measure serum miR-411-3p and thereafter discuss its potential clinical value.</p><p><strong>Results: </strong>Serum miR-411-3p was decreased in AML patients and was even lower in those with M4/M5 subtypes or high white blood cell count or adverse cytogenetic risk. Serum miR-411-3p had a diagnostic value. An association existed between low serum miR-411-3p and worse clinical features and shorter survival, and miR-411-3p was able to predict overall survival and relapse-free survival in AML patients. In addition, serum miR-411-3p was upregulated after treatment, especially in AML patients who achieved complete remission.</p><p><strong>Conclusions: </strong>Serum miR-411-3p is of promising utility regarding AML diagnosis and prognosis.</p>\",\"PeriodicalId\":10384,\"journal\":{\"name\":\"Clinical laboratory\",\"volume\":\"71 9\",\"pages\":\"\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical laboratory\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.7754/Clin.Lab.2025.250149\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2025.250149","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
Diagnostic and Prognostic Ability of Serum miR-411-3p in Patients with Acute Myeloid Leukemia.
Background: This study aimed to identify the diagnostic and prognostic ability of serum miR-411-3p in patients with acute myeloid leukemia (AML).
Methods: Blood samples were collected from 60 AML patients and 60 healthy controls to measure serum miR-411-3p and thereafter discuss its potential clinical value.
Results: Serum miR-411-3p was decreased in AML patients and was even lower in those with M4/M5 subtypes or high white blood cell count or adverse cytogenetic risk. Serum miR-411-3p had a diagnostic value. An association existed between low serum miR-411-3p and worse clinical features and shorter survival, and miR-411-3p was able to predict overall survival and relapse-free survival in AML patients. In addition, serum miR-411-3p was upregulated after treatment, especially in AML patients who achieved complete remission.
Conclusions: Serum miR-411-3p is of promising utility regarding AML diagnosis and prognosis.
期刊介绍：
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
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