A Case Report of False Elevation of CA19-9 and Several Treatment Measures.

IF 0.6 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-09-01 DOI:10.7754/Clin.Lab.2025.250211

Yaner Qian, Hongkun Xu, Lihong Zhang

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引用次数: 0

Abstract

Background: The accuracy of CA19-9 detection results is very important for the early detection and treatment of pancreatic cancer, cholangiocarcinoma and other malignant tumors. At present, endogenous substances such as heterophilic antibodies will cause interference in the commonly used detection method is electrochemilumines-cence immunoassay, resulting in inaccurate results and affecting clinical diagnosis and treatment.

Methods: This paper reports a patient with an abnormal increase in serum CA19-9 level to explore how to accurately identify non-specific interference and anti-interference countermeasures.

Results: The patient's CA19-9 level should be within the reference range, and the results of the Abbott test system were falsely elevated caused by heterophil antibodies.

Conclusions: The laboratory should scrutinize test results more meticulously to identify the occurrence of interference. Once interference is suspected, it is recommended to employ methodologies such as DTT and PEG treatment to counteract the interference and avoid the occurrence of adverse events.

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CA19-9假升高1例及治疗措施。

背景：CA19-9检测结果的准确性对胰腺癌、胆管癌等恶性肿瘤的早期发现和治疗具有重要意义。目前常用的检测方法是电化学发光免疫分析法，内源性物质如嗜异性抗体会造成干扰，导致检测结果不准确，影响临床诊断和治疗。方法：本文报道1例血清CA19-9水平异常升高的患者，探讨如何准确识别非特异性干扰及抗干扰对策。结果：患者CA19-9水平应在参考范围内，嗜异性抗体导致雅培检测系统结果虚高。结论：实验室应更加仔细地检查检测结果，以确定干扰的发生。一旦怀疑有干扰，建议采用DTT和PEG治疗等方法来抵消干扰，避免不良事件的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.