Clinical laboratory最新文献

{"title":"Positive Relationship between Total Calcium and Hyperuricemia in Adults: a Cross-Sectional Study.","authors":"Hong Lei, Haining Guan","doi":"10.7754/Clin.Lab.2024.240726","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240726","url":null,"abstract":"<p><strong>Background: </strong>Calcium (CA) is crucial for a wide range of biological functions. However, the correlation between total calcium and hyperuricemia in US adults remains unclear. This study aimed to assess whether total calcium is associated with hyperuricemia.</p><p><strong>Methods: </strong>Based on data from the NHANES (2011 - 2018), we conducted a cross-sectional study involving 20,028 US adults aged 18 or older. Logistic regression, fitting smooth curves, and interaction effects were utilized to support the research objectives.</p><p><strong>Results: </strong>Regression analyses demonstrated a positive relation between total calcium and hyperuricemia (p < 0.001). Positive association between levels of total calcium and the risk of hyperuricemia was observed after full adjustment for all the confounding variables (odds ratio: 13.28, 95% confidence interval: 10.38 - 16.99, p < 0.001). The interaction of total calcium and hyperuricemia with age and gender was significant (p values for interaction < 0.05), while there was no interaction in other subgroups (p-values for interaction > 0.05). In addition, curve fitting after adjusting for all the confounding variables indicated a nonlinear positive correlation between total calcium and hyperuricemia (p for nonlinearity = 0.024).</p><p><strong>Conclusions: </strong>The present cross-sectional study revealed that a nonlinear positive association existed between total calcium and hyperuricemia in US adults. The results could be beneficial for the management and treatment of hyperuricemia.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune-Related Adverse Event of Immunotherapy: Diabetes.","authors":"Qingqing Su, Lei Zhao, Joshua M Banfield, Zhi Lv, Yinling Jiang, Xuan Zhou, Yadi Zhang, Yujiang Fang, Yongsheng Wang","doi":"10.7754/Clin.Lab.2024.240908","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240908","url":null,"abstract":"<p><strong>Background: </strong>The development of immunotherapy has led to a paradigm shift in the treatment of malignant tumors. Immune checkpoint inhibitors (ICIs) function by blocking the receptors and ligands of T cells from binding one another, empowering them to target and attack cancer cells. ICIs along with other immunotherapy treatments, have seen a significant increase in usage in recent years. However, this increased utilization has been accompanied by a significant rise in immune-related adverse events (irAEs). While the majority of irAEs reported are linked to endocrine dysfunction, less common irAES affecting the gastrointestinal, skin, hepatic, pulmonary, and cardiac systems have also been reported.</p><p><strong>Methods: </strong>In this report, we present a 72-year-old male patient with advanced non-small cell lung cancer in his left lobe, with 20% of their tumor cells positive for PD-L1. The patient's cells tested negative for actionable molecular markers, including as KRAS, EGFR, ALK, MET, and ROS1 alterations.</p><p><strong>Results: </strong>In accordance with the guidelines of the National Comprehensive Cancer Network (NCCN), the patient was treated with a PD-1 inhibitor in combination with chemotherapy. Following treatment, the patient developed severe immunotherapy-related diabetes, which resolved after discontinuation of immunotherapy and the administration of insulin.</p><p><strong>Conclusions: </strong>This case highlights the potential complications of immunotherapy and underscores the critical role of experienced clinicians in recognizing the early warning signs of irAEs and effectively managing the resulting complications.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mean Platelet Volume in Acute Hepatitis A.","authors":"Ha-Eun Cho, Heejung Ham, Sun Young Cho, Young Jin Kim, Kyung Sun Park, Tae Sung Park","doi":"10.7754/Clin.Lab.2024.241013","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241013","url":null,"abstract":"","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance Evaluation of the Automated Cell Image Analyzer DI-60 for Leukocyte Differential Count.","authors":"Soon Hee Chang","doi":"10.7754/Clin.Lab.2024.241027","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241027","url":null,"abstract":"<p><strong>Background: </strong>The Sysmex DI-60 system (Sysmex, Kobe, Japan) is an automated cell image analyzer that captures and analyzes cell images. The aim of this study was to evaluate the performance of DI-60 for leukocyte differential count in comparison with manual differential count and XN-20.</p><p><strong>Methods: </strong>A total of 205 samples were analyzed and the agreement between DI-60 pre-classification and post-verification by medical technicians was determined. The correlation and ability to identify clinically important abnormal cells of DI-60 post-verification were then evaluated.</p><p><strong>Results: </strong>The overall agreement of DI-60 pre-classification was 84.7%. The correlation between DI-60 post-verification and manual differential counts was excellent (r2 > 0.85) for neutrophils, lymphocytes, monocytes, and eosinophils, but was very low for basophils (r2 = 0.3759). The DI-60, post-verification, was able to identify clinically important abnormal cells including blasts, promyelocytes, myelocytes, and metamyelocytes with high efficiency (80.8 - 96.3%), but not NRBCs (51.0%). Overall sensitivity was 63.7 - 88.2%, and specificity was 84.3 - 95.5%, excluding NRBCs (43.7%).</p><p><strong>Conclusions: </strong>DI-60 showed excellent pre-classification accuracy and relatively high correlation compared with manual leukocyte differential counts. Although additional verification with a PBS review by experienced medical technicians may still be required, the DI-60 can be used as an efficient screening tool in clinical laboratories.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cold Atmospheric Plasma for Promoting Healing and Anti-Infection of Chronic Wounds: a Meta-Analysis.","authors":"Yuanzhen Li, Lianglan Li, Hong Lin, Wei Li, Jinglin Wan, Haibin Hao, Zhihui Tong, Weiqin Li","doi":"10.7754/Clin.Lab.2024.241028","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241028","url":null,"abstract":"<p><strong>Background: </strong>Cold atmospheric plasma (CAP) has shown good clinical efficacy in treating chronic wounds, but its superiority over conventional treatment is still under debate. This meta-analysis systematically analyzed the clinical efficacy of CAP compared to control therapy.</p><p><strong>Methods: </strong>Relevant literature was obtained online according to PRISMA guidelines. Randomized controlled trials (RCTs) were selected based on reduced bacterial load and wound size or area in chronic wounds as observation outcomes. The data were pooled and analyzed using REVMAN 5.2.</p><p><strong>Results: </strong>Twelve studies were included in the meta-analysis, comprising two on wound bacterial load, four on wound size or area, and six on both wound bacterial load and size. For the reduction in wound size or area, CAP showed a significant superior effect compared to the control group. Out of the five RCTs that evaluated wound size, CAP showed a higher number of wounds reduced (CAP vs. control: OR = 1.75; 95% CI = 1.11 - 2.77; p = 0.02). The percentage of relative reduced wound area was evaluated by five RCTs (CAP vs. control: MD = 43.24%; 95% CI = 24.95% - 61.54%; p < 0.00001). For reduced bacterial load, CAP also showed significantly better efficacy than control, as evaluated in eight RCTs (CAP vs. control: OR = 2.06; 95% CI = 1.16 - 3.68; p = 0.01).</p><p><strong>Conclusions: </strong>A total of 448 patients with chronic wounds were included in all 12 meta-analysis studies, indicating that CAP has better clinical efficacy in treating chronic wounds. These findings provide a valuable reference for the clinical application of CAP.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Diagnosis of Colorectal Cancer via Plasma-Derived SDC2, KCNQ5, and IKZF1 Methylation Levels.","authors":"Yi Zhang, Xiaoxiao Wang, Khan M I Sh, Yuwen Hao, Haiqiang Zhang, Shaofan Qiu, Haijun Wang, Zhanxue Zhang","doi":"10.7754/Clin.Lab.2024.240146","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240146","url":null,"abstract":"<p><strong>Background: </strong>The incidence of colorectal cancer (CRC) is rapidly increasing, and early detection plays a crucial role in improving the prognosis and survival rates of patients. This study aimed to assess the diagnostic ability of combined SDC2-KCNQ5-IKZF1 methylation levels in plasma for CRC detection.</p><p><strong>Methods: </strong>A total of 92 patients were recruited from the Department of General Surgery at the Second Hospital of Hebei Medical University, including 56 CRC patients, 22 polyp and adenoma patients, and 14 healthy controls. Plasma cfDNA was extracted for methylation test of SDC2, KCNQ5, and IKZF1. Sanger sequencing was conducted to verify the methylation results. The performance of single-gene methylation and triple-gene methylation combined test were analyzed. The positive detection rates of methylation and CEA test were compared to the colonoscopy gold standard. ROC curve was utilized to evaluate the diagnostic value in CRC.</p><p><strong>Results: </strong>The positive detection rates of triple-gene tests in CRC and precancerous lesions were 87.50% and 95.45%, respectively. The triple-gene test performed better than single-gene or CEA test. Combined analysis of triple-gene and CEA test could further improve the detection rate. Univariate analysis showed no statistical correlation between the methylation levels and patients' gender, age, history of diabetes, tumor site, lymph node metastasis, and tumor stage. In ROC curve analysis, AUC areas of SDC2, KCNQ5, and IKZF1 were 0.700, 0.646, and 0.645, respectively. The AUC area of triple-gene test was 0.924.</p><p><strong>Conclusions: </strong>The triple-gene combined methylation test demonstrated excellent diagnostic performance for CRC and precancerous lesions.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Screening Macroprolactinemia Using Polyethylene Glycol Precipitation Method.","authors":"Gangfeng Li, Ningping Shan, Qian Wang","doi":"10.7754/Clin.Lab.2024.241008","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241008","url":null,"abstract":"<p><strong>Background: </strong>Hyperprolactinemia is an endocrine disorder characterized by abnormally elevated levels of prolactin (PRL) in the serum. Macroprolactinemia refers to the condition where more than 60% of the prolactin circulating in the peripheral blood is composed of high molecular weight macroprolactins. These macroprolactins typically have low biological activity but can lead to a false increase in serum prolactin levels.</p><p><strong>Methods: </strong>We report a case of pseudoelevation of prolactin caused by macroprolactin. We used pituitary MRI and other examinations to identify the cause of elevated serum prolactin levels and different detection platforms and polyethylene glycol (PEG) precipitation method to screen for the possibility of pseudo elevation of prolactin caused by macroprolactin.</p><p><strong>Results: </strong>Whether measured using two different testing platforms or using our own testing platform after sample pretreatment with PEG, serum prolactin levels were within the normal range. Therefore, based on the negative results of pituitary MRI, we believe that the patient's pseudo elevation of serum prolactin is caused by interference from macroprolactin.</p><p><strong>Conclusions: </strong>When there is an abnormal increase in serum prolactin but no evidence of related clinical symptoms, staff should consider the possibility of macroprolactin interfering with prolactin testing, take corresponding corrective measures, and avoid unnecessary examinations and treatments for patients.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleural Fluid Amino Acids Contribute to Distinguishing Tuberculosis, Malignant, and Parapneumonic Pleural Effusion Patients.","authors":"Jiangqing Yu, Tanggui Feng, Shengbin Liu, Tongshun Xie, Tiancheng Shi","doi":"10.7754/Clin.Lab.2024.240757","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240757","url":null,"abstract":"<p><strong>Background: </strong>Differential diagnosis of pleural effusions poses a considerable challenge in clinical practice. In this study, we explored biomarkers in pleural fluid for distinguishing tuberculosis, malignant, and parapneumonic pleural effusion patients.</p><p><strong>Methods: </strong>A total of 166 patients with exudative pleural effusion were collected, including 86 patients with tuberculosis pleural effusion (TPE), 52 patients with malignant pleural effusion (MPE), and 28 patients with parapneumonic effusion (PE). Hydrogen nuclear magnetic resonance (1HNMR) based metabolomics and ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS) were employed to analyze the pleural fluid.</p><p><strong>Results: </strong>There were significant differences in the levels of bile acid, leucine, citrulline, pyruvate, betaine, and taurine in the pleural effusion of the three groups (p < 0.05) by 1HNMR, indicating significant changes in amino acid metabolism among groups. Twelve amino acids in pleural effusion were further quantitatively determined by UPLC-MS. The results showed that arginine could be used to distinguish MPE from PE and TPE with the area under the ROC curve (AUC) value of 0.87, and lysine could distinguish PE from TPE with the AUC value of 0.74.</p><p><strong>Conclusions: </strong>Pleural fluid arginine could be used as a potential biomarker for distinguishing MPE from PE and TPE, and lysine could be used for distinguishing PE from TPE, which is worthy of further study.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of In Vitro Activity of Ceftazidime-Avibactam and Colistin with VITEK 2 AST-XN21.","authors":"Nilgun Kansak, Neslihan Arici, Riza Adaleti, Sebahat Aksaray, Nevriye Gonullu","doi":"10.7754/Clin.Lab.2024.240905","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240905","url":null,"abstract":"<p><strong>Background: </strong>Ceftazidime-avibactam and colistin are antibiotics of new and regaining importance used for the treatment of infections caused by multidrug-resistant organisms. The broth microdilution (BMD) test recommended for detecting colistin sensitivity is labor-intensive and difficult to perform under routine conditions. There is a need for alternative methods that produce fast and reliable results in routine laboratory studies. In our study, we aimed to compare the results obtained with the newly introduced Vitek-2 AST-XN21 cards, which allow the detection of ceftazidime-avibactam and colistin sensitivity simultaneously, with the ceftazidime-avibactam disk diffusion and Diagnostics MIC COL results that we use routinely.</p><p><strong>Methods: </strong>A total of 60 isolates, including 51 carbapenem-resistant Klebsiella pneumoniae and three each of Echerichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii isolated from various clinical samples, were included in the study. Identification of strains and antibiotic susceptibility tests were performed with MALDI-TOF MS and Vitek-2 (bioMerieux, France) system. Ceftazidime-avibactam sensitivity was determined by disk (10 - 4 µg) diffusion method. Colistin minimum inhibitory concentration (MIC) was studied with the Diagnostics MIC COL kit at a dilution range of 0.25 - 16 mg/L. Susceptibility results were evaluated according to EUCAST V.14.0 recommendations. The performance of the Vitek-2 AST-XN21 kit was evaluated according to ISO criteria.</p><p><strong>Results: </strong>By disk diffusion method, 31 of 57 isolates (54.4%) were found resistant to ceftazidime-avibactam. With the Diagnostics MIC COL kit, 31 of 60 isolates (51.7%) were detected as colistin resistant. Ceftazidime-avibactam and colistin sensitivity results determined by the AST-XN21 card were found to be categorically compatible with the ceftazidime-avibactam disk diffusion and colistin BMD results (100%); no major or very major errors were detected. Since the colistin BMD MIC reading limits of the Diagnostics MIC COL and AST-XN21 tests are different (16 mg/L; 8 mg/L), the essential agreement for isolates (n = 31) with MIC values < 0.25 mg/L and > 8 mg/L were not compared. The essential agreement for the evaluated 29 isolates was found to be 96.5%.</p><p><strong>Conclusions: </strong>Our results showed that the performance of the Vitek-2 AST-XN21 test was good. According to our data, we believe that the Vitek-2 AST-XN21 test can be used in routine laboratories for the detection of ceftazidime-avibactam and colistin resistance.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Different Relevance of Remnant Cholesterol with Gender and Age Compared to Common Cholesterol.","authors":"Fei Cheng, Haiyi Guo, Lei Sun, Linna Xiao, Di Fan, Chenhao Zhang, Jie Guo","doi":"10.7754/Clin.Lab.2024.240826","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240826","url":null,"abstract":"<p><strong>Background: </strong>Atherosclerotic cardiovascular disease (ASCVD) is one of the biggest threats to public health worldwide. It shows a trend of high incidence rate and younger age. Abnormal lipid metabolism is the main risk factor. The residual risk of remnant cholesterol (RC) has been studied recently. However, the distribution of remnant cholesterol (RC) with gender and age is rarely reported.</p><p><strong>Methods: </strong>Data were collected from the laboratory information system from September 1, 2022, through March 31, 2023. TC, HDL-C, and LDL-C were measured using a Roche cobas 8000 c701 automatic biochemical analyzer. RC was calculated using Sampson formula. The median, 75th percentile, and 25th percentile were used to describe the distributions and were presented using scatter plots of relevant analytes among total subjects, normal cholesterol, and abnormal cholesterol subjects. Gender and age differences were compared using SPSS.25 soft-ware for RC.</p><p><strong>Results: </strong>A total of 20,265 records of individuals were enrolled in this study after ineligible records were removed. The TC, LDL-C, and non-HDL-C concentrations showed peaks in total subjects and females aged 51 - 60 years. Meanwhile the peaks in males were found in males aged 31 - 40 years. The HDL-C concentration showed peaks in females aged 21 - 30 years and in males aged 2 - 20 years. There were lower RC concentrations in females aged 21 - 40 years and in males aged 71 - 90 years. The differences were significant between different genders and different ages.</p><p><strong>Conclusions: </strong>The distribution trend of RC in the population was different from that of the common cholesterol, which means the management of RC in the population should be stratified by gender and age.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}