Clinical laboratory最新文献

{"title":"The Expression of KAP1 and Its Clinical Significance in Newly Diagnosed Acute Myeloid Leukemia Patients.","authors":"Li-Na Liang, Meng-Zhu Ge, Yan-Li Yang","doi":"10.7754/Clin.Lab.2024.241130","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241130","url":null,"abstract":"<p><strong>Background: </strong>The expression level of Kruppel-associated box (KRAB)-associated protein-1 (KAP1) was assessed in patients with acute myeloid leukemia (AML), and its expression and prognostic significance were explored in newly diagnosed AML patients.</p><p><strong>Methods: </strong>Bone marrow samples were collected from 100 newly diagnosed AML patients (experimental group) and 20 healthy volunteers (control group). Clinical data of the AML patients were collected. The expression levels of KAP1 in bone marrow from both groups were measured using real-time fluorescence quantitative PCR (qRT-PCR). The relationship between KAP1 expression and clinical-pathological features, as well as prognosis in newly diagnosed AML patients, was analyzed. Kaplan-Meier curves were used to assess the effect of KAP1 expression on overall survival (OS) in AML patients, and the Cox regression model was applied to identify prognostic factors affecting patient outcomes.</p><p><strong>Results: </strong>Compared with the control group, KAP1 expression was significantly elevated in newly diagnosed AML patients (p < 0.05). Statistically significant differences were found between the high and low KAP1 expression groups in terms of age, high bone marrow blast cell count, and poor treatment response (p < 0.05). The OS in the high KAP1 expression group was significantly shorter than that in the low KAP1 expression group (p < 0.05). High KAP1 expression was identified as an independent risk factor for poor prognosis in AML.</p><p><strong>Conclusions: </strong>High KAP1 expression in AML patients correlates with unfavorable clinicopathological features and poor prognosis. It may serve as a prognostic indicator and potential therapeutic target in AML.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Link between Type 2 Diabetes and Epstein-Barr Virus: a Machine Learning and Mendelian Randomization.","authors":"Ning Song, Bei Jiang, Qingqing Bi, Fenghai Liu, Long Zhao","doi":"10.7754/Clin.Lab.2025.250137","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250137","url":null,"abstract":"<p><strong>Background: </strong>Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that is known to cause infectious mononucleosis and is associated with several autoimmune diseases and cancers through immune system dysregulation and chronic inflammatory mechanisms.</p><p><strong>Methods: </strong>The authors collected 3,624 samples containing EBV DNA test results and 1,872 samples containing EBV antibody test results from Qingdao Central Hospital. The machine learning model was trained using CatBoost classifier, and the data imbalance problem was dealt with using SMOTE method. For the EBV antibody data, normality was assessed using the Shapiro-Wilk test, and the Welch's t-test and Mann-Whitney U test were used to compare the differences between the type 2 diabetic and non-diabetic groups. Finally, the causal relationship between EBV antibodies and type 2 diabetes was verified by Mendelian randomization.</p><p><strong>Results: </strong>Machine learning modeling showed 70% prediction accuracy of EBV DNA in immunoendocrine diseases. Type 2 diabetic patients had significantly higher VCA IgG levels than non-diabetic patients (p < 0.05). Mendelian randomization analysis further validated the positive correlation between type 2 diabetes mellitus and VCA IgG levels (p < 0.05), suggesting that patients with type 2 diabetes mellitus may have higher VCA IgG levels.</p><p><strong>Conclusions: </strong>This study found a significant association between type 2 diabetes and EBV VCA IgG levels, emphasizing the potential relationship between EBV infection and diabetes. Machine learning and Mendelian randomization methods played an important role in determining disease associations, which provides new ideas for future clinical management and prevention strategies.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agarose Gel Electrophoresis versus Capillary Zone Electrophoresis: a Comparative Analysis for Monoclonal Protein Detection in Blood.","authors":"Mael Padelli, Cyril Leven, Edouard Chichmanian","doi":"10.7754/Clin.Lab.2024.241139","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241139","url":null,"abstract":"<p><strong>Background: </strong>Serum protein electrophoresis (SPE) is the first-line test for the diagnosis of monoclonal gammopathies. While agarose gel electrophoresis (AGE) has been the traditional gold standard, capillary zone electrophoresis (CZE) offers potential advantages in terms of resolution and sensitivity. This study aimed to compare the diagnostic accuracy of these two techniques in detecting monoclonal gammopathies.</p><p><strong>Methods: </strong>A retrospective study was conducted on 10,909 adult patients without a prior diagnosis of monoclonal gammopathy who underwent SPE between 2017 and 2019. All patients received both AGE using the HYDRASIS 2 SCAN (Sebia, Issy-les-Moulineaux, France) and CZE using the CAPILLARYS 2 instrument (Sebia). Additional laboratory tests, including immunofixation electrophoresis and free light chain quantification in serum and urine, were performed. The final diagnosis was established one year after the initial diagnostic workup.</p><p><strong>Results: </strong>The sensitivity of AGE was 87.6% (95% confidence interval (CI: 86.9 - 88.2), with a specificity of 99.5%. In contrast, CZE demonstrated a sensitivity of 94.2% (CI: 93.8 - 94.6) and a specificity of 98.9%.</p><p><strong>Conclusions: </strong>CZE is a valuable tool for the diagnosis of monoclonal gammopathies, offering improved sensitivity over AGE. However, CZE may struggle to detect certain monoclonal immunoglobulins due to their insolubility in the CZE buffer, leading to precipitation and undetected results on electrophoretic tracings, even at high serum levels. SPE should be used in conjunction with complementary tests to ensure comprehensive detection of monoclonal immunoglobulins.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical Verification and Method Comparison of the Maglumi X8 for Thyroid Function Tests.","authors":"Levent Deniz, Meltem Yardim, Hale Aral","doi":"10.7754/Clin.Lab.2024.241017","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241017","url":null,"abstract":"<p><strong>Background: </strong>When transitioning to new analytical platforms, laboratories must assess the analytical performances of their methods. This study aimed to verify the precision and trueness of the Maglumi X8 device for thyroid-stimulating hormone (TSH) and free thyroxine (FT4) tests and to compare its performance with that of the Advia Centaur XP system previously used in our laboratory.</p><p><strong>Methods: </strong>Precision and trueness verifications for TSH and FT4 were performed using three levels of Bio-Rad Quality Control (QC) materials following the CLSI EP15-A3 guidelines. Each day consisted of one run with five replicates, resulting in 25 analyses performed using three levels of QC material over five days. Passing-Bablok regression and Bland-Altman analyses were performed for method comparison analysis, following the CLSI EP09c guidelines.</p><p><strong>Results: </strong>The repeatability coefficients of variation (CVs) of TSH for levels 1, 2, and 3 were 2.170, 1.945, and 2.567%, respectively, whereas the within-laboratory (WL) CVs were 2.720, 2.786, and 2.609%, respectively. The repeatability CVs of FT4 for levels 1, 2, and 3 were 3.262, 1.326, and 0.696%, respectively, whereas the WL CVs were 4.848, 4.309, and 4.879%, respectively. The bias or overall mean values obtained in the study for TSH and FT4 levels were within the verification targets. TSH levels were found to be lower on Maglumi X8 [1.770 (1.190 to 2.790)] than Centaur XP [1.975 (1.185 to 3.315)]. FT4 levels were found to be higher on Maglumi X8 [1.305 (1.200 to 1.450)] than Centaur XP [1.210 (1.090 to 1.460)]. The bias between the two methods obtained from the Bland-Altman analysis for TSH and FT4 was -3.76% and 6.68%, respectively. Although the calculated bias for TSH fell within the desirable targets based on biological variation, FT4 did not meet these targets.</p><p><strong>Conclusions: </strong>The precision and trueness verification results for TSH and FT4 demonstrated acceptable performance under the CLSI EP15-A3. TSH results between the two analyzers were consistent and can be transferred; FT4 results from Maglumi X8 require careful interpretation and may need harmonization and standardization due to the observed bias.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T-Acute Lymphoblastic Leukemia/Lymphoma Manifesting as Acute Renal Failure.","authors":"Tianting Ma, Zekang Li, Han Zhang, Xuekong Li","doi":"10.7754/Clin.Lab.2024.241053","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241053","url":null,"abstract":"<p><strong>Background: </strong>T-acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) is a type of cancer that originates from immature blood cells committed to developing into T-cells. These cancerous cells multiply uncontrollably and can lead to the development of leukemia or lymphoma.</p><p><strong>Methods: </strong>We describe a rare case of a 13-year-old male patient who presented with acute renal failure as the first manifestation of acute lymphoblastic leukemia/lymphoma.</p><p><strong>Results: </strong>The patient was ultimately diagnosed with T-ALL/LBL based on a comprehensive diagnosis of bone marrow examination and biopsies of lymph nodes and kidneys.</p><p><strong>Conclusions: </strong>It is uncommon for acute renal failure to be an initial indication of T-ALL/LBL, and a comprehensive diagnosis involving bone marrow and histopathology examinations is crucial for its accurate diagnosis.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombocytopenia after Long-Term Use of Low-Dose Methimazole.","authors":"Işılay Kalan-Sarı, Püsem Patır","doi":"10.7754/Clin.Lab.2024.241122","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241122","url":null,"abstract":"<p><strong>Background: </strong>Methimazole (MMI) is an antithyroid drug and can cause hematologic toxicities. Isolated thrombocytopenia due to MMI has been reported very rarely. Here we present a patient with isolated thrombocytopenia that developed as a result of long-term treatment with low-dose MMI.</p><p><strong>Methods: </strong>A patient with hyperthyroidism who had been taking low-dose MMI for 8 years was referred to our clinic with thrombocytopenia. His platelet count was 55 x 103/mm3. He had no leukopenia. The patient was euthyroid, no other etiology for the thrombocytopenia was identified and MMI was discontinued.</p><p><strong>Results: </strong>The patient's platelet count increased after discontinuation of MMI. 3 weeks after discontinuation of MMI, his platelet count was 112 x 103/mm3. Drug-induced thrombocytopenia was assumed as no other etiology was detected and platelet count increased after drug discontinuation.</p><p><strong>Conclusions: </strong>Although MMI has been reported to cause thrombocytopenia and bleeding, isolated thrombocytopenia due to MMI is quite rare in the literature. This case shows the development of thrombocytopenia in a patient treated with low-dose MMI. Since the patient was euthyroid and this side effect occurred after long-term use of low-dose MMI, it can be assumed that it is a direct toxicity due to dose accumulation of the drug over years or due to immunological mechanisms.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome of a Carbapenem Resistant Acinetobacter baumannii Isolate of a new Sequence Type ST1724 from Saudi Arabia.","authors":"Ahmed M Tolah, Muhammad Yasir, Asad Karim, Asad M Karim, Hani A Shukri, Esam I Azhar","doi":"10.7754/Clin.Lab.2024.240926","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240926","url":null,"abstract":"<p><strong>Background: </strong>The World Health Organization has classified carbapenem-resistant Acinetobacter baumannii as a pathogen of critical priority that poses a serious threat to human health. We report a draft genome sequence of colistin and carbapenem-resistant A. baumannii strain AB134 of a new sequence type ST1724.</p><p><strong>Methods: </strong>A. baumannii strain AB34 was isolated from a tracheal aspirate specimen from a patient diagnosed with atherosclerotic disease and treated at a hospital in Saudi Arabia. Antimicrobial susceptibility was determined via microdilution using a VITEK 2 system. Genome sequencing was performed using a HiSeq 2500 platform (Illumina Inc., USA).</p><p><strong>Results: </strong>A. baumannii strain AB134 was classified as a new sequence type (ST1724) comprised of 3,763 predicted genes and a guanine-cytosine content of 38.8%. The isolate was phenotypically resistant to 16 clinically important antibiotics, and 33 antimicrobial resistance genes were detected, including the beta-lactamase genes of blaOXA-23, blaOXA-66, blaADC-25, and blaTEM-1D. It carries the colistin resistance gene lpsB. In addition, 49 genes associated with virulence factors (biofilm formation, adherence, quorum sensing, iron uptake, and two-component system), and seven insertion sequences were detected in the AB134 genome.</p><p><strong>Conclusions: </strong>This report presents the first draft genome of ST1724 of carbapenem-resistant and extensively drug-resistant A. baumannii. The findings facilitate further understanding of the genomics of this pathogen, which is a leading cause of healthcare-associated infections worldwide.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Systemic Sclerosis with Topo I Positivity and Anti-Topoisomerase I (Scl-70) Antibody Negativity.","authors":"Li-Qin He, Ke-Jie Xie, Hong-Gang Sun","doi":"10.7754/Clin.Lab.2024.241124","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241124","url":null,"abstract":"<p><strong>Background: </strong>Systemic sclerosis is clinically heterogeneous, presenting challenges in diagnosis and treatment. ANA testing, especially positivity for the Topo I nuclear pattern, is commonly part of the diagnostic process for systemic sclerosis as it aids in identifying the presence of the disease. Additionally, anti-Scl-70 antibody is a specific serological marker for systemic sclerosis, positively correlating with disease severity and activity. This report explores the clinical characteristics and treatment strategies of patients with systemic sclerosis who are Topo I nuclear pat-tern positive and anti-Scl-70 antibody negative.</p><p><strong>Methods: </strong>Antinuclear antibodies (ANA) were detected using indirect immunofluorescence (IIF), and autoantibodies were detected using immunoblotting. Patients with IIF positivity and immunoblotting negativity for anti-Scl-70 antibody were analyzed.</p><p><strong>Results: </strong>The patient was clinically diagnosed with systemic sclerosis. Laboratory tests showed ANA Topo I nuclear pattern positivity at 1:640, while anti-Scl-70 antibodies were negative.</p><p><strong>Conclusions: </strong>Patients with systemic sclerosis who are anti-Scl-70 antibody negative but Topo I pattern positive may present different clinical manifestations and prognoses, requiring a comprehensive assessment that integrates clinical presentation, laboratory tests, and potential disease progression.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case Study of Granular Acute Lymphoblastic Leukemia Combined with Pleural Infiltration.","authors":"Yong Chen, Zaixiang Xie, Yuan He, Huan Ding","doi":"10.7754/Clin.Lab.2024.241117","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241117","url":null,"abstract":"<p><strong>Background: </strong>Acute B-lymphoblastic leukemia (B-ALL) is a common hematologic malignancy characterized by blasts with a variable amount of cytoplasm, typically ranging from minimal to moderate, and containing few cytoplasmic granules. However, granular acute lymphoblastic leukemia, as a rare subtype, is distinguished by the presence of abundant coarse, purplishred granules within the cytoplasm of the blasts, which can be confused with other diseases in clinical diagnosis.</p><p><strong>Methods: </strong>The patient was examined using bone marrow morphological analysis, flow cytometry, genetic screening, and chromosome karyotype analysis.</p><p><strong>Results: </strong>The case presented with a high number of coarse, purplishred granules in the cytoplasm of the blasts, which morphologically resembles acute myeloid leukemia and basophilic granulocytic leukemia. Through cytochemical and immunophenotypic analyses, we ultimately diagnosed the case as granular acute lymphoblastic leukemia with pleural infiltration.</p><p><strong>Conclusions: </strong>Granular acute lymphoblastic leukemia, as a rare subtype, requires particular attention in clinical diagnosis. Cases with similar morphological features should undergo comprehensive diagnostic workups, including cytochemical and immunophenotypic analyses, to avoid misdiagnosis. This case report provides an important reference for further understanding of granular acute lymphoblastic leukemia.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PGII Higher than PGI: a Case Analysis and Literature Review.","authors":"Hong-Gang Sun, Ke-Jie Xie, Li-Qin He","doi":"10.7754/Clin.Lab.2024.241104","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241104","url":null,"abstract":"<p><strong>Background: </strong>Serum pepsinogen (PG) testing, including PGI and PGII, is widely used for early screening, diagnosis, and prognostic assessment of gastric cancer. PGI mainly reflects the state of the gastric corpus mucosa, while PGII mainly reflects the state of the gastric fundus mucosa. The levels of PGI and PGII can reflect the degree of gastric mucosal atrophy, and when gastric mucosal lesions occur, the content of PGI and PGII in the serum will also change. In gastric cancer screening, serum pepsinogens can be used to judge the patient's condition through changes in PGI, PGII, and the PGI/PGII index, which is considered as \"serological gastroscopy\".</p><p><strong>Methods: </strong>Chemiluminescence assay was used to detect serum pepsinogen I (PGI) and pepsinogen II (PGII) and to explore their clinical value before and after treatment.</p><p><strong>Results: </strong>The PGI was measured at 89.45 ng/mL (reference range 70 - 240 ng/mL), PGII at 505.4 ng/mL (reference range 0 - 13 ng/mL), and PGR PGI/II at 0.18 (reference range greater than 3). The patient underwent endoscopic local surgery and two weeks later, the PGI was measured at 56.53 ng/mL, PGII at 81.58 ng/mL, and PGR PGI/II at 0.69. The PGI and PGII measurement method was Mindray (Shenzhen, China) chemiluminescence assay. The patient's endoscopic biopsy report indicated precancerous gastric lesions.</p><p><strong>Conclusions: </strong>For the 70-year-old male patient mentioned in the document, the test results of PGI and PGII, as well as the PGR value, all suggest the risk of precancerous gastric lesions. After treatment, although PGI and PGII decreased, PGII is still higher than PGI, and PGR has improved, indicating that the patient still has the possibility of cancer development and requires further endoscopic examination and treatment.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}