{"title":"罕见AML-M1伴杯状胚细胞阳性1例。","authors":"Xiuping Xu, Chunxiao He","doi":"10.7754/Clin.Lab.2025.250130","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Acute myeloid leukemia (AML) is a clonal malignant tumor of hematopoietic stem cells. At present, MICM classification is commonly used in the world, in which morphology is the most basic and important. A bone marrow smear can inform clinicians of a variety of disease information, such as the presence of cup-like blast (CLB) cells often indicates AML with mutations in the NPM1 or FLT3-ITD genes.</p><p><strong>Methods: </strong>Blood routine and bone marrow routine tests were used to detect the cell proliferation condition and morphology in peripheral blood and bone marrow of patients.</p><p><strong>Results: </strong>Blood routine of the patient indicated a WBC of 176.33 x 109/L with 80% blasts. The bone marrow routine showed that blasts showed obvious hyperplasia, AML-M1 was considered for morphology. CLB cells are visible, and FLT3-ITD and NPM1 gene mutation detection was recommended.</p><p><strong>Conclusions: </strong>We investigated the association between CLB cells and FLT3-ITD/NPM1 gene mutation, as well as the value of CLB cells in diagnosis and treatment for AML by combining the case and relevant literature.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 7","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Rare Case of AML-M1 with Positive Cup-Like Blast Cell.\",\"authors\":\"Xiuping Xu, Chunxiao He\",\"doi\":\"10.7754/Clin.Lab.2025.250130\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Acute myeloid leukemia (AML) is a clonal malignant tumor of hematopoietic stem cells. At present, MICM classification is commonly used in the world, in which morphology is the most basic and important. A bone marrow smear can inform clinicians of a variety of disease information, such as the presence of cup-like blast (CLB) cells often indicates AML with mutations in the NPM1 or FLT3-ITD genes.</p><p><strong>Methods: </strong>Blood routine and bone marrow routine tests were used to detect the cell proliferation condition and morphology in peripheral blood and bone marrow of patients.</p><p><strong>Results: </strong>Blood routine of the patient indicated a WBC of 176.33 x 109/L with 80% blasts. The bone marrow routine showed that blasts showed obvious hyperplasia, AML-M1 was considered for morphology. CLB cells are visible, and FLT3-ITD and NPM1 gene mutation detection was recommended.</p><p><strong>Conclusions: </strong>We investigated the association between CLB cells and FLT3-ITD/NPM1 gene mutation, as well as the value of CLB cells in diagnosis and treatment for AML by combining the case and relevant literature.</p>\",\"PeriodicalId\":10384,\"journal\":{\"name\":\"Clinical laboratory\",\"volume\":\"71 7\",\"pages\":\"\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical laboratory\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.7754/Clin.Lab.2025.250130\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2025.250130","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
A Rare Case of AML-M1 with Positive Cup-Like Blast Cell.
Background: Acute myeloid leukemia (AML) is a clonal malignant tumor of hematopoietic stem cells. At present, MICM classification is commonly used in the world, in which morphology is the most basic and important. A bone marrow smear can inform clinicians of a variety of disease information, such as the presence of cup-like blast (CLB) cells often indicates AML with mutations in the NPM1 or FLT3-ITD genes.
Methods: Blood routine and bone marrow routine tests were used to detect the cell proliferation condition and morphology in peripheral blood and bone marrow of patients.
Results: Blood routine of the patient indicated a WBC of 176.33 x 109/L with 80% blasts. The bone marrow routine showed that blasts showed obvious hyperplasia, AML-M1 was considered for morphology. CLB cells are visible, and FLT3-ITD and NPM1 gene mutation detection was recommended.
Conclusions: We investigated the association between CLB cells and FLT3-ITD/NPM1 gene mutation, as well as the value of CLB cells in diagnosis and treatment for AML by combining the case and relevant literature.
期刊介绍：
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
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