Immune Checkpoint Inhibitor-Associated Colitis with Fever as the First Symptom.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-07-01 DOI:10.7754/Clin.Lab.2025.241251

Jingshan Bai, Xiaoning Zhang, Wanyang Xu, Tongtong Cui, Wenrui Li, Kunyang Li, Yi Chang

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Abstract

Background: In recent years, the application of immunotherapeutic agents in the treatment of non-small cell lung cancer has advanced the current treatment landscape. However, side effects associated with immunotherapy should not be underestimated, as these effects can be life-threatening once they occur. In this article, we report a case of immune checkpoint inhibitor-related colitis presenting with fever as the initial symptom.

Methods: Fibercolonoscopy, fiberbronchoscope.

Results: In the case of this patient, fever initially developed after the administration of immune checkpoint inhibitors (ICIs), followed by severe diarrhea. The diagnosis of immune checkpoint inhibitor-related colitis was confirmed through fiber colonoscopy, and the patient's condition improved following treatment with glucocorticoids.

Conclusions: For patients with advanced squamous cell lung cancer undergoing ICIs therapy, the early completion of an endoscopic evaluation to assess the severity of gastrointestinal symptoms, coupled with prompt initiation of steroid treatment, is crucial to improving outcomes.

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以发热为首发症状的免疫检查点抑制相关性结肠炎

背景：近年来，免疫治疗剂在非小细胞肺癌治疗中的应用，推动了当前的治疗前景。然而，与免疫治疗相关的副作用不应被低估，因为这些副作用一旦发生可能危及生命。在这篇文章中，我们报告了一例免疫检查点抑制剂相关性结肠炎的首发症状为发烧。方法：纤维结肠镜、纤维支气管镜。结果：在该病例中，在给予免疫检查点抑制剂（ICIs）后最初出现发烧，随后出现严重腹泻。经纤维结肠镜检查确诊为免疫检查点抑制剂相关性结肠炎，患者经糖皮质激素治疗后病情好转。结论：对于接受ICIs治疗的晚期鳞状细胞肺癌患者，尽早完成内镜评估以评估胃肠道症状的严重程度，并及时开始类固醇治疗，对于改善预后至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.