Clinical laboratory最新文献

{"title":"A Case of Salmonella Enteritis Infection in the Lumbar Spine.","authors":"Jiaqi Liu, Yun Xing","doi":"10.7754/Clin.Lab.2024.241203","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241203","url":null,"abstract":"<p><strong>Background: </strong>In March 2024, our hospital confirmed a case of salmonella enteritis infection in the lumbar spine. The patient was admitted due to \"back pain for 2 years and worsened for 3 months\". Two years ago, the patient underwent lumbar spine fusion surgery at a local hospital due to lumbar spine disc herniation. Afterwards, the patient experienced repeated swelling and pain in the lower back. After rehabilitation therapy, the symptoms of back pain did not show significant relief. Three months ago, the patient's symptoms of lower back pain significantly worsened. Due to \"lower back pain and lower limb pain\", the patient was hospitalized in a local hospital for treatment. During hospitalization, fever, wheezing, and difficulty breathing occurred. The diagnosis was considered lumbar spine infection, and the patient was immediately transferred to the ICU for treatment, including tracheal intubation, invasive ventilator assisted ventilation. After treatment, the patient's breathing difficulties improved compared to before, but there was no significant relief in the symptoms of lower back pain. The patient sought further diagnosis and treatment at our hospital. The patient has had a history of tuberculosis for more than 10 years and has recovered; a history of emphysema for more than 10 years; history of lumbar spine fusion surgery for 2 years, with no history of other diseases.</p><p><strong>Methods: </strong>Magnetic resonance imaging (spinal), CT (spinal), posterior lumbar spine 2 - 3 lesion clearance surgery under general anesthesia, pathological biopsy, bacterial culture, bacterial smear of excited lumbar spine tissue, NGS of lumbar spine tissue, and other auxiliary examinations: urine routine, blood routine, liver function, renal function, coagulation function, blood lipids, electrocardiogram.</p><p><strong>Results: </strong>Magnetic resonance imaging and CT (spine): 1. Postoperative changes in the lumbar spine 3 - 5 vertebral body. 2. Degenerative changes in the lumbar spine. 3. Compression changes in the 9 - 12 vertebrae of the chest, with a compression degree of approximately 1/4 to 1/3. Pathological examination results: Degenerated fibrocartilage and a small amount of dead bone, extensive infiltration of inflammatory cells in fibrous connective tissue, partial necrosis, and local granulation tissue formation. Blood routine +CRP (venous blood): white blood cells 10.81 x 109/L, neutrophil percentage 77.8%, whole blood high-sensitivity C-reactive protein 29.56 mg/L, erythrocyte sedimentation rate measurement (ESR): erythrocyte sedimentation rate 87.0 mm/hour, coagulation function: activated partial thromboplastin time 27.1 second, thrombin time measurement 14.2 second, fibrinogen detection 4.64 g/L, D-dimer measurement 3151.51DDU µg/L, inflammatory markers: procalcitonin 0.094 ng/mL, interleukin-6 26.73 pg/mL. Liver function test: total protein 49.9 g/L, albumin 25.7 g/L. Renal function test: creatinine 40.70 µmol/L. Lumba","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of a Reference Interval for Urinary Protein Markers for the Healthy Population in East China.","authors":"Chen Xiaoling, Wu Jinbiao, Zhao Ying","doi":"10.7754/Clin.Lab.2024.241033","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241033","url":null,"abstract":"<p><strong>Background: </strong>The importance of the ratio of creatinine to urinary microalbumin, low-molecular weight protein, and urinary enzymes as urinary markers in patients with chronic kidney disease is widely recognized. However, to date, no reference intervals (RIs) have been established for these markers in East China. The present study aimed to investigate and establish RIs for urinary protein markers in East China's healthy population using the laboratory information system database.</p><p><strong>Methods: </strong>A total of 6,786 healthy individuals were subjected to periodic health examinations in the First Affiliated Hospital of Zhejiang University School of Medicine from January 2022 through December 2023 and were thus included in the study. We used Box-Cox conversion combined with Tukey's method to normalize the data and eliminate outliers. The Mann-Whitney U test was performed to decide on groupings, and a nonparametric method was used to estimate the RI. The upper limit of the RI was set at the 95th percentile of the urinary protein markers.</p><p><strong>Results: </strong>The urinary protein markers were significantly different between males and females, except for retinol binding protein (RBP). The urinary levels of immunoglobulin G (IgG), α1-microglobulin (α1-MG) (female group), transferrin (TRF), N-acetyl-β-D-glucosidase (NAG), RBP/creatinine (Cr), IgG/Cr, mAlb/Cr, TRF/Cr, α1-MG/Cr, and NAG/Cr increased with age. Significant age-related differences in urinary protein marker levels were observed, except for RBP, mALB, and α1-MG (male group). For the significant differences in RIs between age and gender groups, we recommend establishing gender- and age specific RIs for urinary markers.</p><p><strong>Conclusions: </strong>Our study established age- and gender-specific RIs for six urinary protein markers and their ratios to creatinine based on healthy individuals from East China, which was of great significance for kidney disease screening, treatment, and recurrence monitoring.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Plasma/Serum Electrolyte and Metabolite Testing on Blood Gas ABL90 and Core Laboratory Cobas c501 Analyzers.","authors":"Vera Y Chen, Yu Chen","doi":"10.7754/Clin.Lab.2024.241047","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241047","url":null,"abstract":"<p><strong>Background: </strong>Core medical laboratory chemistry analyzers typically use plasma or serum for electrolytes (sodium, potassium, chloride) and metabolites (glucose, lactate, total carbon dioxide) testing, whereas blood gas analyzers use whole blood. The aim of this study was to compare electrolyte and metabolite results in plasma or serum sample type using blood gas analyzer ABL90 with those generated by a core laboratory Cobas c501 analyzer.</p><p><strong>Methods: </strong>One plasma separator tube and one serum separator tube were drawn from 53 apparently healthy individuals and outpatients. All samples were run on Roche Cobas c501 and were then run on Radiometer ABL90 analyzers for sodium (Na+), potassium (K+), chloride (Cl-), glucose (Glu), lactate, and total carbon dioxide (tCO2) parameters. Paired measurements between the ABL90 and Cobas c501 were compared, and their differences were assessed for statistical and clinical significance.</p><p><strong>Results: </strong>Except for serum glucose, to which ABL90 showed no statistical difference (p = 0.226) compared to Cobas c501, ABL90 demonstrated statistical significance (p < 0.05) vs. c501 on all other plasma and serum parameters. However, most parameters on ABL90 differ insignificantly to those on c501, except Na+ and Cl-. ABL90 also demonstrated excellent correlations with c501 in glucose, lactate, K+, and plasma tCO2 (correlation coefficient r ≥ 0.95) and modest correlations in Na+ and Cl- (r between 0.71 - 0.80).</p><p><strong>Conclusions: </strong>ABL90 blood gas analyzer and c501 chemistry analyzer are comparable when comparing metabolite (glucose, lactate, and plasma tCO2) and electrolyte (K+) values on plasma/serum. Na+ and Cl- plasma/serum testing on ABL90 need further research.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Storage Conditions on the Stability of Urinary Biomarkers.","authors":"Chanyuan Zhang, Tiebing Liu, Shanshan Xu, Lijiao Xia, Chunyang Zhu, Haiyuan Zhao, Guowei Jia, Hongjinwen Gao, Xuejing Wang","doi":"10.7754/Clin.Lab.2024.240939","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240939","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the influence of different storage conditions and pH levels on biomarkers in urine.</p><p><strong>Methods: </strong>Urine samples were collected from 20 healthy individuals and 20 patients with kidney disease. The stability of nine proteins with normal and pathological concentrations was investigated under 4 types of storage conditions: 25°C for 8 hours, 4°C for 7 days, -20°C for 12 weeks, and -80°C for 12 months. Ten pH values (4.0 to 8.5) were also tested. Nine biomarkers included U-α1MG, U-Alb, U-Trf, U-IgG, U-NAG, U-NGAL, U-RBP, U-CysC, and U-TP, mostly measured in the laboratory.</p><p><strong>Results: </strong>U-Alb, U-α1MG, U-Trf, U-TP, and U-CysC were relatively stable across four storage conditions. However, the stability of other biomarkers may be impacted by the storage conditions. For instance, U-IgG was unstable at -20°C after eight weeks and -80°C after one month. U-NAG was unstable at 4°C after four days and -20°C for 12 weeks. U-RBP was unstable at -80°C after five months and showed a significant upward trend at -20°C within 12 weeks in the pathological levels. Regarding the impact of the pH levels, the bias of U-α1MG and U-CysC did not exceed ± 10% across the pH range of 5.0 to 7.5. The bias of another 5 biomarkers (U-Alb, U-Trf, U-IgG, U-NGAL, and U-TP) was less than -10% at pH 5.0 to 6.0. U-NAG and U-RBP were unstable, with bias exceeding -10%.</p><p><strong>Conclusions: </strong>U-NAG and U-RBP should not be stored at -20°C. U-IgG could only be stable for a short period under -20°C and -80°C. Urinary pH should be monitored and adjusted if necessary.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring the Upward Trend of Tumor Marker Levels in Breast Cancer Patients after Surgery.","authors":"Gangfeng Li, Yuanfei Jin","doi":"10.7754/Clin.Lab.2024.241133","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241133","url":null,"abstract":"<p><strong>Background: </strong>Tumor markers refer to a class of substances that are characteristic of malignant tumor cells or abnormally produced by malignant tumor cells, and can reflect the occurrence and development of tumors.</p><p><strong>Methods: </strong>We report a case of breast cancer where the level of tumor markers after radical mastectomy has been monitored. The physician questioned the significantly elevated carbohydrate antigen 50 (CA50) results. We use different detection platforms to assess the possibility of false elevation of CA50. We simultaneously use PET-CT and other examinations to identify the cause of elevated CA50.</p><p><strong>Results: </strong>We rechecked the samples with suspicious CA50 results on different testing platforms and found that the results were not significantly different. Reviewing the medical history, it was found that the patient's CA50 level had slightly increased compared to the reference range three months ago, and showed a significant upward trend compared to the previous CA50 level test, but did not receive sufficient attention and corresponding examination and treatment. During this examination, the patient's CA50 level increased by up to 8 times compared to the normal range. The patient underwent whole body PET-CT examination and found liver metastasis of breast cancer.</p><p><strong>Conclusions: </strong>When using tumor markers for dynamic monitoring of breast cancer patients, clinicians should pay special attention to the trend of tumor markers, even if it is only slightly higher than the reference range, they should also take necessary inspection and treatment to avoid further development of the tumor leading to irreparable loss of patients.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Multiple Allergen Simultaneous Tests: Advansure AlloScreen Max 108 and Protia Allergy-Q 128M.","authors":"Chi-Hun Lee, Min-Seung Park, Jee Ah Kim, Suhyeon Moon, Eun Hye Cho, Min-Jung Kwon, Hyosoon Park, Hee-Yeon Woo","doi":"10.7754/Clin.Lab.2024.241127","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241127","url":null,"abstract":"<p><strong>Background: </strong>Multiple allergen simultaneous test (MAST) is a convenient, cost-effective, semi-quantitative immunoassay widely used for allergy screening. However, cross-reactions, such as those caused by IgE against Bet v 1 or cross-reactive carbohydrate determinants, should be considered when interpreting MAST results. This study aimed to compare two MASTs, Advansure AlloScreen Max108 (AlloScreen assay; LG Chem Ltd., Seoul, Korea) and PROTIA Allergy-Q 128M (Allergy-Q assay; ProteomeTech Inc., Seoul, Korea).</p><p><strong>Methods: </strong>A total of 89 serum samples (56 positive and 33 negative) were analyzed through AlloScreen and Allergy-Q assays for 104 common allergens. Discrepant results were confirmed using the ImmunoCAP assay (Phadia AB, Uppsala, Sweden). In addition, concomitant sIgE reactivity to plant-derived food allergens related to Bet v 1 was assessed in birch pollen-positive samples.</p><p><strong>Results: </strong>The total agreement between the two MASTs was 94.4% (kappa = 0.661), and class consistency was 0.878 (p < 0.001). Among the 78 discrepancies assessable by ImmunoCAP, Allergy-Q showed an agreement of 51.3%, while AlloScreen showed 48.7%. In birch pollen-positive samples, Allergy-Q demonstrated a higher positivity for concomitant sIgE reactions to plant-derived food allergens (46.9%) compared to AlloScreen (23.4%).</p><p><strong>Conclusions: </strong>The AlloScreen and Allergy-Q assays showed good overall agreement and class consistency. However, differences were observed in their detection of concomitant sIgE reactivity to plant-derived food allergens in birch pollen-positive samples. Further studies, incorporating clinical symptom evaluation, are needed to establish the clinical utility and reliability of these assays.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Dual Clonal B-Cell Hairy Cell Leukemia: Diagnostic Challenges.","authors":"Zhaoxia Luo, Jinfeng Lai","doi":"10.7754/Clin.Lab.2024.241119","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241119","url":null,"abstract":"<p><strong>Background: </strong>Hairy Cell Leukemia (HCL) is a rare chronic B-cell disorder characterized by cytopenia, splenomegaly, and bone marrow infiltration. A 42-year-old female presented with gingival swelling and bleeding, later diagnosed with HCL involving lymph nodes, liver, and spleen.</p><p><strong>Methods: </strong>The patient underwent blood tests, PET-CT, bone marrow flow cytometry, biopsy, and lymph node as-piration, confirming HCL. Notably, flow cytometry revealed dual clonal B-cell populations, both CD5-negative and CD10-negative. Immunohistochemistry showed positive B-cell markers (CD20, CD23) and BRAF-V600E mu-tation. Cladribine chemotherapy began on April 18, 2022, followed by supportive treatment.</p><p><strong>Results: </strong>Blood tests showed pancytopenia, and PET-CT indicated lymph node, spleen, liver, and bone marrow involvement. Bone marrow biopsy confirmed HCL with fibrosis. The patient experienced bone marrow suppression during chemotherapy and received supportive care, eventually leading to a successful discharge.</p><p><strong>Conclusions: </strong>HCL is a rare B-cell malignancy causing pancytopenia and organ involvement. The identification of dual clonal B-cell populations is crucial for accurate diagnosis. Early diagnosis and cladribine chemotherapy are effective. Immunohistochemical and genetic testing are key for diagnosis and treatment planning.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Characterization of Carbapenem-Resistant NDM-Producing Escherichia Coli from Recurrent Urinary Tract Infection Patients.","authors":"Liang Chen, Zeqiang Xie, Jiyong Jian","doi":"10.7754/Clin.Lab.2024.241040","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241040","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to clarify the microbiological characteristics of carbapenem-resistant Escherichia coli (CRECO) due to New Delhi metallo-β-lactamase (NDM)-producing from recurrent urinary tract infection (RUTI) patients.</p><p><strong>Methods: </strong>CRECO isolates were isolated from the urine of RUTI patients, identified with VITEK 2 compact system, and confirmed by MALDI-TOF MS. Antimicrobial susceptibility testing (AST) was performed with VITEK 2 compact system and Kirby-Bauer (K-B) method. Disk diffusion was used for extended spectrum beta-lactamase (ESBL) test. Phenotypic assays, including modified Hodge test (MHT), EDTA-modified carbapenem inactivation method (eCIM), and modified carbapenem inactivation method (mCIM), were performed to screen the carba-penemase. The antibiotic resistance genes were detected by polymerase chain reaction (PCR). Multilocus sequence typing (MLST) was performed for molecular typing of the strains.</p><p><strong>Results: </strong>Among 63 CRECO strains, 22 (34.9%) strains were NDM-positive, in which NDM-5 accounted for 68.2% (15/22), NDM-1 accounted for 22.7% (5/22), and NDM-3 accounted for 9.1% (2/22). Among the 22 strains, 20 (90.9%) strains were co-carrying ESBLs genes, 12 (54.6%) strains were co-carrying blaCTX and blaTEM, 8 (36.4%) strains were co-carrying blaCTX or blaTEM, and 5 strains were co-carrying AmpC genes. BlaCMY-6 and blaCMY-156 ac-counted for 9.1% (2/22) and blaCMY-42 and blaDHA-1 accounted for 4.5% (1/22). Ten (45.5%) strains were co-carrying quinolone resistance genes. Three (13.6%) strains were co-carrying colistin resistance genes mcr-1. Six (27.3%) strains showed OmpF-expressed loss. Fourteen strains were positive and 8 strains were negative in the MHT, but mCIM and eCIM were both positive; the results of double-disc synergy method for detection of ESBLs were all negative in NDM-positive CRECO strains. The NDM-producing CRECO strains showed high-resistant rate to most antibiotics.</p><p><strong>Conclusions: </strong>The antibiotic resistance mechanisms of NDM-positive CRECO are the coexistence of multiple resistance genes and/or the loss of or lesser expression of OMP. The emergence of mcr-1 gene in CRECO should be paid more attention by clinicians and microbiologists. Further surveillance should be strengthened to study the microbiological characteristics in order to control infection caused by NDM-positive CRECO better.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of β-Thalassemia Carriers based on Matrix Assisted Laser Desorption Ionization Time-Of-Flight Mass Spectrometry.","authors":"Jiantao Zeng, Dan Yang, Ke Nie, Dingbin Liu, Huahong Ye, Tao Dai","doi":"10.7754/Clin.Lab.2024.241034","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241034","url":null,"abstract":"<p><strong>Background: </strong>The traditional analytical methods for β-thalassemia carriers are time-consuming and costly. This study takes advantage of matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) to directly analyze human whole blood samples and established a preliminary method for screening β-thalassemia carriers.</p><p><strong>Methods: </strong>A sample of 3 µL whole blood was diluted 200-fold with distilled water, mixed with sinapic acid, and subjected to MALDI-TOF MS analysis. The efficacy of the method for the screening of β-thalassemia carriers was assessed using the β-thalassemia gene results as the standard.</p><p><strong>Results: </strong>β-thalassemia gene results showed 109 β-thalassemia carriers and 110 normal individuals out of 219 samples. We developed a δ-globin peak slope index that can simply and effectively distinguish β-thalassemia carriers from healthy individuals, the best cutoff value for the slope index was -0.819.</p><p><strong>Conclusions: </strong>MALDI-TOF MS has the potential to be a valuable tool for β-thalassemia carriers screening.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Homoarginine Serum Levels with HPLC Method and Commercial ELISA Assay.","authors":"Dietmar Enko, Andreas Baranyi, Sieglinde Zelzer, Stefan Pilz, Andreas Meinitzer","doi":"10.7754/Clin.Lab.2024.241115","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241115","url":null,"abstract":"","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 5","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}