Clinical laboratory最新文献

{"title":"Changes in Blood Groups of Patients Cared for in a Third Level Hospital in Istanbul Over the Years.","authors":"Kamuran Sanli","doi":"10.7754/Clin.Lab.2024.241030","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241030","url":null,"abstract":"<p><strong>Background: </strong>There has been a large number of immigration to Turkey after 2011, and in the past 13 years, a mixed population has been formed with both the transition to Turkish citizenship and high fertility rates. Along with numerous human migrations, gene trait transfer also occurs. This study aimed to investigate the effects of migration on blood group changes in Turkey by determining the blood group distribution of Turkish citizens living in Turkey, the blood group distribution of foreign nationals coming to Turkey, and the blood group distribution of 0-year-old babies born in the last four years.</p><p><strong>Methods: </strong>Patients whose blood types were checked at our hospital between 2020 and 2024 were included in the study. For each patient, age, gender, citizenship identification numbers, ABO, and Rh blood groups were obtained from medical records. These constituted the study data.</p><p><strong>Results: </strong>Blood group tests were requested for 507,959 patients in our hospital. A total of 49.8% of them were female and 50.2% were male. The mean age was 38.2 ± 19.1 years. Citizens of the Republic of Turkey constituted 92.7% of the blood groups examined, and of these, A, B, AB, and O blood groups were found to be 44.2%, 15.2%, 7.1%, and 33.6%, respectively. Out of the Rh blood groups, 87.5% were Rh positive and 12.3% were Rh negative. Foreign Turkish citizens constituted 6.5% of the examined blood groups, and A, B, AB, and O blood groups were found to be 36.7%, 20.4%, 8.0%, and 34.9%, respectively; 90.2% of Rh blood groups were Rh positive and 9.7% were Rh negative. When the blood groups of babies born between 2020 - 2024 were examined, ABO and Rh blood groups were similar to the general blood group distribution of Turkey, and there was no difference. In addition, among all blood groups, the A2 and A2B rates were found to be 0.01% and 0.005%, and the variant (weak D - Partial D) Rh blood group rate was 0.2%.</p><p><strong>Conclusions: </strong>In this study, the blood groups of foreign nationals who migrated to Turkey and became citizens were found to be statistically, significantly different from the Turkish blood group distribution (p < 0.05). The blood group distribution of babies born in the last four years still reflected the same blood group distribution as the Turkish blood group distribution. Good blood stock management is required to avoid problems in blood supply. In Turkey, which has become a mixed population due to migration, it was thought that these results could be a guide in the supply of blood and blood products needed by patients and that they would also contribute to our country's blood group database and world literature.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and Epidemiological Analysis of Enterococcal Infection from Beijing Teaching Hospital in China, 2010 - 2021.","authors":"Zeqiang Xie, Jiyong Jian, Liang Chen","doi":"10.7754/Clin.Lab.2024.240801","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240801","url":null,"abstract":"<p><strong>Background: </strong>The purpose of the study was to understand the distribution and drug resistance characteristics of Enterococcus so as to provide a reliable basis for clinical use of antibiotics and hospital infection control.</p><p><strong>Methods: </strong>In total, 3,455 strains of Enterococcus, isolated from January 2010 through December 2021, were col-lected. Bruker MALDI biotyper, MICROSCAN walkaway 40 analysis system, and Vitek-2 compact automatic drug sensitivity identification analyzer were used to identify the strains and to test drug sensitivity, and then the results were analyzed. Whonet 5.6 software and SPSS 20.0 were used for data analysis.</p><p><strong>Results: </strong>Among the 3,455 pathogens, the top three were Enterococcus faecium (1,819 strains, 52.65%), Enterococcus faecalis (1,310 strains, 37.92%), and Enterococcus gallinarum (1,203 strains, 3.47%). There were more strains from females (1,808 strains, 52.33%) than from males (1,647 strains, 47.67%). Furthermore, 1,446 strains (41.85%) were isolated from urine samples, and the resistance rates to vancomycin and linezolid were 15.72% and 0.58%, respectively. The resistance rates to penicillin, ampicillin, ciprofloxacin, and levofloxacin were higher than 50%.</p><p><strong>Conclusions: </strong>Enterococcus faecium was the main pathogen of enterococcal infection. Most of them were cultured in urine. The multi-drug resistance was high. Vancomycin-resistant Enterococcus cannot be ignored. Bacterial resistance monitoring provides an important theoretical basis for clinicians to rationally use antibiotics and prevent nosocomial infection.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Sysmex CN-6000 Coagulation Analyzer for Routine and Specialized Coagulation Testing in a Central Laboratory.","authors":"Marija Kocijancic, Janina Roche, Andreas Peter, Sebastian Hörber","doi":"10.7754/Clin.Lab.2024.240922","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240922","url":null,"abstract":"<p><strong>Background: </strong>The Sysmex CN-6000 is a fully automated high-throughput coagulation analyzer. The objective of this study was to evaluate the analytical performance of the analyzer for routine and special coagulation testing in a high-throughput central laboratory of a university hospital.</p><p><strong>Methods: </strong>The within- and between-day precision and accuracy of 29 coagulation parameters were evaluated on the Sysmex CN-6000 using commercially available quality control materials. Patient plasma samples were used to compare results of coagulation measurements between the Sysmex CN-6000 and the Atellica COAG 360, including plasma samples with visual interference. The sample throughputs of both analyzers were compared using plasma samples from healthy volunteers.</p><p><strong>Results: </strong>Within- and between-day coefficients of variation were acceptable for all assays tested on the Sysmex CN-6000. High correlation and good agreement were observed when comparing coagulation results from the Sysmex CN-6000 and the Atellica COAG 360. Samples with visual interference showed comparable coagulation results between the two analyzers, with slightly better detection by the Sysmex CN-6000. The sample throughput per hour for analysis of a panel of five coagulation parameters was higher with the Sysmex CN-6000 compared to the Atellica COAG 360 (247 vs. 193 tests).</p><p><strong>Conclusions: </strong>The Sysmex CN-6000 demonstrated excellent analytical performance for a large number of coagulation parameters and has a high throughput capacity, ideal for the needs of a central laboratory with a high volume of routine and specialized coagulation testing.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METTL7A as a New Candidate Biomarker in Gastric Cancer by Genomics and Data-Independent Acquisition Proteomic Analysis.","authors":"Xinying Li, Xiaojuan Gao, Xiqiu Yu, Zhiwei Zhou, Dan Xiong, Xiuming Zhang","doi":"10.7754/Clin.Lab.2024.240701","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240701","url":null,"abstract":"<p><strong>Background: </strong>Early diagnosis and intervention are essential for improving the prognosis and survival of gastric cancer (GC) patients. However, specific biomarkers for early GC diagnosis are still unavailable.</p><p><strong>Methods: </strong>Data-independent acquisition (DIA) proteomics was employed to identify differentially expressed proteins (DEPs) between GC and adjacent non-tumor tissues. Functional and pathway enrichment analyses were conducted, with subsequent genomic-level validation. Methyltransferase-like 7A (METTL7A) expression in GC versus adjacent tissues was confirmed via tissue microarray analysis. Correlations between METTL7A expression, clinical characteristics, and immune infiltration were also explored. Additionally, co-expressed genes related to METTL7A were analyzed, and gene set variation analysis (GSVA) was performed.</p><p><strong>Results: </strong>DIA proteomics identified 84 DEPs, mainly involved in protein binding and enriched in complement and coagulation pathways. Eight DEPs overlapped with results from the gene expression omnibus (GEO) dataset. METTL7A expression was significantly lower in GC tissues compared to adjacent tissues, confirmed at the genomic level. The cancer genome atlas (TCGA) analysis revealed an area under the receiver operating characteristic (ROC) curve (AUC) of 0.81, with METTL7A expression inversely correlated with age (p = 7.307e-05). Tissue microarray analysis further confirmed reduced METTL7A expression in GC tissues (p = 0.000). METTL7A expression was positively correlated with activated B cells and negatively correlated with activated CD4 T cells.</p><p><strong>Conclusions: </strong>METTL7A is a promising biomarker for early GC diagnosis.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Exercise-Induced Appetite Suppressor N-Lactoyl-Phenylalanine is Linked with Glucose Metabolism.","authors":"Dietmar Enko, Andreas Meinitzer, Christine Dawczynski, Sieglinde Zelzer, Stefan Pilz, Tobias Niedrist, Giovanny R Blanco, Markus Herrmann","doi":"10.7754/Clin.Lab.2024.241016","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241016","url":null,"abstract":"","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Cloning, Sequence Analysis, and 3D Structure Prediction of Alkhumra Hemorrhagic Fever Virus Envelope (E) Protein Gene.","authors":"Nada M Aljuaid, Ahmed M Hassan, Magdah A Ganash, Sayed S Sohrab, Esam I Azhar","doi":"10.7754/Clin.Lab.2024.240831","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240831","url":null,"abstract":"<p><strong>Background: </strong>Alkhumra hemorrhagic fever virus is a newly discovered tick-borne flavivirus that was first identified in 1994 - 1995 in the Alkhumra district of Jeddah, Kingdom of Saudi Arabia. AHFV was detected in a butcher who developed severe hemorrhagic fever. Since then, a total of 604 confirmed cases have been reported in KSA between 1995 - 2020. Currently, there are no routine screenings or treatments available for AHFV.</p><p><strong>Methods: </strong>In this study, the AHFV-E gene was amplified and cloned into a pET-28a (+) vector. The recombinant clones were confirmed through colony PCR, restriction enzyme digestion, and sequencing. The resulting sequence was submitted to GenBank with the accession number OR785376, and the 3D structure of the E protein was determined using Phyre2 and visualized using PayMol software.</p><p><strong>Results: </strong>The sequence identity matrix ranged from 98 - 99% with other isolates from human and animal samples. The phylogenetic tree analysis revealed that AHFV-E gene formed a closed cluster with AHFV isolates. The 3D structure showed a confidence score of 100%, indicating a strong alignment between the target sequence and template.</p><p><strong>Conclusions: </strong>The successful cloning, sequencing, of the E gene in this study holds promise for developing diagnostic assays, screening, of AHFV in the Kingdom of Saudi Arabia.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Oxidative Stress System in Wound Healing After Severe Burns Treated by Meek Micrografting.","authors":"Meng N Chen, Kai W Zhang, Feng L Yuan","doi":"10.7754/Clin.Lab.2024.240816","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240816","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the effects of total antioxidant capacity (T-AOC), superoxide dismu-tase (SOD), and malondialdehyde (MDA) in blood on the postoperative wound healing process of patients with severe burns treated by Meek micrografting.</p><p><strong>Methods: </strong>In total, 154 patients with severe burns who underwent Meek micrografting treatment were selected as the observation group, and 80 healthy people were taken as the control group. General clinical data were collected, and serum T-AOC, SOD, and MDA were analyzed by biochemical analysis. The patients in the observation group were further divided into high T-AOC group (n = 72) and low T-AOC group (n = 82). Postoperative skin graft fusion time, wound healing time, skin graft survival rate, and treatment outcome were compared based on the follow-up results. The patients in the observation group were divided into the group with good wound healing (n = 82) and the group with poor wound healing (n = 72). The relationship between T-AOC, SOD, and MDA and the degree of wound healing was explored by logistic regression analysis and Spearman's correlation analysis, and ROC was plotted to see whether the three had a predictive value for the degree of wound healing after Meek micrografting in patients with severe burns.</p><p><strong>Results: </strong>Serum T-AOC and SOD levels of patients in the observation group were lower than those of the control group, while the MDA level was higher. The skin graft fusion time and wound healing time of patients in the high T-AOC group were shorter than those in the low T-AOC group, and the patients in the high T-AOC group possessed a higher skin graft survival rate and a better therapeutic effect. Elevated serum T-AOC and SOD levels were protective factors for wound healing, whereas elevated MDA level was a risk factor. T-AOC and SOD showed positive correlation with the degree of wound healing, while MDA showed negative correlation. T-AOC, SOD, and MDA levels had a value in predicting the degree of wound healing.</p><p><strong>Conclusions: </strong>In the postoperative wound healing process of severe burn patients treated by Meek micrografting, the degree of wound healing is positively correlated with the levels of T-AOC and SOD and negatively correlated with the level of MDA, and all three have a certain value in predicting the degree of postoperative wound healing.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Plasma α-Synuclein with Cerebral Blood Flow in Patients with Parkinson Disease with Freezing of Gait.","authors":"Yue Ti, FangFang Liu, Yan Ma, QiaoLi Zhu, ChuangZhou Xie, HePing Xia, Jing Chen","doi":"10.7754/Clin.Lab.2024.240756","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240756","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to investigate the relationship between plasma α-synuclein (α-syn) levels and cerebral blood flow in patients with Parkinson disease (PD) with freezing of gait (FOG).</p><p><strong>Methods: </strong>A total of 120 cases of PD patients were selected, and FOG was evaluated according to the FOG questionnaire, with a score of > 3 classified as FOG. Based on the evaluation results, the patients were divided into the PD-FOG group (58 cases) and the PD-NFOG group (62 cases). Cerebral blood flow parameters including cerebral blood flow velocity (CBFV) of the middle cerebral artery, posterior cerebral artery, and basilar artery, phase difference, and gain were monitored, and plasma α-syn levels were measured by enzyme-linked immunosorbent assay. Multifactorial logistic regression analysis was performed to explore the influencing factors of patients with Parkinson's with FOG.</p><p><strong>Results: </strong>FOG occurred in 58 out of 120 cases of PD patients, and the prevalence rate amounted to 48.3%. CBFV of the middle cerebral artery, posterior cerebral artery, and basilar artery were slower, phase difference was smaller, and plasma α-syn level was higher in the PD-FOG group. CBFV of the middle cerebral artery, posterior cerebral artery, and basilar artery, phase difference, and plasma α-syn level were independent influences on FOG in PD patients.</p><p><strong>Conclusions: </strong>Decreased cerebrovascular reserve function and increased plasma α-synuclein level increase the risk of FOG in PD patients.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Oxacillinase Genes in Clinical Multidrug-Resistant Gram-Negative Bacteria.","authors":"Omar B Ahmed, Majid A Bamaga","doi":"10.7754/Clin.Lab.2024.240835","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.240835","url":null,"abstract":"<p><strong>Background: </strong>The emergence of OXA-type beta-lactamases has become a significant threat to public healthcare systems and may lead to prolonged hospital stays and increased mortality rates among affected patients. This study aimed to determine the prevalence of oxacillinase resistance (OXA) genes in multidrug-resistant (MDR) Gram-negative bacteria.</p><p><strong>Methods: </strong>One hundred and six clinical isolates were collected from a stock of Gram-negative isolates and were identified and tested for antibiotic susceptibility and presence of OXA genes using polymerase chain reaction (PCR).</p><p><strong>Results: </strong>The most common detected isolate was Klebsiella pneumoniae (36.8%), followed by Escherichia coli (33%), Pseudomonas aeruginosa (16%), and Acinetobacter baumannii (14.2%). Out of these isolates, 97.4%, 87.2%, 84.6%, and 79.5% were resistant to ampicillin/sulbactam, cefotaxime, ceftazidime, and aztreonam, respectively. PCR results confirmed the presence of one or more OXA genes in 34% of the samples studied. The blaOXA-1 and blaOXA-10 genes were the most highly detected genes, followed by blaOXA-4 and blaOXA-51. The total number of Pseudomonas aeruginosa isolates was confirmed to carry at least one OXA gene (70.6%), whereas Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli were confirmed to carry at least one OXA gene (53.3, 28.2, and 22.9%, respectively). There was a significant association (p < 0.05) between the resistance genes and the type of isolate.</p><p><strong>Conclusions: </strong>Pseudomonas aeruginosa and Acinetobacter baumannii are the most common MDR Gram-negative strains carrying OXA-type beta-lactamase genes. Monitoring of MDR pathogens in Gram-negative bacteria must be continuously undertaken to implement effective measures for infection control and prevention.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Expression and Clinical Significance of CCDC12 in the Initial Diagnosis of Acute Myeloid Leukemia.","authors":"Yu-Qing Han, Yuan-Yuan Tan, Zhibin Xie, Ting-Ting Zhang, Meng-Meng Zhang, Jia-Jia Li","doi":"10.7754/Clin.Lab.2024.241015","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2024.241015","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the expression and clinical significance of coiled-coil domain containing 12 (CCDC12) in the initial diagnosis of acute myeloid leukemia (AML).</p><p><strong>Methods: </strong>A total of 80 AML patients were enrolled as the experimental group, and 20 normal bone marrow specimens were used as the control group. Clinical data of AML patients were collected. The expression level of CCDC12 was measured using real-time fluorescent quantitative PCR (QRT-PCR) in both groups. The relationship between CCDC12 expression and clinical pathological characteristics and prognosis in AML patients was analyzed. Kaplan-Meier curves were used to evaluate the effect of CCDC12 expression on overall survival (OS) in AML patients, while Cox proportional hazards regression analysis was performed to assess prognosis.</p><p><strong>Results: </strong>CCDC12 expression was significantly higher in AML patients compared to the control group (p < 0.05). Patients in the high CCDC12 expression group were older, had higher platelet counts (PLT), poorer treatment responses, and worse prognoses, with statistically significant differences (p < 0.05). The OS in the high CCDC12 expression group was significantly shorter (p < 0.05). High CCDC12 expression was identified as an independent risk factor for poor AML prognosis.</p><p><strong>Conclusions: </strong>CCDC12 is highly expressed in AML patients. Elevated CCDC12 expression is associated with unfavorable clinical pathological characteristics and poor prognosis. This marker may provide a new approach for the diagnosis, monitoring, and targeted therapy of AML.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}