维生素D通过诱导1型糖尿病小鼠肝脏GLUT2和肌肉GLUT4降低血糖水平和HbA1c

IF 0.6 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-09-01 DOI:10.7754/Clin.Lab.2025.250111

Ayman S Alhazmi

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引用次数: 0

摘要

背景：糖尿病仍然是影响全世界个体的主要健康问题。1型糖尿病的发生是由于胰腺β细胞被破坏而导致胰岛素缺乏。这项研究旨在研究维生素D如何降低血糖水平和糖化血红蛋白。方法：本研究将30只Balb/c小鼠分为对照组、未治疗的糖尿病小鼠和服用维生素D的糖尿病小鼠。结果：补充维生素D后，糖尿病小鼠的血糖水平、糖化血红蛋白和血脂水平均有所降低。与未治疗组相比，维生素D治疗的糖尿病小鼠血浆和肝脏GLUT2升高。此外，补充维生素D可诱导血浆和肌肉GLUT4。结论：本研究得出补充维生素D可诱导1型糖尿病小鼠肝脏GLUT2和肌肉GLUT4。肝脏GLUT2和肌肉GLUT4的诱导分别诱导肝脏和骨骼肌对葡萄糖的摄取，从而降低血糖水平。这种机制可能是维生素D降低1型糖尿病小鼠血糖水平和糖化血红蛋白的方式。

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Vitamin D Reduces Blood Glucose Levels and HbA1c by Inducing Hepatic GLUT2 and Muscular GLUT4 in Type 1 Diabetic Mice.

Background: Diabetes mellitus is still a major health problem affecting individuals all over the world. Type 1 diabetes mellitus occurs due to insulin deficiency resulting from the destruction of pancreatic β-cells. This study aimed to investigate how vitamin D reduces blood glucose levels and HbA1c.

Methods: The present study consists of 30 Balb/c mice classified into control, untreated diabetic mice, and diabetic mice treated with vitamin D.

Results: Blood glucose levels, HbA1c, and lipid profiles were decreased in diabetic mice treated with vitamin D supplementation. Plasma and hepatic GLUT2 were increased in diabetic mice treated with vitamin D compared with the untreated diabetic group. Furthermore, vitamin D supplementation induces plasma and muscular GLUT4.

Conclusions: The present study concluded that vitamin D supplementation induces hepatic GLUT2 and muscular GLUT4 in type 1 diabetic mice. Induction of hepatic GLUT2 and muscular GLUT4 induces glucose uptake by the liver and skeletal muscle, respectively, then reduces blood glucose levels. This mechanism may be the way by which vitamin D reduces blood glucose levels and HbA1c in type 1 diabetes mice.

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.