{"title":"原发性皮肤弥漫性大b细胞淋巴瘤，腿型伴免疫性血小板减少症。","authors":"Yingying Sun, Chunyan Liu, Huaquan Wang, Zonghong Shao","doi":"10.7754/Clin.Lab.2025.250156","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is a rare aggressive vari-ant of non-Hodgkin lymphoma (NHL). It is also clinically uncommon for NHL to primarily manifest as immune thrombocytopenia (ITP).</p><p><strong>Methods: </strong>We report a rare case of PCDLBCL-LT, which was misdiagnosed as primary refractory ITP. He achieved a complete remission of ITP by cyclophosphamide. Five months later, the patient developed recurrent erythematous plaques that disseminated to his entire body, accompanied by extracutaneous lesions.</p><p><strong>Results: </strong>Skin biopsy indicated PCDLBCL-LT. After one cycle of CHOP regimen, the patient's condition improved.</p><p><strong>Conclusions: </strong>When encountering refractory ITP, it is important to identify potential underlying causes.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 8","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type with Immune Thrombocytopenia as the First Primary Presentation.\",\"authors\":\"Yingying Sun, Chunyan Liu, Huaquan Wang, Zonghong Shao\",\"doi\":\"10.7754/Clin.Lab.2025.250156\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is a rare aggressive vari-ant of non-Hodgkin lymphoma (NHL). It is also clinically uncommon for NHL to primarily manifest as immune thrombocytopenia (ITP).</p><p><strong>Methods: </strong>We report a rare case of PCDLBCL-LT, which was misdiagnosed as primary refractory ITP. He achieved a complete remission of ITP by cyclophosphamide. Five months later, the patient developed recurrent erythematous plaques that disseminated to his entire body, accompanied by extracutaneous lesions.</p><p><strong>Results: </strong>Skin biopsy indicated PCDLBCL-LT. After one cycle of CHOP regimen, the patient's condition improved.</p><p><strong>Conclusions: </strong>When encountering refractory ITP, it is important to identify potential underlying causes.</p>\",\"PeriodicalId\":10384,\"journal\":{\"name\":\"Clinical laboratory\",\"volume\":\"71 8\",\"pages\":\"\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical laboratory\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.7754/Clin.Lab.2025.250156\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2025.250156","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type with Immune Thrombocytopenia as the First Primary Presentation.
Background: Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is a rare aggressive vari-ant of non-Hodgkin lymphoma (NHL). It is also clinically uncommon for NHL to primarily manifest as immune thrombocytopenia (ITP).
Methods: We report a rare case of PCDLBCL-LT, which was misdiagnosed as primary refractory ITP. He achieved a complete remission of ITP by cyclophosphamide. Five months later, the patient developed recurrent erythematous plaques that disseminated to his entire body, accompanied by extracutaneous lesions.
Results: Skin biopsy indicated PCDLBCL-LT. After one cycle of CHOP regimen, the patient's condition improved.
Conclusions: When encountering refractory ITP, it is important to identify potential underlying causes.
期刊介绍：
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
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