Yanan Ma, Kun Zhang, Sainan Fan, Shun Liu, Jinping Zhang
{"title":"Case Report and Literature Review of 10 Pediatric Cases of Knee Pigmented Villonodular Synovitis.","authors":"Yanan Ma, Kun Zhang, Sainan Fan, Shun Liu, Jinping Zhang","doi":"10.1177/00099228251316428","DOIUrl":"https://doi.org/10.1177/00099228251316428","url":null,"abstract":"<p><strong>Objective: </strong>This study was aimed to analyze 10 pediatric cases of pigmented villonodular synovitis (PVNS) of the knee to elucidate their clinical features, diagnosis, treatments, and prognosis for providing reference regarding its clinical management in children.</p><p><strong>Methods: </strong>A retrospective analysis was made pertaining to the clinical manifestations, magnetic resonance imaging (MRI) findings, pathology, immunohistochemical results, treatment methods, and follow-up outcomes of 10 pediatric PVNS patients of the knee treated from January 2022 to January 2024 at our hospital. They were compared and analyzed with existing literature.</p><p><strong>Results: </strong>(1) All 10 patients had joint swelling with restricted movement, mainly in older female children with male-to-female ratio of 3:7 and average age of 14.1 ± 3.6 years; (2) diagnostic positive rate of MRI was 80%; (3) significant features of PVNS were the appearance of villous and nodular hyperplasia on synovial surface and deposition of brownish-yellow granular hemosiderin. Immunohistochemical staining results were clusterin (synovial cells+), D2-40 (synovial cells+), CD163 (histiocytes+), KP-1 (histiocytes+), CD31 (vascular+), P63 (-), and Ki67 (+, 1%-10%); and (4) all patients underwent arthroscopic surgery with 20% recurrence rate.</p><p><strong>Conclusion: </strong>Pediatric knee PVNS is more prevalent in older female children. The PVNS diagnosis is carried out by MRI, pathology, and immunohistochemistry. Arthroscopic surgery is effective for treating this condition in children.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228251316428"},"PeriodicalIF":1.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electronic Health Record Clinical Decision Support to Close the Human Papillomavirus Vaccination Gender Disparity in Children Aged 9 and 10 Years.","authors":"Carole H Stipelman, Erica Ulibarri, Natalie Wilson, Alexis Olivas, Andie Sanders, Elly Trepman, Kensaku Kawamoto","doi":"10.1177/00099228251324017","DOIUrl":"https://doi.org/10.1177/00099228251324017","url":null,"abstract":"<p><p>We performed a quality improvement project (31 clinics; July 2021 to October 2023) to increase human papillomavirus vaccination initiation frequency and decrease gender disparity in children aged 9 and 10 years. The 11 process changes included electronic health record clinical decision support (CDS) tools for providers, staff, and parents and medical assistant participation. In phase 1 (preparation), initiation frequency was lower in boys (250 of 1688 visits, 15%) than girls (289 of 1549 visits, 19%; <i>P</i> = .003). In phase 2 (CDS alerts; recommended initiation age lowered from 11 to 9 years), initiation frequency was increased and similar between boys (906 of 1847 visits, 49%) and girls (867 of 1740 visits, 50%; <i>P</i> = .64). In phase 3 (patient portal outreach), initiation frequency was increased further for boys and girls. The multifaceted intervention, including CDS tools and lowering the initiation age, was associated with increased initiation frequency and decreased gender disparity.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228251324017"},"PeriodicalIF":1.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed Badran, Amruta Thakkar, Despoina Galetaki, Assia Miller, Vatcharapan Umpaichitra, Renee Bargman, Vivian L Chin
{"title":"Hyperglycemic Emergencies in Minority Children and Adolescents With Diabetes.","authors":"Ahmed Badran, Amruta Thakkar, Despoina Galetaki, Assia Miller, Vatcharapan Umpaichitra, Renee Bargman, Vivian L Chin","doi":"10.1177/00099228251321899","DOIUrl":"https://doi.org/10.1177/00099228251321899","url":null,"abstract":"<p><p>Mixed presentation of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) has been reported in up to 27% of hyperglycemic emergencies. This 15-year retrospective chart review describes clinical features, risk factors, and outcomes among children presenting with hyperglycemic emergencies at our center. Out of 322 patients, 92% were Afro-Caribbean or Black with a mean age of 13.6 years, comprising 266 (83%) with DKA, 52 (16%) mixed DKA-HHS, and rarely with HHS (1%, <i>n</i> = 4). Most (98%) of DKA and DKA-HHS groups had type 1 diabetes mellitus (T1DM). All 4 patients with HHS had type 2 diabetes mellitus (T2DM). Compared with the DKA group, the mixed DKA-HHS group had higher IV fluid rates (<i>P</i> < .0001), 4.3-fold greater odds of acute kidney injury (AKI), and 3.3-fold greater odds of altered mental status (AMS). In the HHS group, 50% presented had AMS and AKI and required higher IV fluids rates (≥2× maintenance). Clinicians should recognize mixed cases of DKA-HHS to minimize complications.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228251321899"},"PeriodicalIF":1.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-03-01Epub Date: 2024-07-26DOI: 10.1177/00099228241265172
Damien Ridremont, Emilie Boujut
{"title":"Burnout Profiles Among French Pediatric Health Care Professionals: A Cluster Analysis.","authors":"Damien Ridremont, Emilie Boujut","doi":"10.1177/00099228241265172","DOIUrl":"10.1177/00099228241265172","url":null,"abstract":"<p><p>The aim of our study was to identify burnout profiles among pediatric nurses and physicians, and their specificities concerning sociodemographic characteristics, occupational stress, stress specific to pediatric caregivers, and coping. Conducted on a sample of 195 French pediatric health care professionals, a cluster analysis showed 2 endpoint profiles (Engagement, Burnout) and 3 intermediate profiles (Overextended, Disengaged, Ineffective). The Burnout profile showed the highest median scores on hours worked per week, occupational stress, stress related to working conditions, and relationships with colleagues and superiors. The Overextended profile reported more stress related to working conditions than did other intermediate profiles. The Disengaged profile showed the second lowest median score on stress related to relationships with colleagues and superiors and less social support-seeking than other profiles. The Ineffective profile used less problem-focused coping than the Engagement and intermediate profiles. Intervention for the well-being of these professionals should focus primarily on improving their working conditions.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"348-359"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-03-01Epub Date: 2024-08-09DOI: 10.1177/00099228241272008
Nora S Alghamdi, Lujain Aletani, Ibrahim Sandokji, Hasan Aljefri, Khalid Alhasan, Mohammad A Shalaby, Jameela A Kari
{"title":"Multisystemic Inflammatory Syndrome in Children (MIS-C) With COVID-19 and Kidney Involvement: Poor Outcomes in a Case Series.","authors":"Nora S Alghamdi, Lujain Aletani, Ibrahim Sandokji, Hasan Aljefri, Khalid Alhasan, Mohammad A Shalaby, Jameela A Kari","doi":"10.1177/00099228241272008","DOIUrl":"10.1177/00099228241272008","url":null,"abstract":"<p><p>Multisystemic inflammatory syndrome (Mis-C) has emerged in May 2020 as a serious complication of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). A total of 6 children presented to tertiary care hospitals with Mis-C, of which 5 (83%) have died during hospitalization. All included patients presented with respiratory symptoms (ranged from mild to severe acute respiratory distress syndrome) and gastrointestinal symptoms. Most of the patients are known to have medical illnesses. Pediatric Risk of Mortality (PRISM) IV score ranged from 3 to 87. All patients developed acidosis and varying stages of acute kidney injury and electrolyte disturbances. All were treated for coagulopathy, thrombocytopenia, bacterial infections as well as antiviral medications (either ritonavir or lopinavir). Most patients had chest X-ray changes either unilateral or bilateral lung changes. Multisystemic inflammatory syndrome is a rare, yet serious complication of SARS-CoV2 infection in children. Multisystem involvement should be anticipated and promptly treated.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"408-415"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-03-01Epub Date: 2024-07-26DOI: 10.1177/00099228241264359
Ying Shelly Qi, Janice A Espinola, Rebecca E Cash, Ashley F Sullivan, Kohei Hasegawa, Carlos A Camargo
{"title":"Traffic Proximity and Recurrent Wheeze Development by Severe Bronchiolitis Status.","authors":"Ying Shelly Qi, Janice A Espinola, Rebecca E Cash, Ashley F Sullivan, Kohei Hasegawa, Carlos A Camargo","doi":"10.1177/00099228241264359","DOIUrl":"10.1177/00099228241264359","url":null,"abstract":"","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"305-309"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-03-01Epub Date: 2024-08-14DOI: 10.1177/00099228241271938
James Hunter Fly, Kelley R Lee, Sandra R Arnold, Bindiya Bagga, Ajay J Talati, Jeremy S Stultz
{"title":"A Comparison of Sequelae After a Practice Change From Vancomycin to Ampicillin Containing Antibiotic Regimens for Necrotizing Enterocolitis.","authors":"James Hunter Fly, Kelley R Lee, Sandra R Arnold, Bindiya Bagga, Ajay J Talati, Jeremy S Stultz","doi":"10.1177/00099228241271938","DOIUrl":"10.1177/00099228241271938","url":null,"abstract":"<p><p>The aim of this study was to compare sequelae and acute kidney injury (AKI) occurrence among patients with necrotizing enterocolitis (NEC) after changing institutional guidelines replacing vancomycin with ampicillin for gram-positive coverage. This was a retrospective, single-center cohort analysis of patients from 2016-2020 (n = 73) with NEC at a surgical neonatal intensive care unit with a high community prevalence of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). Multivariate logistic regression was utilized to assess associations. Twenty-five (34%) patients had at least 1 sequela related to NEC. Ampicillin containing regimens were not associated with any sequelae type or AKI. Postmenstrual age < 29 weeks at diagnosis ([OR] 5.8 [1.2-28.8], <i>P</i> = .03; and receipt of vasopressors [OR] 3.3 [1.1-10.2], <i>P</i> = .04) were independently associated with sequalae. Stage III NEC was independently associated with AKI, OR 10.6 (2-55.6), <i>P</i> = .005. In conclusion, ampicillin-containing regimens are effective for NEC management at our institution despite a high prevalence of MRSA.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"401-407"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-03-01Epub Date: 2024-07-24DOI: 10.1177/00099228241264769
Deepinder Singh, Heidi K Schumacher, Christine A Pellegrino, Breena W Holmes, Rachel L Garfield, Valerie S Harder
{"title":"Assessing Strengths and Well-Being in Primary Care for Adolescents With Mental Health and Substance Use Concerns.","authors":"Deepinder Singh, Heidi K Schumacher, Christine A Pellegrino, Breena W Holmes, Rachel L Garfield, Valerie S Harder","doi":"10.1177/00099228241264769","DOIUrl":"10.1177/00099228241264769","url":null,"abstract":"<p><p>As the COVID-19 pandemic highlighted gaps in meeting adolescent behavioral health needs, primary care providers (PCPs) were a locus for interventions to address adolescent mental health and substance use concerns. Strength-based approaches may support PCP promotion of positive behavioral health in adolescents, but competing priorities or other factors may inhibit their use. We analyzed health record review data from 31 primary care practices to assess utilization of strength-based approaches during the health supervision visit (HSV) for adolescents with and without behavioral health concerns. We found that most had strengths identified (78%) or well-being topics addressed (83%). However, adolescents screening positive for depression were 40% less likely to have strengths identified, whereas those screening positive for anxiety or substance use were 89% and 163%, respectively, more likely to have well-being topics addressed. Primary care providers may need support for integrating strength-based approaches when managing adolescents screening positive for depression.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"340-347"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-03-01Epub Date: 2024-07-26DOI: 10.1177/00099228241265174
Luke Wohlford, Zola Trotter, Mary Connell, Bikash Bhattarai, Siddharth Pandya
{"title":"The Role of Ultrasound in Pediatric Peritonsillar Infection: A Descriptive Analysis.","authors":"Luke Wohlford, Zola Trotter, Mary Connell, Bikash Bhattarai, Siddharth Pandya","doi":"10.1177/00099228241265174","DOIUrl":"10.1177/00099228241265174","url":null,"abstract":"<p><p>In this study, we describe the role of ultrasound in diagnosing pediatric peritonsillar abscesses (PTAs). A retrospective chart review was conducted on 54 children aged 4 to 17 years who had an ultrasound performed for suspected PTA. Based on ultrasound imaging, the patients were classified into 2 groups: PTA-positive (8, 14.8%) and PTA-negative (46, 85.2 %). Trismus was significantly associated with PTA (50% vs. 13%, <i>P</i> = .03). PTA-positive patients were more likely to be given steroids, be admitted, and have extended hospital stays (<i>P</i> = .04, .004, and .002, respectively). The 2 groups had no significant difference in computed tomography (CT) acquisition, surgical intervention, and return visits (<i>P</i> = .92, .17, and .97, respectively). Larger abscesses trended toward surgical treatment (<i>P</i> = .087). Ultrasound is an efficient diagnostic modality for suspected peritonsillar infections in children, with similar clinical outcomes for PTA-positive and PTA-negative groups.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"391-400"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}