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Thanks to Reviewers. 感谢评论者。
IF 0.7 4区 医学
Clinical Pediatrics Pub Date : 2026-02-06 DOI: 10.1177/00099228261418932
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引用次数: 0
The Significance of Combined Detection of Ultrasonography, Pediatric Appendicitis Score, and C-Reactive Protein in the Diagnosis and Pathological Type of Acute Appendicitis in Children. 超声、小儿阑尾炎评分、c反应蛋白联合检测在小儿急性阑尾炎诊断及病理分型中的意义
IF 0.7 4区 医学
Clinical Pediatrics Pub Date : 2026-02-05 DOI: 10.1177/00099228251414473
Hai Hu, Minghui Lin, Wei Li, Jiabo Chen, Cheng Su, Congjun Wang, Yong Li, Jinhong Li, Jianyuan Huang, Yige Luo
{"title":"The Significance of Combined Detection of Ultrasonography, Pediatric Appendicitis Score, and C-Reactive Protein in the Diagnosis and Pathological Type of Acute Appendicitis in Children.","authors":"Hai Hu, Minghui Lin, Wei Li, Jiabo Chen, Cheng Su, Congjun Wang, Yong Li, Jinhong Li, Jianyuan Huang, Yige Luo","doi":"10.1177/00099228251414473","DOIUrl":"https://doi.org/10.1177/00099228251414473","url":null,"abstract":"<p><p>This study investigates the diagnostic efficacy of combining ultrasonography, Pediatric Appendicitis Score (PAS), and C-reactive protein (CRP) for appendicitis in children. We retrospectively analyzed 268 children with acute abdominal pain from 2017 to 2020. Compared with those of any single diagnostic method, the sensitivity and negative predictive value of ultrasonography combined with the pediatric appendicitis score and C-reactive protein were higher in diagnosing acute appendicitis (<i>P</i> < .05). In addition, the sensitivity of ultrasonography combined with C-reactive protein was also greater for diagnosing acute complicated appendicitis (<i>P</i> < .05). Ultrasonography correlated closely with pathological examination findings for appendicitis types (Kappa = 0.888; <i>P</i> < .05). The combined use of ultrasonography, the Pediatric Appendicitis Score, and C-reactive protein enhances the diagnostic accuracy for acute appendicitis. Furthermore, the integration of ultrasonography with C-reactive protein levels may assist in determining the pathological subtype of appendicitis in pediatric patients.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228251414473"},"PeriodicalIF":0.7,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Features and Outcome of Patients With Juvenile Spondyloarthropathy in a Tertiary Hospital in the Philippines. 菲律宾一家三级医院青少年脊椎关节病患者的临床特征和预后
IF 0.7 4区 医学
Clinical Pediatrics Pub Date : 2026-02-04 DOI: 10.1177/00099228261416166
Maria Catherine Joyce D Garcia, Christine B Bernal, Ma Theresa M Collante
{"title":"Clinical Features and Outcome of Patients With Juvenile Spondyloarthropathy in a Tertiary Hospital in the Philippines.","authors":"Maria Catherine Joyce D Garcia, Christine B Bernal, Ma Theresa M Collante","doi":"10.1177/00099228261416166","DOIUrl":"https://doi.org/10.1177/00099228261416166","url":null,"abstract":"<p><strong>Objective: </strong>To describe the clinical presentation at diagnosis and identify risk factors affecting outcomes in patients with juvenile spondyloarthropathy (JSpA).</p><p><strong>Methods: </strong>This retrospective cohort study reviewed records of patients ≤18 years old diagnosed with JSpA (2008-2023) at a pediatric rheumatology clinic, with at least 2 follow-up visits. Remission was defined as (1) on medication (inactive disease ≥6 months) or (2) off medication (inactive disease ≥12 months).</p><p><strong>Results: </strong>Eighty-eight patients were included; 90.9% were male. The mean age of onset was 12.6 years. Peripheral arthritis (77.3%) and enthesitis (39.8%) were common. Sacroiliitis was found in 56.8% at diagnosis. Risk factors associated with sacroiliitis included peripheral arthritis and enthesitis, polyarticular, and hip involvement. Golimumab and etanercept were anti-tumor necrosis factor (TNF) agents frequently used. Clinical remission on and off medication occurred in 33% and 10.2%, respectively.</p><p><strong>Conclusion: </strong>The JSpA in this cohort demonstrated substantial disease burden, with frequent axial and peripheral involvement. Although 43.2% of patients achieved clinical remission, sustained remission off medication was observed in only 10.2%, reflecting the chronic disease course. Early diagnosis and optimized treatment strategies remain essential to improve outcomes.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228261416166"},"PeriodicalIF":0.7,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge Gaps about Screen Exposure Guidelines for Children: A Comparison between mothers and antenatal women. 关于儿童屏幕暴露指南的知识差距：母亲和产前妇女之间的比较。
IF 0.7 4区 医学
Clinical Pediatrics Pub Date : 2026-02-02 DOI: 10.1177/00099228261416169
Ramya Srinivasa Rangan, Rangasamy Krishnamoorthi, Bharath Champakesan, Pradeep Raj Balasubramaniam, Arun Joe Eldow, Gaayathri Pallauh
{"title":"Knowledge Gaps about Screen Exposure Guidelines for Children: A Comparison between mothers and antenatal women.","authors":"Ramya Srinivasa Rangan, Rangasamy Krishnamoorthi, Bharath Champakesan, Pradeep Raj Balasubramaniam, Arun Joe Eldow, Gaayathri Pallauh","doi":"10.1177/00099228261416169","DOIUrl":"https://doi.org/10.1177/00099228261416169","url":null,"abstract":"<p><p>Excess screen time is an emerging hazard to physical and mental well-being of children. This observational cross-sectional study aimed to assess and compare knowledge regarding screen exposure guidelines among 100 mothers and 150 primigravida antenatal women (AW) using a questionnaire framed based on the Indian Academy of Paediatrics parental guidelines. Only 16% of mothers and none among the AW exhibited good knowledge while 48% of mothers and 79.3% of AW demonstrated poor knowledge (<i>p</i> = .01). Mothers showed higher awareness regarding the minimum permissible age to introduce social media platforms, whereas AW exhibited a higher knowledge regarding ill effects of excess screen use on mental health and physical ill effects like obesity. Women from both groups were unaware of the minimal permissible age to introduce screens and the signs of mobile phone addiction. This emphasizes the need for targeted educational intervention for mothers and AW to promote healthy screen habits among children.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228261416169"},"PeriodicalIF":0.7,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Markers of Inflammation and Autoinflammation in Patients With Gaucher Disease: A Single-Center Observational Study. 戈谢病患者炎症和自身炎症标志物：一项单中心观察研究
IF 0.7 4区 医学
Clinical Pediatrics Pub Date : 2026-02-01 Epub Date: 2025-11-21 DOI: 10.1177/00099228251392699
Ayşe Akyüz, Merve Emecen Şanlı, Ekin Özsaydı Aktaşoğlu, Sabire Gökalp, Gürsel Biberoğlu, Aslı İnci, İlyas Okur, Fatih Süheyl Ezgü, Leyla Tümer
{"title":"Markers of Inflammation and Autoinflammation in Patients With Gaucher Disease: A Single-Center Observational Study.","authors":"Ayşe Akyüz, Merve Emecen Şanlı, Ekin Özsaydı Aktaşoğlu, Sabire Gökalp, Gürsel Biberoğlu, Aslı İnci, İlyas Okur, Fatih Süheyl Ezgü, Leyla Tümer","doi":"10.1177/00099228251392699","DOIUrl":"10.1177/00099228251392699","url":null,"abstract":"<p><p>Lysosomal dysfunction in Gaucher disease (GD) leads to inflammation, impaired cellular homeostasis, and disrupted autophagy. The alteration in immune system and the pro-inflammatory state in GD involves in the pathogenesis of the disease with increased levels of cytokines and chemokines. In this study, we aimed to analyze immunological abnormalities and association with HLA alleles in GD patients. Whole blood count, lyso-Gb3 levels, and immunological status were evaluated. A total of 13 patients confirmed to have GD were enrolled in our study. The most common positive antibody was anti-CCP and ANA. Only one patient's HLA profile was predisposing to autoimmune disease but had no clinical findings. None of the patients had symptoms of any related diseases with detected immunological markers. In our study, clinical status of GD or HLA alleles were not associated with positive markers of autoimmune diseases. Further studies are needed to elucidate inflammatory mechanism in GD.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"208-215"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145562848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional Adequacy of Commercially Available Blenderized Tube Feeds in Pediatric Patients. 市售混合管饲在儿科患者中的营养充分性。
IF 0.7 4区 医学
Clinical Pediatrics Pub Date : 2026-02-01 Epub Date: 2025-10-29 DOI: 10.1177/00099228251346040
Amanda C Fifi, Christy Gardner, Aishwarya Palorath
{"title":"Nutritional Adequacy of Commercially Available Blenderized Tube Feeds in Pediatric Patients.","authors":"Amanda C Fifi, Christy Gardner, Aishwarya Palorath","doi":"10.1177/00099228251346040","DOIUrl":"10.1177/00099228251346040","url":null,"abstract":"<p><p>Commercial blenderized formula for children dependent on feeding tubes is becoming increasingly popular. We aimed to determine if these formula provide complete nutrition for children. We compared the nutrient composition of popular commercial blenderized tube feeds to the Dietary Reference Intake (DRI) for age. We analyzed 3 brands: <i>Compleat Pediatric</i>, <i>Real Food Blends</i>, and <i>Nourish</i>. For children consuming a standard volume, all blenderized tube feeds met macronutrient requirements. None met all the fiber and micronutrient requirements with important deficiencies in vitamin D, calcium, B vitamins, and iron. Deficiencies were common in nonfortified feeds like <i>Real Food Blends</i>. There were micronutrients above the tolerable upper limits, especially in young children, in fortified feeds like <i>Compleat</i> and <i>Nourish</i>. No currently available commercial blenderized tube feeds provide complete nutrition for children compared to DRI for age. Physicians should be aware of possible deficiencies and/or toxicities associated with their long-term use.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"158-168"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145387467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does Vitamin D Deficiency Contribute to Growing Pains? A Case-Control Study. 维生素D缺乏会导致成长烦恼吗？病例对照研究。
IF 0.7 4区 医学
Clinical Pediatrics Pub Date : 2026-02-01 Epub Date: 2025-10-06 DOI: 10.1177/00099228251379209
Isha Jain, Abinaya K, Nikita Agarwal, Snehamayee Nayak, Atul Jindal
{"title":"Does Vitamin D Deficiency Contribute to Growing Pains? A Case-Control Study.","authors":"Isha Jain, Abinaya K, Nikita Agarwal, Snehamayee Nayak, Atul Jindal","doi":"10.1177/00099228251379209","DOIUrl":"10.1177/00099228251379209","url":null,"abstract":"<p><p>Growing pains (GPs) are non-inflammatory pain syndromes affecting children aged 4 to 14 years. This case-control study aims to investigate the role of vitamin D deficiency in GP development. The study was conducted for 6 months. Healthy children without a history of GP were recruited as control subjects. Serum concentrations of calcium, phosphate, and alkaline phosphatase were measured. Vitamin D3 supplementation was administered to those identified with deficient or insufficient 25-hydroxyvitamin D (25-OHD). A total of 95.6% of the GP group and 93.3% of the control group had insufficient or deficient 25-OHD levels. No significant correlations for serum calcium, serum phosphate, and alkaline phosphatase with 25-OHD level in either group. Children with sufficient 25-OHD also experienced similar reduction in pain as those who received supplementation. The study found no significant difference in vitamin D levels between children with GP and those without.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"196-202"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Features and Imaging Abnormalities of Escherichia coli Meningitis: A Nationwide Multicenter Study. 大肠杆菌脑膜炎的临床特征和影像学异常：一项全国多中心研究。
IF 0.7 4区 医学
Clinical Pediatrics Pub Date : 2026-02-01 Epub Date: 2025-10-26 DOI: 10.1177/00099228251382429
Jiating Shou, Xinxin Liu, Zhiwei Xu, Min Shu, Biquan Chen, Yinghu Chen
{"title":"Clinical Features and Imaging Abnormalities of <i>Escherichia coli</i> Meningitis: A Nationwide Multicenter Study.","authors":"Jiating Shou, Xinxin Liu, Zhiwei Xu, Min Shu, Biquan Chen, Yinghu Chen","doi":"10.1177/00099228251382429","DOIUrl":"10.1177/00099228251382429","url":null,"abstract":"<p><p>This study aimed to investigate the clinical features of <i>Escherichia coli</i> (<i>E coli</i>)-induced pediatric pyogenic meningitis and analyze the risk factors for imaging abnormalities. These findings provide evidence for early diagnosis and treatment to improve patient prognosis. A multicenter retrospective study was conducted, which included 321 confirmed cases of <i>E coli</i> meningitis. A total of 98.8% (317/321) of the patients had an age at onset of 1 year or younger. Imaging abnormalities were observed in 63.5% (202/318) of the patients and primarily included subdural effusion and/or abscess (28.9%), hydrocephalus or ventricular dilation (21.4%), and intracranial hemorrhage (18.9%). Multivariate logistic regression analysis revealed that initial cerebrospinal fluid (CSF) glucose concentration (odds ratio [OR] = 0.758, 95% confidence interval [CI] = 0.601-0.956, <i>P =</i> .019) and neurological symptom duration exceeding 1 week were independent risk factors for imaging abnormalities. Cerebrospinal fluid glucose levels and the duration of neurological symptoms are crucial indicators for assessing disease severity.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"187-195"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145372190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Initial Subcutaneous Insulin Requirement in Children With Newly Diagnosed Type 1 Diabetes. 新诊断的1型糖尿病儿童初始皮下胰岛素需要量
IF 0.7 4区 医学
Clinical Pediatrics Pub Date : 2026-02-01 Epub Date: 2025-10-01 DOI: 10.1177/00099228251379206
Seyit Ahmet Uçaktürk, Makbule Çöküş, Muharrem Bayram, Eda Mengen
{"title":"Initial Subcutaneous Insulin Requirement in Children With Newly Diagnosed Type 1 Diabetes.","authors":"Seyit Ahmet Uçaktürk, Makbule Çöküş, Muharrem Bayram, Eda Mengen","doi":"10.1177/00099228251379206","DOIUrl":"10.1177/00099228251379206","url":null,"abstract":"<p><p>This study aimed to assess the factors affecting the daily subcutaneous insulin dose in children with newly diagnosed T1D. A retrospective file review of 85 children (≤18 years old) admitted to the hospital between 2020 and 2023 due to new onset T1D. Whereas total daily subcutaneous insulin dose (TDD) on the first day 1.3 ± 0.16 u/kg/day, it was 0.81 ± 0.28 u/kg/day on the last day. Total daily subcutaneous insulin dose on the first day was significantly higher in patients presenting with diabetic ketoacidosis (DKA) than in those presenting with ketosis and hyperglycemia (1.41 ± 0.14 u/kg/day and 1.19 ± 0.18 u/kg/day respectively). The three groups had similar TDD on the last day. The multiple linear regression analysis identified pH at admission and body weight as parameters affecting TDD. Our results support the high insulin requirement that continues after switching to subcutaneous treatment with the severity of acidosis. Therefore, subcutaneous insulin dose should be adjusted according to presentation characteristics.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"203-207"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Mental Health Landscape: Understanding the Needs, Access, and Barriers for Mothers of Children With Down Syndrome. 探索心理健康景观：了解唐氏综合症儿童母亲的需求、途径和障碍。
IF 0.7 4区 医学
Clinical Pediatrics Pub Date : 2026-02-01 Epub Date: 2025-10-09 DOI: 10.1177/00099228251380459
Mehmet Cantepe, Tugba Karaca Ahat, Halise Metin Baz, Derya Gumus Dogan, Mehmet Akif Buyukavci
{"title":"Exploring the Mental Health Landscape: Understanding the Needs, Access, and Barriers for Mothers of Children With Down Syndrome.","authors":"Mehmet Cantepe, Tugba Karaca Ahat, Halise Metin Baz, Derya Gumus Dogan, Mehmet Akif Buyukavci","doi":"10.1177/00099228251380459","DOIUrl":"10.1177/00099228251380459","url":null,"abstract":"<p><p>This study aimed to determine the mental health needs of mothers of children with Down syndrome, identify their access to mental health support along with the barriers. The study included 64 mothers of children diagnosed with Down syndrome, aged 0 to 42 months. State-Trait Anxiety Scale 1 (STAI-1), Trait Anxiety Scale 2 (STAI-2), and Epidemiologic Studies Depression Scale (CES-D) were administered. According to the STAI-1, 82.8% of mothers exhibited elevated levels of anxiety, while the STAI-2 revealed that 76.6% experienced elevated anxiety. The CES-D indicated that 37.5% of mothers exhibited symptoms of depression. Among the participants, 43.8% expressed the greatest need for support when receiving their child's diagnosis. Additionally, 57.8% of the mothers preferred meeting with families facing similar challenges as the most suitable approach. It was found that 82.8% of the mothers cited acceptance of the disease according to their religious beliefs as the most common barrier to accessing support.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"216-225"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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