Alissa Davis, Sara E Landers, Yihang Sun, Victoria O Nguyen, Niall Bolger, Rachel A Lewis, Susan L Rosenthal
{"title":"Evaluating the Feasibility and Acceptability of a Mobile Mental Health Intervention for Adolescent Depression and Anxiety.","authors":"Alissa Davis, Sara E Landers, Yihang Sun, Victoria O Nguyen, Niall Bolger, Rachel A Lewis, Susan L Rosenthal","doi":"10.1177/00099228251371903","DOIUrl":"https://doi.org/10.1177/00099228251371903","url":null,"abstract":"<p><p>The adolescent mental health crisis is compounded by a shortage of mental health services, which mobile health apps may alleviate. We assessed the feasibility and acceptability of the Wysa app (a commercially available app containing cognitive behavioral therapy-based digital modules and an artificial intelligence-based conversational agent) among 13- to 18-year-old adolescents recruited from a primary care clinic in New York City and online from March to June 2022. We assessed adolescent engagement in the Wysa app over a 3-week period. Out of 44 participants, app uptake was 77.3% (34/44). Among those who used the app, participants used the app a median of 9 times (IQR: 5-19). Over 3-quarters (<i>n</i> = 25) of participants who used the app would recommend the app to others, and 60.6% rated the app 4-5 stars (5 stars maximum rating). Pediatricians may find it a useful tool to recommend in their clinical practice to support adolescent mental health.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228251371903"},"PeriodicalIF":0.7,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-09-01Epub Date: 2025-03-24DOI: 10.1177/00099228251321597
Bei Ye, Shu Teng, Lu Zhan
{"title":"The Link Between Respiratory Syncytial Virus-Induced Lower Respiratory Tract Infection and Type 2 Inflammation in Asthma.","authors":"Bei Ye, Shu Teng, Lu Zhan","doi":"10.1177/00099228251321597","DOIUrl":"10.1177/00099228251321597","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between the type 2 inflammatory response associated with asthma and lower respiratory tract infection (LRTI) caused by respiratory syncytial virus (RSV).</p><p><strong>Methods: </strong>Sixty-seven children with RSV infection hospitalized in our hospital from October 2023 to December 2023 and 27 healthy children undergoing medical examination were included. The study population was divided into the RSV LRTI group (<i>n</i> = 67) and the control group (<i>n</i> = 27). Interleukin-13 (IL-13), serum total immunoglobulin E (IgE), mucin 5AC (MUC5AC), and blood eosinophil count (EOS) were tested and compared between the two groups. The presence or absence of specificity between the two groups was analyzed using the rank sum test and subject operating characteristic curves (Receiver Operating Characteristic curves, ROC curves).</p><p><strong>Results: </strong>The levels of IL-13, IgE, MUC5AC, and EOS were higher in children with RSV LRTI compared to healthy children. These differences were statistically significant (<i>P</i> < .05). The ROC curve analysis results showed that IL-13, IgE, MUC5AC, and EOS predicted type 2 inflammation with areas under the curve of 0.687, 0.762, 0.764, and 0.646, respectively.</p><p><strong>Conclusion: </strong>A type 2 inflammatory response associated with asthma may be observed after RSV-induced LRTIs.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1152-1159"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-09-01Epub Date: 2025-02-23DOI: 10.1177/00099228251319669
William W Shugart, Kristopher G Gross, Bridget E Freeman, Teresa A Williams, Abraham M Quader
{"title":"Rat Bite Fever: A Sobering Lesson in History and Differential.","authors":"William W Shugart, Kristopher G Gross, Bridget E Freeman, Teresa A Williams, Abraham M Quader","doi":"10.1177/00099228251319669","DOIUrl":"10.1177/00099228251319669","url":null,"abstract":"","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1189-1192"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of Hypocalcemia in Pediatrics With Lower Respiratory Tract Infections.","authors":"Usha Sree Puneem, Vanitha Rani Nagasubramanian, Bhima Sridevi, Ranakishor Pelluri, Vasudeva Murthy Sindgi, Hanish Donthula, Vishwas Hunsur Nagendra, Sadagoban Gopal Krishnamoorthy","doi":"10.1177/00099228251321916","DOIUrl":"10.1177/00099228251321916","url":null,"abstract":"<p><p>A retrospective observational study aimed to assess blood calcium levels in children with lower respiratory tract infections (LRTIs) from September 2023 to February 2024. A total of 225 eligible records were evaluated. Calcium deficiency was observed in 44.8% of children, hyperchloremia in 42.6%, and hyperkalemia in 36.8% on admission. The mean age was 16.8 ± 16.2 months, and the mean SpO<sub>2</sub> was 95.8 ± 2.5%. Although the risk of hypocalcemia was slightly higher in nonimmunized subjects (odds ratio = 1.04 [95% confidence interval = 0.59-1.85]), this was not statistically significant (<i>P</i> > .05). A negative correlation between normal calcium levels and body mass (<i>r</i> =-0.295, <i>P</i> = .001) suggests that higher body weight is linked to calcium imbalance. Immunization status and developmental history did not significantly affect the risk of hypocalcemia. The study highlights the importance of regular calcium monitoring in pediatric LRTI patients, as hypocalcemia was prevalent, particularly in those with higher body weight.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1138-1143"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-09-01Epub Date: 2025-05-17DOI: 10.1177/00099228251342105
Ulfat Shaikh, Mark V Avdalovic, Jodi L Nygaard
{"title":"Implementing Electronic Consultations to Increase Pediatric Specialty Access.","authors":"Ulfat Shaikh, Mark V Avdalovic, Jodi L Nygaard","doi":"10.1177/00099228251342105","DOIUrl":"10.1177/00099228251342105","url":null,"abstract":"","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1061-1065"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-09-01Epub Date: 2025-02-07DOI: 10.1177/00099228251316716
Alexander W Hirsch, Jonathan Hatoun, Louis Vernacchio, Laura Patane, Susan C Lipsett, Gabrielle D'Ambrosi, Michael C Monuteaux, Mark I Neuman
{"title":"Chest Radiograph Utilization Among Children Treated for Pneumonia in a Primary Care Network.","authors":"Alexander W Hirsch, Jonathan Hatoun, Louis Vernacchio, Laura Patane, Susan C Lipsett, Gabrielle D'Ambrosi, Michael C Monuteaux, Mark I Neuman","doi":"10.1177/00099228251316716","DOIUrl":"10.1177/00099228251316716","url":null,"abstract":"<p><p>This retrospective cohort study across 77 pediatric practices in Massachusetts assessed the frequency of CXR utilization among children with pneumonia diagnosed in the primary care setting and determined whether CXR utilization was associated with differences in antibiotic treatment and outcomes. Multivariable logistic regression was used to evaluate the association between CXR performance and future clinic revisit, CXR performance, antibiotic change, and a composite treatment failure outcome, adjusting for markers of illness severity. Among 29 528 children treated for pneumonia, 2462 (10.1%) had a CXR performed. CXR utilization varied by practice (range 0%-75% [IQR 2.7%-16.5%]). The odds of a composite outcome of treatment failure did not differ between children who had a CXR performed and those who did not (aOR 1.06; 95% CI [0.68, 1.65]). CXR was performed in the minority of patients diagnosed with pneumonia. Children who had a CXR performed had similar outcomes to those treated for pneumonia without CXR.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1115-1122"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-09-01Epub Date: 2025-03-12DOI: 10.1177/00099228251316428
Yanan Ma, Kun Zhang, Sainan Fan, Shun Liu, Jinping Zhang
{"title":"Case Report and Literature Review of 10 Pediatric Cases of Knee Pigmented Villonodular Synovitis.","authors":"Yanan Ma, Kun Zhang, Sainan Fan, Shun Liu, Jinping Zhang","doi":"10.1177/00099228251316428","DOIUrl":"10.1177/00099228251316428","url":null,"abstract":"<p><strong>Objective: </strong>This study was aimed to analyze 10 pediatric cases of pigmented villonodular synovitis (PVNS) of the knee to elucidate their clinical features, diagnosis, treatments, and prognosis for providing reference regarding its clinical management in children.</p><p><strong>Methods: </strong>A retrospective analysis was made pertaining to the clinical manifestations, magnetic resonance imaging (MRI) findings, pathology, immunohistochemical results, treatment methods, and follow-up outcomes of 10 pediatric PVNS patients of the knee treated from January 2022 to January 2024 at our hospital. They were compared and analyzed with existing literature.</p><p><strong>Results: </strong>(1) All 10 patients had joint swelling with restricted movement, mainly in older female children with male-to-female ratio of 3:7 and average age of 14.1 ± 3.6 years; (2) diagnostic positive rate of MRI was 80%; (3) significant features of PVNS were the appearance of villous and nodular hyperplasia on synovial surface and deposition of brownish-yellow granular hemosiderin. Immunohistochemical staining results were clusterin (synovial cells+), D2-40 (synovial cells+), CD163 (histiocytes+), KP-1 (histiocytes+), CD31 (vascular+), P63 (-), and Ki67 (+, 1%-10%); and (4) all patients underwent arthroscopic surgery with 20% recurrence rate.</p><p><strong>Conclusion: </strong>Pediatric knee PVNS is more prevalent in older female children. The PVNS diagnosis is carried out by MRI, pathology, and immunohistochemistry. Arthroscopic surgery is effective for treating this condition in children.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1107-1114"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-09-01Epub Date: 2025-02-07DOI: 10.1177/00099228251316367
Minna Rodrigo, Bruno P Chumpitazi, Erika A Chiappini, Melanie L Brown, Sofia Wicker Velez, Shaija Kutty
{"title":"Characterization of Multidisciplinary Programs for Abdominal Pain-Related Disorders of Gut-Brain Interaction.","authors":"Minna Rodrigo, Bruno P Chumpitazi, Erika A Chiappini, Melanie L Brown, Sofia Wicker Velez, Shaija Kutty","doi":"10.1177/00099228251316367","DOIUrl":"10.1177/00099228251316367","url":null,"abstract":"<p><p>Abdominal pain-related disorders of gut-brain interaction (DGBIs) are common and challenging conditions affecting many children and adolescents. Multidisciplinary programs represent one promising approach to these complex disorders. However, the composition of these programs and the therapies offered is unknown. We sought to better understand characteristics of these multidisciplinary programs. A survey was taken of pediatric gastroenterologists in the United States who practice in multidisciplinary DGBI programs to determine the characteristics of currently available programs. Fourteen pediatric gastroenterologists reported caring for children with DGBI in multidisciplinary programs distributed across all regions of the United States. The number of disciplines varied from 2 to 5, with the most common aside from pediatric gastroenterologists being dietitians (in 79% of programs) and behavioral psychologists (57%). The least common included physical therapists (14%). The number of therapies offered varied from 2 to 10 and included pharmacologic therapy (100%), dietary therapy (93%), and psychotherapy (86%), among others. The number of patients seen per clinic session varied (range: <3 to 6) across programs, and 6 programs (43%) assessed outcomes using validated questionnaires. Future studies may evaluate patient outcomes to identify an ideal pediatric DGBI multidisciplinary approach (eg, program composition and therapies offered).</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1066-1073"},"PeriodicalIF":0.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}