Clinical nutrition ESPEN最新文献

{"title":"Relationship between homocysteine levels and bone quality in healthy adults - A systematic review and meta-analysis","authors":"Deepti K. Sharma ,&nbsp;Tim Soon Cheok ,&nbsp;Manuela Rogers ,&nbsp;Victor Yan Zhe Lu ,&nbsp;Lucian B. Solomon ,&nbsp;Boopalan Ramasamy ,&nbsp;Peter M. Clifton ,&nbsp;Stuart A. Callary","doi":"10.1016/j.clnesp.2025.06.034","DOIUrl":"10.1016/j.clnesp.2025.06.034","url":null,"abstract":"<div><h3>Background and aims</h3><div>Patients with elevated homocysteine (Hcy) levels are associated with an increased risk of fracture. B-vitamin supplementation studies have consistently shown an ability to reduce Hcy levels but have had no or marginal effect on bone mineral density (BMD), which led us to hypothesize that hyperhomocysteinemia may increase fracture risk by altering bone quality outcome measures beyond BMD. The aim of our systematic review was to investigate the association between Hcy and bone quality outcome measures, i.e. bone turnover, bone microarchitecture, collagen crosslinks and micro damage accumulation, in healthy adults.</div></div><div><h3>Methods</h3><div>A systematic search was performed on Pubmed, Embase, and Scopus from the date of inception to 30th of September^, 2024. Studies were included that had sufficient data to identify the pooled relationship between plasma Hcy and at least one domain of bone quality, such as bone microarchitecture, bone turnover, advanced glycation product (AGE) pentosidine levels, collagen crosslinks, or micro damage accumulation. Studies involving patients who were on medications or had conditions affecting plasma Hcy or bone health were excluded. Osteoporotic patients were included only if they had not been treated.</div></div><div><h3>Results</h3><div>Twenty-seven studies were included in our systematic review. Our meta-analysis found a significant positive correlation between Hcy and osteocalcin [Pearson's coefficient of correlation (r) = 0.39, significance value (p) = 0.023, 95 % Confidence Interval (CI) = 0.36–0.42]. No significant correlation was observed between Hcy and Procollagen type-1 N propeptide (P1NP), C-terminal telopeptide of type 1 collagen (CTX-1), or Bone-specific alkaline phosphatase (Bone ALP). Additionally, we found a strong positive correlation between Hcy and the AGE serum pentosidine [r = 0.72; 95 % CI: 0.67–0.76; p = 0.020], a molecule linked to increased non-enzymatic collagen cross-linkage. Further, two studies measured collagen-crosslinking in the bone, and both reported elevated Hcy to be associated with higher non-enzymatic crosslinks and reduced enzymatic crosslinks.</div></div><div><h3>Conclusion</h3><div>Our results suggest that elevated Hcy impacts bone quality outcome measures. The effect is possibly mediated via increased bone turnover and accumulation of non-enzymatic collagen crosslinking, resulting in decreased bone strength.</div></div><div><h3>PROSPERO Registration No</h3><div>CRD42024595870.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"68 ","pages":"Pages 790-805"},"PeriodicalIF":2.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mind the gap: Which are the gaps in dysphagia management?","authors":"Carlo Pedrolli","doi":"10.1016/j.clnesp.2025.06.039","DOIUrl":"10.1016/j.clnesp.2025.06.039","url":null,"abstract":"<div><div>Dysphagia is underdiagnosed and undertreated; the authors tries to list most important limits at the moment in dysphagia management, together with some proposal to revert the situation.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"69 ","pages":"Pages 1-3"},"PeriodicalIF":2.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of linoleic acid on apolipoprotein B in individuals without previous diagnosis of cardiovascular disease: A Mendelian Randomization study","authors":"Gregory S. Nacarelli ,&nbsp;Tracy Fasolino ,&nbsp;Puya Yazdi ,&nbsp;Vivian Haley-Zitlin ,&nbsp;Stephanie Trammel","doi":"10.1016/j.clnesp.2025.06.008","DOIUrl":"10.1016/j.clnesp.2025.06.008","url":null,"abstract":"<div><h3>Background</h3><div>Apolipoprotein B is an essential causal marker of cardiovascular disease. Studies have attempted to understand the impact of fatty acids on cardiovascular disease risk by measuring changes in apolipoprotein B. Linoleic acid is an omega-6 polyunsaturated fatty acid that has demonstrated effects on cardiovascular disease outcomes.</div></div><div><h3>Objective</h3><div>This study attempts to investigate the causal association of plasma concentrations of linoleic acid with apolipoprotein B via Mendelian Randomization, in addition to confounders of this relationship.</div></div><div><h3>Methods</h3><div>The UK Biobank was used to obtain participant data for omega-6 polygenic risk scores, linoleic acid, and apolipoprotein B concentrations, in addition to confounding variable data. This study excluded individuals with a cardiovascular disease diagnosis or taking cholesterol-lowering medications. Multivariable regression was utilized to identify statistically significant impacts on apolipoprotein B, followed by Mendelian Randomization via two-stage least-squares analysis.</div></div><div><h3>Results</h3><div>Multivariable regression identified a statistically significant association of apolipoprotein B with linoleic acid, monounsaturated fatty acids, saturated fatty acids, age, sex, fasting, BMI, alcohol intake frequency, vigorous exercise, and smoking status. Two-stage least-squares analysis found a statistically significant causal association of genetically predicted linoleic acid on apolipoprotein B concentration (b = 0.23; 95 % CI: 0.207–0.243; p &lt; 0.001), with the first stage of the analysis yielding an eigenvalue of 755.79 and F-statistic of 2796.93 and the second stage of the analysis yielding a statistically significant Wald χ ² value of 27276.48 and R² of 0.62.</div></div><div><h3>Conclusions</h3><div>This study demonstrates a causal association of linoleic acid with apolipoprotein B concentrations. Future studies should evaluate this association and the confounders of this relationship.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"68 ","pages":"Pages 619-625"},"PeriodicalIF":2.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of new bioimpedance equations to estimate skeletal muscle mass percentage in a white, healthy population","authors":"Heliodoro Moya-Amaya ,&nbsp;Daniel Rojano-Ortega ,&nbsp;Antonio Molina-López ,&nbsp;Antonio Jesús Berral-Aguilar ,&nbsp;Alessandro Portolan ,&nbsp;Francisco José Berral-de la Rosa","doi":"10.1016/j.clnesp.2025.06.025","DOIUrl":"10.1016/j.clnesp.2025.06.025","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Skeletal muscle mass (SMM) plays a crucial role in overall health, especially in the aging population, and increased fat deposition elevate the risk of frailty and metabolic disorders. Accurate and accessible SMM assessment is essential for identifying and monitoring these risks. Bioelectrical impedance analysis (BIA) devices, widely used for body composition assessment, provide a non-invasive, practical solution; however, the accuracy of BIA measurements can vary significantly compared to dual-energy X-ray absorptiometry (DXA), particularly across different device types and demographic groups. Given the physiological and lifestyle changes that can influence muscle mass across the adult lifespan, there is a growing need for precise, reliable tools to evaluate SMM in a broad adult population.</div></div><div><h3>Methods</h3><div>We developed novel equations for estimating SMM percentage in a white, healthy population using two different BIA technologies: foot-to-hand device (Akern 101) and hand-to-hand device (TELELAB). These equations were developed to enhance the precision of SMM measurements, calibrating the output to align more closely with DXA values. A sample of 211 individuals (100 women, 111 men) aged 18–65 years was divided into a development group and a validation group to establish and test the predictive reliability of the proposed equations.</div></div><div><h3>Results</h3><div>Bland–Altman analyses revealed minimal fixed bias for both new equations compared to DXA, with substantially reduced mean bias values and lower standard deviations than those observed with use of the original manufacturer's equations.</div></div><div><h3>Conclusions</h3><div>The new equations effectively minimize the overestimation observed when using the manufacturer's equations, demonstrating an average bias close to zero and enhanced consistency across age and ethnic groups. These optimized equations offer a robust, practical solution for accurate SMM assessment in clinical and research settings across diverse adult populations.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"68 ","pages":"Pages 707-714"},"PeriodicalIF":2.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply – Letter to the Editor: “The metabolic Penalty of time: Nutritional vulnerability and cardiovascular risk in the shift work economy”","authors":"Luiz Antônio Alves de Menezes-Júnior","doi":"10.1016/j.clnesp.2025.06.018","DOIUrl":"10.1016/j.clnesp.2025.06.018","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"68 ","pages":"Page 816"},"PeriodicalIF":2.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between metabolic dysfunction-associated steatotic liver disease and sarcopenia: A systematic review and meta-analyses","authors":"Ninglin Xia ,&nbsp;Jiwei Wang ,&nbsp;Qian Lu ,&nbsp;Xue Fan ,&nbsp;Zhenzhou Jiang ,&nbsp;Qinwei Yu","doi":"10.1016/j.clnesp.2025.06.027","DOIUrl":"10.1016/j.clnesp.2025.06.027","url":null,"abstract":"<div><h3>Background and aims</h3><div>Metabolic dysfunction-associated steatotic liver disease (MASLD) and Sarcopenia are highly prevalent health conditions in the world. Our objective was designed to quantify the relationship between the diagnosis of sarcopenia, sarcopenia and the risk of MASLD.</div></div><div><h3>Methods</h3><div>Web of Science, PubMed, Embase, and OVID were systematically searched from inception to 10 March, 2024, to identify all relevant studies.</div></div><div><h3>Results</h3><div>63 studies met the inclusion criteria, encompassing 288,583 participants. Our findings revealed that the risk of MASLD increased in subjects with sarcopenia (OR: 1.37, [95%CI 1.23,1.51]). In MASLD patients, the levels of skeletal muscle index (SMI) (SMD: −0.26, [95%CI -0.34, −0.18]) and gait speed (SMD: −0.17, [95%CI -0.27, −0.06]) were lower than in normal individuals. Moreover, a higher risk of MASLD was associated with decreased SMI (OR: 0.73, [95%CI 0.66, 0.79], decreased muscle strength (OR: 0.97, [95%CI 0.93, 1.00]). Additionally, the risk of advanced liver fibrosis (OR: 1.47, [95%CI 1.23,1.71]), mortality rate (RR: 1.15, [95%CI 1.09, 1.20]) and all-cause mortality (HR: 1.30, [95%CI 1.13,1.47]) increased in MASLD patients with sarcopenia.</div></div><div><h3>Conclusion</h3><div>Sarcopenia individuals have higher occurrence risk of MASLD. Meanwhile, the patients with low SMI and low muscle strength have higher occurrence risk of MASLD. Furthermore, sarcopenia individuals have higher occurrence risk of MASLD advanced stages including liver fibrosis or mortality. Our study suggested that clinicians should be vigilant about symptoms of sarcopenia, such as SMI, gait speed and muscle strength in patients with MASLD, detect susceptible populations early, and reduce the risk of poor prognosis.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"68 ","pages":"Pages 679-690"},"PeriodicalIF":2.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The metabolic penalty of time: Nutritional vulnerability and cardiovascular risk in the shift work economy","authors":"Alina Yang","doi":"10.1016/j.clnesp.2025.06.019","DOIUrl":"10.1016/j.clnesp.2025.06.019","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"68 ","pages":"Pages 814-815"},"PeriodicalIF":2.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of low muscularity in metastatic and recurrent head and neck cancer: Insights from C3-based assessments","authors":"Larissa Ariel Oliveira Carrilho ,&nbsp;Livia Dias Guerra ,&nbsp;Rafaella Caroline de Lellis Moreira ,&nbsp;Fabiana Lascala Juliani ,&nbsp;Fernanda Silva Santos ,&nbsp;Daniela Morais de Holanda Padilha ,&nbsp;Fabíola Furtuoso Zaperlão ,&nbsp;Sandra Regina Branbilla ,&nbsp;Vivian Naomi Horita ,&nbsp;Davi Magalhães Leite Novaes ,&nbsp;Lígia Moraes Antunes-Correa ,&nbsp;Carmem Silvia Passos Lima ,&nbsp;Maria Carolina Santos Mendes ,&nbsp;José Barreto Campello Carvalheira","doi":"10.1016/j.clnesp.2025.06.029","DOIUrl":"10.1016/j.clnesp.2025.06.029","url":null,"abstract":"<div><div>Head and Neck Cancer (HNC) patients often experience a range of symptoms due to disease which can lead to low energy and protein intake. This scenario can impact body composition as the quality and quantity of muscularity and adiposity changes. This work aims to evaluate the impact of muscularity on the overall survival (OS) of patients with metastatic HNC. This is a retrospective and analytical study, with the population studied being patients diagnosed with metastatic or recurrent HNC, between January 2010 and December 2018, treated at the Clinical Oncology outpatient clinic of the Hospital de Clínicas of the Universidade Estadual de Campinas. To assess body composition, CT images were used at the level of the third cervical vertebra (C3), with the areas of muscle tissue and adipose tissue. The total population included in the sample was 101 patients diagnosed with metastatic or recurrent HNC. It has been shown that low muscularity is associated with the elderly population over 70 years old and with a lower BMI value, below 18.5. The population with low muscularity had a lower amount of total adipose tissue and total adipose tissue index, as well as a lower amount of skeletal muscle and skeletal muscle index in relation to normal muscularity, making it possible to conclude that low muscularity in patients with metastatic or recurrent HNC is an independent factor for mortality.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"68 ","pages":"Pages 767-773"},"PeriodicalIF":2.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Comment on “Healthy lifestyle indices are associated with breast cancer immunophenotypes in women”","authors":"Qi Xu,&nbsp;Yuwan Gao","doi":"10.1016/j.clnesp.2025.06.021","DOIUrl":"10.1016/j.clnesp.2025.06.021","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"68 ","pages":"Page 668"},"PeriodicalIF":2.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 15-year cohort study of self-reported fermented soybean (natto) intake and all-cause mortality in elderly men","authors":"Yuki Fujita ,&nbsp;Katsuyasu Kouda ,&nbsp;Junko Tamaki ,&nbsp;Takahiro Tachiki ,&nbsp;Etsuko Kajita ,&nbsp;Jong-Seong Moon ,&nbsp;Nozomi Okamoto ,&nbsp;Masayuki Iki","doi":"10.1016/j.clnesp.2025.06.017","DOIUrl":"10.1016/j.clnesp.2025.06.017","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Fermented soy foods come in different forms, each with varying effects on mortality. However, few epidemiological studies have investigated the effect of intake of individual types of fermented soy products on mortality. The present study aimed to investigate the association between intake of fermented soybeans, ‘natto,’ and all-cause mortality in community-dwelling elderly men, with a follow-up duration of approximately 15 years.</div></div><div><h3>Methods</h3><div>This prospective cohort study included 2174 men aged ≥65 years, of whom 2012 completed the baseline survey. Follow-up surveys were conducted five and 10 years later with mortality as the outcome. Participants completed a questionnaire regarding dairy natto intake. Hazard ratios (HRs) were calculated for the association between natto intake and all-cause mortality using Cox proportional hazards models.</div></div><div><h3>Results</h3><div>The final analysis population consisted of 1548 men. During a mean follow-up period of 12.0 years (18553.3 person-years), 430 deaths were identified. Compared with ‘no consumption’ of natto, HRs for ‘several packs/week’ and ‘pack/day or more’ were 0.603 (95 % confidence interval (CI) 0.441 to 0.825) and 0.786 (95 % CI 0.539 to 1.145), respectively. Compared with the category “No consumption at both baseline and first follow-up,” the HR for the category “Combination of several packs/week and one pack/day at baseline and first follow-up or several packs/week at both baseline and first follow-up” was 0.700 (95 % CI 0.507 to 0.966).</div></div><div><h3>Conclusions</h3><div>Habitual high intake of natto, especially over a long term, was associated with a lower risk of all-cause mortality in elderly men.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"68 ","pages":"Pages 699-706"},"PeriodicalIF":2.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}