Clinical nutrition ESPEN最新文献

{"title":"Malnutrition in patients with advanced head and neck cancer: Exploring the Global Leadership Initiative on Malnutrition (GLIM) criteria, energy balance and health-related quality of life.","authors":"Camilla Wallmander, Ingvar Bosaeus, Ewa Silander, Malin Berg, Hedda Haugen Cange, Jan Nyman, Eva Hammerlid","doi":"10.1016/j.clnesp.2025.01.049","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.01.049","url":null,"abstract":"<p><strong>Background & aims: </strong>Head and neck cancer (HNC) involves several tumor locations, the most common of which are the oropharynx and oral cavity. Patients with HNC are at high risk of developing malnutrition. Together with treatment, the tumor location contributes to difficulties in eating and swallowing, which can lead to a negative energy balance and weight loss. This study aimed to examine malnutrition via the Global Leadership Initiative on Malnutrition (GLIM) criteria, explore the different combinations of the GLIM criteria, study changes in body energy content and evaluate health-related quality of life (HRQoL) in patients with locally advanced HNC.</p><p><strong>Methods: </strong>Malnutrition was diagnosed via the GLIM criteria. Body weight, muscle mass, body fat, C-reactive protein (CRP) levels, energy intake, use of enteral feeding tubes or parenteral nutrition were assessed, and HRQoL scales from the European Organization for Research and Treatment of Cancer (EORTC), including the Quality of Life Questionnaire-Core 30 (QLQ-C30) and the Quality of Life Questionnaire-Head and Neck 35 (QLQ-HN35), and the M.D. Anderson Dysphagia Inventory (MDADI) were completed at baseline, 6 weeks and at 3, 6 and 12 months after the start of treatment. Body composition was measured via dual-energy X-ray absorptiometry, and body energy content was calculated.</p><p><strong>Results: </strong>Eighty patients were included. The prevalence of malnutrition varied over time and peaked at the end of treatment at 71%, and at this time, the most common combination of the GLIM criteria was weight loss + reduced food intake + inflammation (31%), followed by weight loss + reduced muscle mass + reduced food intake + inflammation (20%). At the end of treatment patients were in a negative energy balance, and compared to baseline, body weight, body fat, and muscle mass had decreased with 6.0% (p<0.0001), 5.9% (p<0.0001), and 8.0% (p<0.0001) respectively. At the 3-month follow-up, the reduction in muscle mass had ceased, despite a negative energy balance, and patients started to regain muscle mass. At 12 months body weight had decreased with 7.4% (p<0.0001), body fat with 18.9% (p<0.0001), and muscle mass with 2.4% (p<0.0001) compared to baseline. Patients with malnutrition reported significantly worse HRQoL on a majority of the 16 quality of life scales at all time points, except at the end of treatment, when no significant differences were found between malnourished and nonmalnourished patients.</p><p><strong>Conclusions: </strong>Patients with advanced HNC receiving combined treatment experience major nutritional problems, and malnutrition is common at the end of treatment. Inflammation-driven muscle depletion during treatment is challenging, but it seems possible to recover muscle mass after treatment. Patients with malnutrition reported worse HRQoL at all time points, except at the end of treatment, when all patients' quality of life was very negatively ","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parenterally administered amino acids decrease acute mortality in fasting patients with aspiration pneumonia: A retrospective study","authors":"Takashi Ogasawara ,&nbsp;Yuki Hiraoka ,&nbsp;Natsuko Hosoya ,&nbsp;Masayuki Sugiura ,&nbsp;Ei Kishimoto ,&nbsp;Kimihiko Nagasaki ,&nbsp;Wataru Matsuyama ,&nbsp;Takahito Suzuki ,&nbsp;Mitsuru Niwa ,&nbsp;Yuichi Ozawa ,&nbsp;Masahito Ogiku ,&nbsp;Jun Sato","doi":"10.1016/j.clnesp.2025.01.054","DOIUrl":"10.1016/j.clnesp.2025.01.054","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>To prevent food aspiration, numerous patients with aspiration pneumonia are restricted from eating early during their hospital stay. Although they receive parenteral nutrition (PN) on a fasting regimen, the optimal dose and composition remain unknown. The current study aimed to investigate whether PN with amino acids (AA) affects 30-day mortality of patients with aspiration pneumonia.</div></div><div><h3>Methods</h3><div>This retrospective study included 115 patients with aspiration pneumonia who were admitted to our hospital between November 2019 and November 2023. All patients followed the clinical pathway for aspiration pneumonia, had been fasting for &gt;5 days, and received PN alone on admission. Given that treating physicians could modify the standard PN regimen by including AA, some patients received maintenance infusion without AA. The patients were divided in those who received PN with AA (&gt;15 g/day, AA group) and those who did not (0–15 g/day, non-amino acid [NAA] group). The primary endpoint was 30-day in-hospital mortality.</div></div><div><h3>Results</h3><div>Among the 115 patients, 65 (57 %) received PN with AA from days 2–5. No significant differences in background characteristics and severity of pneumonia were observed, except for heart failure. Serum albumin levels were significantly lower in the AA group than in the NAA group (median, 2.9 vs. 3.2 g/dL; P = 0.003). Median energy intake on days 2 and 5 were significantly higher in the AA group than in the NAA group (day 2: 10.7 vs. 3.7 kcal/kg/day; day 5: 10.6 vs. 4.2 kcal/kg/day, respectively). The AA group had a median protein dose of 0.76 and 0.74 g/kg/day on days 2 and 5, respectively, whereas the NAA group had a median protein dose of 0.00 g/kg/day on both days. After adjusting for age, sex, body mass index, albumin, and pneumonia severity, 30-day in-hospital mortality was lower in the AA group than in the NAA group (hazard ratio, 0.31; 95 % confidence interval, 0.10–0.99).</div></div><div><h3>Conclusions</h3><div>Early PN with AA may play an important role in improving 30-day in-hospital mortality among fasting patients with aspiration pneumonia after hospital admission.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"66 ","pages":"Pages 221-225"},"PeriodicalIF":2.9,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT is no nutrition encyclopedia, but does it need to be?","authors":"Sedat Arslan","doi":"10.1016/j.clnesp.2025.01.055","DOIUrl":"10.1016/j.clnesp.2025.01.055","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"66 ","pages":"Pages 213-214"},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of counselling about complementary food flour soaking on nutritional and health status of children 6–23 months, a quasi-experimental study","authors":"Mekonnen Tegegne ,&nbsp;Kalkidan Hassen Abate ,&nbsp;Tefera Belechew","doi":"10.1016/j.clnesp.2025.01.038","DOIUrl":"10.1016/j.clnesp.2025.01.038","url":null,"abstract":"<div><h3>Background</h3><div>Strategies for achieving improved nutrition in young children in developing countries where plant-based complementary foods are the main source of nutrients can address the challenge of meeting nutritional needs from these foods.</div></div><div><h3>Objectives</h3><div>This study aimed to assess the effect of counseling about complementary food flour soaking on nutritional and health status of children 6–23 months.</div></div><div><h3>Methods</h3><div>A total of 726 mother-child pairs (intervention n = 363 and control n = 363) were enrolled in this study. Participants in the intervention district received personalized nutritional counseling for six months. Interviewer-administered questionnaires and anthropometric measurements were used to collect data. The data were analyzed using SPSS. The difference in difference regression analysis and the Poisson regression analyses were used to estimate the effect of the interventions on anthropometric Z-score and incidence of disease episodes, respectively. Mean differences and Incidence Rate Ratio were computed as a measure of intervention effects.</div></div><div><h3>Result</h3><div>The results showed that the intervention improved the Weight-for-Age Z score of children by 0.30 (β = 0.30, 95 % CI: 0.15–0.45) and Weight-for-length Z score by 0.47 (β = 0.47, 95 % CI: 0.25–0.69). However, the intervention did not improve Length-for-age and health status.</div></div><div><h3>Conclusion</h3><div>The findings imply the need for strengthening social behavior change communication to improve the complementary feeding practices of mothers in the study area.</div><div>The trial was <strong>registered on</strong> ClinicalTrials.gov with a registration number NCT05254717.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"66 ","pages":"Pages 281-289"},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ability of the modified NUTRIC score to predict all-cause mortality among ICU patients with acute pancreatitis: A retrospective analysis using the MIMIC-IV database.","authors":"Ning Tong, Haibin Lu, Na Li, Zhenyu Huo, Feifei Chong, Siyu Luo, Long Li, Zhen Wang, Yaoli Wang, Hongxia Xu","doi":"10.1016/j.clnesp.2025.01.050","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.01.050","url":null,"abstract":"<p><strong>Background: </strong>Acute pancreatitis (AP) is a common acute abdominal condition that can lead to severe complications. Malnutrition significantly impacts the prognosis of patients with AP, so effective tools are needed to identify those at high nutritional risk. This study validated the ability of the modified NUTRIC score to predict all-cause mortality and identify nutritional risk in patients with acute pancreatitis in the ICU.</p><p><strong>Methods: </strong>This retrospective study analyzed data from the MIMIC-IV (v2.2) database, which included patients admitted to the ICU with AP between 2008 and 2019. Patients were categorized into high (mNUTRIC score ≥ 5) and low (mNUTRIC score < 5) nutritional risk groups. The findings were analyzed using Cox regression, ROC curve, and Kaplan-Meier survival analyses.</p><p><strong>Results: </strong>A total of 670 AP patients were included in the study. Patients at high nutritional risk had significantly worse clinical outcomes, including higher 28-day (30.0% vs. 5.4%) and 90-day (39.41% vs. 10.2%) mortality rates, compared to patients with low nutritional risk. The mNUTRIC score demonstrated stronger predictive ability for the 28-day (AUC: 0.797) and 90-day (AUC: 0.772) mortality compared to other nutritional risk tools used in the ICU, including the SOFA, APACHE II, and OASIS scores. A Cox regression analysis revealed that higher mNUTRIC scores were independently associated with increased mortality risk. Kaplan-Meier analyses confirmed that patients at high nutritional risk had significantly lower survival probabilities than those at low risk (P<0.001). Patients with high nutritional risk who received nutrition intervention had a higher survival probability compared to those who did not (P < 0.001).</p><p><strong>Conclusion: </strong>The mNUTRIC score is an effective tool for predicting the mortality in patients with AP. The mNUTRIC score stratifies patients with AP into different risk groups and predicts their all-cause mortality, highlighting the importance of nutritional interventions in improving survival outcomes, especially for patients at high risk.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between Intensive care unit acquired weakness with post-extubation dysphagia and other clinical outcomes-a cohort study in critically ill respiratory patients","authors":"A. García-Grimaldo ,&nbsp;N.C. Rodríguez-Moguel ,&nbsp;M. Godínez-Victoria ,&nbsp;S. Rodríguez-Llamazares ,&nbsp;M.A. Ríos-Ayala ,&nbsp;J.D. Cadeza-Aguilar ,&nbsp;I.A. Osuna-Padilla","doi":"10.1016/j.clnesp.2025.01.044","DOIUrl":"10.1016/j.clnesp.2025.01.044","url":null,"abstract":"<div><h3>Background</h3><div>Intensive care unit-acquired weakness (ICU-AW) is a complication characterized by decreased muscle mass and impairments in strength and physical function and is associated with poor quality of life and worse clinical outcomes. The primary objective of this study is to analyze the prevalence of ICU-AW, and secondary objectives were to assess risk factors and analyze the associations with clinical outcomes.</div></div><div><h3>Methods</h3><div>This is a prospective cohort study of patients on mechanical ventilation (MV). Nutritional risk (mNUTRIC) and the presence of malnutrition (GLIM criteria) were evaluated. A nutritional assessment was performed upon admission and post-extubation. Cumulative energy and protein deficit (CPD) were calculated. ICU-AW was assessed. Post-extubation dysphagia (P-ED), hospital readmission, length of ICU stays post-extubation, and hospital stay post-ICU were reported as clinical outcomes. Comparison tests between groups, univariate and multivariate logistic, and linear regressions were performed.</div></div><div><h3>Results</h3><div>ICU-AW was diagnosed in 55 % of patients. Differences were observed between ICU-AW and normal strength group for sex, days on MV, hospital length of stay, pharmacological therapy for sedation and CPD. The interaction of vecuronium prescription with MV time (RR = 1.09, 95%CI = 1.03–1.16, p &lt; 0.01) and female sex (RR = 4.16, 95%CI = 1.3–13.38, p = 0.01) were independent predictors for ICU-AW development. ICU-AW was associated with P-ED (RR = 11.2, 95%CI = 2.6–48.4, p &lt; 0.01) and length of ICU stay post-extubation (β = 2.11, 95%CI = 0.5–3.7, p = 0.01).</div></div><div><h3>Conclusion</h3><div>ICU-AW is a highly frequent condition in critical patients. Pharmacological therapy, duration of MV and sex were independent predictors for ICU-AW development. This condition was also associated with P-ED development and length of ICU stay post-extubation.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"66 ","pages":"Pages 194-201"},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of dietary factors with amyotrophic lateral sclerosis: A Mendelian randomization study","authors":"Fei Xu ,&nbsp;Hongwei Liu ,&nbsp;Zhaoxu Yin,&nbsp;Xiaolian Xing,&nbsp;Xuan Chen","doi":"10.1016/j.clnesp.2025.01.042","DOIUrl":"10.1016/j.clnesp.2025.01.042","url":null,"abstract":"<div><h3>Background</h3><div>An inconsistent yet notable relationship between dietary habits and the risk of amyotrophic lateral sclerosis (ALS) has been previously established, with the causative nature of this relationship remaining uncertain. This study aims to explore the causal connections at a genetic level.</div></div><div><h3>Methods</h3><div>A two-sample Mendelian Randomization (MR) based analysis was conducted utilizing a comprehensive, publicly assessable Genome-wide association study (GWAS) database. Fourteen dietary variables were examined as potential exposure factors, and the ALS outcome data was statistically analyzed. The inverse-variance weighted (IVW) approach was used as the primary analytical method, supplemented by sensitivity analyses to assess the reliability of our findings.</div></div><div><h3>Results</h3><div>Our analysis identified significant protective effects against ALS from increased intake of water (fixed-effects IVW: OR = 0.700, 95 % CI: 0.524–0.935, P = 0.016), fresh fruit (random-effects IVW: OR = 0.561, 95 % CI: 0.361–0.871, P = 0.010), and cooked vegetable (fixed-effects IVW: OR = 0.200, 95 % CI: 0.090–0.445, P = 0.000). No significant associations were found for the other 11 dietary factors examined.</div></div><div><h3>Conclusion</h3><div>The study highlights the protective association of cooked vegetables and fresh fruit intake with ALS risk reduction. Additionally, an intriguing association between water intake and ALS was observed, warranting further investigation to elucidate the underlying mechanisms.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"66 ","pages":"Pages 226-235"},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cross–sectional association between ultra-processed food intake and metabolic dysfunction-associated steatotic liver disease","authors":"Natalie Sun ,&nbsp;Brenton Prescott ,&nbsp;Jiantao Ma ,&nbsp;Vanessa Xanthakis ,&nbsp;Paula A. Quatromoni ,&nbsp;Michelle T. Long ,&nbsp;Maura E. Walker","doi":"10.1016/j.clnesp.2025.01.045","DOIUrl":"10.1016/j.clnesp.2025.01.045","url":null,"abstract":"<div><h3>Background and aims</h3><div>The prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease has increased in parallel with a rise in consumption of ultra-processed foods (UPF), but little is known about their association.</div></div><div><h3>Methods</h3><div>We cross-sectionally examined associations of UPF with hepatic steatosis and fibrosis in 2458 (mean age 54 years; 55.9 % women) community-dwelling adults who completed vibration-controlled transient elastography and a food frequency questionnaire. Dietary intake was categorized into levels of food processing via the NOVA system. We used multivariable-adjusted logistic regression models to evaluate the association of energy-adjusted UPF intake (per 1-SD unit and by quintile) with clinical hepatic steatosis (Controlled Attenuation Parameter [CAP]≥ 290 dB/m) and fibrosis (Liver Stiffness Measurement [LSM] ≥ 8.2 kPa) and tested for linear trends of UPF intake with CAP and LSM. We adjusted for age, sex, smoking, alcohol intake, physical activity, and intake of minimally processed foods. Additional models adjusted for diet quality index or body mass index (BMI).</div></div><div><h3>Results</h3><div>Higher intake of UPF was directly associated with higher odds of hepatic steatosis (Odds Ratio 1.33 [95 % Confidence Interval 1.21, 1.46] per standard deviation increase). UPF intake and CAP had a dose–response relation (P_trend &lt;0.001). There were 2.50 times higher odds of hepatic steatosis (Confidence Interval 1.81, 3.45) with a 19.49 (standard error: 3.73) unit increase in CAP (P &lt; 0.001) when comparing quintile 5 to quintile 1 of UPF consumption. Higher UPF was not significantly associated with hepatic fibrosis. Adjustment for BMI attenuated the strength of all UPF-hepatic associations.</div></div><div><h3>Conclusions</h3><div>UPF consumption was positively associated with hepatic steatosis. Longitudinal studies are needed to assess whether lowering consumption of UPF can decrease odds of hepatic fibrosis.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"66 ","pages":"Pages 215-220"},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of an online exercise program to improve weight management outcomes in individuals with obesity; A randomised trial","authors":"Sanit Wichansawakun ,&nbsp;Wanwipa Srikhajonjit ,&nbsp;Chomchanok Srichan ,&nbsp;Jutamat Tonglim","doi":"10.1016/j.clnesp.2025.01.039","DOIUrl":"10.1016/j.clnesp.2025.01.039","url":null,"abstract":"<div><h3>Aims</h3><div>To compare the efficacy of an online exercise programme with that of standard physical activity recommendations for weight management.</div></div><div><h3>Methods</h3><div>We conducted an unblinded randomised controlled trial involving individuals with obesity. The study group received dietary advice and participated in an online exercise programme, while the control group received dietary advice and exercise guidance via printed documents.</div></div><div><h3>Results</h3><div>Fifty-four participants completed the trial, with 27 in each group. The mean ages of the study and control groups were 34.11 ± 8.77 and 35.89 ± 10.61 years, respectively. The baseline body mass index, waist circumference, fat mass, and fat-free mass were not significantly different between the groups. After 12 weeks of intervention, the study group showed a significant reduction in body weight and fat mass from 106.54 ± 21.81 to 104.59 ± 21.24 kg (P = 0.004) and 47.92 ± 14.14 to 46.32 ± 13.91 kg (P = 0.005), respectively. The control group also showed a significant reduction in body weight, fat mass, and waist circumference from 103.31 ± 22.2 to 101.3 ± 22.36 kg (P = 0.015), 46.03 ± 16.31 to 41.76 ± 13.57 kg (P = 0.04), and 113.42 ± 17.00 to 111.63 ± 17.29 cm (P = 0.033), respectively. However, no significant differences were observed in any of the parameters between the groups after 12 weeks of the intervention. The study group showed a higher rate of physical activity than the control group.</div></div><div><h3>Conclusion</h3><div>Online exercise programmes can promote weight reduction and engagement in physical activity among individuals with obesity.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"66 ","pages":"Pages 202-207"},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between muscular mass, inflammatory status, tumor metabolic activity and oral intake in head and neck cancer at the outset of management.","authors":"Mathilde Rey, Olivier le Bacquer, Aurélien Mulliez, Justine Becaud, Mathilde Puechmaille, Marion Chanchou, Florian Mallet, Thierry Mom, Nicolas Saroul","doi":"10.1016/j.clnesp.2025.01.052","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.01.052","url":null,"abstract":"<p><strong>Background and aims: </strong>Patients with head and neck cancer (HNC) are often malnourished with a low muscular mass at the outset of management. This is thought to be mainly due to poor nutritional intake. The aim of this study was to assess the correlation between tumor metabolic activity, inflammatory status and body composition in HNC patients.</p><p><strong>Materials and methods: </strong>This retrospective study included 112 patients with HNC. Tumor metabolic activity was assessed using the total lesion glycolysis (TLG) and maximum standardized uptake value (SUVmax). Body composition was measured by the third cervical vertebra skeletal muscle index (C3 SMI). Systemic inflammation was measured by the modified Glasgow Prognostic Score (mGPS) and the neutrophil-to-lymphocyte ratio (NLR). Nutritional status was assessed by the Nutritional Risk Index (NRI).</p><p><strong>Results: </strong>The majority of patients had advanced tumor stage (75%). Malnutrition was found in 39.3% (NRI), and systemic inflammation in 44.7% (mGPS) and 41.1% (NLR) of patients. High TLG was associated with low C3 SMI (p = 0.021), low NRI (p = 0.01), high mGPS (p = 0.001), and high NLR (p = 0.003). A high NLR was associated with a low C3 SMI (p = 0.046) and low body mass index (BMI) (p = 0.01).</p><p><strong>Conclusion: </strong>Our study establishes a relationship between the high metabolic activity of tumor, the loss of muscle mass, and increased systemic inflammation.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}