An interdisciplinary intervention improves lifestyle behaviours in women living with obesity and subfertility: A secondary analysis of a randomized controlled trial

IF 2.6 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-05-28 DOI:10.1016/j.clnesp.2025.05.036

Audrey St-Laurent , Matea Belan , Farrah Jean-Denis , Marie-France Langlois , Marie-Hélène Pesant , Belina Carranza-Mamane , Karine Duval , Anne-Sophie Morisset , Jean-Patrice Baillargeon

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引用次数: 0

Abstract

Background & aims

There are few effective interdisciplinary lifestyle programs aiming to support women with obesity who are seeking fertility treatments. This study aims to determine whether the Obesity-Fertility lifestyle program leads to healthier lifestyle behaviours in women with obesity and subfertility compared to controls.

Methods

This is a secondary analysis of an open-label randomized controlled trial whose primary outcome was live birth rate. Women with obesity and subfertility were randomized to the lifestyle (LSG = 65) or control (CG = 65) groups. The LSG participated in individual and group sessions with a dietitian and a kinesiologist, while the CG received the usual care of the fertility clinic. Data on food consumption, physical activity, sedentary time, and smoking and alcohol use were collected before and 6 months after the intervention. Functional capacity was evaluated with a 6-min walk test (6MWT). Changes in lifestyle after 6 months were compared between groups with p-values corrected for the outcome baseline data.

Results

From January 2012 to September 2016, 130 women were randomized, 85 of whom had data available at 6 ± 1 months (LSG = 42 and CG = 43). Groups had similar sociodemographic characteristics and lifestyle behaviours at baseline, except for lower prevalence of smoking in LSG (9.5 %) vs CG (34.9 %) (p = 0.005). After 6 months of follow-up, and compared to the CG, women in the LSG significantly improved their intake of whole fruits (+1.1 ± 1.2 vs +0.4 ± 0.8/day, p = 0.001), whole grain products (+1.0 ± 1.3 vs +0.04 ± 1.2/day, p < 0.001), dairy products (+0.4[0; 0.9] vs −0.1[-0.7; 0.3]/day, p < 0.001); breakfast frequency (+1.4 ± 2.6 vs +0.5 ± 1.8/week, p < 0.001); proportion of active women (>3 kcal/kg/day: +14.2 % vs +2.3 %, p = 0.003); and time spent in sedentary behaviour (−6.7 vs −0.1 h/week, p < 0.005). Distance covered during the 6MWT tended to increase more in LSG vs CG (+28.8 ± 42.1 vs +5.5 ± 42.6 m, p = 0.06). No significant difference was found between groups for sleep duration, alcohol consumption and smoking use.

Conclusion

After 6 months, the Obesity-Fertility program significantly improved diet quality, physical activity level and sedentary behaviour in women with obesity and subfertility. Such programs can therefore support these women to adopt healthier lifestyle behaviours.

Clinicaltrials.gov registration number

NCT01483612.

查看原文本刊更多论文

一项跨学科干预改善了肥胖和低生育能力妇女的生活方式行为：一项随机对照试验的二次分析。

背景与目的：很少有有效的跨学科生活方式项目旨在支持寻求生育治疗的肥胖妇女。本研究旨在确定与对照组相比，肥胖-生育生活方式计划是否会导致肥胖和生育能力低下的女性更健康的生活方式行为。方法：这是一项以活产率为主要结局的开放标签随机对照试验的二次分析。肥胖和生育能力低下的妇女随机分为生活方式组（LSG=65）和对照组（CG=65）。LSG组参加了一名营养师和一名运动学家的个人和小组会议，而CG组则接受了生育诊所的常规护理。在干预前和干预后6个月收集食物消费、身体活动、久坐时间、吸烟和饮酒的数据。通过6分钟步行试验（6MWT）评估功能能力。比较6个月后各组生活方式的变化，并校正结果基线数据的p值。结果：2012年1月至2016年9月，随机抽取130名妇女，其中85名妇女在6±1个月时可获得资料（LSG=42， CG=43）。各组在基线时具有相似的社会人口学特征和生活方式行为，除了LSG（9.5%）比CG（34.9%）的吸烟率更低（p=0.005）。随访6个月后，与对照组相比，LSG组女性的全水果（+1.1±1.2 vs +0.4±0.8/天，p=0.001）、全谷物产品（+1.0±1.3 vs +0.04±1.2/天，p3 kcal/kg/天：+14.2% vs +2.3%, p=0.003）的摄入量显著提高；结论：6个月后，肥胖-生育项目显著改善了肥胖和生育能力低下女性的饮食质量、身体活动水平和久坐行为。因此，这些方案可以支持这些妇女采取更健康的生活方式。临床试验：政府注册号：NCT01483612。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.