Clinical nutrition ESPEN最新文献

{"title":"Plasma Creatine, Estimated Intramuscular Creatine and Risk of Mortality in Stable Kidney Transplant Recipients: Results from the TransplantLines Biobank and Cohort study.","authors":"Caecilia S E Doorenbos, Adrian Post, Yvonne van der Veen, Casper F M Franssen, Michele F Eisenga, Robin P F Dullaart, Gerjan Navis, Qinglin Wu, Margery A Connelly, Stephan J L Bakker","doi":"10.1016/j.clnesp.2025.07.030","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.07.030","url":null,"abstract":"<p><strong>Background: </strong>Kidney transplant recipients (KTR) have reduced survival rates compared to the general population. Creatine is an endogenous nitrogenous organic acid, essential for energy metabolism. This study investigates sex stratified plasma creatine and estimated intramuscular creatine concentrations, and their transmembrane cellular gradient in relation to mortality in KTR.</p><p><strong>Methods: </strong>We included 700 adult KTR with a functioning graft for at least one year post transplantation (TransplantLines Biobank and Cohort Study (NCT03272841)). Plasma creatine was measured using nuclear magnetic resonance spectroscopy. Intramuscular creatine was estimated using 24-hour urinary creatinine excretion divided by muscle mass, measured with bioelectrical impedance analysis. Transmembrane cellular gradient was defined as intramuscular creatine/plasma creatine. Cox proportional hazard models were used to assess associations with all-cause mortality.</p><p><strong>Results: </strong>The mean age of participants was 56±13 years, mean eGFR_cysc+creat was 55±19 ml/min/1.73m² and 39% were female. Plasma creatine and estimated intramuscular creatine were higher in females than males (36 [24; 49] vs 24 [18; 32] μmol/L; and 29.5±6.6 vs 26.2±6.5 mmol/kg, respectively, both P<0.001), while the transmembrane cellular gradient was lower in females (810 [591; 1189] vs 1062 [781; 1506] L/kg, P<0.001). During a median of 6.1 [5.0; 7.1] years of follow-up, a total of 148 KTR died. When adjusting for potential confounders, higher plasma creatine was associated with increased mortality in males (HR per doubling: 1.42 [1.10; 1.84], P=0.007), but not in females (HR: 1.03 [0.70; 1.51]; P=0.88). Higher estimated intramuscular creatine was associated with lower mortality in both sexes (HR: 0.28 [0.07; 0.46], P<0.001 in females; HR: 0.52 [0.29; 0.91], P=0.022 in males). A higher transmembrane cellular gradient was linked to lower mortality in males (HR: 0.63 [0.50; 0.81], P<0.001), while there was a non-significant trend in females (0.71 [0.48; 1.06]; P=0.09).</p><p><strong>Conclusion: </strong>Creatine homeostasis markers are associated with mortality in a sex-specific manner in KTR, suggesting a potential role for creatine metabolism in patient prognosis. Future studies should explore underlying mechanisms and the potential of creatine-based interventions.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of passive and exercise-induced dehydration on body composition using dual energy X-ray absorptiometry.","authors":"José Moncada-Jiménez, Yamileth Chacón-Araya, Elizabeth Carpio-Rivera","doi":"10.1016/j.clnesp.2025.07.011","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.07.011","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the effect of dehydration on changes in body composition using dual energy x-ray absorptiometry (DXA).</p><p><strong>Methodology: </strong>Sixty college students completed a non-exercise control (NEC) and an exercise-induced dehydration (EID) session. Both sessions were held on a climatized control laboratory at 30°C and a relative humidity of 70%. Exercise was performed on a stationary bicycle for 60-min at an intensity of 65%-75% of the reserve heart rate. Body composition was assessed by DXA before and after the sessions and the mean body composition differences were correlated with the degree of dehydration achieved by the participants.</p><p><strong>Results: </strong>The experimental sessions elicited dehydration in all the participants (NEC= 0.50 ± 0.51% vs. EID= 1.11 ± 0.45%; p ≤ 0.0001; CI95%_diff= -0.75, -0.47%). In the NEC condition, dehydration (β = 0.51, p ≤ 0.0001) and age (β = 0.22, p = 0.046) predicted the difference in trunk tissue (R² = 0.32). Dehydration (β = 0.93, p ≤ 0.0001) and gender (β = -0.11, p = 0.013) predicted the difference in total tissue (R² = 0.90). Dehydration predicted differences in trunk lean mass (β = 0.37, p = 0.004, R² = 0.14), total lean mass (β = 0.36, p = 0.004, R² = 0.13), and total trunk mass (β = 0.52, p ≤ 0.0001, R² = 0.27). Dehydration (β = 0.95, p ≤ 0.0001) and gender (β = -0.09, p = 0.015) predicted the difference in total mass (R² = 0.94). For the EID condition, dehydration and gender predicted the difference in total tissue (β_dehydration = 0.72, p ≤ 0.0001, β_gender = -0.27, p = 0.001, R² = 0.71) and total mass (β_dehydration = 0.75, p ≤ 0.0001, β_gender = -0.27, p ≤ 0.0001, R² = 0.77). Dehydration (β = 0. 32, p = 0.012) predicted differences in total lean mass (R² = 0.10).</p><p><strong>Conclusion: </strong>Age, gender and dehydration predicted differences in body composition scores. Technicians and researchers must control hydration status before DXA scan sessions.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Examining commonalities and differences in food groups, nutrients, and diet quality among popular diets\" [Clin Nutr ESPEN 41 (2021) 377-385].","authors":"Gabrielle Turner-McGrievy, Michael D Wirth, Kathleen L Hill, Emma R Dear, James R Hébert","doi":"10.1016/j.clnesp.2025.06.032","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.06.032","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skeletal muscle gauge: A superior predictor of neoadjuvant chemoimmunotherapy efficacy in locally advanced gastric cancer.","authors":"Zhi-Yong Zhou, Bing Lai, Fa-Yang Lei, Xiang Chen, Jia-Qing Cao, Sheng-Xun Mao, Jiao-Bao Huang","doi":"10.1016/j.clnesp.2025.07.028","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.07.028","url":null,"abstract":"<p><strong>Background: </strong>Muscle parameters are closely related to the efficacy of neoadjuvant therapy, and this study aims to analyze the predictive value of a novel muscle parameter index (skeletal muscle gauge, SMG) for the efficacy of neoadjuvant chemotherapy and immunotherapy(NCI) in locally advanced gastric cancer(LAGC).</p><p><strong>Method: </strong>A retrospective analysis was conducted on the clinical pathological data and abdominal CT images of patients with LAGC who received NCI at the Second Affiliated Hospital of Nanchang University from September 2020 to December 2023. The body composition, including skeletal muscle index (SMI), skeletal muscle radiation attenuation (SMRA), and the new skeletal muscle parameter- SMG (obtained by multiplying SMI and SMRA), was calculated using the SliceOmatic software before and after NCI. The relationships between the three skeletal muscle parameters and the NCI efficacy and postoperative complications were analyzed and compared.</p><p><strong>Results: </strong>A total of 162 patients were included in this study,Before neoadjuvant, the median SMI was 38.1(34.2-44.3)cm/m², SMRA was 44.7(41.1-48.4)HU, and SMG was 1776(1449-1979).Multivariate logistic analysis showed that cN stage (OR: 5.75, 95% CI: 3.21-11.52, p=0.008) and SMG(OR: 0.99, 95% CI: 0.96-0.99, p=0.001) were poor tumor regression (TRG 3 grade). SMI(OR:0.50, 95% CI: 0.29-0.88, p=0.016), SMRA(OR:0.58, 95% CI: 0.36-0.91, p=0.018) and SMG(OR:0.96, 95% CI: 0.96-0.99, p=0.001) are all protective factors for postoperative complications. ROC curve analysis showed that SMG was superior to SMI and SMRA in predicting tumor recession and postoperative complications.</p><p><strong>Conclusion: </strong>The new skeletal muscle parameters showed better predictive performance in the efficacy of NCI for LAGC and are a promising evaluation indicator, but they still need to be verified by prospective studies with larger samples.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of energy and protein delivery with mortality in critically ill patients with low muscularity assessed by computed tomography: A single-center retrospective study","authors":"Carolyn Tze Ing Loh ,&nbsp;M. Shahnaz Hasan ,&nbsp;Prasath Swaminathan ,&nbsp;Ching Choe Ng ,&nbsp;Wai Yee Chan ,&nbsp;Amirah Tengku ,&nbsp;Sher Theng Yap ,&nbsp;Nor'azim Mohd Yunos ,&nbsp;Christian Stoppe ,&nbsp;Charles Chin Han Lew ,&nbsp;Zheng-Yii Lee","doi":"10.1016/j.clnesp.2025.07.020","DOIUrl":"10.1016/j.clnesp.2025.07.020","url":null,"abstract":"<div><h3>Background and aims</h3><div>In the critically ill population, low skeletal muscle mass and quality are associated with worse patient outcomes. Since nutrition may attenuate muscle loss, we aimed to determine whether energy and/or protein delivery during critical illness is associated with 60-day mortality in patients with low muscularity.</div></div><div><h3>Methods</h3><div>This retrospective study included intubated patients with intensive care unit (ICU) stay of ≥72 h and computed tomography (CT) scan within 72 h of admission covering L1/L3 level. Skeletal muscle area (SMA), skeletal muscle density (SMD), and intermuscular adipose tissue were quantitatively derived. CT parameters that independently predicted 60-day mortality were used to establish low muscularity cutoffs using receiver operating characteristics curve analysis. The associations between energy and protein delivered during the first 14 days in ICU with 60-day mortality in low muscularity subgroups were evaluated using multivariable logistic regressions.</div></div><div><h3>Results</h3><div>Among the 199 patients included (mean age 53.2 ± 18.5 years, BMI 25.6 ± 6.3 kg/m², APACHE II score 18.5 ± 7.4), SMA (adjusted odds ratio [aOR] 0.977, p &lt; 0.001) and SMD (aOR 0.960, p = 0.007) were independently predicted 60-day mortality. Low muscularity cut-offs were SMA 119.1/80.8 cm² and SMD 39.4/19.7 HU in males/females, respectively. Energy and protein delivery during the ICU stay were not associated with 60-day mortality in patients with low SMA, low SMD, or low SMA + SMD.</div></div><div><h3>Conclusion</h3><div>In critically ill patients, low SMA and low SMD were independently associated with higher mortality risk; however, energy and protein delivery over the first 14 ICU days had no association with 60-day mortality in those with low SMA and/or low SMD.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"69 ","pages":"Pages 303-310"},"PeriodicalIF":2.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of circulating fatty acids with metabolic dysfunction-associated steatotic liver disease: A cross-sectional analysis and Mendelian randomization study","authors":"Zhibing Liu ,&nbsp;Peng Wang ,&nbsp;Yiming Wang ,&nbsp;Jing Yu ,&nbsp;Qingxuan Wang ,&nbsp;Jibin Li ,&nbsp;Dan Shi","doi":"10.1016/j.clnesp.2025.07.027","DOIUrl":"10.1016/j.clnesp.2025.07.027","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent condition with limited therapeutic options. Circulating fatty acids (FAs) have been linked to MASLD, but their specific roles and potential causality remain unclear. This study aimed to clarify the associations between FAs and MASLD.</div></div><div><h3>Methods</h3><div>This study analyzed data from the National Health and Nutrition Examination Survey 2011–2014, including 3084 participants with serum FAs concentrations (% total FAs). MASLD status was assessed using the Fatty Liver Index (FLI) or the U.S. Fatty Liver Index (USFLI). Odds ratios (OR) and 95 % confidence intervals (CI) of MASLD risk were evaluated using weighted logistic regression. Mendelian randomization (MR) analysis for FAs with MASLD was conducted, and the principal analysis employed the inverse variance weighted approach.</div></div><div><h3>Results</h3><div>In observational analysis, we identified 1500 cases of MASLD. Saturated FAs (SFAs) were positively associated with MASLD risk [OR_Q3vsQ1: 2.41 (95 % CI: 1.56–3.74)], whereas polyunsaturated FAs (PUFAs) and omega-6 PUFAs showed the negative associations [OR_Q3vsQ1: 0.49 (0.30–0.80) and OR_Q3vsQ1: 0.46 (0.27–0.79), respectively]. Among 30 individual FAs, 7 were associated with an increased risk of MASLD, with the highest risk observed for dihomo-gamma-linolenic acid [OR_Q3vsQ1: 2.07 (1.30–3.28)]. In contrast, 3 FAs showed an inverse association, with the lowest risk observed for linoleic acid [OR_Q3vsQ1: 0.50 (0.28–0.90)]. MR analysis revealed negative causal relationships between genetically predicted omega-6 PUFAs/total fatty acids (TFA) [OR: 0.80 (0.65–0.99)], PUFAs/TFA [OR: 0.73 (0.63–0.84)] and MASLD.</div></div><div><h3>Conclusions</h3><div>There are differential associations between individual FAs and collective fatty acid classes with MASLD risk, and omega-6 PUFAs may serve as stable biomarkers for potential prevention and treatment of MASLD.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"69 ","pages":"Pages 294-302"},"PeriodicalIF":2.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between social frailty and malnutrition in community-dwelling older adults undergoing rehabilitation.","authors":"Norito Kobayashi, Shohei Tokuno, Masafumi Nozoe, Yasushi Miura","doi":"10.1016/j.clnesp.2025.07.019","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.07.019","url":null,"abstract":"<p><strong>Background & aims: </strong>Social frailty and malnutrition are considered major health issues in community-dwelling older adults undergoing rehabilitation. This study aimed to examine the relationship between social frailty and malnutrition among community-dwelling older adults undergoing rehabilitation.</p><p><strong>Methods: </strong>This was a multicenter cross-sectional study. The study included older adults requiring Level 1 or 2 support who were undergoing rehabilitation within the Long-Term Care (LTC) system at three facilities between April 2022 and December 2023. This observational study assessed calf circumference, five-meter walking speed, and Timed Up and Go performance. Physical and social frailty were assessed using the Japanese version of Fried's Cardiovascular Health Study criteria, which incorporates Makizako's five-item questionnaire. Malnutrition was evaluated according to the Global Leadership Initiative on Malnutrition (GLIM) diagnostic criteria. Logistic regression analysis was conducted to examine the independent association between each assessment and undernutrition.</p><p><strong>Results: </strong>In total, 211 older participants (median age: 81 years) were included in the study. Physical and social frailties were present in 29.3% (62 cases) and 58.7% (124 cases) of participants, respectively. In the crude model, social frailty was significantly associated with malnutrition (OR (odds ratio) = 2.42, 95%CI (confidential interval): 1.15-5.11, p = 0.020; E-value = 1.57). In the adjusted model, both physical frailty (adjusted OR = 1.18, 95% CI: 1.03-3.31, p = 0.038) and social frailty (adjusted OR = 2.55, 95% CI 1.22-5.34, p = 0.013) were independently associated with GLIM criteria for malnutrition.</p><p><strong>Conclusions: </strong>This study demonstrates that social frailty is significantly associated with malnutrition. Notably, this is the first study to suggest that social frailty may contribute to malnutrition in older adults. These findings highlight the importance of assessing social frailty in older adults undergoing rehabilitation in LTC settings.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emphasis on the benefits of multiple micronutrients in alleviating adverse events in children","authors":"Yi Tian,&nbsp;Ting Chen","doi":"10.1016/j.clnesp.2025.07.026","DOIUrl":"10.1016/j.clnesp.2025.07.026","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"69 ","pages":"Page 266"},"PeriodicalIF":2.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POTASSIUM QUANTIFICATION AND SENSORY ANALYSIS IN PLANT FOOD COOKING PROCESSES IN HEART DISEASE PATIENTS.","authors":"Janete Catarina Martins Corrêa Haider, Izabele Vian, Jessica Werpp Bonfante, Juliana da Silveira Gonçalves, Charles Lecina Hoffmann","doi":"10.1016/j.clnesp.2025.07.003","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.07.003","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background and objectives: &lt;/strong&gt;Low potassium (K) diets are recommended for patients at risk of developing hyperkalemia, particularly those with impaired renal function or those who also use medications that can increase serum K levels. In such cases, a K-restricted diet can help reduce the risk of hyperkalemia and, consequently, cardiac arrhythmias and mortality. A diet rich in vegetables, greens, and fruits is essential for the prevention of chronic diseases and plays a vital role in the nutritional therapy of patients with Chronic Kidney Disease (CKD). Factors such as the method of heat transfer, temperature intensity, duration of the process, and the cooking medium used can cause changes in the chemical, physical, and nutritional characteristics of food. Sensory appeal should not be overlooked in favor of therapy alone; recovery efforts must also consider the importance of offering pleasure in the act of eating. This study aimed to quantify the potassium content in vegetables and legumes prepared using different cooking techniques, adapting to patient preferences in order to stimulate intake.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This was a randomized crossover clinical trial conducted in two phases. The first phase involved potassium content analysis, and the second consisted of a sensory evaluation to assess patient acceptance of the prepared foods at the Institute of Cardiology - University Foundation of Cardiology (IC-FUC), Porto Alegre, Brazil. A total of 68 patients evaluated each food, with a statistical power of 80% and a significance level of 5% (95% confidence interval). Foods were selected based on the TACO table, focusing on those that required cooking and had high potassium content (above 201 mg/100 g). Vegetables and legumes with higher K concentrations were submitted to different cooking techniques.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The vegetables with the lowest potassium values were spinach (74.85 mg/100 g) and zucchini (93.62 mg/100 g), both cooked under pressure. Among the lowest values, only squash (237.83 mg/100 g), also pressure-cooked, exceeded 200 mg/100 g. Among legumes, beans showed potassium levels below this threshold across all methods. For lentils, soaking-regardless of duration-combined with various cooking techniques yielded the best reductions. Pressure cooking resulted in the lowest K losses, followed by boiling in two waters and one water, respectively. These techniques were most effective in preserving potassium. The sautéed method resulted in values above 200 mg/100 g for all vegetables except beetroot (196.23 mg/100 g), while the dry oven method consistently showed values far above recommended levels. ANOVA tests revealed no statistically significant differences in potassium content for legumes across soaking durations or cooking methods. A similar trend was observed for vegetables. Regarding sensory acceptance, no significant differences were found for legumes, as confirmed by the Tukey test. For ","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nomogram model combining sarcopenic obesity and biomarkers to predict the risk of vascular stiffness.","authors":"Wenwen Liu, Mingyu Zhu, Ziyi Wei, Ningxin Chen, Tingting Han, Ting Zhang, Yurong Weng, Yiling Fan, Yaomin Hu","doi":"10.1016/j.clnesp.2025.07.021","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.07.021","url":null,"abstract":"<p><strong>Background & aims: </strong>Accumulating evidence reveals that sarcopenia and obesity display a close association with vascular aging. However, comprehensive analysis of the clinical model for estimating the risk of arterial stiffness based on the co-existence of sarcopenia and obesity has not yet been performed.</p><p><strong>Methods: </strong>Here, we curated anthropometric, serological, clinical and computerized tomography (CT) variables from 1136 patients and applied univariate analysis (to eliminate irrelevant predictors) and logistic regression analysis (p <0.05) in the development cohort to establish the clinical model. The precision of the model was evaluated through area under the curve (AUC) of receiver operator characteristic (ROC), calibration plot and decision curve analysis (DCA), for its discriminative power, calibration consistency and clinical usefulness.</p><p><strong>Results: </strong>Logistic regression analysis identified that body mass index (BMI), total triglyceride (TG), interleukin-6 (IL-6), previous diabetes and hypertension, skeletal muscle fat index (SMFI) and skeletal muscle index (SMI) served as independent predictors for arterial stiffness and three clinical models based on these variables were constructed. The Model incorporating SMI and SMFI simultaneously (model ^SMI+SMFI), exhibited superior performance as compared to the models with only SMI (model ^SMI) or only SMFI (model ^SMFI), with reference to the discriminative power (ROC ^SMI+SMFI 0.795), calibrative ability (Eavg ^SMI+SMFI 0.022, Emax ^SMI+SMFI 0.041) and clinical utility in the validation cohort.</p><p><strong>Conclusions: </strong>This research presents a model for the estimation of pulse wave velocity (PWV), which incorporates BMI, TG, IL-6, previous diabetes and hypertension, SMI and SMFI. The model incorporating sarcopenia and obesity simultaneously instead individually, predicts arterial stiffness more accurately. This advancement could enhance our understanding of the role of sarcopenic obesity in vascular dysfunction.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}