Rafaela Fernandes Mundstock , Caroline Marques de Lima Cunha , Kellen dos Santos de Lima , Caio Wolff Ramos Baumstein , Raquel Canuto , Vera Lúcia Bosa , Vivian Cristine Luft , Valesca Dall’Alba , Zilda de Albuquerque Santos , Thais Ortiz Hammes
{"title":"Achieving nutritional goals in prone position: A cohort study in critically ill patients with coronavirus disease","authors":"Rafaela Fernandes Mundstock , Caroline Marques de Lima Cunha , Kellen dos Santos de Lima , Caio Wolff Ramos Baumstein , Raquel Canuto , Vera Lúcia Bosa , Vivian Cristine Luft , Valesca Dall’Alba , Zilda de Albuquerque Santos , Thais Ortiz Hammes","doi":"10.1016/j.clnesp.2025.03.001","DOIUrl":"10.1016/j.clnesp.2025.03.001","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to describe nutritional therapy and clinical outcomes in critically ill patients with coronavirus disease (COVID-19) hospitalized in an intensive care unit, submitted or not to the prone position.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included adult patients with COVID-19 admitted to the intensive care unit (ICU) of a public university hospital from June to December 2020. Sociodemographic, clinical, nutritional, and anthropometric data were collected in electronic medical records with a prestructured collection instrument. Patients who underwent a prone position at least once during hospitalization were considered in the prone group.</div></div><div><h3>Results</h3><div>677 patients were included and 35.4 % were placed in the prone position. Pronated patients had a higher prevalence of obesity (p = 0.005), pressure ulcers (p < 0.001), required more mechanical ventilation (p < 0.001) and renal replacement therapy (p = 0.004), had longer hospital length of stay (p < 0.001) and higher mortality rate (p < 0.001). They required enteral nutrition more frequently and remained on this therapy for a longer duration, despite having similar caloric and protein targets. No significant differences were found in the ability to achieve nutritional goals between pronated and non-pronated patients.</div></div><div><h3>Conclusion</h3><div>Critically ill patients in the prone position had longer hospital stays and higher mortality rates, while being more likely to initiate and remain on enteral nutrition for a longer period. However, no significant differences were observed in the time to achieve protein and caloric goals compared to those in the supine position.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"67 ","pages":"Pages 50-55"},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Habitual Intake of Macronutrients and Fermentable Oligo-, Di-, Monosaccharides and Polyols is not associated with Irritable Bowel Syndrome-like Symptoms in Inflammatory Bowel Disease.","authors":"Insaf Zerouga, Jørgen Valeur, Christine Sommer, Monica Hauger Carlsen, Milada Hagen, Marte Lie Høivik, Vendel Ailin Kristensen, Randi Opheim, Laila Arnesdatter Hopstock, Vibeke Strande, Charlotte Lund, Raziye Boyar, Øivind Asak, May-Bente Bengtson, Tone Bergene Aabrekk, Øistein Hovde, Gert Huppertz-Hauss, Trond Espen Detlie, Petr Ricanek, Svein Oscar Frigstad, Audun Stubhaug, Anne-Marie Aas","doi":"10.1016/j.clnesp.2025.03.005","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.03.005","url":null,"abstract":"<p><strong>Purpose: </strong>Almost a third of patients with inactive inflammatory bowel disease (IBD) suffer from symptoms compatible with irritable bowel syndrome (IBS-like symptoms). The relation between these symptoms and diet in patients with IBD is not fully established. We aimed to assess associations between IBS-like symptoms and intake of macronutrients and fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs) in patients with inactive IBD compared to an IBD-free background population.</p><p><strong>Methods: </strong>Patients with IBD at one-year follow-up from the IBSEN III (Inflammatory bowel disease in South-Eastern Norway) study were compared to an IBD-free general population (the Tromsø7 sample). A food frequency questionnaire (FFQ) was used to collect dietary data including FODMAP intake, which was compiled as gram/100 gram of food and assessed in patients with active versus inactive IBD. Rome IV criteria were applied to define IBS-like symptoms in patients with inactive IBD.</p><p><strong>Results: </strong>A sample of 154 patients ≥40 years with inactive IBD was compared to 11078 adults from the IBD-free background population (Tromsø7). There were no significant associations between IBS-like symptoms and FODMAP and macronutrient intake, neither in patients with inactive IBD nor in the IBD-free background population. Patients with IBD ≥40 years had higher intake of fructans and total FODMAPs compared to the Tromsø7 sample. Intake of nutrients and FODMAPs was similar in patients with active IBD (n=105), inactive IBD with IBS-like symptoms (n=55), and without IBS-like symptoms (n=197).</p><p><strong>Conclusion: </strong>FODMAP and macronutrient intake were not associated with IBS-like symptoms in patients with inactive IBD one-year after diagnosis.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High adherence to a food guide may be associated with lower 24-hour urinary sodium excretion and sodium-to-potassium ratio, and higher potassium excretion.","authors":"Marina Yamagishi, Ribeka Takachi, Junko Ishihara, Ayane Shiraishi, Kayo Kurotani, Sachiko Maruya, Yuri Ishii, Kumiko Kito, Kazutoshi Nakamura, Junta Tanaka, Taiki Yamaji, Hiroyasu Iso, Motoki Iwasaki, Shoichiro Tsugane, Norie Sawada","doi":"10.1016/j.clnesp.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.03.008","url":null,"abstract":"<p><strong>Background & aims: </strong>Salt reduction remains an important issue in population-level studies of diet. One unresolved issue is whether adherence to a food guide which does not assess dietary salt can lead to a reduction in salt intake.</p><p><strong>Methods: </strong>This study aimed to investigate the association between adherence to a food guide calculated by weighed food records (WFRs) or a Food Frequency Questionnaire (FFQ), and urinary sodium and potassium excretion and sodium-to-potassium ratio. Further, salt-added scores were developed and analyzed. We used cross-sectional data, including data from 12-day WFRs, five 24-hour urine collections, and an FFQ. A total of 248 participants aged 35-80 years were surveyed between 2012 and 2013. Main outcomes were 24-hour urinary sodium and potassium excretion and sodium-to-potassium excretion ratio. Multiple regression analysis was performed with urinary excretion as the dependent variable and the food guide score calculated by WFRs and the FFQ as independent variables. Because scores are not proportional to intake under this food guide scoring method, Spearman's correlation coefficients were calculated between the score and urinary excretion, and between the number of servings and urinary excretion.</p><p><strong>Results: </strong>When scored by WFRs, the higher food guide score group tended to have lower sodium excretion (-129 mg/day per one quartile increase; P for trend, 0.051), higher potassium excretion (137 mg/day per one quartile increase, P <0.01), and lower sodium-to-potassium ratio (-0.32 per one quartile increase, P <0.01). When accompanied by salt-added scores, total score was associated with further reductions in sodium excretion (-218 mg/day per one quartile increase; P for trend, <0.001).</p><p><strong>Conclusions: </strong>Even with a study food guide which does not assess dietary salt, high adherence to the guide tended to be associated with lower sodium excretion and sodium-to-potassium ratio and higher potassium excretion. This inverse association with sodium excretion was strengthened by the addition of a salt-added score.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Felix Oladele Okunlola, Abimbola Rafiat Okunlola, Babatunde Oluwafemi Adetuyi, Mahmoud E S Soliman, Athanasios Alexiou, Marios Papadakis, Mohamed N Fawzy, Gaber El-Saber Batiha
{"title":"Beyond the Gut: Unraveling the Multifaceted Influence of Microbiome on Cardiovascular Health.","authors":"Felix Oladele Okunlola, Abimbola Rafiat Okunlola, Babatunde Oluwafemi Adetuyi, Mahmoud E S Soliman, Athanasios Alexiou, Marios Papadakis, Mohamed N Fawzy, Gaber El-Saber Batiha","doi":"10.1016/j.clnesp.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.03.002","url":null,"abstract":"<p><p>Cardiovascular disease is one of the leading causes of death worldwide. Even while receiving adequate pharmacological treatment for their hypertension, people are nonetheless at greater risk for cardiovascular disease. There is growing evidence that the gut microbiota may have major positive and negative effects on blood pressure and illnesses related with it as more study into this topic is conducted. Trimethylamine n-oxide (TMAO) and short-chain fatty acids (SCFA) are two major by-products of the gut microbiota. TMAO is involved in the formation of other coronary artery diseases, including atherosclerosis and hypertension, while SCFAs play an important role in controlling blood pressure. Numerous investigations have confirmed the established link between dietary salt intake and hypertension. Reducing sodium in the diet is linked to lower rates of cardiovascular disease morbidity and mortality as well as lower rates of blood pressure and hypertension. In both human and animal research, high salt diets increase local and systemic tissue inflammation and compromise gut architecture. Given that the gut microbiota constantly interacts with the immune system and is required for the correct maturation of immune cells, it is scientifically conceivable that it mediates the inflammatory response. This review highlights the therapeutic possibilities for focusing on intestinal microbiomes as well as the potential functions of the gut microbiota and its metabolites in the development of hypertension.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abisola M Oyelere, Femke Fleur Verstraete, Dieuwertje E Kok, Daniel Bos, Marc J Gunter, Johannes H W de Wilt, Pekka Keski-Rahkonen, Fränzel J B van Duijnhoven, Ellen Kampman
{"title":"Coffee consumption and mortality in colorectal cancer patients: does the co-existence of cardiometabolic disease matter?","authors":"Abisola M Oyelere, Femke Fleur Verstraete, Dieuwertje E Kok, Daniel Bos, Marc J Gunter, Johannes H W de Wilt, Pekka Keski-Rahkonen, Fränzel J B van Duijnhoven, Ellen Kampman","doi":"10.1016/j.clnesp.2025.02.025","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.02.025","url":null,"abstract":"<p><strong>Background: </strong>Although coffee consumption may have a U-shaped nonlinear relationship with all-cause mortality in colorectal cancer (CRC) patients, it is unclear whether this association could differ in the presence of prevalent cardiometabolic disease (CMD). Therefore, we assessed the association of coffee consumption with mortality in CRC patients stratified by CMD status at diagnosis.</p><p><strong>Methods: </strong>We used data from a prospective cohort of 1,769 patients with stage I-III CRC. Coffee consumption was self-reported using a food frequency questionnaire at diagnosis. Mortality data were retrieved from the Personal Records Database. CMD was defined as prevalent cardiovascular disease (CVD) or diabetes at diagnosis of CRC. We estimated hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazards models with and without restricted cubic splines (RCS) while adjusting for relevant confounders.</p><p><strong>Results: </strong>During a median (quartile1, quartile 3) follow-up of 7.7 (5.6, 9.3) years, we observed 128 deaths in participants without CMD and 250 deaths in those with CMD. The five-year survival rate was 88% and 83% for participants without and with CMD, respectively. Among participants without CMD, consuming 2-4 cups/d and > 4 cups/d of coffee compared to < 2 cups/d was associated with a 60% (HR: 0.40, 95% CI: 0.26-0.63) and a 41% (HR: 0.59, 95% CI: 0.39-0.89) lower risk of mortality, respectively. In participants with CMD, consuming 2-4 cups/d of coffee compared to < 2 cups/d was associated with a 31% (HR: 0.69, 95% CI: 0.51-0.93) lower risk of mortality, while no association was observed for > 4 cups/d (HR:0.82, 95%CI:0.59-1.14). The RCS showed a U-shaped, nonlinear inverse association between coffee consumption and mortality in participants without and with CMD (P-value for nonlinearity: 0.001), but the inverse association was stronger in those without CMD.</p><p><strong>Conclusion: </strong>We observed a U-shaped, nonlinear inverse association between coffee consumption and mortality in CRC patients regardless of their CMD status. More mechanistic studies are needed to understand how consuming coffee may lower mortality risk in CRC patients.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rianne van Lieshout, Lidwine W Tick, Erik A M Beckers, Willemijn Biesbroek, Stephanie Custers, Jeanne P Dieleman, Myrthe Dijkstra, Wanda Groenesteijn, Aniek Heldens, Martine M Hengeveld, Harry R Koene, Suzanne Kranenburg, Debbie van der Lee, Liesbeth van der Put, Nicky Rademakers, Josien C Regelink, Marta Regis, Maaike Somer, Claudia J van Tilborg, Peter E Westerweel, Moniek de Witte, Sandra de Zeeuw, Harry C Schouten, Sandra Beijer
{"title":"Associations of various medical nutrition therapy strategies with body composition, and physical and clinical outcomes in acute myeloid leukemia patients undergoing intensive remission-induction treatment: a multicenter prospective correlational study.","authors":"Rianne van Lieshout, Lidwine W Tick, Erik A M Beckers, Willemijn Biesbroek, Stephanie Custers, Jeanne P Dieleman, Myrthe Dijkstra, Wanda Groenesteijn, Aniek Heldens, Martine M Hengeveld, Harry R Koene, Suzanne Kranenburg, Debbie van der Lee, Liesbeth van der Put, Nicky Rademakers, Josien C Regelink, Marta Regis, Maaike Somer, Claudia J van Tilborg, Peter E Westerweel, Moniek de Witte, Sandra de Zeeuw, Harry C Schouten, Sandra Beijer","doi":"10.1016/j.clnesp.2025.02.028","DOIUrl":"https://doi.org/10.1016/j.clnesp.2025.02.028","url":null,"abstract":"<p><strong>Background & aims: </strong>Medical nutrition therapy (MNT) is commonly used in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) undergoing intensive remission-induction treatment to prevent malnutrition, particularly the loss of fat-free mass (FFM)/muscle mass, as well as associated adverse outcomes. However, studies examining the associations between proactive versus wait-and-see approaches toward MNT and nutritional, physical, and clinical outcomes in these patients are lacking. Therefore, this study aimed to explore the associations between these different MNT approaches and body composition changes, as well as physical and clinical outcomes in AML/MDS patients undergoing intensive remission-induction treatment. Additionally, the study aimed to explore the relationships between body composition changes and physical and clinical outcomes, and whether these associations varied between the proactive and wait-and-see strategies.</p><p><strong>Methods: </strong>In this multicenter prospective correlational study, newly diagnosed AML/MDS patients undergoing intensive remission-induction treatment were included. Patients were treated in one of five hospitals using a proactive approach toward MNT, initiating MNT when nutritional intake became inadequate, or in the single hospital in the Netherlands that followed a wait-and-see strategy, limiting the use of MNT to exceptional and severe cases only. Body composition was assessed at the start of treatment, weekly during admission and at discharge, and handgrip strength, and patient-reported physical functioning and fatigue at treatment initiation and discharge. Information on number of complications, and duration of fever and LOS was collected from medical records. Within-group changes in body composition and between-group differences were tested using paired or independent t, Wilcoxon signed-rank or two-sample tests, respectively, or chi-square/Fisher's exact tests for proportions. The longitudinal patterns between proactive MNT approach/wait-and-see strategy hospitals were compared by means of linear mixed effects models. Associations between body composition changes and physical and clinical outcomes were explored using multiple linear regression models, and compared between proactive MNT approach/wait-and-see strategy hospitals.</p><p><strong>Results: </strong>In this study, 204 AML/MDS patients (54% male, mean age: 56.3±13.0 years) were included, of whom 140 underwent treatment in a hospital using a proactive approach toward MNT and 64 in the hospital following a wait-and-see strategy. In the proactive MNT approach hospitals, 57% of patients received MNT during the first chemotherapy cycle versus 8% of patients in the wait-and-see hospital (p < 0.0001). Both approaches toward MNT were associated with significant decreases in body weight, FFM/muscle mass, and muscle strength. However, body weight loss was lower with the proactive approach (estimated between-gro","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gut microbiome diversity is associated with muscle mass, strength and quality in post-stroke patients","authors":"Yoshihiro Yoshimura , Hidetaka Wakabayashi , Fumihiko Nagano , Ayaka Matsumoto , Sayuri Shimazu , Ai Shiraishi , Yoshifumi Kido , Takahiro Bise , Takenori Hamada , Kouki Yoneda , Keisuke Maeda","doi":"10.1016/j.clnesp.2025.02.027","DOIUrl":"10.1016/j.clnesp.2025.02.027","url":null,"abstract":"<div><h3>Background</h3><div>The gut microbiome has emerged as a potential influencer of muscle health; however, its role in hospitalized patients remains unclear. This study aimed to investigate the association between gut microbiome diversity and skeletal muscle mass, strength, and quality in hospitalized post-stroke patients.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study of post-stroke patients admitted to a rehabilitation facility. Gut microbiome diversity was assessed using 16S ribosomal ribonucleic acid (rRNA) gene sequencing, calculating Operational Taxonomic Unit (OTU) Richness, Faith's Phylogenetic Diversity (PD), and Shannon index. Muscle health was evaluated using skeletal muscle index (SMI) for muscle mass, handgrip strength (HGS) for muscle strength, and bioimpedance analysis-derived phase angle (PhA) for muscle quality. Multiple linear regression analyses were performed, adjusting for potential confounders.</div></div><div><h3>Results</h3><div>A total of 156 patients (mean age 78.4 years; 55.7 % male) were analyzed. OTU Richness showed significant positive associations with SMI (β = 0.197, p = 0.025), HGS (β = 0.180, p = 0.005), and PhA (β = 0.178, p = 0.022). The Shannon index was also positively associated with SMI (β = 0.120, p = 0.041), HGS (β = 0.140, p = 0.028), and PhA (β = 0.164, p = 0.032). Faith's PD did not demonstrate significant associations with muscle health parameters.</div></div><div><h3>Conclusions</h3><div>Higher gut microbiome diversity, assessed by OTU Richness and Shannon index, is associated with better muscle mass, strength, and quality in post-stroke patients. These findings suggest a potential role for gut microbiota in muscle health during stroke rehabilitation.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"67 ","pages":"Pages 25-33"},"PeriodicalIF":2.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bidirectional association between sarcopenia and diabetes: A prospective cohort study in middle-aged and elderly adults","authors":"Yu Zhang, Miao Gong, Xu-Man Feng, Yu-Xiang Yan","doi":"10.1016/j.clnesp.2025.02.026","DOIUrl":"10.1016/j.clnesp.2025.02.026","url":null,"abstract":"<div><h3>Background and aims</h3><div>Sarcopenia and diabetes are prevalent diseases among middle-aged and elderly population. This study aimed to investigate the bidirectional association between sarcopenia and diabetes.</div></div><div><h3>Methods</h3><div>This study comprised two longitudinal analyses. In cohort 1, the association between baseline diabetes and the risk of new-onset sarcopenia was assessed. In cohort 2, the association between baseline sarcopenia and the risk of new-onset diabetes was examined. Multivariate logistic regression models were used to calculate odds ratios (OR) and 95 % confidence intervals (95 % CI). Cross-lagged panel analysis was used to further validate their bidirectional associations.</div></div><div><h3>Results</h3><div>Significant bidirectional associations were observed between sarcopenia and diabetes in both cross-sectional and longitudinal analyses (<em>P</em> < 0.05). After four years of follow-up, low handgrip strength (OR: 2.31, 95 % CI: 1.74–3.08) and appendicular skeletal muscle mass index (ASM/Ht<sup>2</sup>) (OR: 1.25, 95 % CI: 1.20–1.30) were associated with an increased risk of diabetes. Conversely, elevated fasting plasma glucose (FPG) (OR: 1.52, 95 % CI: 1.17–1.96) and glycated hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>) (OR: 1.35, 95 % CI: 1.05–1.73) were associated with a higher risk of sarcopenia. Cross-lagged analysis further confirmed their bidirectional longitudinal association.</div></div><div><h3>Conclusions</h3><div>This study identified significant longitudinal bidirectional association between sarcopenia and diabetes, highlighting that each condition serves as a risk factor for the other. Clinically, early assessments of handgrip strength and ASM/Ht<sup>2</sup> may aid in diabetes prevention, while monitoring FPG and HbA<sub>1c</sub> could help reduce the risk of sarcopenia.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"66 ","pages":"Pages 556-563"},"PeriodicalIF":2.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}