Clinical nutrition ESPEN最新文献

{"title":"Letter to the editor:Comment on\"Joint association of triglyceride-glucose index and body roundness index for sarcopenia risk: A national cohort study\".","authors":"Yazhou Zhang, Shihong Luo","doi":"10.1016/j.clnesp.2026.103325","DOIUrl":"https://doi.org/10.1016/j.clnesp.2026.103325","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"103325"},"PeriodicalIF":2.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence on protein intake on lean body mass and function in community-dwelling adults aged 50 years and over living with multiple long-term conditions: systematic review.","authors":"Saima Ahmed, Aylish MacKenzie, Charlotte Eost-Telling, Chloe French, Rachel A Christie, Ahmadreza Karami, Chris Todd, Emma Vardy, Sorrel Burden, Annemarie Money","doi":"10.1016/j.clnesp.2026.103323","DOIUrl":"https://doi.org/10.1016/j.clnesp.2026.103323","url":null,"abstract":"<p><strong>Background: </strong>Older adults are at higher risk of developing multiple long-term conditions (MLTCs) in later life and diet can play an important role in the development/management of these conditions. Healthy eating policies can improve nutrition in people with MLTCs. However, specialised diets may lead to restrictive eating patterns and lower protein intake.</p><p><strong>Objectives: </strong>The current evidence around protein intake and MLTCs is limited. This review aims to examine the available evidence on protein intake on body composition and function in older adults with MLTCs.</p><p><strong>Methods: </strong>A systematic review was conducted to assess the impact of protein intake on muscle mass, body mass index, muscle strength and muscle quality in community-dwelling older adults aged 50+ years living with MLTCs (PROSPERO:CRD42024528580).</p><p><strong>Results: </strong>Seven studies were included in this review (median age 71, range 64 to 85+ years). Sample sizes ranged from 28 to 932 participants, comprising of community-dwelling adults with chronic kidney disease, sarcopenia, cancer, and obesity. Only two studies had protein intake as their intervention of interest. None of the studies analysed the impact of protein intake on body composition and function in relation to MLTCs.</p><p><strong>Conclusion: </strong>Evidence examining the impact of protein intake in adults with MLTCs was limited. Protein intake was reported as a patient characteristic for many studies, with inadequate follow-up assessments. Comparability of findings was challenging due to the range of outcome measures used. Future studies need to focus on protein intake as the primary intervention and incorporate long-term post-intervention follow-up periods with adequately powered study samples.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"103323"},"PeriodicalIF":2.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility assessment of an emulsifier-free diet in healthy subjects - a sub-analysis of the FOAM trial.","authors":"Judith Wellens, Martijn Luppens, Sien Hoekx, Julie Vanderstappen, Lies Van Elst, Eva Vissers, Marc Ferrante, Bram Verstockt, Kristin Verbeke, Christophe Matthys, Séverine Vermeire, João Sabino","doi":"10.1016/j.clnesp.2026.103321","DOIUrl":"https://doi.org/10.1016/j.clnesp.2026.103321","url":null,"abstract":"<p><strong>Background & aims: </strong>Dietary emulsifiers are omnipresent in our diet and have been associated with intestinal inflammation. Therefore, an Emulsifier-Free Diet (EFD) represents a desirable intervention in Inflammatory Bowel Diseases (IBD). We aimed to assess the feasibility of an EFD in healthy volunteers.</p><p><strong>Methods: </strong>Sixty healthy subjects were recruited to a six-week dietary intervention. After one week of their habitual diet, participants followed an EFD for six weeks with bi-weekly questionnaires on acceptability, feasibility, and barriers. Adherence, emulsifier, and ultra-processed food (UPF) intake was assessed through daily food logs including photographs starting at baseline.</p><p><strong>Results: </strong>Two subjects were excluded due to NSAID use, and one for nutritional analysis due to implausible food logs. During the EFD, emulsifier intake decreased by 96.6% (IQR 85.6-100%, baseline vs. week 2; p=9x10^-11, baseline vs. week 6; p=9x10^-11), whereas UPF consumption decreased by 37.1 % (IQR 15.4-65.8%, baseline vs. week 2; p=2x10^-7, baseline vs. week 6; p=1x10^-9). Median adherence was 88.1% (IQR 75.6-94.9%). During the EFD, participants consumed a median of six emulsifier servings (IQR 2-13) for a median of three different products (1-5), mostly from the categories of dairy-like, meat, and bakery products. By the end of the trial, the diet was acceptable, feasible, tasty, and easy to follow for 72.4%, 72.6%, 70.7% and 50.0% of participants, respectively.</p><p><strong>Conclusions: </strong>An EFD was acceptable and feasible with high adherence rates, meanwhile, an inadvertent and stable decrease in UPF intake was noted. These results show promise in the applicability of an EFD in IBD management and prevention (NCT06552156).</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"103321"},"PeriodicalIF":2.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Association of oral frailty with 1-year all-cause mortality in older patients with heart failure: A retrospective cohort study\".","authors":"İbrahim Kuran, Ayşegül Erdoğdu Bakır, Kiraz Hilal Gümüşbuğa, Mert Eşme","doi":"10.1016/j.clnesp.2026.103318","DOIUrl":"https://doi.org/10.1016/j.clnesp.2026.103318","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"103318"},"PeriodicalIF":2.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Agreement and Clinical Utility of Anthropometric Equation-Estimated Appendicular Skeletal Muscle Mass Compared to Dual-Energy X-ray Absorptiometry in Patients with Type 2 Diabetes Mellitus.","authors":"Zhenchao Liu, Yuqian Ren, Yun Wang, Xinbo Zhao, Yu Cao","doi":"10.1016/j.clnesp.2026.103315","DOIUrl":"https://doi.org/10.1016/j.clnesp.2026.103315","url":null,"abstract":"<p><strong>Objective: </strong>Sarcopenia is increasingly recognized as a critical complication of type 2 diabetes mellitus (T2DM), representing the convergence of global population ageing and escalating metabolic disease prevalence. Reliable assessment of appendicular skeletal muscle mass (ASM) is essential for timely detection and effective intervention. This study evaluated the validity of a widely adopted anthropometric equation for estimating ASM in healthy adults and T2DM patients, using dual-energy X-ray absorptiometry (DXA) as the reference method.</p><p><strong>Methods: </strong>We retrospectively analyzed 402 adults who underwent DXA at Linyi People's Hospital from January 2016 to December 2022, including 175 patients with T2DM and 227 healthy controls. DXA-derived ASM and skeletal muscle index (SMI) were obtained from whole-body scans. Predicted ASM (ASM2) was calculated using the Wen equation, and predicted SMI (SMI2) was derived accordingly. Low muscle mass was defined by Asian Working Group for Sarcopenia 2019 criteria. Correlation, Bland-Altman analysis, Lin's concordance correlation coefficient, calibration, receiver operating characteristic (ROC) analysis, multivariable regression, and age-stratified analyses were performed. Shannon entropy was used exploratorily to describe subgroup distributional heterogeneity.</p><p><strong>Results: </strong>ASM2 correlated strongly with DXA-measured ASM in both healthy controls (r = 0.882) and T2DM patients (r = 0.871; both P < 0.001), with no significant difference between groups. However, Bland-Altman analysis showed systematic overestimation of ASM by the Wen equation, with only moderate agreement overall and wider limits of agreement in T2DM, especially in women. Concordance was better in men than women. For low muscle mass detection, SMI2 performed well in healthy men (area under the curve (AUC) = 0.851) and men with T2DM (AUC = 0.858), acceptably in healthy women (AUC = 0.793), but poorly in women with T2DM (AUC = 0.596), who also had the highest misclassification rate (40.0%). Higher body mass index independently predicted greater estimation error; age did not.</p><p><strong>Conclusions: </strong>The Wen equation may be useful for preliminary population-level screening, but its individual diagnostic utility is limited by systematic overestimation and moderate agreement with DXA. Caution is especially needed in women with T2DM, for whom confirmatory DXA should be considered when feasible.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"103315"},"PeriodicalIF":2.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient and Healthcare Professional Perspectives on Short Bowel Syndrome Management and Preferred Treatment Attributes.","authors":"Syed-Mohammed Jafri, Jenny E Harrison, Vanessa Kumpf, Gail Mitchell, Daniel Wolin, Laurie Zografos, Mindy Yang, Laurin Jackson, Jinyi Wang, Mena Boules, Roopa Vemulapalli","doi":"10.1016/j.clnesp.2026.103310","DOIUrl":"https://doi.org/10.1016/j.clnesp.2026.103310","url":null,"abstract":"<p><strong>Background & aims: </strong>Short bowel syndrome (SBS) is a debilitating malabsorptive condition where patients often require life-sustaining parenteral support (PS), such as total parenteral nutrition (TPN) and intravenous (IV) hydration, to maintain health, growth, and survival. This study aimed to characterize patient and healthcare provider (HCP) experiences with current SBS management strategies and treatments and their attributes for novel SBS therapies.</p><p><strong>Methods: </strong>A noninterventional, cross-sectional online survey was conducted in the United States (US), France, Germany, Spain, and the United Kingdom. Two complementary surveys were separately administered to adult patients with SBS dependent on PS and HCPs who manage patients with SBS dependent on PS.</p><p><strong>Results: </strong>Ninety-one patients (US, n = 50; Europe, n = 41) and 336 HCPs (US, n = 123; Europe, n = 213) participated. Most patients (63.7%) used a combination of TPN and IV hydration, and ∼80% reported consistent use for > 1 year. Patients frequently reported experiencing sleep disturbances (64.6%), fatigue (53.7%), weight gain/loss (40.2%), and abdominal pain/discomfort (37.8%), while HCPs reported that their patients often experienced central line infections (59.8%) and central line pain/discomfort (43.2%) because of TPN use. Top patient-reported treatment attributes were eliminating TPN (65.6%) and/or IV hydration (50.0%) and maximizing the duration of treatment effectiveness (43.9%). HCPs emphasized decreasing the need for central venous access and its related risks (73.5%), decreasing hospitalizations and/or therapy-related complications (72.8%), and decreasing the frequency of administration (63.4%). Patients (71.4%) and HCPs (46.4%) generally preferred fewer days of TPN use per week, and one-third of participants reported that modest reductions of 1 to 2 days per week would be clinically meaningful (patients, 33.0%; HCPs, 44.3%).</p><p><strong>Conclusions: </strong>Findings from this multinational study emphasize the ongoing burden of SBS management and provide valuable insights into patients' and HCPs' treatment preferences and priorities. While patients and HCPs identified distinct but related treatment preferences (e.g., reduced lifestyle disruptions and improved clinical outcomes, respectively), both groups prioritized enteral autonomy and identified significant limitations and reduced quality of life associated with current strategies to manage and treat SBS.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"103310"},"PeriodicalIF":2.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of 5:2 Intermittent Fasting Compared with Continuous Caloric Restriction in the Treatment of Recurrent Weight Gain After Metabolic Bariatric Surgery: A non-inferiority, short-term, pilot feasibility study.","authors":"Diana Cristina Henao-Carrillo, Ana Milena Forero, Ana María Gómez, Sofia Robledo, Fabio Pinzón, Rami Mikler, Carlos Yepes, Oscar Muñoz-Velandia","doi":"10.1016/j.clnesp.2026.103316","DOIUrl":"https://doi.org/10.1016/j.clnesp.2026.103316","url":null,"abstract":"<p><strong>Introduction: </strong>Intermittent fasting (IF) is a form of calorie restriction that has recently gained notoriety. However, there is currently no data on its effectiveness for patients with recurrent weight gain (RWG) after metabolic bariatric surgery (MBS).</p><p><strong>Methods: </strong>A randomized non-inferiority, short-term, pilot feasibility trial was conducted to evaluate the effectiveness of 5:2 intermittent fasting (IF) (75% caloric restriction on two days per week) compared with continuous caloric restriction (CCR) (25% divided into three meals) over 12 weeks, in patients with RWG who had undergone MBS.</p><p><strong>Results: </strong>Twenty patients were included (mean age 53±9.5 years, body mass index 32.4±3.5 kg/m²). The CCR group showed no change in weight at 12 weeks (mean difference -0.88 kg; 95% CI: -2.2 to 3.9 kg; p=0.51), whereas the 5:2 IF group experienced an average weight loss of -1.025 kg (95% CI: -0.09 to -1.96 kg; p=0.03). The difference between the two groups remained within the predefined non-inferiority margin of 4 kg (-0.13;95% CI: -2.90 to 2.62). No differences in body composition or metabolic profile measurements were observed in either group compared to baseline values. The caloric intake was lower and the treatment adherence higher in the IF group. No serious adverse events occurred during follow-up.</p><p><strong>Conclusion: </strong>The 5:2 IF appears non-inferior to CCR at 12 weeks, suggesting it could be a promising dietary strategy for RWG. Further research with extended follow-up is essential to assess long-term feasibility, safety, and adherence. Such data will be crucial in establishing the clinical utility and practical implementation of this intervention in RWG management.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"103316"},"PeriodicalIF":2.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Effect of extra virgin olive oil on mild cognitive impairment and dementia in older adults: a systematic review and meta-analysis of clinical trials\".","authors":"Amit Jaiswal, Vineet Sinnarkar, D B Sharma","doi":"10.1016/j.clnesp.2026.103313","DOIUrl":"https://doi.org/10.1016/j.clnesp.2026.103313","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"103313"},"PeriodicalIF":2.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Get a grip! - Baseline Handgrip Strength and Sarcopenia as Predictors of Survival in Patients with Head and Neck Squamous Cell Carcinoma.","authors":"Helena Orell, Anne Pohju, Paula Ravasco, Ursula Schwab, Pia Osterlund, Antti A Mäkitie","doi":"10.1016/j.clnesp.2026.103312","DOIUrl":"https://doi.org/10.1016/j.clnesp.2026.103312","url":null,"abstract":"<p><strong>Background: </strong>Low handgrip strength (HGS) and sarcopenia are common in patients with head and neck squamous cell carcinoma (HNSCC). This study aimed to explore associations between baseline HGS, fat-free mass index (FFMI), nutritional indices, and survival.</p><p><strong>Methods: </strong>This was a prospective observational sub-study of a randomized nutritional intervention trial, including 50 male patients with HNSCC undergoing curative-intent treatment (surgery and/or (chemo)radiotherapy). Sarcopenia was defined as low HGS (<27 kg) and FFMI (<17 kg/m²). Chi-square, Kaplan-Meier, and Cox analyses were used.</p><p><strong>Results: </strong>Low HGS was observed in 16%, low FFMI in 46%, and sarcopenia in 12%. Patients with low HGS had lower body weight, BMI, and FFMI, alongside more malnutrition, elevated CRP, and heavy smoking. Low HGS and sarcopenia were associated with shorter overall survival (HR 3.7, [95% CI 1.5-9.1] and 5.5, [2.2-14.5], respectively); FFMI was not. Adjustment removed significance. Findings should be interpreted cautiously due to the small, all-male cohort size.</p><p><strong>Conclusion: </strong>In this small exploratory cohort HGS may serve as a simple screening surrogate for sarcopenia and survival.</p><p><strong>Clinical trial registration: </strong>www.</p><p><strong>Clinicaltrials: </strong>gov, identifier NCT02159508.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"103312"},"PeriodicalIF":2.6,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Understanding dietary beliefs, behaviors, and barriers in inflammatory bowel disease: A scoping review\".","authors":"Asmita P Alekar","doi":"10.1016/j.clnesp.2026.103314","DOIUrl":"10.1016/j.clnesp.2026.103314","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"103314"},"PeriodicalIF":2.6,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}