比较含嗜粘乳杆菌益生菌酸奶与含鼠李糖乳杆菌益生菌酸奶对超重或肥胖成年人体成分、生化指标、食欲和抑郁评分的影响：一项随机、双盲、对照临床试验。

IF 2.6 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-05-30 DOI:10.1016/j.clnesp.2025.05.045

Erfaneh Aalipanah , Moein Askarpour , Mohammad Hadi Eskandari , Morteza Zare , Mandana Famouri , Alireza Bedeltavana , Mohammad Ali Mohsenpour , Zahra Sohrabi

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引用次数: 0

摘要

目的：本研究的目的是比较每日食用嗜粘乳杆菌后强化酸奶（AMY）和鼠李糖乳杆菌后强化酸奶（LRY）对超重和肥胖患者健康参数的影响。方法：在为期8周的随机双盲临床试验中，66例超重和肥胖患者随机分为3组：1)AMY组（n=22）， 2) LRY组（n=22）， 3)低脂酸奶（LFY）作为安慰剂（n=22）。在研究开始和结束时，测量了人体测量、空腹血糖、血脂、肝酶、炎症和抗氧化剂生物标志物、食欲和情绪状态、身体活动和饮食摄入量。注册号为IRCT20230522058257N1。结果：与对照组相比，AMY组腰围（P = 0.003）、腰高比（P = 0.004）、体脂率（P = 0.032）、天冬氨酸转氨酶水平（P = 0.045）、食欲评分（P = 0.047）均显著降低。然而，结果表明，强化鼠李糖乳杆菌酸奶对健康参数没有任何有益的影响。结论：我们的研究结果表明，富含嗜黏液阿克曼氏菌的乳制品可能对超重和肥胖个体的体重管理和肝酶水平有有利的影响；然而，需要进一步的研究来证实这些结果并探索潜在的机制。

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Comparing the effects of yogurt containing Akkermansia muciniphilia postbiotic with yogurt containing Lactobacillus rhamnosus postbiotic on body composition, biochemical indices, appetite, and depression scores in overweight or obese adults: A randomized, double-blind, controlled clinical trial

Objective

The objective of this study was to compare the impact of daily consumption of Akkermansia muciniphila postbiotic-fortified yogurt (AMY) with Lactobacillus rhamnosus postbiotic-fortified yogurt (LRY) on the health parameters in overweight and obese patients.

Methodes

In this 8-week randomized double-blinded clinical trial, 66 people with overweight and obesity were randomly allocated to three groups: 1) AMY group (n = 22), 2) LRY group (n = 22), and 3) low-fat yogurt (LFY) as placebo (n = 22). The anthropometrics measurements, fasting blood glucose, lipid profile, liver enzymes, inflammatory and antioxidants biomarkers, appetite and mood status, physical activity and dietary intakes were measured at the beginning and end of the study. The registration number was IRCT20230522058257N1.

Results

In the AMY group, significant reductions were observed in waist circumference (P = 0.003), waist-to-height ratio (P = 0.004), body fat percentage (P = 0.032), aspartate aminotransferase levels (P = 0.045), and appetite scores (P = 0.047) compared with the control group. However, the results indicated that Lactobacillus rhamnosus-fortified yogurt did not demonstrate any beneficial impact on the health parameters.

Conclusion

Our findings suggest that a dairy product enriched with Akkermansia muciniphila postbiotic may have favorable effects on weight management and liver enzyme levels in overweight and obese individuals; however, further studies are needed to confirm these results and explore underlying mechanisms.

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.