Prognostic impact of low muscularity in metastatic and recurrent head and neck cancer: Insights from C3-based assessments

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-06-13 DOI:10.1016/j.clnesp.2025.06.029

Larissa Ariel Oliveira Carrilho , Livia Dias Guerra , Rafaella Caroline de Lellis Moreira , Fabiana Lascala Juliani , Fernanda Silva Santos , Daniela Morais de Holanda Padilha , Fabíola Furtuoso Zaperlão , Sandra Regina Branbilla , Vivian Naomi Horita , Davi Magalhães Leite Novaes , Lígia Moraes Antunes-Correa , Carmem Silvia Passos Lima , Maria Carolina Santos Mendes , José Barreto Campello Carvalheira

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引用次数: 0

Abstract

Head and Neck Cancer (HNC) patients often experience a range of symptoms due to disease which can lead to low energy and protein intake. This scenario can impact body composition as the quality and quantity of muscularity and adiposity changes. This work aims to evaluate the impact of muscularity on the overall survival (OS) of patients with metastatic HNC. This is a retrospective and analytical study, with the population studied being patients diagnosed with metastatic or recurrent HNC, between January 2010 and December 2018, treated at the Clinical Oncology outpatient clinic of the Hospital de Clínicas of the Universidade Estadual de Campinas. To assess body composition, CT images were used at the level of the third cervical vertebra (C3), with the areas of muscle tissue and adipose tissue. The total population included in the sample was 101 patients diagnosed with metastatic or recurrent HNC. It has been shown that low muscularity is associated with the elderly population over 70 years old and with a lower BMI value, below 18.5. The population with low muscularity had a lower amount of total adipose tissue and total adipose tissue index, as well as a lower amount of skeletal muscle and skeletal muscle index in relation to normal muscularity, making it possible to conclude that low muscularity in patients with metastatic or recurrent HNC is an independent factor for mortality.

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低肌肉对转移性和复发性头颈癌预后的影响：基于c3评估的见解。

头颈癌（HNC）患者通常会经历一系列疾病引起的症状，这些症状可能导致低能量和蛋白质摄入。随着肌肉和脂肪的质量和数量的变化，这种情况会影响身体成分。这项工作旨在评估肌肉力量对转移性HNC患者总生存期（OS）的影响。这是一项回顾性和分析性研究，研究人群是2010年1月至2018年12月期间在坎皮纳斯大学（universsidade Estadual de Campinas） Clínicas医院临床肿瘤门诊治疗的转移性或复发性HNC患者。为了评估身体组成，在第三颈椎（C3）水平使用CT图像，包括肌肉组织和脂肪组织区域。样本中包括101例被诊断为转移性或复发性HNC的患者。研究表明，肌肉不足与70岁以上的老年人以及BMI值较低（低于18.5）有关。与正常肌肉量相比，低肌肉量人群的总脂肪组织量和总脂肪组织指数较低，骨骼肌量和骨骼肌指数也较低，因此可以得出结论，转移性或复发性HNC患者的低肌肉量是死亡率的独立因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.