Clinical and Experimental Dental Research最新文献

{"title":"Development and Evaluation of the Antibacterial Properties of an Experimental Herbal Gel Against Cariogenic Bacteria","authors":"Marco Sánchez-Tito,&nbsp;Lidia Yileng Tay,&nbsp;Francisco Zea-Gamboa,&nbsp;Raúl Cartagena-Cutipa,&nbsp;Alysson Flores-Gómez,&nbsp;Bruno Spigno-Paco,&nbsp;Brando Raul Mendoza Salinas,&nbsp;Jose Elias Zuñiga Calcina,&nbsp;Ingrit Elida Collantes Díaz","doi":"10.1002/cre2.70076","DOIUrl":"10.1002/cre2.70076","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Recently, products with antibacterial properties derived from medicinal plants have increased as an alternative to conventional drugs. Thus, this study aimed to formulate and evaluate the antibacterial activity of an experimental gel based on <i>Grindelia tarapacana</i> essential oil in a bacterial consortium.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>The composition of the essential oil (EO) was determined using gas chromatography-mass spectrometry (GC-MS). The antibacterial activity of the EO against <i>Streptococcus mutans</i> ATCC 25175, <i>Streptococcus sanguinis</i> ATCC 10556, and <i>Streptococcus salivarius</i> ATCC 13419 was evaluated using an Agar disc diffusion and minimum inhibitory concentration methods. Five formulations of the experimental gel were prepared at 0.25%, 0.5%, 1%, 1.5%, and 2% (v/v). The antibacterial susceptibility test was evaluated using an Agar-Well diffusion assay against a bacterial consortium of <i>S. mutans</i>, <i>S. sanguinis</i>, and <i>S. salivarius</i>. The physical properties, pH, spreadability, gel morphology, phase separation, and drug release were evaluated. The experimental gels were compared with a chlorhexidine gel. Data were analyzed with one-way ANOVA and Kruskal–Wallis tests with a significant level of 5%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The major components of the EO were bornyl acetate, α-isomethyl-<i>E</i>-nerolidol, germacrene B, <i>E</i>-nerolidol, α-cedrene-epoxide, fokienol, and 10-epi-γ-eudesmol. All formulations were effective in inhibiting bacterial growth. The 2% concentration presented inhibition zones (18.14 ± 1.01 mm) similar to those observed for the chlorhexidine gel (<i>p</i> &gt; 0.05). All formulations were stable, without signs of separation, with adequate physical properties, and no significant differences were observed regarding the drug content with the chlorhexidine gel (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The experimental gels based on <i>G. tarapacana</i> EO presented good physicochemical properties and were highly effective in inhibiting the growth of a cariogenic bacterial consortium.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Occlusal Scheme and Bone-Level Implant Number and Position on Stress Distribution in Kennedy Class II Implant-Assisted Removable Partial Dentures: A 3D Finite Element Analysis","authors":"Solmaz Barati,&nbsp;Safoura Ghodsi,&nbsp;Somayeh Zeighami","doi":"10.1002/cre2.70078","DOIUrl":"10.1002/cre2.70078","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To assess the effect of occlusion and implant number/position on stress distribution in Kennedy Class II implant-assisted removable partial denture (IARPD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>IARPDs were designed in six models: with one implant (bone level with a platform of 4 mm and length of 10 mm) at the site of (I) canine, (II) between first and second premolars, (III) first molar, (IV) second molar, or two implants at the sites of (V) canine-first molar, and (VI) canine-second molar. A conventional RPD served as control. Loads were applied according to the group function (GF) (500N load was applied to the left canine/premolar/molar teeth in the ratio of 1:1:2) or canine guidance (CG) (125N load was to the canine tooth) occlusions. Maximum displacement and Von Mises Stress in different components were analyzed by finite element analysis (FEA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The control model showed the highest displacement followed by the IARPD with a canine implant in both occlusal schemes. In GF, the maximum and minimum jaw stress were recorded in IARPDs with canine implants (16.45 MPa) and canine-first molar implants (13.47 MPa), respectively. In CG, the maximum and minimum jaw stress was recorded in IARPD with first/second premolar implant (15.91 MPa) and canine-first molar implants (12.38 MPa), respectively. The highest stress in resin, framework, and implant(s) was noted in IARPD with canine implant in both schemes. The lowest stress in the implant(s) was recorded in IARPD with canine-second molar implants in GP and IARPD with canine-first molar implants in CG.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Dental implants reduced the total displacement of IARPDs, increased stress in mechanical components, and did not affect stress distribution in biological components. Insertion of two implants decreased implant stress. The GP scheme caused greater stress on mechanical components.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11746924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Trends in Endodontic Clinical Practice in Croatia: A Report From a Croatian National Survey","authors":"Josipa Sović,&nbsp;Sanja Šegović,&nbsp;Jurica Matijević,&nbsp;Božidar Pavelić,&nbsp;Ivica Anić,&nbsp;Ivan Tomasic","doi":"10.1002/cre2.70073","DOIUrl":"10.1002/cre2.70073","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess the state of endodontic practices and identify factors influencing the use of modern endodontic techniques among dental practitioners in Croatia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A questionnaire was distributed to all dental offices in Croatia, yielding 819 responses (27% response rate). Data were descriptively analyzed and statistically modeled.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nearly 74% of endodontic treatments in Croatia are performed by general practitioners (17 teeth per month per practitioner), while endodontic specialists handle the highest number of treatments per specialist (67 teeth per month, representing 15% of total treatments). 56% of respondents use radiography before the procedure “always” or “almost always” with intra-oral periapical radiography being the most commonly used technique. Rubber dams are used “never” to “rarely” by 74% of respondents. Apex-locators are highly prevalent, used “almost always” to “always” by 83% of practitioners. Magnifiers are rarely used, with 63% of respondents reporting they “never” use them. Lasers are never used by 92% of respondents, whereas 59% frequently use engine-driven instrumentation. 76% of respondents “always” or “almost always” determine the working length of the root canal. Sodium hypochlorite is the most common irrigant (88%), and EDTA for smear layer removal is used by 36% of respondents. The cold lateral condensation is the most popular obturation technique (64%). CBCT is unused by 59% of responders, most probably because it is not accessible.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Croatian endodontic practices are comparable to those in countries with similar economic status, but there is substantial potential, particularly among general practitioners, to enhance knowledge and awareness of modern technologies through continuous education. Underused techniques in Croatia include rubber dams, magnifiers, lasers, and CBCT.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Reported Outcomes Following Systemic Antibiotic Adjunct to Nonsurgical Treatment of Periodontitis: A Randomized Controlled Clinical Trial","authors":"Parastoo Parhizkar,&nbsp;Jaber Yaghini,&nbsp;Omid Fakheran","doi":"10.1002/cre2.70067","DOIUrl":"10.1002/cre2.70067","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Considering the importance of patient-centered care, we aimed to evaluate the impact of systemic antibiotics on oral health–related quality of life during nonsurgical periodontal treatment. This controlled trial addresses a gap in understanding how systemic antibiotics influence patient-reported outcomes, focusing on Stage III periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Sixty-one adults participated in a double-blind, randomized clinical trial, with participants divided into two groups: the test group, which received antibiotics, and the control group. All the participants received nonsurgical periodontal treatment. We conducted follow-up assessments at one and 3 months posttreatment, including recording clinical parameters and administering the Oral Health Impact Profile-14 (OHIP-14) questionnaire.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed a notable improvement in the quality of life for patients in the test group compared to the control group at 1 month (<i>p</i> value = 0.012) and 3 months (<i>p</i> value = 0.014) after treatment. While there were improvements in pocket probing depth, gingival index, and clinical attachment loss in both groups, it is worth noting that only bleeding on probing exhibited a significant improvement in the test group after 3 months compared to the control group (<i>p</i> value = 0.008).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In summary, incorporating systemic antibiotics alongside nonsurgical periodontal treatments appears to bring about positive outcomes for individuals dealing with Stage III periodontitis during nonsurgical treatment, ultimately enhancing their oral health-related quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Iranian Registry of Clinical Trials (IRCT Id): IRCT20201221049786N1.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the Difficulty of Endodontic Cases Treated by Undergraduate Students at a University Clinic Between 1971 and 2019","authors":"Pia Titterud Sunde,&nbsp;Erling Skallevold,&nbsp;Manpreet Kaur,&nbsp;Dag Solmund Ørstavik","doi":"10.1002/cre2.70071","DOIUrl":"10.1002/cre2.70071","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to assess the proportions of complicated endodontic cases treated by undergraduate dental students in a University clinic now and in the past.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Data were obtained from the electronic records and previous publications from the Faculty of Dentistry, University of Oslo, Norway. The operators were dental undergraduate students in their final 2 years of training. Proportions of tooth types, diagnosis, and retreatments were studied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The amount of endodontically treated molars increased from 18% in 1971% to 44% in 2019. The number of teeth with preoperative apical periodontitis increased from 31% to 46%, and retreatments from 9% to 15%. The changes were highly significant, with the greatest change occurring from 1984 to 2009.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Undergraduate students are exposed to more complicated teeth now than 50 years ago.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Reported Oral Health-Related Quality of Life and Orofacial Esthetics Among Young Adults With Treated Dental Trauma","authors":"Mari Louise Odersjö,&nbsp;Lina Johansson,&nbsp;Agneta Robertson,&nbsp;Nina Sabel","doi":"10.1002/cre2.70068","DOIUrl":"10.1002/cre2.70068","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to explore how young adults with a history of dental trauma and restored teeth perceive their oral health–related quality of life (OHRQoL) and orofacial esthetics, with a focus on gender-based differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This pilot study is a retrospective case–control study. Young adults experiencing dental trauma and consequently receiving dental treatment were asked to answer CPQ11-14, Oral Esthetic Scale (OES), and some complimentary questions concerning the esthetics of their teeth. A control group was recruited. <i>t</i>-Test was used to analyze the scores of CPQ_11-14 and OES, comparing both the study group and the control group, as well as assessing differences between the genders. Regression analysis ANOVA was used to examine the relationship between the OES questions and CPQ_11-14 domains.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study group comprised 74 individuals (mean age = 23 years, SD 2.8), including 48 females and 26 males, with an equivalent number in the control group (mean age = 23 years, SD 3.4), with 49 females and 25 males. The mean score of the CPQ_11-14 was 8.8 (SD 7.2) for the study group and 8.0 (SD 6.8) for the control group. Within the emotional well-being domain, the study group exhibited a higher mean score (3.4, SD 3.6) compared to the control group (1.5, SD 2.6) (<i>p</i> &lt; 0.001 <i>t</i>-test). Females in the study group scored higher in the emotional well-being domain (4.0, SD 3.7) compared to females in the control group (1.8, SD 2.7), (<i>p</i> &lt; 0.01 independent <i>t</i>-test). The study group, who reported low satisfaction with their tooth color or alignment in the OES, also scored higher in the social well-being domain of CPQ_11-14 (<i>p</i> &lt; 0.026, ANOVA). This was not observed in the control group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Young adults with treated dental trauma trend to report a negative impact on their oral health-related quality of life and oral esthetics, particularly females.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized, Placebo-Controlled Pilot Study of Naproxen During Dental Implant Osseointegration","authors":"Hattanas Kumchai,&nbsp;Daniel I. Taub,&nbsp;Ryan E. Tomlinson","doi":"10.1002/cre2.70065","DOIUrl":"10.1002/cre2.70065","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Nonsteroidal anti-inflammatory drugs (NSAIDs) are often prescribed following the placement of dental implants, but the effects of these drugs on the osseointegration process are poorly understood. We designed a randomized, placebo-controlled pilot study to quantitatively assess the effect of NSAIDs during early implant osseointegration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Subjects receiving a maxillary dental implant were randomized to take naproxen or placebo for 7 days after the surgery. Implant osseointegration was quantified using Resonance Frequency Analysis device. Implant-Stability-Quotient (ISQ) measurement was performed at the time of surgery and at follow-up visits 1, 4, and 16 weeks after surgery. Periapical radiographs were taken to measure the marginal bone level. Separately, a questionnaire of NSAIDs usage was provided to subjects presenting with early implant failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 4 weeks, ISQ values increased modestly ( + 1%) in subjects receiving naproxen whereas subjects receiving placebo had a much larger increase in ISQ value (+41%). We observed 55% more marginal bone loss at 4 weeks, and 52% at 16 weeks in the naproxen group compared to the placebo group. These results were not found to have statistically significant between groups (<i>p</i> ≥ 0.05). These effect sizes and variance were used to conduct a power analysis to determine the necessary sample size for future studies. Furthermore, our separate questionnaire study revealed that 68% of our patients with early failed dental implants reported a history of NSAIDs usage after the surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In conclusion, this pilot study provides effect sizes and sample size estimates for future studies to definitively determine recommendations regarding NSAID usage following dental implant surgery. Nonetheless, our study did not observe any statistically significant differences in ISQ value or marginal bone loss after up to 16 weeks of follow-up between subjects from naproxen and placebo groups.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Self-Reported Oral Health and Dental Fear Among Illicit Drug Users in Northern Finland","authors":"Raija Vainionpää,&nbsp;Antti Tiisanoja,&nbsp;Outi Kokkola,&nbsp;Pirkko Riipinen,&nbsp;Vuokko Anttonen","doi":"10.1002/cre2.70055","DOIUrl":"10.1002/cre2.70055","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>About 10% of adults in northern Finland have severe dental fear, but there is a lack of detailed knowledge about dental fear among illicit drug users. The aim of the study was to evaluate the prevalence of dental fear and its association with self-reported oral health and health behavior as well as background factors of the customers of substance abuse services living in the region of Oulu, Northern Ostrobothnia, Finland.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>One hundred seventeen volunteers, either active or former illicit drug users, were interviewed face-to-face about their background factors, health and health behaviors, and use of illicit drugs. The Modified Dental Anxiety Scale (MDAS) was used to assess a situation-specific level of dental anxiety. For analyses, Pearson's <i>χ</i>² test, Fisher's exact test, ANOVA, and logistic regression analysis were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Three out of four participants had at least moderate dental fear (MDAS ≥ 10) and 24% had severe dental fear (MDAS ≥ 19), with the average MDAS being 14.0 (SD 5.7). Participants in drug rehabilitation reported significantly more dental fear than the rest of the participants. Severe dental fear was associated (adjusted) with previous painful experiences OR 10.8 (2.3–52.0) and poor behavior by dental personnel OR 4.1 (1.2–13.9).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Dental fear is common among illicit drug users, and it is, particularly, associated with previous painful experiences and poor behavior by dental personnel.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of a Quantitative Method for the Extraction of Nicotine and Cotinine in Gingival Tissue and Relationship Between Gingival Intoxication With Conventional Smoking Biomarkers: A Pilot Study","authors":"Leila Salhi,&nbsp;Samuel Hazout,&nbsp;Dorien Van hede,&nbsp;France Lambert,&nbsp;Corinne Charlier,&nbsp;Marine Deville","doi":"10.1002/cre2.70022","DOIUrl":"10.1002/cre2.70022","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Smoking is considered a major risk factor for periodontitis genesis and progression. In clinical studies, specific indicators have been used to characterize the smoking status of the patient as the number of cigarettes consumed (NCC), the pack-years (PY), or Fagerström Test for Nicotine Dependence (FTND). However, available literature is missing on the relationship between cotinine gingival intoxication and smoking indicators. First, the development of a quantitative method for the extraction of nicotine and cotinine in gingival tissue. Second, to investigate the relationship between gingival intoxication and conventional smoking biomarkers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Fourteen smoker patients were included in the study. After clinical data collection, salivary and gingival samples collection, toxicological analyses were performed using liquid extraction after enzymatic digestion (subtilisin) and ultra-performance liquid chromatography coupled to mass spectrometry (UPLC-MS/MS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Gingival cotinine quantification was successfully performed in 14 samples (100%) with a mean of 0.280 ng/mg (range = 0.094–0.505). Only FTND was statistically associated with gingival cotinine levels (<i>p</i> = 0.0072; <i>r</i>² = 0.60). Gingival nicotine quantification was achieved in 12 of the 14 gingival samples (86%) with a mean of 0.384 ± 1.00 ng/mg (range = 0.03–3.84). Gingival nicotine was statistically associated with NCC (<i>p</i> = 0.032; <i>r</i>² = 0.55), PY (<i>p</i> = 0.0011; <i>r</i>² = 0.76), and FTND (<i>p</i> = 0.016; <i>r</i>² = 0.60). Salivary nicotine and cotinine levels were statistically associated with, respectively, NCC (<i>p</i> = 0.030; <i>r</i>² = 0.34), and NCC (<i>p</i> = 0.0094; <i>r</i>² = 0.63) + PY (<i>p</i> = 0.0078; <i>r</i>² = 0.64).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This pilot study established a quantitative extraction method for nicotine and cotinine from human gingival samples. Additionally, FTND was associated with gingival cotinine. However, further large-scale studies are needed to confirm the relationship between nicotine dependence and gingival intoxication.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Implant Position Accuracy in Guided Implantology: The Role of Drill Play Under Lateral Forces","authors":"Vasilios Alevizakos,&nbsp;Yannick Stryga,&nbsp;Constantin von See","doi":"10.1002/cre2.70056","DOIUrl":"10.1002/cre2.70056","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study investigates the impact of drill play on the precision of implant positioning under lateral forces in guided implantology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>An in vitro experiment was conducted using artificial bone blocks and the SIC Invent-guided surgery implant system. Custom drill guides were designed, and 3D-printed, using three sleeve types: sleeveless, a big sleeve, and a small sleeve. Drillings were performed with varying lateral forces, and deviations in angle, depth, and position were measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sleeveless guides showed the highest variability in deviations, with a maximum deviation of 3.92 mm under extreme lateral forces. Big sleeve guides provided the most consistent precision, with deviations ranging from 0.42 to 1.33 mm. Small sleeve guides showed moderate precision, with deviations from 0.14 to 2.17 mm. Higher lateral forces generally increased deviations across all guide types.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Drill play significantly affects the precision of guided implant drilling, with lateral forces causing deviations from the planned implant position. Big sleeve guides offer better precision under lateral loads compared to sleeveless and small sleeve guides. Strict adherence to the drilling protocol is essential to minimize errors and ensure optimal implant positioning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}