Clinical and Experimental Dental Research最新文献

{"title":"Computer-Assisted Implant Surgery: Patients' Experience and Perspectives","authors":"Xin Hui Yeo,&nbsp;Lin Jing Uei,&nbsp;Man Yi,&nbsp;Kajorn Kungsadalpipob,&nbsp;Keskanya Subbalehka,&nbsp;Bilal Al-Nawas,&nbsp;Nikos Mattheos","doi":"10.1002/cre2.70143","DOIUrl":"https://doi.org/10.1002/cre2.70143","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Although computer-assisted implant surgery (CAIS) has increased significantly the precision of dental implant placement, documentation of the impact of such technologies in the patient-reported experience and outcomes remains, however, limited. The aim of this white paper was to assess the impact of CAIS on key aspects of the patient experience, such as its potential benefits on (1) patients' understanding and engagement with implant surgery, (2) patient's confidence with treatment outcomes, (3) patients' preferences, (4) intra- and (5) Postoperative experience and (6) long-term patient-reported outcomes and oral health-related quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A review of the literature compiled existing evidence from clinical studies up to November 2024, which was later discussed and synthesized with expert opinions and the best currently documented experience and practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No evidence was found that CAIS improves patient engagement or confidence with treatment outcomes, while comparative studies showed no difference in the intra- and postoperative experience when CAIS is used. Impact of the cost of CAIS procedures on patients perceptions and preferences has also not been explored, with the majority of studies significantly subsidizing patient costs, in particular randomized trials. At the same time, studies that compare interventions cannot assess the overall benefits of a complex workflow such as immediacy or minimally invasive approaches, to which CAIS is an essential part.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Research on patient outcomes with CAIS might not fully reflect the potential of these technologies when limited to the level of the surgical intervention. Major anticipated benefits of CAIS for the patient such as the potential to reduce complexity and facilitate faster, safer and more predictable execution of digitally designed treatments, could be better approached in the future by studies aimed at assessing patient-reported outcomes from entire treatment workflows.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence and Hand Hygiene Accuracy: A New Era in Infection Control for Dental Practices","authors":"Salwa A. Aldahlawi,&nbsp;Amr H. Almoallim,&nbsp;Ibtesam K. Afifi","doi":"10.1002/cre2.70150","DOIUrl":"https://doi.org/10.1002/cre2.70150","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The study aimed to assess the efficacy of an artificial intelligence (AI) model in evaluating hand hygiene (HH) performance compared to infection control auditors in dental clinics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Method</h3>\u0000 \u0000 <p>The AI model utilized a pretrained convolutional neural network (CNN) and was fine-tuned on a custom data set of videos showing dental students performing alcohol-based hand rub (ABHR) procedures. A total of 66 videos were recorded, with 33 used for training and 11 for validating the model. The remaining 22 videos were designated for testing and the AI- infection control auditors comparison experiment. Two infection control auditors assessed the HH performance videos using a standardized checklist. The model's performance was evaluated through precision, recall, and F1 score across various classes. The level of agreement between the auditors and the AI assessments was measured using Cohen's kappa, and the sensitivity and specificity of the AI were compared to those of the infection control auditors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The AI model has learned to differentiate between classes of hand movement, with an overall F1 score of 0.85. Results showed a 90.91% agreement rate between the AI model and infection control auditors in evaluating HH steps, with a sensitivity of 85.7% and specificity of 100% in identifying acceptable HH practices. Step 3 (back of fingers to opposing palm with fingers interlocked) was consistently identified as the most frequently missed step by both the AI model and the infection control auditors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The AI model assessment of HH performance closely matched auditors' evaluations, suggesting its reliability as a tool for evaluating and mentoring HH in dental clinics. Future research should explore the application of AI technology in different dental settings to further validate its feasibility and adaptability.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication Purchases Are Associated With the Number of Dental Treatments","authors":"Freja Frankenhaeuser,&nbsp;Håkan Källmén,&nbsp;Jukka Meurman,&nbsp;Esa Korpi,&nbsp;Birgitta Söder","doi":"10.1002/cre2.70121","DOIUrl":"https://doi.org/10.1002/cre2.70121","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Little is known whether the number of systemic medications, indicating worsened general health, affects the number of dental appointments needed. The hypothesis is that patients purchasing more systemic medications would have an increased number of dental appointments and respective need for treatments than patients who do not purchase as many medications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Our cohort consists of 1495 participants from the Stockholm area, Sweden, initially examined in 1985. Using national population and patient registers (2005–2017), the association between the number of medication purchases and dental appointments was analyzed. The Anatomical Therapeutic Chemical Classification System for Medicines (ATC) was used. Descriptive statistics, chi-square tests, and logistic regressions were used with several covariates like gender and socioeconomic status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Purchases above the median of all medications showed a statistically significant association with more dental appointments and respective treatments. Most of the ATC system's main drug categories were significantly associated with more dental appointments, even when adjusting for covariates. Purchases of medications from 32 different ATC subgroups were significantly associated with the number of dental appointments above the median.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In the group of adult Swedes who were studied, it was found that increased purchasing of nearly all types of drugs was associated with an increased number of dental appointments between the study years 2005–2017.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Evaluation of Flexural Strength, Impact Strength, and Surface Microhardness of Vaccinium macrocarpon Reinforced Polymethyl Methacrylate Denture Base Resin","authors":"Anitha Kuttae Viswanathan,&nbsp;Rajkumar Krishnan","doi":"10.1002/cre2.70145","DOIUrl":"https://doi.org/10.1002/cre2.70145","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The antimicrobial efficacy of cranberry (CA) against oral infections was well evidenced. Influence of cranberry on the mechanical properties of heat-activated polymethyl methacrylate (HA-PMMA) denture base resin (DBR) is unexplored till date and is significant for a better understanding of the reinforcement. This study aimed to evaluate the flexural strength (FS), impact strength (IS), and surface microhardness (VHN) of heat-cure PMMA DBR reinforced with varying concentrations of <i>Vaccinium macrocarpon</i> (cranberry) extract.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A total of 150 samples were categorized into five groups (<i>n</i> = 10) by weight percentage of 0, 0.5, 1.0, 1.5, and 2.0 cranberry extract added into HA-PMMA polymer after the performance of antimicrobial efficacy testing of CA. Three-point bending test for FT, Izod impact testing for IS, and Vickers microhardness test were performed. Fractured sample surface was characterized by a high-resolution scanning electron microscope (HR-SEM). Raw data were statistically analyzed with one-way ANOVA and post hoc Bonferroni test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant improvement in flexural strength of 76.88 ± 0.73 MPa, impact strength of 6.66 ± 0.24 kJ/m², and microhardness of 18.44 ± 0.27 kg/mm² was observed at 2 wt.% (<i>p</i> &lt; 0.0001). Fractured surface topography showed dispersion of cranberry particles as a thin fibrous band intermeshed within resin matrix.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Addition of up to 2 wt.% cranberry improved the FS, IS, and VHN on comparison to 0 wt.% control HA-PMMA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA Methylation of iNOS, eNOS, TP53 and LINE-1 in Gingival Tissues of Cigarette Smokers, Heat-Not-Burn Smokers and Never Smokers: An Exploratory Study","authors":"Giulio Rasperini,&nbsp;Michele Codari,&nbsp;Alessandra Moiana,&nbsp;Letizia Tarantini,&nbsp;Valentina Bollati,&nbsp;Gionata Bellucci,&nbsp;Dario Consonni,&nbsp;Lena Larsson,&nbsp;Farah Asa'ad","doi":"10.1002/cre2.70141","DOIUrl":"https://doi.org/10.1002/cre2.70141","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>In this exploratory study, the influence of traditional cigarette smoking and heat-not-burn device smoking (HnB) on DNA methylation of cancer-associated genes in smokers compared to never smokers was evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials &amp; Methods</h3>\u0000 \u0000 <p>Twenty-eight healthy individuals undergoing dental care were enrolled into three groups: (i) 10 traditional smokers, (ii) 8 HnB smokers, and (iii) 10 never smokers. Gingival biopsies were obtained, and DNA methylation analysis was performed by pyrosequencing for the cancer-associated genes: <i>iNOS</i>, <i>eNOS</i> and <i>TP53</i>. LINE-1 sequence was selected for genome-wide methylation readout.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>HnB smokers exhibited approximately a 13% higher <i>iNOS</i> methylation compared to both traditional smokers and never smokers (<i>p</i> = 0.004 in a crude analysis and <i>p</i> = 0.01 in a multivariable linear regression model adjusted for gender and age). However, HnB smoking did not influence the DNA methylation levels of <i>TP53, eNOS</i>, and LINE-1 in gingival tissues, as these were comparable to the levels observed in traditional smokers and never smokers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>HnB device smoking increased DNA methylation levels of <i>iNOS</i> gene, which might indicate a decreased iNOS expression in HnB smokers, compared to traditional smokers and never smokers. Implications of the observed <i>iNOS</i> methylation status in the development of oral cancer needs to be investigated in future studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positional Accuracy of Dental Implants Placed by Means of Fully Guided Technique in Partially Edentulous Patients: A Retrospective Study","authors":"Mariano Tia,&nbsp;Alessia Teresa Guerriero,&nbsp;Antonio Carnevale,&nbsp;Ilaria Fioretti,&nbsp;Gianrico Spagnuolo,&nbsp;Gilberto Sammartino,&nbsp;Roberta Gasparro","doi":"10.1002/cre2.70144","DOIUrl":"https://doi.org/10.1002/cre2.70144","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Computer-aided implant surgery (CAIS) is a fully digital approach that guides the biological and prosthetic ideal implant position. The aim of this retrospective clinical study was to assess the accuracy of implant position using CAIS and clinical outcomes, in partially edentulous patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This study was designed as retrospective study. Twenty-one patients requiring a maximum of two implants were recruited from 2023 to 2024 at the University of Naples Federico II. For all patients, 3D cone-beam computed tomography (CBCT) and intraoral scans were obtained and superimposed by matching the resulting DICOM and STL data files in a software to create the tooth-supported surgical guide. All implants were placed using a fully guided implant surgery protocol. The accuracy of the technique was measured by the deviation between the actual implant position (mesio-distal deviation, depth error, and axis deviation) obtained from the postoperative CBCT and the preoperative planned implant position. Clinical outcomes assessed included biological complications, implant and prosthetic failures, esthetic outcomes, and patient satisfaction. Descriptive analysis was performed using mean and standard deviation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 37 implants were analyzed. The mean results were as follows: 0.43 ± 0.20 mm of mesio-distal linear deviation at the implant shoulder, 0.24 ± 0.07 mm of depth error, and 1.46° ± 0.31° of axis deviation. At 6 months, healing was uneventful for all patients, with no complications or implant or prosthetic failures reported. Patients with implant-supported restorations expressed high levels of functional and esthetic satisfaction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The fully guided technique achieved clinically acceptable accuracy positioning of dental implants in partially edentulous patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-Implant Diseases: Enhanced Antibacterial Photodynamic Therapy","authors":"Hanna Lähteenmäki,&nbsp;Tommi Pätilä,&nbsp;Ismo T. Räisänen,&nbsp;Rauni Kalliala,&nbsp;Timo Sorsa","doi":"10.1002/cre2.70146","DOIUrl":"https://doi.org/10.1002/cre2.70146","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The number of dental implants is constantly on the rise, and inflammation of their surrounding tissues is an increasing problem. In this randomized controlled trial, we investigated the effects of antibacterial dual-light photodynamic therapy (aPDT) in peri-implant disease in reduction of inflammation in the peri-implant tissues.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Forty patients with newly diagnosed peri-implant disease were recruited. The diagnoses were established clinically and by radiological bone loss (RBL). Dual-light aPDT was provided by indocyanine green mouth rinsing and 50:50, 405 nm, and 810 nm light applicator. The treatment group (<i>n</i> = 20) was randomized to use aPDT treatment at home for 4 weeks. The treatment was carried out once daily for 2 weeks, then twice daily for the next 2 weeks. The control group (<i>n</i> = 20) continued enhanced self-care during the study period. Traditional measurement methods around the implant were measured at the beginning, at 2 weeks and at 4 weeks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During the study period, VPI decreased in both groups. In the treatment group BOP decreased from mean (SD) 4.7 ± 1.3 to 1.8 ± 1.6, <i>p</i> &lt; 0.0001, but no change was observed in the control group (3.5 ± 2.3 to 3.0 ± 2.3, <i>p</i> = 0.39). In the aPDT treatment group aMMP-8 decreased from mean (SD) 100 ± 41 to 72 ± 38, <i>p</i> = 0.027, but not in the control group (86 ± 54 to 86 ± 60, <i>p</i> = 0.38).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Regularly applied dual-light aPDT reduces inflammation in the dental implant adjacent tissues. Dual-light aPDT approach holds promise as an effective home care tool for implant patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Recombinant Human Bone Morphogenetic Protein-2 in Socket Preservation: A Randomized Controlled Clinical and Sequential Human Histological Trial (BMP-2 TRIAL)","authors":"Saravanan Sampoornam Pape Reddy,&nbsp;Delfin Lovelina Francis,&nbsp;Harshini Thirumoorthi,&nbsp; Rahul,&nbsp;Manish Rathi,&nbsp;Harjeet Singh,&nbsp;Shaswata Karmakar,&nbsp;Shaili Pradhan","doi":"10.1002/cre2.70134","DOIUrl":"https://doi.org/10.1002/cre2.70134","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this study was to evaluate the effectiveness of recombinant human bone morphogenetic protein-2 (rhBMP-2) coated biphasic calcium phosphate (BCP) in socket preservation in comparison to BCP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Patients who underwent extraction of maxillary premolars were randomized to receive rhBMP-2/BCP (<i>n</i> = 15) and BCP alone (<i>n</i> = 15). All sites were primarily closed using a pedicled connective tissue flap. Biopsy was carried out in patients at 3 (<i>n</i> = 10), 6 (<i>n</i> = 10), and 9 (<i>n</i> = 10) months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At 3 months, BMP and non-BMP groups had 3.17% and 3.12% new bone formation, respectively, and 3.8% and 37.85% of residual grafts, respectively, and 25.86% and 25.99% connective tissue component, respectively. At 6 months, both groups revealed 67.42% and 16.55% essential bone growth, 1.74% and 3.04% of residual graft, and 1.3% and 67% connective tissue component, respectively. At 9 months, the BMP group revealed 93.6% new bone formation, 0.68% residual graft, and 1.9% connective tissue component, while the non-BMP groups had 23.35% new bone formation, 4.45% residual graft, and 44.06% connective tissue component.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study demonstrated that rhBMP-2 coated BCP significantly enhanced early graft substitution in socket preservation sites compared to BCP alone. There was a significantly higher percentage of new bone formation in the rhBMP-2/BCP group both at 6 and 9 months. Additionally, the rhBMP-2/BCP group exhibited faster resorption of the graft material and earlier maturation of newly formed bone. These findings strongly suggest that rhBMP-2/BCP can be an effective treatment modality for socket preservation, promoting predictable and accelerated bone regeneration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes of the Occlusal Relationship in Patients With Temporomandibular Disorders (TMD) After Manual Therapy: A Pilot Study","authors":"Tobias Dieter Peter Pohl,&nbsp;Alessia Celine Harhoff,&nbsp;Johannes Ries,&nbsp;Manfred Wichmann,&nbsp;Ragai-Edward Matta","doi":"10.1002/cre2.70147","DOIUrl":"https://doi.org/10.1002/cre2.70147","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Temporomandibular disorders (TMD) are often linked to changes in dental occlusion, yet the impact of therapeutic interventions remains unclear. This pilot study investigates the effects of manual therapy on occlusion in TMD patients through quantitative analysis of intraoral scans.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Ten individuals were diagnosed with TMD and underwent a 40-min session of manual therapy (Group MT). Ten subjects were allocated to the healthy control group (Group C) and did not receive any therapy during the 10-week control period. Occlusion measurements were obtained using the TRIOS 3 intraoral scanner (3Shape, Denmark) both before and after the therapy or control period. The digital models were analyzed regarding occlusal changes using the GOM Inspect Professional software (GOM, Germany). The differences in the individual axes <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 \u0000 <mrow>\u0000 <msub>\u0000 <mi>dX</mi>\u0000 \u0000 <mi>Pat</mi>\u0000 </msub>\u0000 \u0000 <mo>,</mo>\u0000 \u0000 <msub>\u0000 <mi>dY</mi>\u0000 \u0000 <mi>Pat</mi>\u0000 </msub>\u0000 \u0000 <mo>,</mo>\u0000 \u0000 <msub>\u0000 <mi>dZ</mi>\u0000 \u0000 <mi>Pat</mi>\u0000 </msub>\u0000 \u0000 <mo> </mo>\u0000 \u0000 <mrow>\u0000 <mo>(</mo>\u0000 \u0000 <mi>mm</mi>\u0000 \u0000 <mo>)</mo>\u0000 </mrow>\u0000 </mrow>\u0000 </mrow>\u0000 <annotation> ${{dX}}_{{Pat}},{{dY}}_{{Pat}},{{dZ}}_{{Pat}}{unicode{x02007}}(mathrm{mm})$</annotation>\u0000 </semantics></math> and Euclidean distance <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 \u0000 <mrow>\u0000 <msub>\u0000 <mrow>\u0000 <mi>d</mi>\u0000 ","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Accuracy: Clinical Outcomes of Computer Assisted Implant Surgery","authors":"Sofya Sadilina,&nbsp;Kay Vietor,&nbsp;Romain Doliveux,&nbsp;Adam Siu,&nbsp;Zhuofan Chen,&nbsp;Bilal Al-Nawas,&nbsp;Nikos Mattheos,&nbsp;Allesandro Pozzi","doi":"10.1002/cre2.70129","DOIUrl":"https://doi.org/10.1002/cre2.70129","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Computer Assisted Implant Surgery (CAIS) with different technologies and modalities is becoming increasingly utilized in clinical practice. The aim of this White Paper was to synthesize evidence, reported experience, and best practices with regard to clinically relevant outcomes of static, dynamic, and robotic CAIS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A review of the literature compiled existing evidence from clinical studies up to November 2024, which was later discussed and synthesized into clinically relevant questions with a panel of international experts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There is overwhelming evidence for the superiority of static, dynamic, and robotic CAIS with regard to the accuracy of implant placement and some limited evidence of superior esthetic outcomes. At the same time, outcomes related to implant primary stability, survival rates, intra- and postoperative complications, marginal bone loss, and peri-implant tissue health appear similar between guided and non-guided implant surgery, while efficiency is poorly defined and studied. The importance of accuracy in the execution of a comprehensive, prosthetically driven treatment plan is not reflected in most studies, which focus mainly on the assessment of procedures rather than entire treatment workflows. Such inherent limitations of available research might conceal some of the potential of guided CAIS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Guided CAIS can achieve at least as good clinical outcomes as non-guided implant surgery. Studies that can assess the benefits of CAIS as part of a treatment workflow, rather than isolated procedures, could improve our understanding of the potential of these technologies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}