Clinical and Experimental Dental Research最新文献

{"title":"A Comprehensive Analysis of the Radiographic Characteristics and Bilateral Symmetry of the Mental Foramen","authors":"Radhwan Algabri,&nbsp;Faisal Abulohoom,&nbsp;Abdelrahman Fadag,&nbsp;Hesham Al-Sharani,&nbsp;Sami Al-Aqab,&nbsp;Nassr Al-Hutbany,&nbsp;Emad Alryashi,&nbsp;Ahmed Keshk,&nbsp;Ahmed Yaseen Alqutaibi","doi":"10.1002/cre2.70081","DOIUrl":"https://doi.org/10.1002/cre2.70081","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>There is currently a scarcity of data on the frequency and bilateral symmetry of the position and other characteristics of the mental foramen (MF) and accessory mental foramina in Yemen. The objective of this study was to analyze the position and other characteristics, as well as the symmetry of the MF, in a sample of the Yemeni population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A retrospective analysis was conducted on a sample of 500 digital panoramic radiographs (1000 sides). The study examined various characteristics of the MF, including horizontal and vertical positions, shapes, appearances, and the presence of accessory mental foramina. Additionally, the study explored potential associations between these characteristics and variables such as the subject's gender, sides, and symmetry. Data analysis was performed using SPSS, and statistical significance was evaluated using chi-square tests; the <i>p</i> value was set at 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The horizontal position of the MF was most frequently observed between the first and second lower premolars (63.2%). The vertical position of the MF was predominantly below the apices of the lower premolars (66.2%). The majority of MFs had a round shape (46.3%). In 72% and 75.6% of cases, there was a continuous and descending relationship between the MF and the mandibular canal, respectively. Accessory mental foramina was present in 3.8% of cases. Gender differences were significant for the shape of the MF and the pattern of the canal on the right side. The symmetry rates for various features included horizontal positions (87.4%), vertical positions (82.6%), and shapes (80.4%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The MF is most commonly situated horizontally between the lower premolars and vertically below the apices of these teeth. The majority of MFs showed a round shape and a continuous and descending relationship with the mandibular canal. In most instances, characteristics of the MF were symmetrical on both sides.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Anatomic Study of the Lingual Nerve and Associated Branches","authors":"René Human-Baron,&nbsp;Alexander Procos,&nbsp;André Uys","doi":"10.1002/cre2.70051","DOIUrl":"https://doi.org/10.1002/cre2.70051","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of the study was to investigate the course and anatomy of the lingual nerve (LN) to minimize the risk of iatrogenic damage during dental procedures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>The LN was dissected in 25 cadavers (dentulous and edentulous). The intersection of the LN and submandibular duct (SMD), the bifurcation location from the mandibular nerve, the branching patterns of the main trunk, and the number of terminal branches were recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In dentulous females, LN distances to the third, second, and first molars were 11.46 ± 2.51, 15.50 ± 5.24, and 18.75 ± 5.91 mm, while in dentulous males, they were 10.98 ± 1.27, 15.75 ± 2.61, and 19.65 ± 4.50 mm, respectively. For edentulous mandibles, all distances were shorter compared to the dentulous group. In 39.13%, the LN passed superior to the SMD. The LN is bifurcated above the mandibular notch in all cases. The number of branches entering the tongue ranged from 2 to 9, with a Type 1 branching pattern found to be the most prevalent.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The study incorporated both dentulous and edentulous cadavers from a South African population. The findings hold significance for surgical procedures, providing valuable insights into minimizing potential damage.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the Presence of Adjacent Tooth and Material Type on the Marginal and Internal Adaptation of Endocrowns Fabricated by the Digital Impression Technique","authors":"Mehran Falahchai,&nbsp;Fatemeh Razavi Ardekani,&nbsp;Naghme Musapoor,&nbsp;Yasamin Babaee Hemmati,&nbsp;Hamid Neshandar Asli","doi":"10.1002/cre2.70077","DOIUrl":"https://doi.org/10.1002/cre2.70077","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To assess the effects of the presence of adjacent tooth and material type on the marginal and internal adaptation of endocrowns fabricated by the digital impression technique.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>An endodontically treated molar tooth was used for the fabrication of endocrowns in this in vitro study. Five groups of specimens (<i>n</i> = 17) were evaluated based on the material type and presence of adjacent tooth: three groups of monolithic zirconia (Zir), lithium disilicate (LDS), and zirconia-reinforced lithium silicate (ZLS) in the presence of adjacent teeth, and two groups of zirconia endocrowns, one in the absence of an adjacent anterior tooth (second premolar; Zir-no ant.) and one in the absence of a posterior adjacent tooth (second molar; Zir-no post.). Marginal and internal adaptation of endocrowns was evaluated by the silicone replica technique. Data were analyzed by ANOVA with Tukey test for pairwise comparisons and generalized estimating equation with Bonferroni correction for pairwise comparisons (α = 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The largest marginal gap was found in the ZLS, followed by the LDS and Zir groups (<i>p</i> &lt; 0.05). The Zir group showed significantly higher internal adaptation than the ZLS group (<i>p</i> &lt; 0.05); LDS had no significant difference with the ZLS and Zir groups (<i>p</i> &gt; 0.05). The Zir group showed larger marginal and internal gaps than the Zir-no ant. and Zir-no post. groups (<i>p</i> &lt; 0.05); the latter two groups had no significant difference (<i>p</i> &gt; 0.05). All groups showed the largest gap at the pulpal and the smallest gap at the marginal and cervical areas (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Zirconia endocrowns showed the highest marginal and internal adaptation. Digital impression technique in absence of anterior or posterior adjacent tooth would result in higher marginal and internal adaptation of endocrowns.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Electrical Heat Carrier Temperature on Bacterial Leakage of Endodontically Treated Teeth Using a Bioceramic Sealer","authors":"Mir Ahmad Nabavi,&nbsp;Mahmood Reza Kalantar Motamedi,&nbsp;Pedram Fattahi,&nbsp;Saber Khazaei","doi":"10.1002/cre2.70059","DOIUrl":"10.1002/cre2.70059","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this study is to investigate the effect of electrical heat carrier temperature on bacterial leakage of root canals obturated with the continuous wave of condensation (CWC) technique and a bioceramic sealer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This ex vivo experimental study was conducted on 92 extracted single-rooted teeth. The teeth were subjected to endodontic treatment and obturated with the Endoseal MTA bioceramic sealer by the CWC technique using two different temperature settings of the electrical heat carrier: 120°C (group G120, <i>n</i> = 41) and 200°C (group G200, <i>n</i> = 41). A positive and a negative control group were also considered (<i>n</i> = 5 each). Bacterial leakage was assessed over a 40-day period using a bacterial leakage model. The incidence of bacterial leakage was compared between the experimental groups using the log-rank test. The significance level was set at 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median survival rate was 39.0 (25.0) days in the G120 group and 34.0 (25.0) days in the G200 group. Despite a slightly higher survival rate in the G120 group, the difference between the two experimental groups was not statistically significant (<i>p</i> = 0.612).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The tested temperatures of the electrical heat carrier (120°C and 200°C) did not have a significant effect on bacterial leakage of root canals obturated by the CWC technique and the Endoseal MTA bioceramic sealer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Expression of Hard Tissue Proteins in Hypomineralized Second Primary Molars in Comparison to Normal Teeth","authors":"Sharon Jessica,&nbsp;Ramya Sekar,&nbsp;Snehashish Ghosh,&nbsp;Safal Dhungel,&nbsp;Kavitha B.,&nbsp;Mahesh Ramakrishnan,&nbsp;Shazia Fathima Jh,&nbsp;Monisha Prasad,&nbsp;Jaiganesh I.,&nbsp;Sindhu Subramani","doi":"10.1002/cre2.70079","DOIUrl":"10.1002/cre2.70079","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to identify the proteins in hypomineralized second primary molars (HSPMs) and correlate their function in Amelogenesis. HSPM is a qualitative defect of the enamel of the second primary molars with no clear etiology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Total protein quantification was performed using the Bradford Protein Assay, followed by the electrophoretic separation of samples using 2D-Gel electrophoresis to identify the proteins.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results from the Bradford Protein Assay unveiled a five-fold increase in the protein content in HSPM. Proteins such as Dentin sialo-phosphoprotein (DSPP), Keratin, type I, Serum Albumin, Anti-thrombin III, Alpha-1-Antitrypsin, Histone H3.2, Actin, Heat shock Protein, Vimentin, Desmoglein-3, Glyceraldehyde-3-phosphate dehydrogenase, Inosine-5'-monophosphate dehydrogenase 2, Zinc Alpha 2 glycoprotein, Lysozyme C, Prothrombin, Vit-D binding Protein, Apolipoprotein A-1, Defensin 1, Immunoglobulin Gamma, Immunoglobulin Kappa, and Alpha-Amylase were all upregulated (<i>p</i> &lt; 0.05) in HSPM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This investigation conclusively demonstrates that HSPM-affected teeth have higher protein content than healthy teeth. The study also supports the theory of proteolytic inhibition attributed to reduced protease activity and heightened protease inhibitor activity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Choice of Flavor of Fluoride Varnish on Behavior in Dental Visits in Schoolchildren","authors":"R. Karim,&nbsp;C. H. Splieth,&nbsp;J. Schmoeckel","doi":"10.1002/cre2.70069","DOIUrl":"10.1002/cre2.70069","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the effect of choosing the taste of a fluoride varnish on the behavior and acceptance of the children during the dental visit.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This single-blinded, randomized controlled trial (NCT05285228) involved 70 healthy children aged 5–10 years who presented for a dental recall visit including the indication of an application of fluoride varnish to the specialized pediatric university dental service. The control group received the fluoride varnish (Profluorid varnish, VOCO Germany) with an allocated taste, whereas the test group had to choose the taste of the fluoride varnish just before the dental check-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The vast majority of the children (<i>n</i> = 53, 75.7%) felt <i>happy/very happy</i> (Facial image scale) regarding the taste of the fluoride varnish, with no significant difference between both groups (<i>p</i> = 0.188). Dental behavior (Frankl behavior rating scale) was assessed generally as <i>positive/definitely positive</i> (<i>n</i> = 58, 82.2%). Interestingly, children with a history of previous negative dental behavior in the test group showed a tendency of more positive behavior than in the control group (66.6% vs. 33.4%, <i>p</i> = 0.244).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Sense of control performed via choosing the flavor of the fluoride varnish increases the chance for positive behavior during the dental visit, especially in children with a history of negative dental behavior. Concurrently, it improves the child's taste acceptance, which is important for dental caries prevention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>The study protocol was registered on Cli ClinicalTrials.gov (NCT05285228).</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Force Degradation of Intermaxillary Latex Elastics: Comparative In Vitro and In Vivo Study","authors":"Lucie Ptáčková,&nbsp;Barbora Ličková,&nbsp;Wanda Urbanová,&nbsp;David Sluka,&nbsp;Klaudia Portašíková,&nbsp;Soňa Chamlarová,&nbsp;Iva Voborná,&nbsp;Ivana Dubovská","doi":"10.1002/cre2.70072","DOIUrl":"10.1002/cre2.70072","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to compare the force degradation of intermaxillary elastics (IE) in vitro and in vivo while stretching the IE to a precise diameter.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>IE 3/16″ medium Dentaurum from five different batches of packaging were analyzed. The in vivo study involved 10 volunteers, of which 100 IE were examined. To achieve three times the original diameter of the elastic, the distance between the upper canine and the lower dental arch was measured. Buttons were then placed in the mouth accordingly, and IE and passive aligners were inserted for five sessions of 48 h each. To investigate in vitro, 100 IE were placed in an incubator set at 37°C in a humid environment and stretched three times their diameter. The force of the elastics was measured in both investigations using a force meter at 0, 2, 8, 24, and 48 h.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In all patients except one, the three times diameter distance extended from the upper canine to the lower second premolar. The force degradation in vivo at 2, 8, 24, and 48 h was 20.58%, 26.78%, 34.81%, and 38.56% and in vitro was 16.38%, 22.83%, 28.32%, and 30.78%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The amount of stretching of IE varies for each patient when using standard insertion points. The force of IE decreases exponentially, the force degradation in vivo being higher. The clinician must consider the force decrease when advising the patient of the time interval to change the elastics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Multimodality Treatment Including Stabilization Splint and Low-Level Laser Therapies on Managing Temporomandibular Disorders: A Pilot Randomized Controlled Trial","authors":"Zahra Afshari,&nbsp;Nazieh Abdollah Kookhi,&nbsp;Mahdi Shamali,&nbsp;Majid Sedaghat Monfared,&nbsp;Sara Tavakolizadeh","doi":"10.1002/cre2.70038","DOIUrl":"10.1002/cre2.70038","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Temporomandibular disorder (TMD) encompasses various clinical issues affecting the temporomandibular joint, masticatory muscles, and surrounding structures. Common symptoms include pain, joint and muscle tenderness, and limited jaw movement. Diverse treatment options have been utilized to manage TMD. However, evidence of the combined modality treatment approach is scarce. This pilot trial aimed to evaluate the effectiveness of combining stabilization splint therapy (SST) with low-level laser therapy (LLLT) in managing TMD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This pilot parallel randomized clinical trial included 30 patients with TMD. Patients were randomly allocated equally into three treatment groups: SST, LLLT, and combined treatment (CT). Outcomes, including pain and functional limitations, were measured at baseline, 1, 2, 3, and 4 weeks after the start of each treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>CT was significantly more effective in reducing pain in patients with TMD compared to LLLT and SST. Although patients in the LLLT group reported significantly reduced pain, they still had higher pain scores compared to the SST group at certain time points, indicating that LLLT was not as effective as SST. Most functional limitations were improved over time, more consistently within the CT group, but without significant differences between the three groups. Patients were more satisfied with CT compared to LLLT and SST.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The superior results of the CT group over the SST and LLLT groups were evident in this pilot trial's outcomes. The combined modality treatment approach seems to yield the greatest improvement for TMD patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Correlation Between Langerhans Cells Population and Prognosis of Tongue Squamous Cell Carcinoma","authors":"Narges Ghazi,&nbsp;Nasrollah Saghravanian,&nbsp;Pooya Saeedi,&nbsp;Mohammad Mahdi Maboudinezhad","doi":"10.1002/cre2.70080","DOIUrl":"10.1002/cre2.70080","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Objective</h3>\u0000 \u0000 <p>Tongue squamous cell carcinoma (TSCC) is the most prevalent oral cancer. Despite considerable advancements in treatment, the 5-year survival rate remains relatively unchanged. Langerhans cells (LCs) play an important role in antitumor immunity. Therefore, we attempt to evaluate the correlation between the LC count and disease prognosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Histopathologic slides from 24 cases, with at least 2 years of follow-up, were selected and categorized into early-stage (12 cases) and advanced-stage (12 cases) groups. An additional 12 slides of normal tissue comprised the control group. Immunohistochemical staining with the CD1a marker was performed to analyze the density of LCs. Statistical analysis assessed the impact of CD1a immune expression on patient survival and other variables such as age, gender, stage, and histopathological grade.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Comparison of CD1a+ cell counts across the three groups revealed a significant decrease in the advanced group. Furthermore, a lower count of CD1a+ cells correlated with poorer disease-free survival (DFS) (<i>p</i> &lt; 0.001) and overall survival (OS) (<i>p</i> = 0.049). Although the CD1a+ cell count did not independently affect OS significantly (<i>p</i> = 0.210), it did show a significant impact on DFS as an independent variable (<i>p</i> = 0.002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The significant correlation between CD1a expression and patients' prognosis and survival rates suggests that CD1a+ cells could serve as a crucial prognostic factor in the management and treatment of TSCC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marginal Fit and Fracture Resistance of Vertical Versus Horizontal Margins in Monolithic Zirconia Crowns","authors":"Mohamed A. Salama,&nbsp;Mohamed F. Aldamaty,&nbsp;Moamen A. Abdalla,&nbsp;Elsayed Ali Omar,&nbsp;Mohammed H. AbdElaziz,&nbsp;Ahmed Yaseen Alqutaibi","doi":"10.1002/cre2.70064","DOIUrl":"10.1002/cre2.70064","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The use of vertical margin design in all-ceramic restoration has generated inquiries regarding its clinical efficacy under diverse dynamic oral conditions. This research aims to assess the marginal fit and fracture resistance of monolithic zirconia crowns featuring vertical margin design as opposed to those with conventional horizontal margin design.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Two metal dies were employed to generate replicated resin dies mimicking mandibular first molar preparation. The metal dies were precision-engineered with two margin designs: vertical margin design presenting a shoulderless configuration (Featheredge) and horizontal margin design (Radial Shoulder). Forty zirconia crowns were produced on the replicated resin dies using two varieties of monolithic zirconia, with twenty crowns in each category: pre-shaded and multilayered zirconia. Both sets were further subdivided into two groups based on the finish line configuration utilized (n = 10). The vertical marginal gap of the zirconia crowns was gauged before and after thermocycling (5-55oC/5000 cycles), followed by loading the crowns until fracture occurred. Statistical analysis was performed using one-way analysis of variance (ANOVA), accompanied by Bonferroni's post hoc test and independent <i>t</i>-test for pairwise comparisons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The Shoulder subgroup of BruxZir exhibited the highest mean marginal gap value (120.06 ± 10.15 µ), while the Featheredge subgroup of BruxZir displayed the lowest value (49.72 ± 6.53 µ). Among the BruxZir group, the Featheredge subgroup showcased the highest mean fracture resistance value (4251.57 ± 279.90 N), whereas the Shoulder subgroup recorded the lowest value (1721.60 ± 225.16 N).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Monolithic zirconia crowns with vertical margin design (Featheredge) demonstrated statistically enhanced performance compared to conventional horizontal margin design, as evidenced by lower marginal gap values and increased fracture resistance tolerance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}