Environmental analysis, health and toxicology最新文献

{"title":"Concentrations of trace metals in serum: Implications for type 2 diabetes mellitus and gender difference.","authors":"Jae Min Lee, An Na Jung, Sujeong Han, Jae Woong Sull, Chunhwa Ihm, Jin Hyun Jun","doi":"10.5620/eaht.2025001","DOIUrl":"10.5620/eaht.2025001","url":null,"abstract":"<p><p>Trace metals play a pivotal role in maintaining normal and healthy physiology due to their various metabolic functions in humans. This study was performed to identify the association between trace metals and type 2 diabetes mellitus (T2DM) through a comparative analysis of serum samples from both healthy controls and T2DM patients. Additionally, we aim to explore the potential connection between gender differences and the concentration of trace metals in T2DM patients. The study included 103 participants, comprising 53 healthy controls and 50 T2DM patients, with blood samples stored at Eulji University Hospital (Daejeon, Korea). Serum concentrations of copper (Cu), zinc (Zn), manganese (Mn), and selenium (Se) and chromium (Cr) levels were measured and statistically analyzed by t-tests and logistic regression after the outliers replaced by mean. In the overall participants, serum concentrations of Cu and Mn in T2DM group was significantly different compared to the control group (P < 0.01). Logistic regression analysis indicated that Cu, Se and Mn concentration was significantly different in T2DM patients than in healthy controls in adjusted for age and sex. When examining trace metal concentrations by gender difference, Se were significantly lower in T2DM men (P < 0.01), while T2DM women exhibited significantly higher levels of Zn, Se and Mn (P < 0.05). Especially in women, logistic regression analysis indicated that Cu, Se and Mn concentration was significantly different in T2DM patients than in healthy control (adjusted for age OR of Cu, 0.92; 95 % CI 0.87 - 0.98, adjusted OR of Se, 3.04; 95 % CI, 1.71 - 5.34; adjusted OR of Mn, 4.50; 95 % CI, 2.09 - 9.68). This study showed that trace metal imbalances related to Se and Mn in patients with T2DM were particularly relevant in women. It highlights the significance of gender difference and suggests the potential benefits of regular monitoring of trace metal concentrations in the management of T2DM patients.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"40 1","pages":"e2025001-0"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organic compounds in the atmosphere and their potential impact on health in Ondo State, Nigeria.","authors":"Ediagbonya Thompson Faraday, Osaruwemnse Peter Osarodion, Uche Joseph Ifeanyi, Famuyiwa Susan Omowunmi, Olowofoyeku Ayobamiji Emmanuel","doi":"10.5620/eaht.2025006","DOIUrl":"10.5620/eaht.2025006","url":null,"abstract":"<p><p>The present investigation aimed to detect volatile organic compounds (VOCs) in the atmospheric environment of Ondo State, Nigeria. This study used a thorough analytical process to measure VOCs in air samples taken from various places within Ondo State using a portable gas detector and their connection with meteorological data. These fluctuations were related to both natural and anthropogenic activity, such as burning of forest, industrial processes, transportation, and agricultural practices. This study offers important information to the larger discussion on environmental contamination and provides a framework for Ondo State's decision-making and policy development. The average TVOC concentration (measured in mg/m3) during wet conditions is 0.96 ± 0.84, which is significantly lower than the average of 1.98 ± 0.85 during dry conditions. The mean temperature (°C) in wet conditions is 32.83 2.03, which is a little lower than the mean (33.77 ± 2.06) in dry conditions. The mean wind speed (in m/s) during wet conditions is 1.77 ± 0.69, which is greater than the mean wind speed (in m/s) during dry conditions of 1.37 ± 0.69. Mean value of humidity for wet situations is 71.80 ± 3.91, which is a little lower than the mean value for dry conditions, which is 73.47 ± 4.07.similar to those for temperature, show that this difference in humidity is not statistically significant. This work evaluated the potential health risks associated with TVOC. The total hazard quotient (THQ) for adult was 4.0 x 10⁻⁷ for children 4.40 x 10⁻⁷. The children's HQ ranged from 0.36 to 1.70. The adult's ranged from 1.31 to 6.19. However, it was discovered that the health risk posed by breathing in atmospheric TVOC was far higher than the USEPA limits, where HQ >1.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"40 1","pages":"e2025006-0"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental health risk analysis of microplastics due to consumption of squid and mussels at coastal area.","authors":"Muhammad Addin Rizaldi, R Azizah, Lilis Sulistyorini, Khaidar Ali","doi":"10.5620/eaht.2025009","DOIUrl":"10.5620/eaht.2025009","url":null,"abstract":"<p><p>Microplastic in marine environment represent a global issue, originating from both land-based and ocean-based activities. The microplastic contamination in marine biota can lead to the ingestion of microplastics by human through the consumption. This study aims to investigates the abundance of microplastic in marine biota and to assess human health risk among community in coastal area of Muncar District - Banyuwangi Regency. This study was conducted in the coastal area of Muncar district in 2023. The sample of mussels and squid was collected 100 gr, respectively, used to measure the abundance of microplastics. Additionally, 130 respondents were recruited to assess the health risk among community. Partial Least Square Structural Equation Modeling (PLS-SEM) with was used to examine the influence of microplastic concentration, the intake rate, and human health risk with Smart PLS 3. The total abundance of microplastic in mussels and squid was found 23 particles or 0.23 particle per gram. The microplastics identified were primarily fiber, with colors including transparent, purple, red and black. The microplastics consisted of polyethylene (PE), polypropylene (PP), Polyethylene terephthalate (PET), polyester terephthalic acid and Polyvinyl acetate ethylene. The indirect effect between microplastics concentration, intake rate and hazard quotient are significant (p-value < 0.05). Therefore, microplastic concentrations in marine biota can influence carcinogenic intake, which in turn becomes an indirect factor affecting hazard quotient associated with microplastic consumption. Prolonged or excessive consumption of marine biota with high levels of microplastics can lead to increased carcinogenic intake, thereby elevating the potential health risks to humans.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"40 1","pages":"e2025009-0"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution and human health risk of N-nitrosamines in tap water in the central region of South Korea.","authors":"Dahae Park, Sungjin Jung, Dasom Kim, Hekap Kim","doi":"10.5620/eaht.2025005","DOIUrl":"10.5620/eaht.2025005","url":null,"abstract":"<p><p>This study aims to evaluate the concentrations and potential risks associated with seven volatile N-nitrosamines (NAs), a category of disinfection by-products, present in tap water, while considering realistic human exposure. Tap water samples were collected across four seasons from three central regions (Gangwon State, Gyeonggi-do, and Seoul Metropolitan City) in South Korea and analyzed for the NAs using high-performance liquid chromatography with fluorescence detection, following solid-phase extraction and derivatization. Among the NAs examined, three compounds, namely N-nitrosomorpholine (NMOR), N-nitrosodimethylamine (NDMA), and N-nitrosodiethylamine (NDEA), were identified in all samples. NDMA had the highest concentration at 53.4 ± 19.5 ng/L, while NMOR and NDEA had 3.83 ± 10.56 ng/L and 37.5 ± 25.6 ng/L, respectively. These compounds exhibited similar concentrations across the three regions, with higher levels observed during winter than other seasons. The estimated cancer risk of NDEA was above 10-6, which is a concern. However, actual risk might be even lower when considering Korean drinking water intake patterns such as hot soups and stews. Nevertheless, it is imperative to improve regulatory practices to comprehensively address health risks from food intake, air contamination, and other sources.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"40 1","pages":"e2025005-0"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of an organophosphorus pesticide, chlorpyrifos (from different local sources), on the testicular tissue in adult male albino rats.","authors":"Rania A Mohamed, Heba Ali Abd El-Rahman","doi":"10.5620/eaht.2025010","DOIUrl":"10.5620/eaht.2025010","url":null,"abstract":"<p><p>Chlorpyrifos is a widely used organophosphorus pesticide for agricultural purposes to control early disease in crops. Acting as an endocrine disrupting agent for male reproductive systems which leads to reproductive toxicity. Accordingly, this study aimed to investigate the potential mechanisms by which three commercial formulations of chlorpyrifos interfere with androgen receptor function and expression in male rats. The research was conducted according to the ethical guidelines established by the institutional animal care and use committee (IACUC), and the protocol received approval from Cairo University- Faculty of Science under approval number (CU/IF/12/23). Twenty-four male Wistar rats were equally allocated to four groups. The control group, chlorpyrifos groups orally received (17.43, 23.43, 21.40 mg/kg) for 28 days (5 days /week). The serum testosterone hormone was estimated, and the testes were collected, and fixed in 10% buffered formalin for histopathological and immunohistochemical examination. Results indicated that chlorpyrifos formulations caused a marked decrease in testosterone levels and downregulation of androgen receptor expression. Moreover, a significant reduction in tubular diameter, lumen diameter, and thickness of germinal epithelial cells was detected along with the Jonson score. In summary, exposure to the three chlorpyrifos formulations resulted in notable alterations in testosterone levels, decreased expression of androgen receptors, and compromised spermatogenesis, culminating in testicular damage and male infertility. Of the formulations assessed, chlorpyrifos-W was identified as the most effective disruptor of androgen signalling, demonstrating higher toxicity compared to the other formulations.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"40 1","pages":"e2025010-0"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Usefulness of physiological and biochemical stress response of soil collembola (Xenylla welchi Folsom, 1916) as a biomarker in a lead-amended garden soil.","authors":"Priyanka Sarangi, Partha Pratim Chakravorty, Bhabatosh Das","doi":"10.5620/eaht.2025004","DOIUrl":"10.5620/eaht.2025004","url":null,"abstract":"<p><p>This study investigates the physiological and biochemical stress responses of the microarthropod Xenylla welchi to different sublethal doses of lead-contaminated garden soil in microcosms, aiming to assess the impact of metallic contamination in tropical ecosystems. 24-hour LC50 for lead acetate was determined to be 2653.23 mg/kg. Chronic exposure to various sublethal concentrations (1/2, 1/4, 1/6, and 1/8 of LC50) revealed significant reductions in exuvia production, fecundity, and lifespan, particularly at higher lead concentrations. Several biochemical parameters were assessed to further understand lead-induced stress responses. A marked decrease in glutathione (GSH) levels indicated oxidative stress, while glutathione-S-transferase (GST) activity displayed temporal variations, initially increasing and then declining with prolonged exposure. Acetylcholinesterase (AChE) activity was consistently inhibited across the treatment groups, reflecting neurotoxicity. Additionally, metallothionein (MT) levels were significantly elevated after extended lead exposure, suggesting an adaptive response to metal detoxification. The cumulative responses of Xenylla welchi suggest that they could be reliable biomarkers for assessing the ecological impact of lead pollution in soil ecosystems, highlighting their potential usefulness in monitoring heavy metal contamination.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"40 1","pages":"e2025004-0"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress response to gasoline generator exhaust emission in adult male wistar rats.","authors":"Akinpelu Moronkeji, Ayodeji Olayanju, Temidayo Daniel Adeniyi, Adedeji David Atere, Adebimpe Iyanuoluwa Moronkeji, Michael Chuks Igunbor, Abiodun Oyeleke, Frederick Olusegun Akinbo","doi":"10.5620/eaht.2024030","DOIUrl":"10.5620/eaht.2024030","url":null,"abstract":"<p><p>Petroleum-powered generators are commonly used in many developing countries as an alternative to meet utility demands. Generator exhaust emission significantly contributes to air pollution, which remains a constant threat to human health due to the presence of aromatic hydrocarbons and other harmful gases. This study assessed oxidative stress parameters in response to exhaust emission from gasoline generator engine in adult male wistar rats. Forty-eight (48) adult wistar rats weighing between 180-200g were randomly allocated to four (4) groups (A-D) of twelve (12) rats each. After the acclimatization period, the control group (A) were kept unexposed, whereas rats in groups (C-D) were exposed daily at 2, 4, and 8-hour intervals for 4, 8, and 12 weeks, respectively. Tissue samples were obtained at four weeks intervals. Fresh lung tissues weighing 1g were rinsed twice in phosphate-buffered saline (PBS, pH 8.0), homogenized and centrifuged at 3000 revolutions per minute for 20 min at 4°C. Supernatant levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione S-transferase (GST), reduced glutathione (GSH), nitric oxide (NO), hydrogen peroxide (H2O2), catalase (CAT), and total antioxidant status (TAS) were determined using standard protocols. The findings revealed elevated oxidant levels of MDA, NO, and H2O2, whereas SOD, GPX, GST, GSH, CAT, and TAS were significantly reduced across the exposure time points compared to the unexposed control rats (p < 0.05). The research findings revealed that exposure to emissions from gasoline generators induced oxidative stress in the exposed rats, with the extent of disruption to their oxidative balance dependent on the duration and length of exposure time.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"39 4","pages":"e2024030-0"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative neuro-study of solo or accompanied low and high boric acid doses with date molasses in adult male albino rats.","authors":"Mohamed M Rezk","doi":"10.5620/eaht.2024026","DOIUrl":"10.5620/eaht.2024026","url":null,"abstract":"<p><p>Boric acid (BA) is a weak acid and the simplest compound resulting from the dissolution of boron in water. There is great competition to determine whether boron is an essential or nonessential nutrient. Date molasses is a potent type of sweetener with valuable components, such as flavonoids and phenolics, and has significant health benefits. This study investigated the neuro-essentiality and neurotoxicity of boric acid boron in adult male albino rat cortex and cerebellum brain areas and the impact of date molasses treatment. Animals were grouped into the following groups: control, low and high boric acid doses, 10 and 500 mg/kg, respectively, with or without 250 mg/kg date molasses. The results revealed the ability of BAs to cross the blood-brain barrier and accumulate in the cerebellum and cortex, revealing the ability of date molasses to decrease BA accumulation at different time intervals. Additionally, the results varied between a nonsignificant increase or decrease in calcium ion content, monoamines (norepinephrine, dopamine, and serotonin), glucose, adenosine triphosphate, malondialdehyde and glutathione, depending on the BA dose. Moreover, date molasses mitigated any unwanted BA results. In conclusion, boric acid, which is within a permissible limit, could be essential and have a neuroprotective effect, whereas at a sublethal level, it could have a neurotoxic effect. Additionally, Date molasses can have neuroprotective effects and antagonize the neurotoxic effects of boric acid through its antioxidant and scavenging effects.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"39 4","pages":"e2024026-0"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143461563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of cellular immune response in rabbits after exposure to cobra venom and purified toxin fraction.","authors":"Sunutcha Suntrarachun, Panithi Laoungbua, Suchitra Khunsap, Jureeporn Noiporm, Rattana Suttisee","doi":"10.5620/eaht.2024029","DOIUrl":"10.5620/eaht.2024029","url":null,"abstract":"<p><p>Snakebite by a cobra is considered neurotoxic as the cause of neuromuscular paralysis mediated by low molecular weight toxins, which are major toxin components of cobra. However, these toxins represent a problem in generating antibodies owing to their low immunogenicity. Developing complementary strategies to improve the antibody response could be a useful approach to creating better therapeutic antivenoms with higher neutralizing potencies. To develop simple immunization strategies for more potent antivenoms by studying the effects of combining crude cobra venom and toxin fraction in a complementary way. The evaluation of specific cell immunology and cytokine mediators for relevant immune responses will be measured in a rabbit model using four simple immunization strategies. Flow cytometry will be used to quantify the number of B and T cells, and qRT-PCR will be used to ascertain the cytokine genes expressed. B cells with anti-CD20 were seen on D14, and a booster dose was insufficient to maximize the antibodies. Conversely, anti-CD5 for T cells decreased periodically but remained stable. Using a mixture of crude cobra venom and its <10 kDa fraction, peak expression of pro-inflammatory cytokine genes was seen in D42 or D58, with a rise of 4 and 6 folds. Similarly, gene expression of pro-inflammatory cytokines was greater than that of anti-inflammatory cytokines (IL-4 and IL-10), which were up-regulated after D42. Thus, immunization with both the crude and its <10 kDa fraction of cobra venom seems to have synergistic effects that boost cytokines, activate the immune system, and cause lymphocyte differentiation.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"39 4","pages":"e2024029-0"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143461574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levels of OH-PAHs and markers of oxidative stress in urine of taxi drivers and controls.","authors":"Na-Youn Park, Geurim Song, Kyungmu Lee, Younglim Kho","doi":"10.5620/eaht.2024027","DOIUrl":"10.5620/eaht.2024027","url":null,"abstract":"<p><p>Polycyclic aromatic hydrocarbons are pervasive in the atmosphere, originating from sources like vehicle emissions and incomplete combustion. Exposure to PAHs occurs through diet, tobacco smoke, and air pollutants, and they are recognized as carcinogens. This study, conducted from July to October 2021 in Seoul, Gyeonggi, and Ulsan regions, focused on taxi drivers, a group with elevated PAH exposure due to prolonged vehicle use. The study involved 19 male taxi drivers and 46 control participants (18 male, 28 female). LC-MS/MS analysis was employed to quantify urinary levels of 18 hydroxy-PAHs, oxidative damage markers (MDA, 8-OHdG), and cotinine. The detection rates of OH-PAHs were 1-naphthol (96.9 %), 2-naphthol (90.8 %), 2-hydroxyfluorene (86.2 %), and 1-hydroxypyrene (80.0 %). Compared to the male controls, taxi drivers showed higher median concentrations of 2-OH-Na (1.698 ng/mL), 1-OH-Na (0.666 ng/mL), 2-OH-Flu (0.067 ng/mL), and 1-OHP (0.045 ng/mL). Similarly, significant differences were observed between taxi drivers and female controls for 1-OH-Na, 2-OH-Na, 2-OH-Flu, 3-OH-Phe, and 1-OHP. MDA and 8-OHdG were detected in over 90% of all groups, with significant differences between taxi drivers. Strong positive correlations were revealed between urinary OH-PAHs, MDA, and 8-OHdG (r ranging from 0.589 to 0.770, p<0.01). The findings suggest that taxi drivers, due to prolonged exposure to traffic-related air pollutants, have elevated levels of PAH metabolites and oxidative stress, especially among smokers. Further studies with larger sample sizes are recommended to validate these results and explore the long-term health implications of occupational PAH exposure in urban transportation workers..</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"39 4","pages":"e2024027-0"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143461575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}