Environmental analysis, health and toxicology最新文献

{"title":"Tannic acid inhibits pain mediators, inflammation and oxidative stress in mice exposed to glyphosate-based herbicide.","authors":"Patrick Oluwole Abolarin, Bamidele Victor Owoyele","doi":"10.5620/eaht.2024019","DOIUrl":"10.5620/eaht.2024019","url":null,"abstract":"<p><p>Chronic exposure to glyphosate-based herbicide (Gly) has been associated with neurological disorders. Tannic acid (TA) is an antioxidant with attenuating action against neuroinflammation-associated conditions. This study evaluated the effect of Gly on pain perception alongside antinociceptive and anti-inflammatory actions of TA in Gly-exposed mice. Male Swiss mice were randomly divided into six groups (n=8): control (distilled water 0.2 ml/kg), Gly (Gly 500 mg/kg), Pre-TA + Gly (TA 50 mg/kg pre-treatment, afterwards Gly-administered), TA + Gly (TA 50 mg/kg and Gly co-administered), Pre-AA + Gly (ascorbic acid (AA) 10 mg/kg pre-treatment, afterwards Gly-administered), and AA + Gly (AA 10 mg/kg and Gly co-administered). Mechanical, thermal, and chemical pain were evaluated six weeks post vehicle/drugs administrations orally, followed by brain biochemical measurements. TA treatment alleviated Gly-induced hyperalgesia in similar version to the values of control and AA groups by increasing significantly (p < 0.05) nociceptive thresholds. Moreover, TA-treatment significantly decreased malondialdehyde (MDA) and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) levels, significantly increased anti-inflammatory cytokines (IL-10, IL-4, and TGF-1β) levels, and antioxidant enzymes, catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities compared to Gly-treated mice (p < 0.05). Conclusively, TA treatment exerted antinociceptive and anti-inflammatory actions, possibly through its antioxidant and anti-inflammatory actions in Gly-exposed mice. Notably, TA pre-treatment showed a better response than TA and Gly co-administration. We propose the potential neuroprotective and ameliorative functions of TA in Gly-induced hyperalgesia. This merits further clinical research into protective roles of TA against pesticide-related conditions.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"39 2","pages":"e2024019-0"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11294660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term exposure to di(2-ethylhexyl)phthalate may disrupt hepatic lipid metabolism through modulating the oxidative stress in male adolescent rats.","authors":"Eui-Jin Lee, Yeon-Pyo Hong, Yun-Jung Yang","doi":"10.5620/eaht.2024007","DOIUrl":"10.5620/eaht.2024007","url":null,"abstract":"<p><p>Di(2-ethylhexyl)phthalate (DEHP) is commonly used to increase the flexibility of plastics. In our previous study, DEHP may increase hepatic lipid accumulation through modulating of acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) expression. Nevertheless, it is hard to understand the association between DEHP and DGAT1 in the liver because only one dosage of DEHP was used. Thus, this study performed to investigate the role of DGAT1 on hepatic lipid metabolism after various dosages of DEHP exposure. Four-week-old male Sprague-Dawley rats (n = 5/group) were administered corn oil (vehicle) or DEHP (0.75, 7.5, 15, or 150 mg/kg/day) once daily for seven days. DEHP 150 mg/kg/day treated group increased body weight gain and relative liver weight compared to the control (P = 0.044 and P = 0.049, respectively). In histological observation, elevation of hepatic lipid accumulation was observed in all DEHP-treated groups, except DEHP 150 mg/kg/day, compared to that in the control (all P < 0.001). Portal inflammatory infiltration and acidophilic bodies were observed in the liver at DEHP 7.5 mg/kg/day and above treated groups. In addition, malondiadehyde levels, a marker of lipid peroxidation, in the liver were increased in DEHP 7.5, 15 and 150 mg/kg/day compared to the control (P = 0.017, P = 0.001, and P = 0.002, respectively). The expression of Dgat1 in the liver was significantly increased in DEHP 7.5, 15 and 150 mg/kg/day compared to the control group (P = 0.019, P = 0.002, and P < 0.001, respectively); however, there were no significant changes in the protein levels. Therefore, excessive oxidative stress caused by DEHP may induce liver damage such as inflammation rather than hepatic lipid accumulation by regulating DGAT1 transcription.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"39 1","pages":"e2024007-0"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropogenic determination and risk assessment of total petroleum hydrocarbons of ground water within Orji auto repair workshops, Owerri, Imo State, Nigeria.","authors":"Chukwu Fidelis Opia, Ibe Francis Chizoruo","doi":"10.5620/eaht.2024008","DOIUrl":"10.5620/eaht.2024008","url":null,"abstract":"<p><p>The research determined the anthropogenic source and risk evaluation of total petroleum hydrocarbons of some ground water sources within Orji auto repair workshops, Owerri, Imo State, Nigeria. The concentrations of total petroleum hydrocarbons in different groundwater samples within this vicinity were determined by selecting samples from five sampling locations using the liquid-liquid extraction process and gas chromatography fitted with a flame ionization detector. The concentrations of TPHs were determined with C15 (Pentadecane) and C30 (Triaconate) having the highest total concentrations in all sample locations of 29.67μg/mL and 23.17 μg/mL respectively while C13 (Tridecane) had the lowest combined concentration of 0.13 μg/mL with the presence of both low molecular weight and high molecular weight TPHs, an indication that the water samples had significant levels of carcinogens. Diagnostic ratio and correlation analyses of the samples analyzed showed contamination of the groundwater sources were both of petrogenic and pyrogenic sources. TPHs concentrations found in this study also revealed considerable amount of pollution with respect to contamination factors, pollution load index and degree of contamination. Elevated hazard index was equally observed for adults and children indicating a potential harm to the health of children and adults suggesting a higher risk of cancer from interaction with the polluted water. These results indicate that in remediation actions needs to be carried out before consumption to avoid fatal long term heath consequences.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"39 1","pages":"e2024008-0"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecological pollution features and health risk exposure to heavy metals via street dust and topsoil from Nkpor and Onitsha in Anambra, Nigeria.","authors":"John Kanayochukwu Nduka, Theresa Chisom Umeh, Henrietta Ijeoma Kelle, Francisca Chioma Okeke, Genevieve Chinyere Iloka, Perpetua Chioma Okafor","doi":"10.5620/eaht.2024005","DOIUrl":"10.5620/eaht.2024005","url":null,"abstract":"<p><p>The manuscript presents the investigation results on the pollution and risk of metal mines, and it is considered an important report on environmental pollution near mines in Nigeria, with archival value. The research involved soil sampling and heavy metal analysis for about 12 months in three metal mines. Based on these results, the paper provides information on pollution levels and hazards using well-known methods like pollution and ecological risk indexes. The increasing population in urban communities attracted by various industrial, economic and social activities causes contamination of atmospheric environment that can affect human health. We investigated heavy metal distributions, correlation coefficient among elements, ecological indices and probable health risk assessment in street dust and topsoil from Nkpor and Onitsha urban suburb, Nigeria. The mean concentration of heavy metals in car dust from Onitsha and Nkpor suburb follows thus: Fe > Mn > Cu > As > Pb > Ni > Cr. The decreasing trend of heavy metal in rooftop dust from both area: Fe > Mn > Cu > Pb > As > Ni > Cr whereas metal contents in topsoil were: Fe > Mn > Cu > Pb > Ni > Cr > As for both areas. The degree of pollution indices was characterized by contamination factor (CF), geo-accumulation factor (I-geo), pollution load index (PLI), Nemerow (PN), ecological and potential ecological risk index (ER and PERI) which indicated low pollution in the urban street environment. The results of Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA) showed that the estimated heavy metals displayed sources from atmospheric deposition, natural origin and anthropogenic sources. Risk assessment revealed that ingestion of dust and soil was the significant route for heavy metals exposure to the populace followed by inhalation, then dermal contact. Considering all factors, non-cancer risk was more prominent in children than adults and no significant health hazard could be attributed to both aged groups as of the period of study except for As and Ni that needs constant monitoring to avoid exceeding organ damaging threshold limit of 1 × 10-4.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"39 1","pages":"e2024005-0"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using neutron activation to assess heavy metal pollution in water and sediment along Savannah River.","authors":"Krishnakumar Divakar Nangeelil, Colby Fleming, Zaijing Sun","doi":"10.5620/eaht.2024006","DOIUrl":"10.5620/eaht.2024006","url":null,"abstract":"<p><p>A comprehensive study was conducted to assess heavy elemental pollution in the Savannah River, which flows through diverse landscapes encompassing agricultural, industrial, and commercial zones in South Carolina and Georgia. The investigation focused on the impacts of various anthropogenic activities on the river, potentially harming human health and aquatic ecosystems. Thirty samples, collected from the beginning of the Savannah River at Lake Hartwell to the Savannah River estuary near the Atlantic Ocean, were analyzed using Instrumental Neutron Activation Analysis. In regions of intense industrial activities, water samples exhibited elevated concentrations of elements such as Al (0.04-1.99 mg/L), Mg (0.4-5.5 mg/L), Ba (0.08-2.8 mg/L), Zn (0.017-0.9 mg/L), Cr (0.005-1.5 mg/L), and Fe (2.8-110.13 mg/L). Similarly, sediment samples near industrial areas also exhibited enhanced concentrations of heavy elements like Cr, Zr, Rb, Co, Zn, Mg, Mn, and Al. The outcome of this study has identified a spatial trend along the Savannah River, revealing major elements responsible for pollution that could disrupt the ecological environment and potentially impact human health.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"39 1","pages":"e2024006-0"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antagonistic effectiveness of Anacardium occidentale leaf extract on lead-acetate exposure-induced hepatorenal toxicity in rats.","authors":"Aisha Aminu, Hauwa Onozasi Umar, Wusa Makena, Zakaria Alhaji Isa, Zainab Muhammad Goni, Onyinoyi Bethel Onimisi, Barka Ishaku","doi":"10.5620/eaht.2023028","DOIUrl":"10.5620/eaht.2023028","url":null,"abstract":"<p><p>Lead (Pb) poisoning is an environmental substance that accumulates in the hepato-renal tissue, which is hazardous to health, while Anacardium occidentale L. is a tropical herb used to treat oxidative stress and inflammatory diseases. The aim of this study was to investigate the antagonistic effect of Anacardium occidentale leaf extract on lead acetate exposure-induced hepatorenal toxicity in rats. Thirty-six adult Wistar rats were split into six equal groups (n = 6). Group I served as a control, and groups II and III were administered lead acetate (50 mg/kg) and Anacardium occidentale leaf extract (400 mg/kg), respectively, while rats in groups IV-VI were administered Anacardium occidentale (L) extract (200 mg/kg and 400 mg/kg) and 10 mg/kg of Succimer, respectively, and were then administered lead acetate (50 mg/kg). When compared to the group I, rats administered lead acetate showed an increase in hepatic enzymes, urea, creatinine, MDA, TNF-α, and IL-1β (p < 0.001) levels and decreased levels of SOD, CAT, and GSH, whereas Anacardium occidentale prevented the increase in hepatorenal function parameters, oxidative stress, and inflammatory markers (TNF-α and IL-1β) induced by lead acetate. Rats administered only lead acetate had a marked increase in hepatic Pb concentration, severe hepatic steatosis, and renal glomerulus degeneration. However, treatment with Anacardium occidentale extract and succimer decreases the Pb concentration, oxidative stress, and inflammation, and also reduces histological liver steatosis and glomerular cytoarchitecture deterioration in the kidney. The results of this study revealed that Anacardium occidentale extract protects against lead acetate-induced liver and kidney toxicity by decreasing oxidative stress and inflammation.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"38 4","pages":"e2023028-0"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10834079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-occurrence of heavy metals and antibiotics resistance in bacteria isolated from metal-polluted soil.","authors":"Oluwarotimi John Joseph, Gbemisola Elizabeth Ogunleye, Kubrat Abiola Oyinlola, Augustina I Balogun, Damilola Tolulope Olumeko","doi":"10.5620/eaht.2023024","DOIUrl":"10.5620/eaht.2023024","url":null,"abstract":"<p><p>The indiscriminate deposition of metal-containing substances into the environment contributes significantly to high concentrations of metals in the soil resulting in resistance to metals and consequentially to antibiotics by inherent microbes which may eventually spread to other pathogenic microbes thereby elevating disease burden due to antibiotic resistance. The study aimed at determining the co-occurrence of resistance of bacteria isolated from metal-contaminated soil to heavy metals and subsequently, antibiotics. Metal-tolerant bacteria were randomly isolated from top soils from a battery waste site using the pour plate method. Selected isolates were identified using biochemical tests, then, subjected to elevating supplemented concentrations of different metal salts at 100-500 μg/mL to determine the minimum inhibitory concentration. Isolates tolerant to minimum three metals up to 400 μg/mL were subjected to Sulfamethoxazole-trimethoprim (25 μg), Imipenem (10 μg), Amoxicillin (30 μg), Ciprofloxacin (10 μg) and Tigecycline (15 μg) and observations interpreted using the guiding principle of the Clinical and Laboratory Standards Institute. Metal concentrations in the soils exceeded permissible limits. In total, 16 isolates were selected and identified as Proteus sp. (1), Pseudomonas spp. (5), Enterobacter spp. (2), Klebsiella spp. (2), Escherichia spp. (3), Raoultella spp. (2) and Rahnella sp. (1). Thirteen (81.25 %) of all isolates showed multi-resistance to the metals and seven exhibited multidrug-resistance, with 4 (57.1 %) showing resistance to three different classes of antibiotics and 3 (42.9 %) showed resistance to four antibiotic classes. Heavy metal-tolerant bacteria isolated from this study possess co-selection potentials as they showed resistance to different metals and antibiotics classes which is a concern to public health.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"38 4","pages":"e2023024-0"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10834071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of fenobucarb based-Excel Basa 50EC on brain cholinesterase of juvenile snakehead fish (Channa striata) in the Vietnamese Mekong Delta's rice fields.","authors":"Huynh Van Thao, Bui Thi Chuyen, Pham Van Toan, Tran Sy Nam, Nguyen Van Cong","doi":"10.5620/eaht.2023027","DOIUrl":"10.5620/eaht.2023027","url":null,"abstract":"<p><p>Fenobucarb is one of most common insecticides applied to rice crops in the Vietnamese Mekong Delta. Paddy fields are preferred habitats for snakehead fish (Channa striata). Therefore, the probability of exposure risks and growth effects is highly. This paper aimed to examine the effects of using fenobucarb based - Excel Basa 50EC on the brain cholinesterase (ChE) of snakehead fish. Two rice fields, in which a single dose of Excel Basa 50EC was applied to one field, whilst the other acted as a control. Each field was subdivided into three plots by earthen dikes. In each plot, one fish cage (1.2 m x 1.2 m x 1.2 m) was installed that was stocked with 20 snakehead fish. The Excel Basa 50EC was applied once at the indication dose. The results highlighted that the concentration of fenobucarb in water at 1 hr after application was 116.72 ppb ± 12.64, which decreased to 23.96 ± 6.61 ppb after d and then to below detection limits (0.02 ppb). For fish living in this field, no mortality was seen, but ChE was significantly inhibited for 31 % on the first day and recovery following 7 days of exposure. Residues of fenobucarb in soil and fish should also be investigated furthermore.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"38 4","pages":"e2023027-0"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10834075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Comments on \"Mitigating potential public health risks and challenges from hazardous materials contained in electronic waste items in a developing country setting\".","authors":"Slamet Wardoyo","doi":"10.5620/eaht.2023021","DOIUrl":"10.5620/eaht.2023021","url":null,"abstract":"","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"38 4","pages":"e2023021-0"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10834073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethanol extract of aloe vera ameliorates Artemether-Lumefantrine-induced reproductive toxicity in adult male Albino rats (Wistar Strain).","authors":"Mustapha Olamide Oluwayemisi, Fatola Olanrewaju, Ola-Davies Olufunke, Ajayi Olusola Lawrence, Oyeyemi Matthew","doi":"10.5620/eaht.2023025","DOIUrl":"10.5620/eaht.2023025","url":null,"abstract":"<p><p>Artemether-Lumefantrine (AL) is one of the alternative drugs used in treating malaria - an endemic scourge in Africa. AL has been reported to generate free radicals with long term use implicated in testicular pathologies. The antioxidative properties of Aloe vera (AV) has been well documented. This study investigated the ameliorative effect of ethanol extract of Aloe Vera on Artemether-Lumefantrine induced testicular toxicity. Thirty adult male albino rats were randomly divided into 5 groups (Control, AL-dosed, AV-dosed, AL+AV concurrently administered and AV-pretreated). Spermiogram, serum testosterone, testicular histopathology and inducible nitric oxide synthase (iNOS) immunohistochemistry were carried out. AL-dosed rats had poor spermiogram indices which were greatly improved in AV-dosed and AV-pretreated rats. These also corresponded with the testicular histopathology observations and were further buttressed by oxidative stress marker (iNOS) as AL-dosed rats had higher signal intensity compared to the control and AV-pretreated rats. Authors posit that concurrent administration of AV and AL protected testicular architecture while pretreating with AV prior AL administration improved the spermiogram. AL induces testicular pathology, thus should be used with care in male subjects. AV can confer a level of protection against these defects if used prior to administration of the drug.</p>","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"38 4","pages":"e2023025-0"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10834072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}