Environmental analysis, health and toxicology最新文献_第7页

Experimental modeling of the acute toxicity and cytogenotoxic fate of composite mixtures of chromate, copper and arsenate oxides associated with CCA preservative using Clarias gariepinus (Burchell 1822) 使用Clarias gariepinus对与CCA防腐剂相关的铬酸盐、铜和砷酸盐氧化物复合混合物的急性毒性和细胞基因毒性结局进行实验建模(Burchell 1822)

Environmental analysis, health and toxicology Pub Date : 2019-09-01 DOI: 10.5620/eaht.e2019010

Olukunle S. Fagbenro, C. Alimba, A. A. Bakare

{"title":"Experimental modeling of the acute toxicity and cytogenotoxic fate of composite mixtures of chromate, copper and arsenate oxides associated with CCA preservative using Clarias gariepinus (Burchell 1822)","authors":"Olukunle S. Fagbenro, C. Alimba, A. A. Bakare","doi":"10.5620/eaht.e2019010","DOIUrl":"https://doi.org/10.5620/eaht.e2019010","url":null,"abstract":"Concurrent occurrence of chromium (Cr), copper (Cu) and arsenic (As) from chromated copper arsenate (CCA) wood preservative in aquatic ecosystems demands that their joint-actions in eliciting toxic effects be assessed for adequate understanding of the health risk they may pose to biota. Clarias gariepinus was exposed to As2O3 , CrO3 and CuO and their composite mixtures (1:1 and 1:1:1) at various concentrations (0 – 600 mg/L) for 96-h to determine the acute toxicity using OECD (1992) protocol. C. gariepinus was then exposed to sub-lethal concentrations corresponding to 6.25, 12.5, 25.0, 50.0 and 100% of the 96-h LC50 for 7 days to assess the cytogenotoxic effects using piscine micronucleus (MN) test. The 96-h LC50 showed that the metals/metalloid demonstrated differential interactions in a concentration dependent pattern. The 96-h LC50 showed that Cr was the most toxic while Cu and As:Cu were indeterminate (Cr > Cr:Cu > As:Cr > As > As:Cr:Cu > Cu = As:Cu indeterminate). Isobologram and synergistic ratio (SR) models predicted antagonistic interaction between Cu:Cr and As:Cr and synergism between As:Cu in the causation of morbidity and mortality of C. gariepinus. Interaction factor model predicted antagonism as common interactive mechanism among the metal/metalloid mixtures in the induction of MN and abnormal nuclear erythrocytes in C. gariepinus. Predicted interactions among the three metals/ metalloid were largely antagonism and synergism towards the induction of acute toxicity and cytogenotoxicity. The models employed herein may be useful in establishing environmental safe limits for mixtures of metals/metalloids against the induction of acute toxicity and DNA damage in lower aquatic vertebrates.","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"158 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76887846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Acute toxicity of benzalkonium chloride in Balb/c mice following intratracheal instillation and oral administration 苯扎氯铵对Balb/c小鼠气管内滴注和口服的急性毒性研究

Environmental analysis, health and toxicology Pub Date : 2019-09-01 DOI: 10.5620/eaht.e2019009

Handule Lee, Kwangsik Park

引用次数: 12

Swimming pools quality risk assessment for heavy metal deposition and intake via oral and dermal exposure 游泳池重金属沉积及经口腔及皮肤接触摄入的质量风险评估

Environmental analysis, health and toxicology Pub Date : 2019-08-12 DOI: 10.5620/eaht.e2019008

Agomuo Emmanuel Nnabugwu, Amadi Peter Uchenna

{"title":"Swimming pools quality risk assessment for heavy metal deposition and intake via oral and dermal exposure","authors":"Agomuo Emmanuel Nnabugwu, Amadi Peter Uchenna","doi":"10.5620/eaht.e2019008","DOIUrl":"https://doi.org/10.5620/eaht.e2019008","url":null,"abstract":"The deplorable environmental conditions coupled to poor management practices employed by public swimming pool owners have led to suspicions over the safety of these recreational sites. This study was carried out to determine the physicochemical properties, heavy metal contents and accumulation, and associated risks of six swimming pools in Owerri, Capital of Imo State, Nigeria. Physicochemical analysis was conducted using standard methods while determination of heavy metals was carried out using an atomic absorption spectrophotometer. Results obtained showed that the turbidities and total dissolved solutes exceeded the Nigeria standard for water quality. Iron (Fe), cadmium (Cd), mercury (Hg), arsenic (As), nickel (Ni), and lead (Pb) exceeded the drinking safety values from United States Environmental Protection Agency, National Standards for Drinking Water Quality, and World Health Organization, while selenium (Se), chromium (Cr), and zinc (Zn) values fell within the permissible limits. From the bioaccumulation models applied, the enrichment factors showed anthropogenic source of deposition of the metals in all swimming pool while the heavy metal index were in a range of 27.30-70.19. For the risk assessment results, the chronic daily intake showed that Hg, and As levels for all the swimming pools, and Cu for some swimming pools exceeded the oral reference doses, while the hazard quotient for Hg (5.65-16.95), As (2.26-3.77), and Cu (1.13-4.11) indicated potentials of causing related toxicities. This study has shown that the aesthetic quality of the swimming pools were compromised, and contained elevated levels of Hg, As, and Cu significant enough to threaten the health safety of users of these swimming pools, which should instigate tough measures from Nigerian water regulatory bodies to ensure compliance from public swimming pool owners.","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76669653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First issue of EAHT EAHT第一期

Environmental analysis, health and toxicology Pub Date : 2019-08-01 DOI: 10.5620/EAHT.E2019007

Jung-Hwan Kwon

引用次数: 0