Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology最新文献

{"title":"Intestinal Microflora of BALB/c-Mice and Function of Local Immune Cells","authors":"K. Roszkowski ,&nbsp;H.L. Ko ,&nbsp;J. Beuth ,&nbsp;Y. Ohshima ,&nbsp;W. Roszkowski ,&nbsp;J. Jeljaszewicz ,&nbsp;G. Pulverer","doi":"10.1016/S0176-6724(88)80163-9","DOIUrl":"10.1016/S0176-6724(88)80163-9","url":null,"abstract":"<div><p>BALB/c-mice were treated for 7 days with oral nonabsorbable dosages of mezlocillin to achieve digestive tract decontamination. Such a procedure resulted in rapid eradication of most species of aerobic and anaerobic intestinal microflora. Various functions of peritoneal macrophages (e. g. chemiluminescence response, chemotactic motility, bactericidal and cytostatic ability) and lymphocyte proliferation were decreased in decontaminated animals as compared to non-treated controls.</p></div><div><p>BALB/c-Mäuse wurden sieben Tage oral mit Mezlocillin behandelt, um eine Elimination der aeroben und anaeroben Mikroflora des Gastrointestinaltraktes herbeizuführen und deren Auswirkungen zu studieren. Verglichen mit Kontrolltieren zeigten Mezlocillin-behandelte Mäuse mit dekontaminiertem Gastrointestinaltrakt eine Einschränkung der Phagozytose-Aktivität (Chemilumineszenz-Test), der chemotaktischen Beweglichkeit (Chemotaxis-Test), des direkten Abtötungseffektes (Bakterienabtötungstest) und des zytostatischen Effektes (Thymidin-Inkorporationstest) von Peritonealmakrophagen sowie Reduktion der Lymphozytenproliferation.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"270 1","pages":"Pages 270-279"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80163-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14350446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAMP-like Phenomena of Vibrios","authors":"Werner Köhler","doi":"10.1016/S0176-6724(88)80139-1","DOIUrl":"10.1016/S0176-6724(88)80139-1","url":null,"abstract":"<div><p>The CAMP test was proposed by <em>Lesmana</em> and <em>Rockhill</em> (11) as a method to differentiate between classical V. cholerae (negative) and <em>V. cholerae</em> biotype <em>El Tor</em> (positive). Typical CAMP phenomena with a crescent-like zone of complete hemolysis were observed also with some strains of <em>V. metschnikovii, V. parahaemolyticus</em>, and <em>V. anguillarum</em> when the cultures were incubated anaerobically (mostly also at aerobic conditions). No CAMP reaction was seen with <em>V. harveyi</em> and <em>V. costicola</em>.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"270 1","pages":"Pages 35-40"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80139-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14350450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Species Identification and Serotyping (Capsular Antigen) of Pasteurella Strains from Sheep Flocks in South Germany and in Syria","authors":"Mario Younan,&nbsp;Hans Schmid,&nbsp;Ernst Hellmann","doi":"10.1016/S0176-6724(88)80145-7","DOIUrl":"10.1016/S0176-6724(88)80145-7","url":null,"abstract":"<div><p>135 <em>Pasteurella</em> strains were cultivated from nasal swabs of sheep as well as pneumonic lungs of dead and slaughtered sheep. The specimen originated from 41 flocks in South Germany and from 15 flocks and 60 slaughter sheep in Syria (Hama region).</p><p>Serovariety A2 prevailed amongst <em>P. haemolytica</em> strains (6) isolated in South Germany (53 strains) and in Syria (41 strains). In addition 10 further serovarieties were identified in South Germany (next frequent were A8, A1 and A6) and 7 in Syria. Untypable strains appeared to be more frequent in Syria.</p><p>Other <em>Pasteurellae</em> (17) represented ¼ of isolates in Syria and ⅓ of isolates in South Germany. Species identification resulted in <em>P. multocida ssp. multocida</em> (25), <em>P. multocida ssp. septica</em> (4 strains, Syria only), <em>P. canis</em> (3 strains, South Germany only) and <em>Pasteurella</em>-like strains (9 strains). Twelve <em>P. multocida ssp. multocida</em> strains carried capsular antigen D and 7 capsular antigen A.</p><p>In most cases where multiple samples were examined from one flock, strains with different capsular antigens and/or belonging to different <em>Pasteurella</em> species were isolated (max. 8).</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"270 1","pages":"Pages 98-109"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80145-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14350451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro-bakterizidieeffekte von ofloxacin bei S. aureus","authors":"H.C. Korting ,&nbsp;W. Maier ,&nbsp;M. Schäfer-Korting","doi":"10.1016/S0176-6724(88)80182-2","DOIUrl":"https://doi.org/10.1016/S0176-6724(88)80182-2","url":null,"abstract":"<div><p>Two <em>Staphylococcus aureus (S. aureus)</em> strains with differing susceptibility to penicillin G as expressed by the minimum inhibitory concentration were exposed in vitro over a period of 8 h to the continuously changing concentrations of ofloxacin achieved in human serum and cantharides blister fluid (CBF) after the single oral application of 600 mg. In both strains bacterial density was rapidly, but not totally reduced: a reduction by 99 percent took no longer than about 1 and 1.5 h resp. facing the serum level profile and about 1.5 h facing the tissue level profile. The maximum reduction of staphylococcal density in percent (k_n) amounted to 0.0007 and 0.0034 and to 0.0038 and 0.0047 resp. Thus not only the serum level profiles but also the skin tissue level profiles obtainable in man proved highly effective in vitro against <em>S. aureus</em> irrespective of the bacterial suspectibility against penicillin G. Therefore oral ofloxacin should prove useful in staphylococcal diseases especially in so far as cutaneous tissue is involved.</p></div><div><p>Zwei <em>Staphylococcus aureus (S. aureus)</em>-Stämme mit unterschiedlicher Penicillin G-Empfindlichkeit gemessen an der minimalen Hemmkonzentration (MHK) wurden in vitro über 8 h hinweg den ständig schwankenden Ofloxacin-Konzentrationen ausgesetzt, die beim Menschen in Serum- und Kantharidinblasenflüssigkeit (CBF) nach der einmaligen peroralen Gabe von 600 mg erreicht werden. Bei beiden Stämmen wurde die Bakteriendichte rasch, wenn auch nicht vollständig verringert: eine Reduktion um 99% beanspruchte in Gegenwart des Serumspiegelprofils nur etwa 1 bis 1,5 h.</p><p>In Gegenwart des Gewebsspiegelprofils lag dieser Wert bei etwa 1,5 h. Die maximale Verringerung der Staphylokokkendichte in Prozent (k_n) belief sich auf 0,0007 und 0,0034, bzw. 0,0038 und 0,0047.</p><p>Somit erwies sich nicht nur das beim Menschen erreichbare Serumspiegelprofil, sondern auch das entsprechende Gewebsspiegelprofil als in vitro gegenüber <em>S. aureus</em> überaus wirksam. Dabei spielte die Penicillinempfindlichkeit der Erreger keine wesentliche Rolle. Die orale Anwendung von Ofloxacin bei Staphylokokkenerkrankungen dürfte sich demzufolge als nützlich erweisen, nicht zuletzt, was Hautinfektionen anbetrifft.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"269 3","pages":"Pages 387-394"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80182-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91983099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies on a Biological Response Modifying LYSAT from Propionibacterium avidum KP 40","authors":"G. Pulverer ,&nbsp;H.L. Ko ,&nbsp;J. Beuth ,&nbsp;K. Roszkowski ,&nbsp;W. Roszkowski ,&nbsp;J. Jeljaszewicz","doi":"10.1016/S0176-6724(88)80159-7","DOIUrl":"10.1016/S0176-6724(88)80159-7","url":null,"abstract":"<div><p><em>Propionibacterium avidum</em> KP 40 cells were mechanically disintegrated in order to obtain the soluble immunostimulatory (antineoplastic) LYSAT. Chemiluminescence measurements of human leukocyte function yielded enhanced activation of the cells after incubation with 2.5 and 5 mg of LYSAT. As compared to non-treated controls, administration of LYSAT to BALB/c-mice (1, 2.5 and 5 mg; intraperitoneally, subcutaneously, intranasal; 7, 4 and 2 days prior to challenge) induced a significant enlargement of the spleen as well as significantly reduced sarcoma L-1 lung colonization 14 days after challenge and evidently enhanced chemiluminescence response of peritoneal macrophages.</p></div><div><p><em>Propionibacterium avidum</em> KP 40 Zellen wurden in einer Zellmühle mechanisch aufgelöst und weiter verarbeitet zum Immunstimulans LYSAT. Im Chemilumineszenz-Test offenbarten menschliche Leukozyten (Granulozyten und Monozyten) nach Inkubation mit 2,5 und 5 mg LYSAT eine gesteigerte Aktivität. Im Vergleich mit einer unbehandelten Kontroll-gruppe bewirkte die dreimalige LYSAT-Gabe in BALB/c-Mäusen (1, 2,5 und 5 mg; intraperitoneal, subkutan, nasal; 7, 4 und 2 Tage vor Testbeginn) eine signifikante Gewichtszunahme der Milz sowie eine signifikant reduzierte Anzahl von Lungenmetastasen 14 Tage nach Tumorzellinokulation und eine deutlich gesteigerte Aktivität der Peritoneal-makrophagen im Chemilumineszenz-Assay.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"270 1","pages":"Pages 237-245"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80159-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14350445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies on Serum Resistance in E scherichia coli","authors":"Britta S. Kubens,&nbsp;Wolfgang Opferkuch","doi":"10.1016/S0176-6724(88)80141-X","DOIUrl":"10.1016/S0176-6724(88)80141-X","url":null,"abstract":"<div><p>Serum-sensitive mutants and their serum-resistant smooth parental <em>E. coli</em> strains (Wf8, Wf26, and WF 52) have been investigated in respect to their binding of different complement components. These pairs consisting of a wild-type and its mutants represent a better model for the investigation of the mechanism of serum resistance than the comparison of unrelated strains. Both strains of a pair bind equivalent amounts of C3. In binding assays using radiolabeled terminal components C6, C7, C8, and C9, the serum-sensitive strains do bind more late acting components than their resistant parental strains. An active membrane attack complex stably bound to the cell surface was found on the mutants, whereas with wild-type bacteria a complex could be isolated from the supernatant which is composed of the late acting complement components and S-protein. This complex is released from the surface of the wild-type bacteria without participation of C9.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"270 1","pages":"Pages 52-65"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80141-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14277632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical classification of campylobacters by DNA-restriction endonuclease analysis","authors":"D. Bruce ,&nbsp;J.V. Hookey ,&nbsp;Sheena A. Waitkins","doi":"10.1016/S0176-6724(88)80172-X","DOIUrl":"10.1016/S0176-6724(88)80172-X","url":null,"abstract":"<div><p>Reference strains from five different species of <em>Campylobacter</em> were examined by DNA-restriction endonuclease analysis. The DNA profiles were resolved as absorbence peaks and converted to numerical values which were analysed by a Sirius microprocessor. The percentage similarity between each profile was calculated and the strains clustered together by the computer on shared similarities and the results displayed as an abbreviated dendrogram.</p><p>Each of the species of <em>Campylobacter</em> were clearly separated from each other and the different biotypes within a species could also be differentiated.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"269 3","pages":"Pages 284-297"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80172-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14197164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Inhibitors for Aminoglycoside-Adenylyltransferase","authors":"N.A. Saleh ,&nbsp;A. Zwiefak ,&nbsp;W. Peczyńska-Czoch ,&nbsp;M. Mordarski ,&nbsp;G. Pulverer","doi":"10.1016/S0176-6724(88)80142-1","DOIUrl":"10.1016/S0176-6724(88)80142-1","url":null,"abstract":"<div><p>Two hydroxymethyltropolones and two tropolone acetate derivatives were found to inhibit an aminoglycoside-adenylyltranferase in a gentamicin-resistant <em>Escherichia coli</em> strain. The inhibitory effect of tropolones depends on the nature of the aminoglycoside antibiotic subject to adenylation.</p><p>Combinations of hydroxymethyltropolones with tobramycin were more active compared with tropolone acetates against gentamicin-resistant strains displaying adenylyltransferase activity. On the contrary a combination of the investigated acetate with gentamicin was of lower activity.</p><p>It could be shown that these inhibitors inhibit, to a varying degree, the transfer of radioactive ATP to different aminoglycoside molecules.</p></div><div><p>Zwei Hydroxymethyltropolone und zwei Tropolonacetat-Verbindungen hemmten die Aminoglykosid-Adenylyl-Transferase eines Gentamycin-resistenten <em>Escherichia coli</em> Stammes. Dieser Hemmeffekt der Tropolone hängt auch ab vom Aminoglykosid-Antibiotikum. Die Kombinationen von Hydroxymethyltropolonen mit Tobramycin waren aktiver als Tropolonazetate gegen Gentamycin-resistente Stämme mit Adenylyltransferase-Aktivität. Demgegenüber erwies sich die Kombination der untersuchten Azetate mit Gentamycin als schwächer wirksam. Es konnte gezeigt Verden, daß diese Hemmsubstanzen den Transfer der radioaktiven ATP auf verschiedene Aminoglykosid-Moleküle im wechselnden Ausmaß hemmten.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"270 1","pages":"Pages 66-75"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80142-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13989390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunological characterization of yersinia enterocolitica O:9 and O:3 LPS antigens by monoclonal antibodies","authors":"Jürgen Weninger,&nbsp;Klaus Wartenberg,&nbsp;Martin Röllinghoff","doi":"10.1016/S0176-6724(88)80173-1","DOIUrl":"10.1016/S0176-6724(88)80173-1","url":null,"abstract":"<div><p>LPS-specific monoclonal antibodies induced against <em>Y. enterocolitica</em> serotype O:9 bacteria and against <em>Y. enterocolitica</em> O:3 were used in a comparative study to characterize the O:9 and O:3 LPS. <em>Yersinia</em> bacteria grown at 22 °C and 37°C and LPS preparations thereof were tested. SDS-PAGE, Western blot analysis and adsorption procedures revealed that LPS of <em>Y. enterocolitica</em> O:9 differed from that of <em>Y. enterocolitica</em> O:3 in: (i) its repeating LPS O-side-chain sugar, (ii) its shorter length of the LPS O-side-chain and (iii) its failure to show temperature-dependent variation in the length of O-side-chains.</p></div><div><p>Zu einer vergleichenden immunologischen Charakterisierung von <em>Y. enterocolitica</em> Serotyp O:9 und O:3 LPS wurden entsprechende monoklonale Antikörper eingesetzt. Als Antigen wurden bei 22 °C und 37°C gewachsene intakte Yersinien, sowie LPS-Präparationen von diesen verwendet. SDS-PAGE, Western-Blot-Analysen und Adsorptionsexperimente zeigten, daß sich das LPS von <em>Y. enterocolitica</em> O:9 von dem von <em>Y. enterocolitica</em> O:3 in (a) seinem LPS O-Seitenkettenzucker, (b) in der Länge der O-Seitenketten und (c) in einer temperaturunabhängigen Länge der O-Seitenketten unterscheidet.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"269 3","pages":"Pages 298-313"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80173-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14347370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lectin-Mediated Cell-Attachment and Phagocytosis of Staphylococcus Saprophyticus Strain S1","authors":"J. Beuth ,&nbsp;H.L. Ko,&nbsp;Y. Ohshima,&nbsp;F. Schumacher-Perdreau,&nbsp;G. Peters,&nbsp;G. Pulverer","doi":"10.1016/S0176-6724(88)80137-8","DOIUrl":"10.1016/S0176-6724(88)80137-8","url":null,"abstract":"<div><p>Adhesion studies with cryotome sections of human kidney and lung respectively uroepithelial cells together with blocking experiments with competitive carbohydrates suggested that specific attachment of <em>S. saprophyticus</em> strain S 1 to host cells apparently is mediated by lectins. Accordingly, microbial lectin blocking with specific glycoconjugates or lectin dysfunction (after treatment of bacteria with subinhibitory concentrations of tunicamycin) significantly decreased staphylococcal adherence to epithelial cells. Chemiluminescence measurements of human polymorphonuclear leukocyte (PMN) function yielded results suggesting importance of lectin-receptor interaction in phagocytosis, too, since PMN activity was significantly decreased after staphylococcal lectin blocking or dysfunction.</p></div><div><p>Adhäsions- und Inhibitionsstudien mit Kryotomschnitten menschlicher Niere und Lunge bzw. mit Uroepithelzellen demonstrierten, daß die spezifische Adhäsion von <em>S. saprophyticus</em> Stamm S 1 an Wirtszellen offensichtlich durch bakterielle Lektine vermittelt wird. Lektinblockade durch rezeptorkomplementäre Kohlenhydrate bzw. Funktionseinschränkung der Lektine (nach Inkubation der Mikroorganismen in subinhibitorischen Konzentrationen des Antibiotikums Tunicamycin) bewirkte eine signifikant reduzierte Adhäsion von <em>S. saprophyticus</em> an die Epithelzellen. Chemilumineszenz-Messungen zeigten, daß Rezeptor-Ligand-Wechselwirkungen auch für den Prozeß der Granulozytenstimulation von Bedeutung sind. Blockade der Staphylokokken-Lektine sowie deren Funktionseinbuße (nach Tuni-camycininkubation) schränkte die Aktivierbarkeit von Granulozyten signifikant ein.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"270 1","pages":"Pages 22-27"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80137-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14350444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}