World Science and Technology最新文献

{"title":"Effect of Glytan on the Expression of the Nicotinic Acetylcholine Receptor a7 in Portal Hypertensive Rats","authors":"Jiang Junjie,&nbsp;Du Qinghong,&nbsp;Han Lin,&nbsp;Arezou Mashoufi,&nbsp;Li Pengtao","doi":"10.1016/S1876-3553(11)60018-5","DOIUrl":"https://doi.org/10.1016/S1876-3553(11)60018-5","url":null,"abstract":"<div><p>This study aimed to observe the expression of the nicotinic acetylcholine receptor nAchRa7 in liver tissue after portal hypertension (PHT). In the study, 40 male Sprague-Dawley rats, with weights between 240 g and 260 g, were randomly divided into sham-operated group, model group, and Glytan group according to their weights. Each group was observed at two time points, namely, two and four weeks after PHT. Common bile duct ligation was carried out on rats to induce PHT. The portal pressure of each group was measured, and the expression of nAchR a7 in the liver was detected by Western blotting at each time point. Results showed that the portal pressure and the expression of nAchRa7 in the model group increased significantly at two and four weeks after PHT. The portal pressure of the Glytan group was decreased compared to the model group, especially at four weeks after PHT. The expression of nAchRa7 in the liver of the Glytan group decreased significantly at four weeks after PHT. It is concluded that the change of portal pressure and the expression of nAchRa7 in the model and Glytan groups is consistent with the time sequence. Glytan may downregulate the portal pressure by affecting the nAchRa7 level in the liver.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 3","pages":"Pages 383-386"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60018-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91626912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the Gensini Score of Blood-Stasis Syndrome in Coronary Heart Disease and VEGF","authors":"W. Shihan, Wang Jie, L. Ji","doi":"10.1016/S1876-3553(11)60015-X","DOIUrl":"https://doi.org/10.1016/S1876-3553(11)60015-X","url":null,"abstract":"","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"1 1","pages":"355-357"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88577755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of Association Rules between TCM Properties in Drug Pairs by Association Mining between Datasets and Probability Tests","authors":"Shang Erxin,&nbsp;Ye Liang,&nbsp;Fan Xinsheng,&nbsp;Tang Yuping,&nbsp;Duan Jinao","doi":"10.1016/S1876-3553(11)60017-3","DOIUrl":"https://doi.org/10.1016/S1876-3553(11)60017-3","url":null,"abstract":"<div><p>Crude Drug Pairs in Traditional Chinese medicine (TCM) constitute an important link node between TCM drugs and medicinal formulae. In TCM theory, there are many descriptions regarding the multiple aspects of medicines. However, they seem still scattered compared to the formulae theories. In this article, the association-rule mining method was applied to discover the meaningful associations with reference to the structure of a crude drug-pair. Standard and enhanced Apriori algorithms were applied and run on the crude drug-pair database, including 625 drug pairs, 347 drugs, and 49 properties. The results from the two algorithms were compared and analyzed, and the new enhanced Apriori algorithm was found to be more suitable for the detection of association between drugs in a drug pair or formulae.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 3","pages":"Pages 377-382"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60017-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91626913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Patient-reported Outcome in Cancer Study","authors":"Liu Weimin ,&nbsp;He Liyun ,&nbsp;Liu Baoyan ,&nbsp;Zi Mingjie","doi":"10.1016/S1876-3553(11)60011-2","DOIUrl":"10.1016/S1876-3553(11)60011-2","url":null,"abstract":"<div><p>Patient-reported outcome (PRO), which is directly obtained from patients, is a multidimensional measure to evaluate the health condition of a patient. The obtained data give evidence of effectiveness from patients' point of view. This article reviews the application of PRO in the study of cancer. The application of PRO is studied from aspects, such as evaluating cancer clinical trials, formulating health policies, evaluating adverse events, evaluating compliance, approving new drugs, and studying the relation between health-related quality of life and PRO.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 2","pages":"Pages 177-180"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60011-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76368297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research of Traditional Chinese Medicine in Terms of Herbalomics","authors":"Li Haiyan ,&nbsp;Guo Zhen ,&nbsp;Peter York ,&nbsp;Qun Shao ,&nbsp;Gu Jingkai ,&nbsp;Zhang Jiwen","doi":"10.1016/S1876-3553(11)60008-2","DOIUrl":"10.1016/S1876-3553(11)60008-2","url":null,"abstract":"<div><p>With the rapid development of systems biology promoted by multitargeted drug discovery, traditional Chinese medicine (TCM) studies have been regressing to holism. More holistic concepts and methods of TCM herbalomics are appearing, and this will consequently facilitate the research and development of TCM in research model and pattern. This article describes a research road map and theory frame- work of herbalomics.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 2","pages":"Pages 160-164"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60008-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85134526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical System of Ecocare and Its Applications in Health Care and Product Development of Traditional Chinese Medicine","authors":"Yang Depo ,&nbsp;Ji Junfeng ,&nbsp;Huang Yongping ,&nbsp;Lu Binshan ,&nbsp;Liang Linhua","doi":"10.1016/S1876-3553(11)60013-6","DOIUrl":"10.1016/S1876-3553(11)60013-6","url":null,"abstract":"<div><p>Ecocare methodology is a science of health care, which focuses on human health and the relationship between human body and its external environment using modern ecological balance theory and basic theory of traditional Chinese medicine (TCM). It is the reflection of natural healthy principle of “correspondence between man and universe,” the concept of holism of “body-soul unity,” the idea of “prevention treatment of disease” that prevention is more important than therapy and the methodology of treatment combined with rehabilitation through care, rest, and nourishment and treatment focusing on relieving both the secondary and primary symptoms. In this system, its core values are a healthy attitude (<em>Yang xin</em>). Everyone should first determine his or her own appropriate ecological niche well, which is the best way to promote healthy and harmonious development. The core connotation of Ecocare is the balance of body ecosystem that is to achieve a relative balance between yin and yang of human tissue, organ, physiology, and psychology by removing the disadvantageous factors, replenishing the advantageous ones, and adjusting the body functions. The theory of Ecocare can be widely used in clinical TCM, health care by Chinese medicine, and research and development of TCM health products, as well as in agriculture, gardens, landscape, and leisure vacation designs for the demands of health care by Chinese Materia Medica.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 2","pages":"Pages 155-159"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60013-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76924196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Research of Si wu tang and Blood Deficiency","authors":"Gao Yue ,&nbsp;Ma Zengchun ,&nbsp;Liang Qiande ,&nbsp;Tan Hongling ,&nbsp;Liu Ming ,&nbsp;Hong Qian ,&nbsp;Shao Shuai ,&nbsp;Wang Yuguang ,&nbsp;Lu Beibei ,&nbsp;Xiao Chengrong ,&nbsp;Zhang Boli","doi":"10.1016/S1876-3553(11)60009-4","DOIUrl":"10.1016/S1876-3553(11)60009-4","url":null,"abstract":"<div><p>Combined research on prescriptions and <em>zheng hou</em> sets up a bridge between theory and therapy in traditional Chinese medicine (TCM). Based on Si wu tang (SWT) and blood deficiency (BD), three BD animal models were induced by ⁶⁰Co irradiation, cyclophospha- mide, or chronic bleeding. Factors such as circulating blood cells, the ability of colony-forming unit of bone marrow cells, CD34⁺ count, cell cycle, and apoptosis play important roles in the pathogenesis and development of BD. Based on pharmacology mechanism research on the entire body, tissue, cell and molecular level, polysaccharide, paeoniflorin, tetramethylpyrazine, and ferulic acid were found to be hematopoietic constituents of SWT. And hematopoietic cytokines are also involved in hematopoietic mechanism of SWT.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 2","pages":"Pages 211-216"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60009-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88758864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biotransformation of Chinese Herbs and Their Ingredients","authors":"Ma Baiping,&nbsp;Feng Bing,&nbsp;Huang Hongzhi,&nbsp;Cong Yuwen","doi":"10.1016/S1876-3553(11)60012-4","DOIUrl":"10.1016/S1876-3553(11)60012-4","url":null,"abstract":"<div><p>Biotransformation has been extensively applied in herbal fermentation processing, metabolism study of traditional Chinese medicine (TCM), structural modification and synthesis of active components of TCM. Selecting steroidal saponins as the subject, the selective hydrolysis of glycosyl residues, glycosylation of molecules, and the modification of their aglycone were systematically studied by biotechnology in this work. Some active microorganisms were screened, several specific enzymes were purified, and their substrate specificities and transformed regularities were summarized. These results lay a better foundation for determining the key core of the active components, specifically modifying their structures, constructing the focused library with the structural diversity, and manufacturing some new drug candidates which are rare in herbs. They may also provide a kind of valuable strategy and approach support for herbal substance library construction as well as the active ingredients research of Herbalome Project.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 2","pages":"Pages 150-154"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60012-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73894321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies on the Metabonomics of Premenstrual Syndrome Liver-Qi Invasion Patient Interfered by Jingqianping Granules","authors":"Sun Peng ,&nbsp;Luo Guo'an ,&nbsp;Qiao Mingqi ,&nbsp;Wei Sheng ,&nbsp;Huang Hao ,&nbsp;Wei Na ,&nbsp;Zhang Huiyun ,&nbsp;Song Hongyun","doi":"10.1016/S1876-3553(11)60014-8","DOIUrl":"10.1016/S1876-3553(11)60014-8","url":null,"abstract":"<div><p>This work deals with the variation of urinary metabolite of patients suffering from premenstrual syndrome (PMS) and the function of <em>Jingqianping</em> granules (JG) in intervening liver-Qi invasion by metabonomic. The metabonomic characteristics and the micromolecular marking compound, which are closely related to the pathogenesis of PMS liver-Qi invasion cases, are also investigated. PMS liver-Qi invasion cases are calibrated according to the diagnostic criteria, including criteria, and excluding criteria. The urine samples from PMS liver-Qi invasion patients are analyzed at different times using UPLC-Q-TOF in combination with PCA pattern analysis, followed by discrimination of the metabolic outline and searching for the possible biological tags and metabolic pathways. The metabolic outline of premenstrual urine samples has significant difference among the control group, the PMS liver-Qi invasion group, and the PMS liver-Qi invasion treatment group. The metabolic outline of premenstrual urine sample of the PMS liver-Qi invasion group diverges from the premenstrual and postmenstrual urine samples of the control group and the postmenstrual urine sample of the PMS liver-Qi invasion group. Compared with the control group, N-acetyl-2-glutamate-5-semialdehyde has decreased greatly in the N-acetyl-2-glutamate-5-semialdehyde liver-Qi invasion group, and histidine and 3-methoxy-4-hydroxymandelaldehyde have increased significantly. This research, for the first time, deals with the metabolic pattern differences between the control group and the administration group. It shows that JG may repair metabolic disturbance of endogenous micromolecules in PMS liver-Qi invasion cases in terms of metabonomics. It also demonstrates that symptoms present before menstruation in PMS patients and the characteristic of PMS is that the symptoms appear before menstruation and disappear after it among PMS liver-Qi invasion cases.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 2","pages":"Pages 195-201"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60014-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72985319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Some Thoughts on the Standardization Study of Moxibustion","authors":"Chang Xiaorong,&nbsp;Yan Jie,&nbsp;Yi Shouxiang,&nbsp;Yue Zenghui,&nbsp;Lin Yaping,&nbsp;Lan Lei,&nbsp;Liu Mi","doi":"10.1016/S1876-3553(11)60010-0","DOIUrl":"10.1016/S1876-3553(11)60010-0","url":null,"abstract":"<div><p>This article stated the moxibustion application and the standards of moxibustion manipulating techniques, moxibustion quantity, moxibustion position, moxibustion materials, moxa smoke, and moxibustion courses in ancient medical documents; fully analyzed their influence on clinical effects and explained the importance and necessity of moxibustion standardization study. It also reviewed the formulation and revision of standards in China, and then gave some ideas on the moxibustion standardization system construction, steps of moxibustion standardization construction, international moxibustion standards construction, acupuncture standardization talents training in order that the medical personnel and researchers can focus on the moxibustion standardization in clinic and research and can give basis for moxibustion objectification and standardization in clinic and experiment, facilitate moxibustion to develop in objectification, standardization, and scientization.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 2","pages":"Pages 172-176"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60010-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89929413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}