Jiang Junjie, Du Qinghong, Han Lin, Arezou Mashoufi, Li Pengtao
{"title":"甘氨酸对门脉高压大鼠烟碱乙酰胆碱受体a7表达的影响","authors":"Jiang Junjie, Du Qinghong, Han Lin, Arezou Mashoufi, Li Pengtao","doi":"10.1016/S1876-3553(11)60018-5","DOIUrl":null,"url":null,"abstract":"<div><p>This study aimed to observe the expression of the nicotinic acetylcholine receptor nAchRa7 in liver tissue after portal hypertension (PHT). In the study, 40 male Sprague-Dawley rats, with weights between 240 g and 260 g, were randomly divided into sham-operated group, model group, and Glytan group according to their weights. Each group was observed at two time points, namely, two and four weeks after PHT. Common bile duct ligation was carried out on rats to induce PHT. The portal pressure of each group was measured, and the expression of nAchR a7 in the liver was detected by Western blotting at each time point. Results showed that the portal pressure and the expression of nAchRa7 in the model group increased significantly at two and four weeks after PHT. The portal pressure of the Glytan group was decreased compared to the model group, especially at four weeks after PHT. The expression of nAchRa7 in the liver of the Glytan group decreased significantly at four weeks after PHT. It is concluded that the change of portal pressure and the expression of nAchRa7 in the model and Glytan groups is consistent with the time sequence. Glytan may downregulate the portal pressure by affecting the nAchRa7 level in the liver.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 3","pages":"Pages 383-386"},"PeriodicalIF":0.0000,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60018-5","citationCount":"1","resultStr":"{\"title\":\"Effect of Glytan on the Expression of the Nicotinic Acetylcholine Receptor a7 in Portal Hypertensive Rats\",\"authors\":\"Jiang Junjie, Du Qinghong, Han Lin, Arezou Mashoufi, Li Pengtao\",\"doi\":\"10.1016/S1876-3553(11)60018-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This study aimed to observe the expression of the nicotinic acetylcholine receptor nAchRa7 in liver tissue after portal hypertension (PHT). In the study, 40 male Sprague-Dawley rats, with weights between 240 g and 260 g, were randomly divided into sham-operated group, model group, and Glytan group according to their weights. Each group was observed at two time points, namely, two and four weeks after PHT. Common bile duct ligation was carried out on rats to induce PHT. The portal pressure of each group was measured, and the expression of nAchR a7 in the liver was detected by Western blotting at each time point. Results showed that the portal pressure and the expression of nAchRa7 in the model group increased significantly at two and four weeks after PHT. The portal pressure of the Glytan group was decreased compared to the model group, especially at four weeks after PHT. The expression of nAchRa7 in the liver of the Glytan group decreased significantly at four weeks after PHT. It is concluded that the change of portal pressure and the expression of nAchRa7 in the model and Glytan groups is consistent with the time sequence. Glytan may downregulate the portal pressure by affecting the nAchRa7 level in the liver.</p></div>\",\"PeriodicalId\":101287,\"journal\":{\"name\":\"World Science and Technology\",\"volume\":\"12 3\",\"pages\":\"Pages 383-386\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60018-5\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World Science and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1876355311600185\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1876355311600185","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of Glytan on the Expression of the Nicotinic Acetylcholine Receptor a7 in Portal Hypertensive Rats
This study aimed to observe the expression of the nicotinic acetylcholine receptor nAchRa7 in liver tissue after portal hypertension (PHT). In the study, 40 male Sprague-Dawley rats, with weights between 240 g and 260 g, were randomly divided into sham-operated group, model group, and Glytan group according to their weights. Each group was observed at two time points, namely, two and four weeks after PHT. Common bile duct ligation was carried out on rats to induce PHT. The portal pressure of each group was measured, and the expression of nAchR a7 in the liver was detected by Western blotting at each time point. Results showed that the portal pressure and the expression of nAchRa7 in the model group increased significantly at two and four weeks after PHT. The portal pressure of the Glytan group was decreased compared to the model group, especially at four weeks after PHT. The expression of nAchRa7 in the liver of the Glytan group decreased significantly at four weeks after PHT. It is concluded that the change of portal pressure and the expression of nAchRa7 in the model and Glytan groups is consistent with the time sequence. Glytan may downregulate the portal pressure by affecting the nAchRa7 level in the liver.
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