World Science and Technology最新文献

{"title":"Penetration of Dialysis Tubes to Components Absorbed in the Plasma of the Extract of Fructus Evodiae: Methodology of the Preparation of Herbal Extract for Pharmacological Experiment in Vitro","authors":"Li Huiying ,&nbsp;Wang Xiukun ,&nbsp;Wang Yugang ,&nbsp;Zhan Honglei ,&nbsp;Hu Jun ,&nbsp;Hua Lei ,&nbsp;Lei Fan ,&nbsp;Xing Dongming ,&nbsp;Wang Zhimin ,&nbsp;Du Lijun","doi":"10.1016/S1876-3553(11)60022-7","DOIUrl":"10.1016/S1876-3553(11)60022-7","url":null,"abstract":"<div><p>Dialysis tubes (Mw 100 D and Mw 500 D) were used to dialyze and purify the water extraction of <em>Wuzhuyu</em> (Fructus Evodiae) and <em>Wuzhuyu</em> decoction, and three parts of molecular weight less than 100 D, between 100 and 500 D, and more than 500 D were obtained. To ascertain the peak time point efficiency, several chemicals treated at different time periods by high performance liquid chromatography (HPLC) were analyzed, and the activity of blood vessels was studied <em>in vitro</em>. By comparing different dialyzing times for three chemicals including evodiamine, isorhamnetin, and limonin in 100–500 D, the best treatment time was found to be 48 h. The portion more than 100 D significantly contracted blood vessels, while the portion less than 100 D did not. In conclusion, it may be feasible to dispose samples using dialysis tubes with different apertures and apply the extract to pharmacological evaluation <em>in vitro</em>.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 4","pages":"Pages 515-520"},"PeriodicalIF":0.0,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60022-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87972961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biotransformation of Chinese Herbs and Their Ingredients","authors":"Yue Rongcai ,&nbsp;Shan Lei ,&nbsp;Yan Shikai ,&nbsp;Zhao Jing ,&nbsp;Zhang Weidong","doi":"10.1016/S1876-3553(11)60019-7","DOIUrl":"https://doi.org/10.1016/S1876-3553(11)60019-7","url":null,"abstract":"<div><p>A key task for the traditional Chinese medicine (TCM) modernization is to interpret the scientific connotation of TCM through the development of new theories and modern techniques. Chemical proteomics is a powerful mass spectrometry-based affinity chromatography approach for identifying proteome-wide small molecule–protein interactions. Chemical proteomics is used to study and detect proteomes with specific chemical molecules that interact with target proteins. Here, we review the main techniques of chemical proteomics and their applications in the research of active ingredients, target proteins and synergistic mechanisms and in drug discoveries of TCM. Chemical proteomics study provides new ideas for the TCM modernization, which may help to reveal the essential principles of TCM at the molecular level, and thus facilitates the new drug discovery of TCM and the inheritance and development of TCM theories.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 4","pages":"Pages 502-510"},"PeriodicalIF":0.0,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60019-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137272420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Relationship between Sugar Content and Cold–Hot Nature of 20 Kinds of Herbs by Fisher Analysis","authors":"Zhou Zhengli,&nbsp;Li Feng,&nbsp;Li Jingwen","doi":"10.1016/S1876-3553(11)60020-3","DOIUrl":"10.1016/S1876-3553(11)60020-3","url":null,"abstract":"<div><p>Twenty kinds of herbs were studied for the relationship between sugar content and Cold–Hot nature. The Fehling method was used for determining the total sugar content, the sulfuric acid-anthraquinone colorimetric method for measuring the total polysaccharides content, and the alkaline copper sulfate method for testing the monosaccharide content. After that, the obtained data were analyzed by the Fisher method. The 10 kinds of Hot herbs showed significantly higher total sugar content and monosaccharide content than the 10 kinds of Cold herbs, with <em>P</em>&lt;0.05; however, they showed no significant differences in the total polysaccharides content, with <em>P</em>&gt;0.05. A discriminant function was established by the Fisher method, with the group back substitution result of the Fisher analysis reaching 85%. The results demonstrate that there exists a certain relationship between the sugar content and the Cold–Hot nature of the 20 kinds of herbs. The Fisher analysis can be used to distinguish the Cold–Hot nature, and sugar is one of the material bases of Cold–Hot nature.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 4","pages":"Pages 558-561"},"PeriodicalIF":0.0,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60020-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78980100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thinking About the Healthy Development of Traditional Chinese Medicine Injection","authors":"Luo Jiabo","doi":"10.1016/S1876-3553(11)60023-9","DOIUrl":"10.1016/S1876-3553(11)60023-9","url":null,"abstract":"<div><p>Traditional Chinese medicine (TCM) injection is an innovative and quick-acting dosage form. It plays a significant role in clinical treatment of acute, severe syndromes. Some TCM injections have become the drug of first choice for treating certain diseases, such as virus infection, cardiovascular diseases, and tumors. With the rapid development and wide application of TCM injections in combination with western drugs, a number of adverse events of TCM injections have incessantly been reported, which has drawn broad attention. This study elucidates the quick-acting and broad-spectrum advantages of TCM injections by comparing TCM injections with oral TCM preparations and western medicine injections. The study also emphasizes the indispensable status and great values of TCM injections in terms of species diversity, clinical penetration rate, and high-level participation in modern health care. In conclusion, the study emphasizes the fact that the adverse events of TCM injection require objective analyses. Reevaluations of TCM injections, exclusive production of some varieties, secondary development of advantageous varieties, and effective monitoring systems are suggested for establishment in enterprises, hospitals, and drug-control institutes, which will pave a road of sound development for TCM injections.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 4","pages":"Pages 497-501"},"PeriodicalIF":0.0,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60023-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75305422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Process of Traditional Chinese Medicine on “Omics”","authors":"Xu Dan ,&nbsp;Jia Tianzhu ,&nbsp;Zhou Ling","doi":"10.1016/S1876-3553(11)60021-5","DOIUrl":"10.1016/S1876-3553(11)60021-5","url":null,"abstract":"<div><p>Establishing an effective research system for the processing of Chinese herb is one of the key issues to be solved in the study of modern medicine. In this article, based on the fundamentals of the combination of traditional Chinese medicine (TCM) and Chinese Materia Medica (CMM), the system theory and reductionism, global and piece, <em>in vivo</em> and <em>in vitro</em>, a system that consists of chemical, pharmacology, and metabolomics was established. The CMM processing has also been investigated based on the above-mentioned system. This system is able to provide a methodology in modern TCM research, and it also promotes the development of new technology of CMM processing and TCM theories.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 4","pages":"Pages 553-557"},"PeriodicalIF":0.0,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60021-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76561905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the Gensini Score of Blood-Stasis Syndrome in Coronary Heart Disease and VEGF","authors":"Wang Shihan,&nbsp;Wang Jie,&nbsp;Li Ji","doi":"10.1016/S1876-3553(11)60015-X","DOIUrl":"https://doi.org/10.1016/S1876-3553(11)60015-X","url":null,"abstract":"<div><p>This work aimed to discuss the relationship between the Gensini score of blood-stasis syndrome (BSS) in coronary heart disease (CHD) and vascular endothelial growth factor (VEGF) levels. Ninety-six patients with BSS in CHD were divided into 48 cases with qi deficiency and blood-stasis pattern and 48 cases of intermingled phlegm and blood-stasis pattern, based on traditional Chinese medicine (TCM) syndrome differentiation. Coronary angiography was carried out, and VEGF level was determined. Simultaneously, the extent of blood stasis was assessed with the blood-stasis score. Furthermore, the result of coronary angiography was assessed with the Gensini score system. The result showed that the blood-stasis score and coronary artery stenosis in the group with qi deficiency and blood stasis were higher than those in the intermingled phlegm and blood-stasis group. The levels of serum VEGF and endothelin1 increased with the increase of the blood-stasis and Gensini scores, whereas the level of insulin-like growth factor-1 decreased with the increase of the blood-stasis and Gensini scores. Thus, the coronary Gensini score is in correlation with the VEGF level and blood-stasis score.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 3","pages":"Pages 355-357"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60015-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91626911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of Association Rules between TCM Properties in Drug Pairs by Association Mining between Datasets and Probability Tests","authors":"Shang Erxin, Ye Liang, Xin-Sheng Fan, Yu-Ping Tang, J. Duan","doi":"10.1016/S1876-3553(11)60017-3","DOIUrl":"https://doi.org/10.1016/S1876-3553(11)60017-3","url":null,"abstract":"","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"115 1","pages":"377-382"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80347753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Glytan on the Expression of the Nicotinic Acetylcholine Receptor a7 in Portal Hypertensive Rats","authors":"Jiang Junjie, Du Qinghong, Han Lin, A. Mashoufi, L. Pengtao","doi":"10.1016/S1876-3553(11)60018-5","DOIUrl":"https://doi.org/10.1016/S1876-3553(11)60018-5","url":null,"abstract":"","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"3440 1","pages":"383-386"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86632425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothesis on the Principle of Danggui-Shao yao-San (DSS) for Treating Different Diseases via the Histamine H1 Receptor Pathway","authors":"Kou Junping, Chai Chengzhi, G. Zhen, Yu Boyang, Zhu Dan-ni, Yan Yong-qing","doi":"10.1016/S1876-3553(11)60016-1","DOIUrl":"https://doi.org/10.1016/S1876-3553(11)60016-1","url":null,"abstract":"","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"22 1","pages":"325-330"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87721375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothesis on the Principle of Danggui-Shao yao-San (DSS) for Treating Different Diseases via the Histamine H1 Receptor Pathway","authors":"Kou Junping,&nbsp;Chai Chengzhi,&nbsp;Gao Zhen,&nbsp;Yu Boyang,&nbsp;Zhu Danni,&nbsp;Yan Yongqing","doi":"10.1016/S1876-3553(11)60016-1","DOIUrl":"https://doi.org/10.1016/S1876-3553(11)60016-1","url":null,"abstract":"<div><p>The principle of “same treatment for different diseases” is the major reflection of treatment determination based on pathogenesis obtained through the differentiation of symptoms and signs in traditional Chinese medicine (TCM). It is of great importance to explore such principles from the viewpoint of TCM prescriptions, so as to propagate and develop TCM theory. Danggui-Shaoyao-San (DSS), a famous TCM complex prescription first recorded in the book of <em>Jin Kui Yao Lue</em>, has been widely used in the treatment for various diseases in China. Previous reference mining showed that its pathogenesis linked with “liver depression and spleen deficiency,” and there were a lot of similarities between pharmacological activities of DSS and the physiological and pathological function of histamine. This study suggested that DSS significantly inhibited local skin vascular permeability and remarkably decreased the scratching number and time, decreased locomotive activities increased by histamine, and exerted analgesia activities via the H1 receptor. A hypothesis has been proposed that DSS can modulate histamine H1 receptor expression and the relevant signal transduction pathway so as to treat various diseases, while “liver depression and spleen deficiency” would be related to the dysfunction of the histaminergic neuron system, whose regulating center is considered to be the histamine neurons located in the posterior hypothalamus based on a great deal of previous studies, casual findings, and international academic progress. Further investigation is under way to explore the principles or mechanism of DSS for treating different diseases, which may provide some new ideas or methods for the fundamental research of Integrated Chinese and Western Medicine. It provides some reference for reasonable and normative application of DSS in the clinic, accumulates new data for enriching scientific connotation of “liver depression and spleen deficiency” and the pathological mechanism of related diseases, and consequently academically enhances the TCM development.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 3","pages":"Pages 325-330"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60016-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91626910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}