World Science and Technology最新文献

{"title":"Moxibustion on Carbonyl Stress and Expression of p19ARF and p53 mRNA in Livers of D-galactose-Induced Aging Rats","authors":"Ma Xiaopeng ,&nbsp;Mo Wenquan ,&nbsp;Zhao Chen ,&nbsp;Wu Huangan ,&nbsp;Zhou Cili ,&nbsp;Zhang Shujing ,&nbsp;Cui Yunhua ,&nbsp;Tan Linying ,&nbsp;Liu Huirong","doi":"10.1016/S1876-3553(11)60034-3","DOIUrl":"10.1016/S1876-3553(11)60034-3","url":null,"abstract":"<div><p>This study deals with the effect of moxibustion on carbonyl stress and the expression of p19ARF and p53 mRNA in livers of subacute aging rats. The SD rats were randomly divided into four groups: normal group, model group, moxibustion group, and Vit E group. Subacute aging rats were prepared with continuous high-dose intraperitoneal injection of D-galactose (D-gal). The moxibustion group received moxibustion at acupoint <em>Shenshu</em> (BL-23). Protein carbonyl content in livers was determined by biochemical chromatometry; p19ARF and p53 mRNA expressions were detected by fluorescence quantitative PCR. The results showed that compared with the normal group, protein carbonyl content, p19ARF, and p53 mRNA expressions were significantly higher in the model group (<em>P</em> &lt; 0.01). Compared with the model group, protein carbonyl content, p19ARF, and p53 mRNA expressions were significantly lower in the moxibustion group and Vit E group (<em>P</em> &lt; 0.01, <em>P</em> &lt; 0.05). Our findings suggest that moxibustion at acupoint BL-23 reduced the protein carbonyl content, as well as the expression of p19ARF and p53 mRNA in livers of D-galactose-induced aging rats.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 6","pages":"Pages 892-896"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60034-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77299467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to Revealing the Relation between the Processing and Property of Chinese Medicines","authors":"Zhang Cun,&nbsp;Li Li,&nbsp;Xiao Yongqing","doi":"10.1016/S1876-3553(11)60031-8","DOIUrl":"10.1016/S1876-3553(11)60031-8","url":null,"abstract":"<div><p>This article discusses the research approaches to exploring the relation between the therapeutic processes and the features of Chinese medicine. It is generally considered that studying the combination of the functional properties and pharmacological effects is the most significant and convenient way to understand the fundamental theory of traditional Chinese medicine against modern scientific technologies. Therefore, the theory of functional properties of Chinese medicine and their relation to therapeutic processes can be obtained through modern scientific research.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 6","pages":"Pages 876-881"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60031-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85525386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Advancement of Traditional Chinese Medicine Syndromes of Heart Failure","authors":"Yao Kuiwu ,&nbsp;Wang Jie ,&nbsp;Zhang Liangdeng ,&nbsp;Hu Yuanhui ,&nbsp;Wang Shihan","doi":"10.1016/S1876-3553(11)60030-6","DOIUrl":"10.1016/S1876-3553(11)60030-6","url":null,"abstract":"<div><p>Traditional Chinese medicine (TCM) syndromes of heart failure (HF) are considered as the key to realize the integration of disease and syndrome differentiation, as well as the correspondence between recipes and syndromes. The evolution of HF syndromes starts with changing of <em>yin-yang</em> and ends with collapsing of <em>yin-yang</em>. This process depends on five viscera, the center of which is the heart and kidneys. Then we present a hypothesis of <em>yin-yang</em> and five viscera on the evolution of HF syndromes. Standardization of HF syndromes is urgently needed, while methodology sheds light on the establishment and usage of standardization of HF syndromes in future. Objective of HF syndromes may lead to the discovery of the syndromes essence, which relies on case-based TCM evidence via integration of modern science and technology.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 6","pages":"Pages 864-869"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60030-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81828419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Distribution of Traditional Chinese Medicine Syndromes on Cardiovascular Diseases","authors":"Xu Zhaoxia,&nbsp;Wang Yiqin,&nbsp;Liu Guoping,&nbsp;Xu Jin,&nbsp;Li Fufeng,&nbsp;Yan Haixia,&nbsp;Guo Rui,&nbsp;Hao Yiming","doi":"10.1016/S1876-3553(11)60032-X","DOIUrl":"10.1016/S1876-3553(11)60032-X","url":null,"abstract":"<div><p>This study aimed at analyzing the clinical distribution of traditional Chinese medicine (TCM) syndrome on cardiovascular diseases and at providing the basis for clinical diagnosis and treatment. Cases of cardiovascular disorder were collected on the basis of unified scales. Syndrome differentiation criteria were used in the identification of the scales. Then the distribution of TCM syndromes on cardiovascular diseases was analyzed. There were 3021 cases, including 1677 cases (55.51%) of heart-qi deficiency, 603 cases (19.96%) of heart- yang deficiency, 699 cases (23.14%) of heart-yin deficiency, 1121 cases (37.11%) of phlegm accumulation, 1624 cases (53.76%) of blood stagnation, and 2057 cases (68.10%) of the syndrome of mixed deficiency and excess. There were 517 cases (17.11%) with only deficiency syndromes and 447 cases (14.80 %) with only excess syndromes. The syndrome of the <em>zang-fu</em> organ is mostly related to the kidney and the spleen. It is concluded that the common clinical distribution of TCM syndromes on cardiovascular diseases is the syndrome of mixed deficiency and excess, which includes heart-qi deficiency, heart-yang deficiency, and heart-yin deficiency and excess syndromes of phlegm accumulation, blood stagnation, and qi stagnation.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 6","pages":"Pages 888-891"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60032-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76819122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mathematical analysis of Si-Wu-Tang model in TCM","authors":"Liu Ming ,&nbsp;Ma Zengchun ,&nbsp;Liang Qiande ,&nbsp;Wang Yuguang ,&nbsp;Tan Hongling ,&nbsp;Xiao Chengrong ,&nbsp;Xiao Rui ,&nbsp;Zhang Boli ,&nbsp;Gao Yue","doi":"10.1016/S1876-3553(11)60026-4","DOIUrl":"10.1016/S1876-3553(11)60026-4","url":null,"abstract":"<div><p>It is a better way to establish a mathematical model of formulae for finding out therapeutic laws. On the basis of complex system theory, complex network theory and qualitative mathematics, we proposed a combined components evaluation model, a multi-level evaluation model and a targets evaluation model. The comprehensive model was established using multi-source causality theory, which provided a scientific basis for systematically studying formulae.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 5","pages":"Pages 684-690"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60026-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75813310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Same Syndrome Existing in RA and DM through Data Mining","authors":"Guo Hongtao ,&nbsp;Zheng Guang ,&nbsp;He Xiaojuan ,&nbsp;Zhang Chi ,&nbsp;Lu Cheng ,&nbsp;Zha Qinglin ,&nbsp;Jiang Miao ,&nbsp;Lu Aiping","doi":"10.1016/S1876-3553(11)60029-X","DOIUrl":"10.1016/S1876-3553(11)60029-X","url":null,"abstract":"<div><p>It is meaningful to search for the same syndromes existing among different diseases. One important terminology in Chinese medicine is called treating different diseases with the same therapy. In the clinical practice of Chinese medicine, some patients with rheumatoid arthritis and some other patients with diabetes mellitus can be treated with similar therapies. This suggests that there should be something commonly existing in the literature of different diseases unrevealed, i.e., biological networks. It is possible to mine those similar biological networks out. In this paper, we propose an algorithm to retrieve simple and meaningful networks from large data sets of rheumatoid arthritis and diabetes mellitus. We transfer XML type data sets to the structured database of Microsoft® SQL® and visualize them into different graphs by software Cytoscape. The results suggest that Huangqi (Radix Astragali), Guizhi (Ramulus Cinnamomi), Shaoyao (Radix Paeonise Alba), Zhimu (Rhizoma Anemarrhenae), Danggui (Radix Angelicae Sinensis), Chuanxiong (Rhizoma Chuanxiong), Maidong (Tuber Ophiopogonis), Shaoyao (Radix Dioscoreae), and Xuanshen (Radix Scrophulariae) are the commonly used herbal medicines. Huangqi (Radix Astragali) and Danggui (Radix Angelicae Sinensis) are of the core association. Quickening the blood and transforming stasis is the treatment principles for some pattern of rheumatoid arthritis and diabetes mellitus. The network visualized in these figures shows that those pairs of herbs in the two diseases are associated with the central commonly-existing biological networks.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 5","pages":"Pages 818-822"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60029-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79937326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of Xinning tablet on acute myocardial ischemia in anesthesia dogs","authors":"Cai Guangxian ,&nbsp;Wang Yuhong","doi":"10.1016/S1876-3553(11)60027-6","DOIUrl":"10.1016/S1876-3553(11)60027-6","url":null,"abstract":"<div><p>This work aimed to observe the protective effect of Xinning tablets on experimental myocardial ischemia. The canine model of acute myocardial infarction was established by ligating the anterior descending coronary artery of dogs. The ultrasound Doppler method was adopted to determine myocardial blood flow. Heart membrane electrical diagram coup and nitro blue tetrazolium (N-BT) staining were used to calculate the extent of myocardial ischemia and myocardial infarct size. Radioimmunoassay was used to determine plasma ET, TXB₂ and 6-Keto-PGF_1α levels. 30-180 min after administration of Xinning tablets at 1.2 and 0.6 g/kg, the dog myocardial ischemia icon measured from the epicardial electrogram was significantly reduced; the infarct area was decreased according to NBT staining. 30-120 min after the administration, cardiac blood flow was significantly increased in the myocardial ischemia area, the levels of plasma ET and TXB₂ were greatly inhibited, and the 6-Keto-PGF1α content to TXB₂/6-Keto-PGF1α ratio was increased. Taken together, Xinning tablets have significant protective effect on dog acute myocardial ischemia and myocardial infarction, the mechanism of which may be related to ET inhibition, TXA₂ release and increased myocardial blood flow, consequently improving the impaired heart function.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 5","pages":"Pages 752-758"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60027-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81980351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constructing Method of the Functional Network of Activating Blood and Dissolving Stasis","authors":"Wang Yun,&nbsp;Wang Gang,&nbsp;Xiao Bin,&nbsp;Qiao Yanjiang","doi":"10.1016/S1876-3553(11)60024-0","DOIUrl":"10.1016/S1876-3553(11)60024-0","url":null,"abstract":"<div><p>The mechanism of Chinese herbal medicine remains unrevealed because we know little about the interacting targets of its constituents. Taking the function of “Activating Blood and Dissolving Stasis” (ABDS) as an example, a method to construct a functional network is proposed, and the functional network of ABDS is established. The results indicate that this method can not only establish a theoretical basis for explaining the mechanism of Chinese herbal medicine, but also provide new clues for the clinical treatment of complex diseases and drug development. This method may serve as a practical solution to functional network construction.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 5","pages":"Pages 764-767"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60024-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76416639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Basis of Cold and Heat Pattern of Rheumatoid Arthritis in Traditional Chinese Medicine","authors":"Lu Cheng ,&nbsp;Liu Yuanyan ,&nbsp;Xiao Cheng ,&nbsp;Jiang Miao ,&nbsp;Zha Qinglin ,&nbsp;Lu Aiping","doi":"10.1016/S1876-3553(11)60028-8","DOIUrl":"10.1016/S1876-3553(11)60028-8","url":null,"abstract":"<div><p>An integrative mode of the disease classification in Western medicine and the syndrome differentiation in Chinese medicine is already the chief mode of sorting applied in clinical practice of Chinese medicine and integrative medicine. In this study, the cold and heat pattern of rheumatoid arthritis were comparatively analyzed. A range of facts, including the correlation of syndrome differentiations and therapeutic effects, the difference of laboratorial examination and omics expression between cold and heat pattern of RA were reviewed to demonstrate the biological basis of RA syndrome differentiations. It indicates that the better knowledge of the biological basis involved in syndrome differentiations of Chinese medicine might help to choose the most appropriate treatment.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 5","pages":"Pages 814-817"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60028-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82016324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Tangshenping Capsule on the Renal Protection and Expressions of TGF-β1 and mRNA in Streptozotocin induced Diabetic Nephropathy Rats","authors":"Zhao Zongjiang,&nbsp;Dou Xiaoni,&nbsp;Zhang Xinxue,&nbsp;Zhang Xuekai,&nbsp;Yang Meijuan","doi":"10.1016/S1876-3553(11)60025-2","DOIUrl":"10.1016/S1876-3553(11)60025-2","url":null,"abstract":"<div><p>This work aimed to observe the effects of “Tangshenping Capsule” on the renal protection and expressions of TGF-β₁ protein and mRNA in streptozotocin-induced diabetic nephropathy (DN) rats. 50 SD rats were randomly divided into the normal control group (<em>n</em>=10) and the model group (<em>n</em>= 40). 55 mg/kg one-time intraperitoneal injection of streptozotocin was used to induce diabetes model rats. 72 hours after injection, rats with blood glucose higher than 16.7 mmol/L and urinary glucose higher than 4+, were selected as diabetes rats. Then those modeling success rats were re-randomized into the model group, the irbesartan group and the Tangshenping capsule group. Body weight was weighed every week, 24 h divla cage urine was collected at week 4, 8 and 12 after streptozotocin injection, and 24 h urine protein was detected. All rats were sacrificed after 12 weeks treatment. Blood urea nitrogen (BUN), serum creatinine (Scr), and triglyceride (TG) were detected in blood serum. Pathological changes of renal tissue were observed by Mallory staining, TGF-β₁ protein and mRNA expression of the renal tissue were detected by immunohistochemistry and <em>in situ</em> hybridization. Rats of the model groups had different levels of feeding and sleeplessness, slow activity, weight loss, 24 h urinary protein increase, and abnormal blood biochemical indicators, while the rats from the irbesartan and the Tangshenping capsule group were all improved in different degrees in the above aspects, and the Tangshenping capsule group was superior to the irbesartan group; the model group showed obvious DN pathological renal changes; in the normal group and the treatment groups, renal tubular epithelial cells and interstitial cells had mild TGF-β₁ and mRNA expression, while there was strong expression in the model group. The TGF-β₁ and mRNA expression in the Tangshenping capsule group was significantly reduced (<em>P</em> &lt;0.05) compared to the model group. Therefore “Tangshenping capsule” may prevent DN via regulating TGF-β₁ and mRNA balance.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 5","pages":"Pages 759-763"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60025-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73323385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}