World Science and Technology最新文献

{"title":"Empirical Study of Changes of Pre-Menstrual Syndrome Model Rats with Liver-qi Invasion and Liver-qi Depression in Peripheral Blood, Sexual Hormones, Different Encephalic Regions and Accommodate Hormones","authors":"Zhang Huiyun,&nbsp;Wei Sheng,&nbsp;Sun Peng,&nbsp;Xue Ling,&nbsp;Qiao Mingqi","doi":"10.1016/S1876-3553(11)60005-7","DOIUrl":"10.1016/S1876-3553(11)60005-7","url":null,"abstract":"<div><p>This work successfully used model rats with Pre-Menstrual Syndrome (PMS) liver-qi invasion and liver-qi depression in the early development days to detect the content levels of estradiol (E2), progesterone (P) and prolactin (PRL) in their blood serums and different encephalic regions, to explore the micro-mechanism of the syndrome of the liver failing to maintain the normal flow of qi. 40 rats with estrous cycles not in accepting time were selected and divided randomly into five groups: the normal control group, PMS liver-qi invasion model group, PMS liver-qi depression model group, PMS liver-qi invasion medication-administered group and PMS liver-qi depression medication-administered group. Emotional stimulation and multiple factors combination were used to prepare the PMS liver-qi invasion model. Chronic stress constraints were used to prepare the PMS liver-qi depression model. Jingqianping granules were administered to rats to interfere with the PMS liver-qi invasion mode, and Jingqianshu granules were administered to rats to interfere with the PMS liver-qi depression mode. Radioimmunity was used to determine the content levels of E2, P and PRL in the blood serum and centrum, and to compare and analyze the differences among the five groups. In the open-field experiment, the crossing scores, rearing scores and open-field experiment total scores of rats in the PMS liver-qi invasion model group increased remarkably (<em>P</em> &lt; 0.05) compared with the scores of the normal control group, while the scores of the PMS liver-qi depression model group decreased remarkably (<em>P</em> &lt; 0.05). The tendency was retrieved remarkably after medications (<em>P</em> &lt; 0.05). The content levels of E2 and P in the blood serum of the PMS liver-qi invasion model group tended to decrease compared with rats in the normal control group. The content levels of E2 and P in the blood serum of rats in the PMS liver-qi depression model group decreased remarkably. The changes of hormones in centrum were opposite to the blood serum. Taken togeterh, the occurrence of PMS may be related with the abnormal fluctuations of sexual hormones and accommodated hormones. Jingqianping and Jingqianshu granules can accommodate these abnormal fluctuations in blood serum and centrum, respectively.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 1","pages":"Pages 51-56"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60005-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81829299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Chromatographic and Chemometric Methods for Quality Standardisation of Chinese Herbal Medicines","authors":"Valentina Razmovski-Naumovski ,&nbsp;Wannit Tongkao-on ,&nbsp;Benjamin Kimble ,&nbsp;Vincent L. Qiao ,&nbsp;Lin Beilun ,&nbsp;Kong M. Li ,&nbsp;Basil Roufogalis ,&nbsp;Yang Depo ,&nbsp;Yao Meicun ,&nbsp;George Q. Li","doi":"10.1016/S1876-3553(11)60003-3","DOIUrl":"10.1016/S1876-3553(11)60003-3","url":null,"abstract":"<div><p>Quality standardisation of complementary medicine is fundamental for industry and practice as it strengthens their quality, safety and efficacy. Current herbal standardisations are often based on the quantitative analysis of a single compound, which may not reflect the total characteristic, bioactive and toxic nature of the herbs or products. Therefore, there is a need to establish internationally recognised methodology for quality standardisation of Chinese herbal medicines. The analytical methods reviewed in this article are pharmacognosy, TLC, HPLC, LCMS, CE and chemometrics. This article covers their developments and applications in quality standardisation. Recent advances show that a combination of these methods can create an overall chemical profile for each herb. This is supported by results reviewed in this article and obtained in our laboratories on medicinal herbs including <em>Hypericum perforatum, Morinda officinalis</em> and <em>Centella asiatica</em>. Significant variations in active ingredients have been observed between herbal samples and products. It is proposed that the identification of active ingredients, pharmacological activities and eventual clinical applications are required for a comprehensive quality standardisation system. The findings of this article indicate that the combination of various chromatographic and chemometric methods could advance the methodology of quality standardisation and enhance the overall confidence in herbal medicine for the health practitioner and the public.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 1","pages":"Pages 99-106"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60003-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89154981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Engineering Study and Analysis of the Factors Affecting Evaporation Rate Under the Vacuum Drying Process","authors":"Shen Pingniang,&nbsp;Liu Zhiyuan,&nbsp;Huang Kaizhong,&nbsp;Xiao Qiong","doi":"10.1016/S1876-3553(11)60007-0","DOIUrl":"10.1016/S1876-3553(11)60007-0","url":null,"abstract":"<div><p>As a drying process is an essential key process for pharmaceutical processing of traditional Chinese medicine, a systematic study of processing and engineering technology was carried out. Based on the fundamental research on factors affecting the water evaporation rate of the vacuum drying process, the laws of the vacuum drying process were explored, and basic technical support was provided to the vacuum drying process research and facilities development. According to the characteristics of different stages of the process, appropriate technical measures were taken to provide a foundation for achieving a continuous process of vacuum drying.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 1","pages":"Pages 118-121"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60007-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77739894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Antihypertensive Effect on Essential Hypertension From Acupuncture by Ambulatory Blood Pressure Monitoring","authors":"Shen Pengfei,&nbsp;Shi Xuemin","doi":"10.1016/S1876-3553(11)60001-X","DOIUrl":"10.1016/S1876-3553(11)60001-X","url":null,"abstract":"<div><p>The purpose of this study was to evaluate the antihypertensive effect of acupuncture on patients with mild to moderate essential hypertension by 24-hour ambulatory blood pressure monitoring (ABPM). Fifty patients with mild to moderate essential hypertension were treated with 80 mg telmisartan once a day for four weeks. The 24-hour ABPM was performed before and after the treatment and the trough/peakratio and smoothness index were calculated. The mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) reduced significantly (<em>P</em> &lt; 0.05) in 24-hour period, day-time period and night-time period. The blood pressure loads of SBP and DBP also decreased significantly (<em>P</em> &lt; 0.05). The trough/peak ratio of SBP and DBP was 76% and 72%, respectively. The Smoothness index of SBP and DBP was 1.34±0.13 and 1.16±0.22, respectively. The results showed that compound telmisartan was an effective and safe antihypertensive drug with satisfactory trough/peak ratio and smoothness index.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 1","pages":"Pages 44-46"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60001-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86046333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research and Development of QingNao Capsules of TCM Using the SFE Technique","authors":"Hou Jinjun,&nbsp;Yao Shuai,&nbsp;Hu Haitao,&nbsp;Da Juan,&nbsp;Long Huali,&nbsp;Yang Zhou,&nbsp;Cai Luying,&nbsp;Wu Wanying,&nbsp;Guo De'an","doi":"10.1016/S1876-3553(11)60002-1","DOIUrl":"10.1016/S1876-3553(11)60002-1","url":null,"abstract":"<div><p>Supercritical Fluid Extraction (SFE) technology has been used in Traditional Chinese Medicine (TCM), but some disadvantages still remain in the research and development of new drugs of TCM, especially when the drug is comprised of several plants. Through reviewing the R&amp;D process of QinNao Capsules, the impacts on process and potential problems which may be caused in new drug R&amp;D by SFE are discussed. Possible scenarios are proposed.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 1","pages":"Pages 89-93"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60002-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77896720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Function of the Diaphoretic Recipe and Toll-like Receptor","authors":"Jiang Tingliang ,&nbsp;Zhao Baosheng ,&nbsp;Du Xinliang ,&nbsp;Zhang Changbin ,&nbsp;Sui Feng ,&nbsp;Li Lanfang ,&nbsp;Zhang Hongwei","doi":"10.1016/S1876-3553(11)60004-5","DOIUrl":"10.1016/S1876-3553(11)60004-5","url":null,"abstract":"<div><p>In this research, molecules with similar structures to those of viral or bacterial components or the sera from patients with distinct syndromes of upper respiratory tract infections were used as stimulants. Through the intervening treatments by the sera containing exterior-relieving or heat-clearing recipes on RAW264.7 cells, the responses of the Toll-like receptor (TLR), its intracellular signal pathway adaptor proteins and the corresponding induced products were observed. Based on the above research, the medicative categorization basis of different recipes was further studied. The current results showed that the diaphoretic recipes and heat-clearing recipes selectively affected different subtypes of the TLR family. This indicated that the TLR system, which could recognize the pathogen-associated molecular patterns, initiate innate immunity and regulate adaptive immunity, may contribute to the biological basis of the function classifications of the diaphoretic recipes and heat-clearing recipes. Moreover, the results, that is, the abnormal expression of TLR induced by the serum from the patients with Guizhi-decoction syndrome could only be completely reversed by the serum containing Guizhi decoction, might support the concept of interrelationship between syndrome and prescription (“prescription-syndrome correspondence”) in traditional Chinese medicine.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 1","pages":"Pages 115-117"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60004-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78957788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Theories and Methods of Systems Science to the Study of the Complexity of Traditional Chinese Medicine","authors":"Yan Guangle ,&nbsp;Zhang Lei ,&nbsp;Su Shibing","doi":"10.1016/S1876-3553(11)60006-9","DOIUrl":"10.1016/S1876-3553(11)60006-9","url":null,"abstract":"<div><p>The complexity of Traditional Chinese Medicine has been explored from different aspects with the theories and methods of systems science. In this paper, the principle of system science and the complicated characteristics of Traditional Chinese Medicine are introduced first. Then, the current research status is reviewed. Finally, the research approaches and the future developmental trend are predicted at three levels of systems science, including the fundamental theory level, the technical science level and the engineering technology level.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"12 1","pages":"Pages 15-19"},"PeriodicalIF":0.0,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(11)60006-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85126805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel GC-MS Bioanalytical Method for Natural Borneol and Its Application in Investigating Natural Borneol Distribution in Mice","authors":"Huang Ping ,&nbsp;Jiang Xiaofei ,&nbsp;Zou Jiali ,&nbsp;Yuan Yuemei ,&nbsp;Yao Meicun ,&nbsp;Lu Yasong","doi":"10.1016/S1876-3553(10)60038-5","DOIUrl":"https://doi.org/10.1016/S1876-3553(10)60038-5","url":null,"abstract":"<div><h3>Abstract</h3><p>One of the major goals of our group is to understand the meridian tropism of natural borneol (NB). As a first step, this study served two purposes: to develop a GC-MS bioanalytical method for NB, and with the aid of this method to investigate NB distribution in mice. Mouse tissue samples, spiked with naphthalene as internal standard, were homogenated with NS and extracted using hexane. The extract supernatant was analyzed in GC-MS with conditions of DB-5MS capillary column (0.25mm×30m×0.25μm), electron impact (EI) ionization with energy of 70 eV and multiplier voltage of 1100 V, and Selected Ion Monitor (SIM, m/z 95 for camphor and NB, whereas m/z 128 for naphthalene) detection mode. The calibration curve was linear in the range from 22 ng/mL to 22 μg/mL with a regression equation Y= 0.000486X + 0.00036, R²=0.999 (n=3). The limit of detection was 10 ng/mL. The lower limit of quantitation was 22 ng/mL. The within-day and inter-day precisions were 3.72∼6.11% and 7.29∼17.6%, respectively. The relative recovery was 85.95∼107.93% and extraction recovery was 93.04∼103.03%. This bioanalytical method has sufficient recovery and is accurate and reliable for quantitating NB in tissues. The tissue distribution up to 150 min after a single oral dose of NB was investigated in mice. This compound was detected in most tissues. The liver had the highest concentration, followed by kidney, heart, brain, and others. Tissue concentration-time curves had double or triple peaks. The tissue distribution pattern suggested that NB may attribute to the cardio-system.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"11 6","pages":"Pages 821-827"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(10)60038-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72283034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies on the “Xiehuo” Effect and Compositions of Guangdong Herbal Tea","authors":"He Rongrong, Yao Xinsheng, Kurihara Hiroshi","doi":"10.1016/S1876-3553(10)60039-7","DOIUrl":"https://doi.org/10.1016/S1876-3553(10)60039-7","url":null,"abstract":"","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"48 1","pages":"834-839"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77114115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies on the “Xiehuo” Effect and Compositions of Guangdong Herbal Tea","authors":"He Rongrong ,&nbsp;Yao Xinsheng ,&nbsp;Kurihara Hiroshi","doi":"10.1016/S1876-3553(10)60039-7","DOIUrl":"https://doi.org/10.1016/S1876-3553(10)60039-7","url":null,"abstract":"<div><h3>Abstract</h3><p>In recent years, people are concerned about the “xiehuo” effect of Guangdong Herbal Tea (GHT). Study results found that GHT not only elevated the decreased levels of neurotransmitters and reduced immunocompetence in restraint stressed mice, but also prevented stressed mice against liver injury and inflammation. We also noticed that GHT accelerated the utilization of sugar energy and improved the capability of lipid tolerance in stressed mice. These results indicated that the effect of GHT on “xiehuo” may be related to its anti-stress effects. The results of mechanism study showed that GHT had the effects of anti-stress by regulating RNS and ROS generation in cells of restrained mice, at the same time regulating the activities and gene expressions of the key enzymes in the free radical chain reaction. Therefore, the anti-stress mechanism of GHT was related, at least partly, to the protection effect against oxidative stress in stress-loaded organisms. The main compounds of GHT identified were Gallic acid, Protocatechuic acid, (+)-Catechin, 4-Hydroxybenzoic acid, Caffeic acid, Ellagic acid-4-O-xylopyranoside, Isoquercitrin, and Ellagic acid. Results showed that most of these compounds are the active ingredients that are responsible for the “xiehuo” effect of GHT.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"11 6","pages":"Pages 834-839"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(10)60039-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72283035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}